(8 nodes) Methionine metabolic process, and One-carbon metabolism network (Nonlabens marinus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Predicted Interactions

gene neighborhood

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Your Input:
	NMS_0387	5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (317 aa)
	NMS_0388	5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1033 aa)
	NMS_0389	5-methyltetrahydrofolate--homocysteine methyltransferase. (341 aa)
	NMS_0394	Aspartokinase. (363 aa)
	NMS_0395	Aspartokinase. (334 aa)
	NMS_0396	O-acetylhomoserine sulfhydrylase. (430 aa)
	metK	S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (455 aa)
	ahcY	Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (438 aa)

Your Current Organism:

Nonlabens marinus

NCBI taxonomy Id: 1454201
Other names: Flavobacteria bacterium S1-08, N. marinus S1-08, Nonlabens marinus S1-08

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NMS_0387	NMS_0388	NMS_0387	NMS_0388	5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.995
NMS_0387	NMS_0389	NMS_0387	NMS_0389	5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	5-methyltetrahydrofolate--homocysteine methyltransferase.	0.997
NMS_0387	NMS_0394	NMS_0387	NMS_0394	5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	Aspartokinase.	0.589
NMS_0387	NMS_0395	NMS_0387	NMS_0395	5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	Aspartokinase.	0.965
NMS_0387	NMS_0396	NMS_0387	NMS_0396	5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	O-acetylhomoserine sulfhydrylase.	0.491
NMS_0387	ahcY	NMS_0387	NMS_0681	5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.	0.617
NMS_0387	metK	NMS_0387	NMS_0398	5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.	0.834
NMS_0388	NMS_0387	NMS_0388	NMS_0387	5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.995
NMS_0388	NMS_0389	NMS_0388	NMS_0389	5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	5-methyltetrahydrofolate--homocysteine methyltransferase.	0.999
NMS_0388	NMS_0394	NMS_0388	NMS_0394	5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Aspartokinase.	0.911
NMS_0388	NMS_0395	NMS_0388	NMS_0395	5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Aspartokinase.	0.983
NMS_0388	NMS_0396	NMS_0388	NMS_0396	5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	O-acetylhomoserine sulfhydrylase.	0.913
NMS_0388	ahcY	NMS_0388	NMS_0681	5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.	0.925
NMS_0388	metK	NMS_0388	NMS_0398	5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.	0.924
NMS_0389	NMS_0387	NMS_0389	NMS_0387	5-methyltetrahydrofolate--homocysteine methyltransferase.	5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.997
NMS_0389	NMS_0388	NMS_0389	NMS_0388	5-methyltetrahydrofolate--homocysteine methyltransferase.	5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.999
NMS_0389	NMS_0394	NMS_0389	NMS_0394	5-methyltetrahydrofolate--homocysteine methyltransferase.	Aspartokinase.	0.911
NMS_0389	NMS_0395	NMS_0389	NMS_0395	5-methyltetrahydrofolate--homocysteine methyltransferase.	Aspartokinase.	0.986
NMS_0389	NMS_0396	NMS_0389	NMS_0396	5-methyltetrahydrofolate--homocysteine methyltransferase.	O-acetylhomoserine sulfhydrylase.	0.954
NMS_0389	ahcY	NMS_0389	NMS_0681	5-methyltetrahydrofolate--homocysteine methyltransferase.	Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.	0.926