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apt apt NMS_0115 NMS_0115 carA carA pyrE pyrE NMS_0260 NMS_0260 NMS_0430 NMS_0430 NMS_0431 NMS_0431 NMS_0437 NMS_0437 NMS_0444 NMS_0444 thyA thyA purN purN NMS_0595 NMS_0595 NMS_0596 NMS_0596 NMS_0608 NMS_0608 gmk gmk NMS_0644 NMS_0644 dut dut tdk tdk NMS_0794 NMS_0794 NMS_0822 NMS_0822 purD purD NMS_0917 NMS_0917 tadA tadA dxs dxs NMS_1098 NMS_1098 NMS_1146 NMS_1146 NMS_1269 NMS_1269 NMS_1277 NMS_1277 NMS_1344 NMS_1344 purH purH surE surE NMS_1449 NMS_1449 purK purK NMS_1485 NMS_1485 queE queE folE folE NMS_1547 NMS_1547 pyrD pyrD guaB guaB NMS_1803 NMS_1803 NMS_1807 NMS_1807 NMS_1861 NMS_1861 NMS_1867 NMS_1867 NMS_1868 NMS_1868 NMS_1901 NMS_1901 ribH ribH purE purE purA purA NMS_2254 NMS_2254 ndk ndk purC purC purL purL NMS_2481 NMS_2481 folE-2 folE-2 NMS_2506 NMS_2506 NMS_2570 NMS_2570 pyrB pyrB NMS_2578 NMS_2578 ribB ribB pyrG pyrG guaA guaA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (173 aa)
NMS_0115Phosphoribosyltransferase. (162 aa)
carACarbamoyl-phosphate synthase small chain; Belongs to the CarA family. (372 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (201 aa)
NMS_0260Biotin-protein ligase. (238 aa)
NMS_0430Ribonucleotide reductase of class Ia (aerobic), beta subunit. (424 aa)
NMS_0431Ribonucleotide reductase of class Ia (aerobic), alpha subunit. (594 aa)
NMS_0437dCMP deaminase. (161 aa)
NMS_0444Riboflavin kinase; Belongs to the ribF family. (309 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (274 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (187 aa)
NMS_0595Ribokinase. (306 aa)
NMS_0596Amidophosphoribosyltransferase. (632 aa)
NMS_0608Queuosine biosynthesis QueD, PTPS-I. (150 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (199 aa)
NMS_06442-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. (349 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (144 aa)
tdkThymidine kinase. (212 aa)
NMS_0794Riboflavin synthase eubacterial/eukaryotic. (194 aa)
NMS_0822Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (108 aa)
purDPhosphoribosylamine--glycine ligase; Belongs to the GARS family. (423 aa)
NMS_0917Hypothetical protein. (186 aa)
tadAtRNA-specific adenosine-34 deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (149 aa)
dxs1-deoxy-D-xylulose 5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (588 aa)
NMS_1098Dihydrofolate reductase. (308 aa)
NMS_1146Dihydroorotase. (446 aa)
NMS_1269Hydrolase. (274 aa)
NMS_1277Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (272 aa)
NMS_1344Dihydrofolate synthase. (390 aa)
purHIMP cyclohydrolase. (515 aa)
surE5-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (260 aa)
NMS_1449Cytidine deaminase. (134 aa)
purKPhosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (380 aa)
NMS_14856-pyruvoyl tetrahydrobiopterin synthase. (120 aa)
queEQueuosine Biosynthesis QueE Radical SAM; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (209 aa)
folEGTP cyclohydrolase I. (223 aa)
NMS_1547Dihydropteroate synthase. (258 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (368 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (491 aa)
NMS_1803Orotidine 5'-phosphate decarboxylase. (271 aa)
NMS_1807Phosphoribosylformylglycinamidine cyclo-ligase. (392 aa)
NMS_1861Diaminohydroxyphosphoribosylaminopyrimidine deaminase. (317 aa)
NMS_18675'-nucleotidase; Belongs to the 5'-nucleotidase family. (309 aa)
NMS_18685'-nucleotidase. (261 aa)
NMS_1901Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (444 aa)
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (172 aa)
purEPhosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (163 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (423 aa)
NMS_2254Purine nucleoside phosphorylase. (292 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (139 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (318 aa)
purLPhosphoribosylformylglycinamidine synthase, synthetase subunit; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1229 aa)
NMS_2481Uridine kinase. (202 aa)
folE-2GTP cyclohydrolase I. (198 aa)
NMS_2506Dihydroorotase. (419 aa)
NMS_2570Carbamoyl-phosphate synthase large chain. (950 aa)
pyrBAspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (312 aa)
NMS_2578Uracil phosphoribosyltransferase. (182 aa)
ribB3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (381 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (550 aa)
guaAGMP synthase; Catalyzes the synthesis of GMP from XMP. (509 aa)
Your Current Organism:
Nonlabens marinus
NCBI taxonomy Id: 1454201
Other names: Flavobacteria bacterium S1-08, N. marinus S1-08, Nonlabens marinus S1-08
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