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| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (431 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (414 aa) |
| | hisB | Histidinol-phosphatase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. (369 aa) |
| | hisH | Imidazole glycerol phosphate synthase amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (210 aa) |
| | hisA | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (256 aa) |
| | hisF | Imidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (268 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; In the N-terminal section; belongs to the PRA-CH family. (206 aa) |
| | NMS_0298 | Hypothetical protein. (108 aa) |
| | NMS_0301 | Phenylalanine-4-hydroxylase. (550 aa) |
| | NMS_0350 | Biosynthetic arginine decarboxylase. (463 aa) |
| | NMS_0351 | Agmatinase; Belongs to the arginase family. (312 aa) |
| | NMS_0366 | 5-Enolpyruvylshikimate-3-phosphate synthase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (414 aa) |
| | dtd | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (148 aa) |
| | NMS_0374 | 2-keto-3-deoxy-D-arabino-heptulosonate-7- phosphate synthase I beta. (360 aa) |
| | NMS_0375 | Prephenate and/or arogenate dehydrogenase. (286 aa) |
| | NMS_0376 | Biosynthetic Aromatic amino acid aminotransferase alpha. (387 aa) |
| | NMS_0377 | Prephenate dehydratase. (270 aa) |
| | NMS_0387 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (317 aa) |
| | NMS_0388 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1033 aa) |
| | NMS_0389 | 5-methyltetrahydrofolate--homocysteine methyltransferase. (341 aa) |
| | NMS_0394 | Aspartokinase. (363 aa) |
| | NMS_0395 | Aspartokinase. (334 aa) |
| | NMS_0396 | O-acetylhomoserine sulfhydrylase. (430 aa) |
| | NMS_0408 | Radical SAM. (357 aa) |
| | NMS_0446 | seryl-tRNA synthetase. (423 aa) |
| | NMS_0458 | Aspartokinase; Belongs to the aspartokinase family. (428 aa) |
| | ileS | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1136 aa) |
| | NMS_0498 | Pyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (326 aa) |
| | asnS | asparaginyl-tRNA synthetase. (482 aa) |
| | NMS_0534 | L-asparaginase. (357 aa) |
| | NMS_0553 | Homogentisate 1,2-dioxygenase. (387 aa) |
| | NMS_0555 | 4-hydroxyphenylpyruvate dioxygenase. (387 aa) |
| | NMS_0557 | Tryptophan 2,3-dioxygenase. (322 aa) |
| | pgi | Glucose-6-phosphate isomerase; Belongs to the GPI family. (545 aa) |
| | NMS_0569 | NADP-specific glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (447 aa) |
| | NMS_0571 | Cystathionine gamma-lyase. (380 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (78 aa) |
| | NMS_0589 | 3-oxoacyl-[acyl-carrier-protein] synthase, KASII; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (415 aa) |
| | NMS_0592 | Pyruvate kinase; Belongs to the pyruvate kinase family. (477 aa) |
| | NMS_0596 | Amidophosphoribosyltransferase. (632 aa) |
| | NMS_0610 | Hypothetical protein. (259 aa) |
| | NMS_0622 | Aldehyde dehydrogenase B; Belongs to the aldehyde dehydrogenase family. (517 aa) |
| | NMS_0666 | leucyl-tRNA synthetase. (961 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (364 aa) |
| | NMS_0703 | 3-oxoacyl-[acyl-carrier-protein] synthase, KASII; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (376 aa) |
| | NMS_0704 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (426 aa) |
| | bioD | Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (205 aa) |
| | glmS | Glucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (615 aa) |
| | panC | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (293 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (116 aa) |
| | pheS | phenylalanyl-tRNA synthetase alpha chain; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (339 aa) |
| | NMS_0738 | acyl-CoA hydrolase. (169 aa) |
| | NMS_0756 | tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (322 aa) |
| | NMS_0781 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (368 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (331 aa) |
| | NMS_0787 | Biotin carboxylase of acetyl-CoA carboxylase. (387 aa) |
| | NMS_0789 | Biotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (161 aa) |
| | fabH | 3-oxoacyl-[acyl-carrier-protein] synthase, KASIII; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (331 aa) |
| | NMS_0797 | Beta-lactamase-like. (285 aa) |
| | NMS_0806 | Lactoylglutathione lyase and related lyases. (135 aa) |
| | NMS_0822 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (108 aa) |
| | NMS_0823 | glutaminyl-tRNA synthetase. (561 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (504 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (394 aa) |
| | NMS_0865 | N-acetyl-L,L-diaminopimelate deacetylase. (425 aa) |
| | glyQS | glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. (551 aa) |
| | NMS_0888 | Succinylglutamate desuccinylase. (325 aa) |
| | NMS_0935 | Cysteine desulfurase; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. (404 aa) |
| | NMS_0939 | AttM/AiiB family protein. (298 aa) |
| | metG | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (695 aa) |
| | NMS_0975 | Fatty acid desaturase occurring in virulence cluster. (333 aa) |
| | NMS_0979 | enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (255 aa) |
| | NMS_0995 | Hypothetical protein. (291 aa) |
| | NMS_1069 | xaa-Pro dipeptidase family enzyme. (427 aa) |
| | aspS | aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (583 aa) |
| | NMS_1093 | Dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (444 aa) |
| | NMS_1097 | Malonyl CoA-acyl carrier protein transacylase. (296 aa) |
| | NMS_1098 | Dihydrofolate reductase. (308 aa) |
| | NMS_1099 | Cysteine desulfurase. (362 aa) |
| | NMS_1130 | NADP-dependent malic enzyme. (770 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa) |
| | tyrS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (432 aa) |
| | NMS_1158 | Succinate-semialdehyde dehydrogenase. (461 aa) |
| | NMS_1160 | Phosphoenolpyruvate synthase. (965 aa) |
| | NMS_1165 | N-formylkynurenine (Aryl-) formamidase. (247 aa) |
| | NMS_1189 | Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. (462 aa) |
| | accD | Acetyl-coenzyme A carboxyl transferase beta chain; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. (286 aa) |
| | NMS_1302 | Fructose-bisphosphate aldolase class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (355 aa) |
| | NMS_1313 | Delta-1-pyrroline-5-carboxylate dehydrogenase. (542 aa) |
| | gpmI | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (504 aa) |
| | kmo | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid; Belongs to the aromatic-ring hydroxylase family. KMO subfamily. (464 aa) |
| | kynU | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (420 aa) |
| | NMS_1349 | Glu/Leu/Phe/Val dehydrogenase family protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (408 aa) |
| | NMS_1350 | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (340 aa) |
| | NMS_1371 | Formiminoglutamase; Belongs to the arginase family. (386 aa) |
| | NMS_1391 | Asparagine synthetase. (620 aa) |
| | pdhA | Pyruvate dehydrogenase E1 component alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (332 aa) |
| | NMS_1451 | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (564 aa) |
| | NMS_1461 | Cystathionine beta-synthase. (329 aa) |
| | fabH-2 | 3-oxoacyl-[acyl-carrier-protein] synthase, KASIII; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (336 aa) |
| | NMS_1498 | Dihydrolipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex. (451 aa) |
| | NMS_1511 | Exoenzymes regulatory protein AepA precursor. (544 aa) |
| | mdh | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (306 aa) |
| | cysS | cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (495 aa) |
| | proS | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (492 aa) |
| | NMS_1551 | Protein secretion chaperonin CsaA. (113 aa) |
| | NMS_1555 | Leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (367 aa) |
| | NMS_1580 | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (271 aa) |
| | NMS_1589 | Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (424 aa) |
| | NMS_1602 | Aldo-keto reductase family 1 member B10. (315 aa) |
| | aroQ | 3-dehydroquinate dehydratase II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (144 aa) |
| | NMS_1611 | hydroxymethylglutaryl-CoA lyase. (295 aa) |
| | NMS_1615 | phenylacetate-CoA oxygenase, PaaG subunit. (320 aa) |
| | NMS_1616 | phenylacetate-CoA oxygenase, PaaH subunit. (62 aa) |
| | NMS_1617 | phenylacetate-CoA oxygenase, PaaI subunit. (273 aa) |
| | NMS_1619 | enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (259 aa) |
| | NMS_1622 | 3-hydroxybutyryl-CoA dehydrogenase. (404 aa) |
| | NMS_1625 | 3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (404 aa) |
| | lysS | lysyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (563 aa) |
| | NMS_1640 | methylglutaconyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (250 aa) |
| | NMS_1644 | Dihydrolipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex. (456 aa) |
| | NMS_1645 | Branched-chain alpha-keto acid dehydrogenase, E1 component, alpha subunit. (692 aa) |
| | NMS_1651 | Hypothetical protein. (51 aa) |
| | NMS_1654 | 1-aminocyclopropane-1-carboxylate deaminase. (314 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (250 aa) |
| | NMS_1695 | Fumarylacetoacetate hydrolase family protein. (204 aa) |
| | NMS_1743 | Hexapeptide transferase family protein. (128 aa) |
| | thrS | threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). (648 aa) |
| | NMS_1800 | methylcrotonyl-CoA carboxylase carboxyl transferase subunit. (542 aa) |
| | NMS_1802 | O-acetylhomoserine sulfhydrylase. (401 aa) |
| | NMS_1862 | Uncharacterized acetyltransferase YjgM. (161 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (272 aa) |
| | NMS_2545 | Branched-chain amino acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (353 aa) |
| | NMS_2524 | L-allo-threonine aldolase. (337 aa) |
| | NMS_2520 | Cystathionine beta-synthase. (346 aa) |
| | NMS_2518 | 2-amino-3-ketobutyrate coenzyme A ligase. (418 aa) |
| | NMS_2510 | Metal-dependent hydrolases of the beta-lactamase superfamily I. (257 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (353 aa) |
| | hisS | histidyl-tRNA synthetase. (459 aa) |
| | NMS_2462 | Aminodeoxychorismate lyase. (278 aa) |
| | NMS_2446 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (457 aa) |
| | NMS_2426 | Acyl carrier protein phosphodiesterase. (197 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (243 aa) |
| | NMS_2391 | long-chain-fatty-acid--CoA ligase. (630 aa) |
| | NMS_2366 | Putative periplasmic ATP/GTP-binding protein. (273 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (283 aa) |
| | fumC | Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (464 aa) |
| | NMS_2317 | Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (853 aa) |
| | NMS_2316 | Hypothetical protein. (82 aa) |
| | NMS_2315 | 3-oxoacyl-[acyl-carrier-protein] synthase, KASI; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (428 aa) |
| | NMS_2314 | (3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase. (153 aa) |
| | NMS_2308 | Branched-chain alpha-keto acid dehydrogenase, E1 component, alpha subunit. (659 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (399 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (275 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (266 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (366 aa) |
| | NMS_2245 | Hypothetical protein. (672 aa) |
| | fabZ | N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the thioester dehydratase family. FabZ subfamily. (466 aa) |
| | NMS_2230 | Alanine dehydrogenase. (399 aa) |
| | NMS_2228 | Carbapenem antibiotics biosynthesis protein carD. (389 aa) |
| | NMS_2226 | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (357 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (410 aa) |
| | NMS_2206 | Hypothetical protein. (614 aa) |
| | NMS_2196 | Shikimate 5-dehydrogenase I alpha. (264 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (327 aa) |
| | NMS_2167 | Secreted enzyme, contains two amidohydrolase related domains. (989 aa) |
| | NMS_2166 | Hypothetical protein. (434 aa) |
| | NMS_2154 | Succinate-semialdehyde dehydrogenase. (452 aa) |
| | NMS_2089 | Ferredoxin-dependent glutamate synthase; Belongs to the glutamate synthase family. (501 aa) |
| | NMS_2072 | Amine oxidase, flavin-containing. (349 aa) |
| | NMS_2025 | 3-hydroxybutyryl-CoA dehydrogenase. (296 aa) |
| | NMS_2016 | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine. (199 aa) |
| | NMS_2010 | xaa-Pro dipeptidase family enzyme. (418 aa) |
| | NMS_2006 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (635 aa) |
| | NMS_1927 | Glycine dehydrogenase; Belongs to the GcvP family. (945 aa) |
| | NMS_1926 | 3-oxoacyl-[acyl-carrier-protein] synthase, KASIII. (352 aa) |
| | pheT | phenylalanyl-tRNA synthetase beta chain; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (827 aa) |
| | NMS_1876 | Enoyl-[acyl-carrier-protein] reductase. (268 aa) |
| | NMS_1873 | Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (402 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (260 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (388 aa) |
| | trpF | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (212 aa) |
| | NMS_0286 | Indole-3-glycerol phosphate synthase. (267 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (330 aa) |
| | NMS_0281 | Asparagine synthetase. (553 aa) |
| | lipA | Lipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (290 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (877 aa) |
| | NMS_0266 | Hypothetical protein. (92 aa) |
| | NMS_0263 | Hypothetical protein. (207 aa) |
| | carA | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (372 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa) |
| | argS | arginyl-tRNA synthetase. (594 aa) |
| | NMS_0176 | Lysine ketoglutarate reductase. (410 aa) |
| | folD | Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (296 aa) |
| | NMS_0138 | D-2-hydroxyglutarate dehydrogenase. (460 aa) |
| | NMS_0137 | Hypothetical protein. (113 aa) |
| | aroK | Shikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (180 aa) |
| | accA | Acetyl-coenzyme A carboxyl transferase alpha chain; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (320 aa) |
| | NMS_0092 | Cysteine synthase B. (292 aa) |
| | NMS_0091 | Serine acetyltransferase. (266 aa) |
| | NMS_0081 | Cysteine desulfurase. (408 aa) |
| | NMS_0051 | Cystathionine gamma-lyase. (384 aa) |
| | NMS_0050 | Metal-dependent hydrolase. (267 aa) |
| | NMS_0049 | Isocitrate dehydrogenase; Belongs to the monomeric-type IDH family. (739 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (873 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (425 aa) |
| | NMS_2789 | Fumarylacetoacetase. (434 aa) |
| | guaA | GMP synthase; Catalyzes the synthesis of GMP from XMP. (509 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (550 aa) |
| | NMS_2760 | Hypothetical protein. (365 aa) |
| | NMS_2746 | UDP-glucose dehydrogenase; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (464 aa) |
| | NMS_2737 | Putative acyl carrier protein. (74 aa) |
| | NMS_2710 | Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (393 aa) |
| | murQ | N-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. (271 aa) |
| | gcvT | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (363 aa) |
| | NMS_2665 | acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa) |
| | NMS_2616 | 3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa) |
| | pyrB | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (312 aa) |
| | NMS_2569 | Acyl CoA thioester hydrolase family protein. (181 aa) |
