(6 nodes) S-methyltransferase activity, and One-carbon metabolic process network (Serpentinomonas raichei)

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Your Input:
	metK	S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (393 aa)
	metE	Methionine synthase II (cobalamin-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (783 aa)
	SRAA_1961	Methionine synthase I, cobalamin-binding domain; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (900 aa)
	SRAA_1969	5,10-methylenetetrahydrofolate reductase; Identified by MetaGeneAnnotator; putative; Belongs to the methylenetetrahydrofolate reductase family. (281 aa)
	ahcY	S-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (478 aa)
	SRAA_2360	Methionine synthase I (cobalamin-dependent), methyltransferase domain; Identified by MetaGeneAnnotator; putative. (350 aa)

Your Current Organism:

Serpentinomonas raichei

NCBI taxonomy Id: 1458425
Other names: Comamonadaceae bacterium A1, Comamonadaceae bacterium H1, S. raichei, strain A1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SRAA_1961	SRAA_1969	SRAA_1961	SRAA_1969	Methionine synthase I, cobalamin-binding domain; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	5,10-methylenetetrahydrofolate reductase; Identified by MetaGeneAnnotator; putative; Belongs to the methylenetetrahydrofolate reductase family.	0.979
SRAA_1961	SRAA_2360	SRAA_1961	SRAA_2360	Methionine synthase I, cobalamin-binding domain; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Methionine synthase I (cobalamin-dependent), methyltransferase domain; Identified by MetaGeneAnnotator; putative.	0.998
SRAA_1961	ahcY	SRAA_1961	SRAA_1970	Methionine synthase I, cobalamin-binding domain; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	S-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.	0.937
SRAA_1961	metE	SRAA_1961	SRAA_1076	Methionine synthase I, cobalamin-binding domain; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Methionine synthase II (cobalamin-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.	0.931
SRAA_1961	metK	SRAA_1961	SRAA_0260	Methionine synthase I, cobalamin-binding domain; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.	0.932
SRAA_1969	SRAA_1961	SRAA_1969	SRAA_1961	5,10-methylenetetrahydrofolate reductase; Identified by MetaGeneAnnotator; putative; Belongs to the methylenetetrahydrofolate reductase family.	Methionine synthase I, cobalamin-binding domain; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.979
SRAA_1969	SRAA_2360	SRAA_1969	SRAA_2360	5,10-methylenetetrahydrofolate reductase; Identified by MetaGeneAnnotator; putative; Belongs to the methylenetetrahydrofolate reductase family.	Methionine synthase I (cobalamin-dependent), methyltransferase domain; Identified by MetaGeneAnnotator; putative.	0.978
SRAA_1969	ahcY	SRAA_1969	SRAA_1970	5,10-methylenetetrahydrofolate reductase; Identified by MetaGeneAnnotator; putative; Belongs to the methylenetetrahydrofolate reductase family.	S-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.	0.884
SRAA_1969	metE	SRAA_1969	SRAA_1076	5,10-methylenetetrahydrofolate reductase; Identified by MetaGeneAnnotator; putative; Belongs to the methylenetetrahydrofolate reductase family.	Methionine synthase II (cobalamin-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.	0.949
SRAA_1969	metK	SRAA_1969	SRAA_0260	5,10-methylenetetrahydrofolate reductase; Identified by MetaGeneAnnotator; putative; Belongs to the methylenetetrahydrofolate reductase family.	S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.	0.762
SRAA_2360	SRAA_1961	SRAA_2360	SRAA_1961	Methionine synthase I (cobalamin-dependent), methyltransferase domain; Identified by MetaGeneAnnotator; putative.	Methionine synthase I, cobalamin-binding domain; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.998
SRAA_2360	SRAA_1969	SRAA_2360	SRAA_1969	Methionine synthase I (cobalamin-dependent), methyltransferase domain; Identified by MetaGeneAnnotator; putative.	5,10-methylenetetrahydrofolate reductase; Identified by MetaGeneAnnotator; putative; Belongs to the methylenetetrahydrofolate reductase family.	0.978
SRAA_2360	ahcY	SRAA_2360	SRAA_1970	Methionine synthase I (cobalamin-dependent), methyltransferase domain; Identified by MetaGeneAnnotator; putative.	S-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.	0.938
SRAA_2360	metE	SRAA_2360	SRAA_1076	Methionine synthase I (cobalamin-dependent), methyltransferase domain; Identified by MetaGeneAnnotator; putative.	Methionine synthase II (cobalamin-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.	0.965
SRAA_2360	metK	SRAA_2360	SRAA_0260	Methionine synthase I (cobalamin-dependent), methyltransferase domain; Identified by MetaGeneAnnotator; putative.	S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.	0.934
ahcY	SRAA_1961	SRAA_1970	SRAA_1961	S-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.	Methionine synthase I, cobalamin-binding domain; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.937
ahcY	SRAA_1969	SRAA_1970	SRAA_1969	S-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.	5,10-methylenetetrahydrofolate reductase; Identified by MetaGeneAnnotator; putative; Belongs to the methylenetetrahydrofolate reductase family.	0.884
ahcY	SRAA_2360	SRAA_1970	SRAA_2360	S-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.	Methionine synthase I (cobalamin-dependent), methyltransferase domain; Identified by MetaGeneAnnotator; putative.	0.938
ahcY	metE	SRAA_1970	SRAA_1076	S-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.	Methionine synthase II (cobalamin-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.	0.971
ahcY	metK	SRAA_1970	SRAA_0260	S-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.	S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.	0.769