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| | SRAA_0767 | Molybdopterin biosynthesis enzyme; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (437 aa) |
| | SRAA_2288 | Uncharacterized MobA-related protein; Identified by MetaGeneAnnotator; putative. (233 aa) |
| | SRAA_2274 | Metal-dependent hydrolase of the beta-lactamase superfamily I; Identified by MetaGeneAnnotator; putative. (259 aa) |
| | SRAA_2271 | Predicted transmembrane sensor domain; Identified by MetaGeneAnnotator; putative. (732 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (371 aa) |
| | purC | Phosphoribosylaminoimidazolesuccinocarboxamide SAICAR synthase; Identified by MetaGeneAnnotator; putative; Belongs to the SAICAR synthetase family. (308 aa) |
| | purE | Phosphoribosylcarboxyaminoimidazole NCAIR mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (167 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (412 aa) |
| | SRAA_2215 | Hypothetical protein; Identified by MetaGeneAnnotator; putative. (361 aa) |
| | SRAA_2210 | Phosphotransacetylase; Identified by MetaGeneAnnotator; putative. (496 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (408 aa) |
| | SRAA_2064 | Pentose-5-phosphate-3-epimerase; Identified by MetaGeneAnnotator; putative; Belongs to the ribulose-phosphate 3-epimerase family. (228 aa) |
| | thiL | Thiamine monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (339 aa) |
| | SRAA_2059 | Uncharacterized protein; Competence- and mitomycin-induced; identified by MetaGeneAnnotator; putative; Belongs to the CinA family. (167 aa) |
| | lpxC | UDP-3-O-acyl-N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (307 aa) |
| | purB | Adenylosuccinate lyase; Identified by MetaGeneAnnotator; putative; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (498 aa) |
| | SRAA_1950 | Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase; Identified by MetaGeneAnnotator; putative. (320 aa) |
| | SRAA_1917 | Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA; Identified by MetaGeneAnnotator; putative. (273 aa) |
| | amn | Nucleoside phosphorylase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. (528 aa) |
| | SRAA_1871 | acyl-CoA hydrolase; Identified by MetaGeneAnnotator; putative. (155 aa) |
| | SRAA_1860 | 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterase; Identified by MetaGeneAnnotator; putative; Belongs to the 5'-nucleotidase family. (509 aa) |
| | apt | Adenine/guanine phosphoribosyltransferase and related PRPP-binding protein; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (181 aa) |
| | pyrF | Orotidine-5'-phosphate decarboxylase; Identified by MetaGeneAnnotator; putative; Belongs to the OMP decarboxylase family. Type 2 subfamily. (284 aa) |
| | SRAA_1830 | Putative Mg2+ and Co2+ transporter CorC; Identified by MetaGeneAnnotator; putative. (272 aa) |
| | SRAA_1825 | 1-acyl-sn-glycerol-3-phosphate acyltransferase; Identified by MetaGeneAnnotator; putative. (251 aa) |
| | SRAA_1779 | FAD synthase; Identified by MetaGeneAnnotator; putative; Belongs to the ribF family. (352 aa) |
| | purN | Folate-dependent phosphoribosylglycinamide formyltransferase PurN; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (193 aa) |
| | SRAA_1770 | Hypothetical protein; Identified by MetaGeneAnnotator; putative. (309 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (243 aa) |
| | SRAA_1755 | Fructose-2,6-bisphosphatase; Identified by MetaGeneAnnotator; putative. (212 aa) |
| | icmF | methylmalonyl-CoA mutase, N-terminal domain/subunit; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. (1130 aa) |
| | purM | Phosphoribosylaminoimidazole AIR synthetase; Identified by MetaGeneAnnotator; putative. (350 aa) |
| | SRAA_1731 | Phosphoserine phosphatase; Identified by MetaGeneAnnotator; putative. (224 aa) |
| | pdxH | Pyridoxamine-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (210 aa) |
| | plsX | Fatty acid/phospholipid biosynthesis enzyme; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (342 aa) |
| | accD | acetyl-CoA carboxylase beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (292 aa) |
| | SRAA_1683 | Citrate lyase beta subunit; Identified by MetaGeneAnnotator; putative; Belongs to the HpcH/HpaI aldolase family. (336 aa) |
| | SRAA_1671 | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Identified by MetaGeneAnnotator; putative. (291 aa) |
| | SRAA_1662 | Putative transcriptional regulator; Identified by MetaGeneAnnotator; putative; Belongs to the UPF0301 (AlgH) family. (242 aa) |
| | pyrB | Aspartate carbamoyltransferase, catalytic chain; Identified by MetaGeneAnnotator; putative; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (317 aa) |
| | SRAA_1658 | Dihydroorotase and related cyclic amidohydrolase; Identified by MetaGeneAnnotator; putative. (446 aa) |
| | SRAA_1657 | 1-acyl-sn-glycerol-3-phosphate acyltransferase; Identified by MetaGeneAnnotator; putative. (275 aa) |
| | accC | Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa) |
| | nrdB | Ribonucleotide reductase, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (378 aa) |
| | pdxA | Pyridoxal phosphate biosynthesis protein; Identified by MetaGeneAnnotator; putative; Belongs to the PdxA family. (338 aa) |
| | moaA | Molybdenum cofactor biosynthesis enzyme; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (385 aa) |
| | nadE | NAD synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (581 aa) |
| | SRAA_1583 | Diacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (136 aa) |
| | plsY | Predicted membrane protein; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (209 aa) |
| | purF | Glutamine phosphoribosylpyrophosphate amidotransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (501 aa) |
| | cmk | 5-enolpyruvylshikimate-3-phosphate synthase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate; Belongs to the cytidylate kinase family. Type 1 subfamily. (688 aa) |
| | surE | Predicted acid phosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (289 aa) |
| | SRAA_1362 | Lactoylglutathione lyase and related lyase; Identified by MetaGeneAnnotator; putative. (180 aa) |
| | SRAA_1345 | Hypothetical protein; Identified by MetaGeneAnnotator; putative. (230 aa) |
| | SRAA_1313 | Molybdopterin converting factor, small subunit; Identified by MetaGeneAnnotator; putative. (84 aa) |
| | SRAA_1312 | Molybdopterin converting factor, large subunit; Identified by MetaGeneAnnotator; putative. (164 aa) |
| | prpE | Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; Identified by MetaGeneAnnotator; putative. (639 aa) |
| | SRAA_1302 | Thiamine monophosphate synthase; Identified by MetaGeneAnnotator; putative. (325 aa) |
| | thiG | Uncharacterized enzyme of thiazole biosynthesis; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (267 aa) |
| | thiS | Sulfur transfer protein involved in thiamine biosynthesis; Identified by MetaGeneAnnotator; putative. (77 aa) |
| | SRAA_1296 | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Identified by MetaGeneAnnotator; putative. (291 aa) |
| | SRAA_1266 | Guanosine polyphosphate pyrophosphohydrolase/synthetase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (752 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (206 aa) |
| | SRAA_1259 | Xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (209 aa) |
| | lpxH | Uncharacterized protein conserved in bacteria; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (326 aa) |
| | accA | acetyl-CoA carboxylase alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (336 aa) |
| | ispH | Penicillin tolerance protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (312 aa) |
| | purH | AICAR transformylase/IMP cyclohydrolase PurH; Identified by MetaGeneAnnotator; putative; only IMP cyclohydrolase domain in Aful. (534 aa) |
| | acs | Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (664 aa) |
| | nadA | Quinolinate synthase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (380 aa) |
| | thiC | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (643 aa) |
| | nadB | Aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (544 aa) |
| | SRAA_1154 | Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; Identified by MetaGeneAnnotator; putative. (619 aa) |
| | dfp | Phosphopantothenoylcysteine synthetase/decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (405 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (182 aa) |
| | prs | Phosphoribosylpyrophosphate synthetase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (327 aa) |
| | ispE | 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (289 aa) |
| | ppnK | Predicted sugar kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (296 aa) |
| | folD | 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (286 aa) |
| | aceE | Pyruvate dehydrogenase complex, dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (905 aa) |
| | pdhC | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (442 aa) |
| | icd-2 | Uncharacterized protein conserved in bacteria; Identified by MetaGeneAnnotator; putative. (449 aa) |
| | purL | Phosphoribosylformylglycinamidine FGAM synthase, synthetase domain; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1398 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (228 aa) |
| | SRAA_1011 | Nucleotide-binding protein implicated in inhibition of septum formation; Nucleoside triphosphate pyrophosphatase that hydrolyzes 7- methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids; Belongs to the Maf family. YceF subfamily. (193 aa) |
| | SRAA_1001 | Phosphatidylglycerophosphate synthase; Identified by MetaGeneAnnotator; putative; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (189 aa) |
| | SRAA_0982 | Dihydrolipoyl dehydrogenase; Identified by MetaGeneAnnotator; putative. (479 aa) |
| | sucB | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (420 aa) |
| | sucA | 2-oxoglutarate dehydrogenase complex, dehydrogenase E1 component, and related enzymes; Identified by MetaGeneAnnotator; putative. (959 aa) |
| | adk | Adenylate kinase and related kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (218 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (319 aa) |
| | SRAA_0944 | Transcriptional regulators; Identified by MetaGeneAnnotator; putative. (282 aa) |
| | glk | Glucokinase; Identified by MetaGeneAnnotator; putative; Belongs to the bacterial glucokinase family. (333 aa) |
| | zwf | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (487 aa) |
| | pgl | 6-phosphogluconolactonase/Glucosamine-6- phosphate isomerase/deaminase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (272 aa) |
| | pgi | Glucose-6-phosphate isomerase; Identified by MetaGeneAnnotator; putative; Belongs to the GPI family. (544 aa) |
| | guaA | GMP synthase, PP-ATPase domain/subunit; Catalyzes the synthesis of GMP from XMP. (538 aa) |
| | guaB | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (489 aa) |
| | lpxK | tetraacyldisaccharide-1-P 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (373 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (277 aa) |
| | dcd | Deoxycytidine deaminase; Catalyzes the deamination of dCTP to dUTP. (188 aa) |
| | SRAA_0846 | Nicotinate-nucleotide pyrophosphorylase; Identified by MetaGeneAnnotator; putative; Belongs to the NadC/ModD family. (291 aa) |
| | gpsA | Glycerol-3-phosphate dehydrogenase; Identified by MetaGeneAnnotator; putative; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (341 aa) |
| | gpmA | Phosphoglycerate mutase 1; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (247 aa) |
| | SRAA_0837 | Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2; Identified by MetaGeneAnnotator; putative. (268 aa) |
| | folE | GTP cyclohydrolase I; Identified by MetaGeneAnnotator; putative. (241 aa) |
| | clsB | Phosphatidylserine/phosphatidylglycerophosphate/ cardiolipin synthase and related enzymes; Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. (411 aa) |
| | SRAA_0796 | Nucleotide-binding protein implicated in inhibition of septum formation; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (220 aa) |
| | nadD | Nicotinic acid mononucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (229 aa) |
| | purD | Phosphoribosylamine-glycine ligase; Identified by MetaGeneAnnotator; putative; Belongs to the GARS family. (430 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (253 aa) |
| | carB | Carbamoylphosphate synthase large subunit; Identified by MetaGeneAnnotator; putative; split gene in MJ; Belongs to the CarB family. (1097 aa) |
| | carA | Carbamoylphosphate synthase small subunit; Identified by MetaGeneAnnotator; putative; Belongs to the CarA family. (390 aa) |
| | lpxB | Lipid A disaccharide synthetase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (376 aa) |
| | lpxA | Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (278 aa) |
| | fabZ | 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (152 aa) |
| | lpxD | UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (346 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (391 aa) |
| | SRAA_0719 | CDP-diglyceride synthetase; Identified by MetaGeneAnnotator; putative; Belongs to the CDS family. (275 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (236 aa) |
| | nnrD | Predicted sugar kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. In the C-terminal section; belongs to the NnrD/CARKD family. (538 aa) |
| | SRAA_0700 | Glycerol-3-phosphate dehydrogenase; Identified by MetaGeneAnnotator; putative; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (529 aa) |
| | rpiA | Ribose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (223 aa) |
| | pyrD | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (362 aa) |
| | purA | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (471 aa) |
| | ispG | Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (420 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (551 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa) |
| | SRAA_0581 | benzoate-CoA ligase family; Identified by MetaGeneAnnotator; putative. (528 aa) |
| | SRAA_0548 | Guanosine polyphosphate pyrophosphohydrolase/synthetase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (728 aa) |
| | ispF | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF). (440 aa) |
| | SRAA_0525 | Phosphatidylserine synthase; Identified by MetaGeneAnnotator; putative; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (298 aa) |
| | mogA | Molybdopterin biosynthesis enzymes; Identified by MetaGeneAnnotator; putative. (201 aa) |
| | SRAA_0452 | Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family; Identified by MetaGeneAnnotator; putative; Belongs to the inositol monophosphatase superfamily. (281 aa) |
| | SRAA_0436 | Fructose-2,6-bisphosphatase; Identified by MetaGeneAnnotator; putative. (219 aa) |
| | dut | dUTPase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (149 aa) |
| | dxs | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (631 aa) |
| | SRAA_0376 | 1-acyl-sn-glycerol-3-phosphate acyltransferase; Identified by MetaGeneAnnotator; putative. (199 aa) |
| | SRAA_0357 | NTP pyrophosphohydrolase including oxidative damage repair enzymes; Identified by MetaGeneAnnotator; putative. (219 aa) |
| | SRAA_0350 | Flagellar biosynthesis/type III secretory pathway ATPase; Identified by MetaGeneAnnotator; putative. (486 aa) |
| | SRAA_0276 | dGTP triphosphohydrolase; Identified by MetaGeneAnnotator; putative; Belongs to the dGTPase family. Type 2 subfamily. (414 aa) |
| | coaX | Putative transcriptional regulator, homolog of Bvg accessory factor; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (266 aa) |
| | SRAA_0245 | Uncharacterized protein conserved in bacteria; Identified by MetaGeneAnnotator; putative. (317 aa) |
| | psd | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (301 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (212 aa) |
| | glmU | N-acetylglucosamine-1-phosphate uridyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (467 aa) |
| | purU | Formyltetrahydrofolate hydrolase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (282 aa) |
| | moaC | Molybdenum cofactor biosynthesis enzyme; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (162 aa) |
| | mobA | Molybdopterin-guanine dinucleotide biosynthesis protein A; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (215 aa) |
| | fdhD | Uncharacterized protein required for formate dehydrogenase activity; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (301 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (348 aa) |
| | SRAA_0053 | Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase; Identified by MetaGeneAnnotator; putative. (384 aa) |
| | SRAA_0029 | Glycerol-3-phosphate dehydrogenase; Identified by MetaGeneAnnotator; putative. (520 aa) |
| | glpK | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (515 aa) |
| | atpC | F0F1-type ATP synthase, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (138 aa) |
| | atpF1B | F0F1-type ATP synthase, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (476 aa) |
| | atpF1G | F0F1-type ATP synthase, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (289 aa) |
| | atpF1A | F0F1-type ATP synthase, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (518 aa) |
| | atpH | F0F1-type ATP synthase, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (176 aa) |
| | atpF | F0F1-type ATP synthase, subunit b; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (156 aa) |
| | atpE | F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (82 aa) |
| | atpB | F0F1-type ATP synthase, subunit a; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (301 aa) |
| | SRAA_2354 | Phosphotransacetylase; Identified by MetaGeneAnnotator; putative. (477 aa) |
| | fbaA-2 | Fructose/tagatose bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (355 aa) |
| | pgk | 3-phosphoglycerate kinase; Identified by MetaGeneAnnotator; putative; Belongs to the phosphoglycerate kinase family. (446 aa) |
| | pyk | Pyruvate kinase; Identified by MetaGeneAnnotator; putative; Belongs to the pyruvate kinase family. (476 aa) |
