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| | dapA | Dihydrodipicolinate synthase/N-acetylneuraminate lyase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (298 aa) |
| | lipA | Lipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (329 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (314 aa) |
| | aroG | 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (375 aa) |
| | SRAA_0066 | Uncharacterized anaerobic dehydrogenase; Identified by MetaGeneAnnotator; putative; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (711 aa) |
| | SRAA_0067 | Uncharacterized anaerobic dehydrogenase; Identified by MetaGeneAnnotator; putative. (244 aa) |
| | SRAA_0079 | 3-hydroxyacyl-CoA dehydrogenase; Identified by MetaGeneAnnotator; putative. (283 aa) |
| | SRAA_0097 | FAD/FMN-containing dehydrogenase; Identified by MetaGeneAnnotator; putative. (507 aa) |
| | glmS | Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (637 aa) |
| | argJ | N-acetylglutamate synthase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (409 aa) |
| | SRAA_0221 | Isopropylmalate/homocitrate/citramalate synthase; Identified by MetaGeneAnnotator; putative. (305 aa) |
| | SRAA_0226 | acetyl-CoA carboxylase, carboxyltransferase component, subunits alpha and beta; Identified by MetaGeneAnnotator; putative. (535 aa) |
| | SRAA_0234 | 4-hydroxyphenylpyruvate dioxygenase and related hemolysins; Identified by MetaGeneAnnotator; putative. (299 aa) |
| | SRAA_0236 | Shikimate 5-dehydrogenase; Identified by MetaGeneAnnotator; putative. (277 aa) |
| | lysS | lysyl-tRNA synthetase class II; Identified by MetaGeneAnnotator; putative; Belongs to the class-II aminoacyl-tRNA synthetase family. (515 aa) |
| | SRAA_0255 | acyl-CoA-binding protein; Identified by MetaGeneAnnotator; putative. (85 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (431 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (181 aa) |
| | aroB | 3-dehydroquinate synthetase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (345 aa) |
| | SRAA_0278 | Glutamate synthase domain 2; Identified by MetaGeneAnnotator; putative. (1581 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (239 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (455 aa) |
| | hisC | Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; Identified by MetaGeneAnnotator; putative; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (355 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase; Identified by MetaGeneAnnotator; putative. (195 aa) |
| | hisH | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (231 aa) |
| | hisA | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide ProFAR isomerase; Identified by MetaGeneAnnotator; putative. (246 aa) |
| | hisF | Imidazoleglycerol-phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (268 aa) |
| | ilvE | Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (325 aa) |
| | thrB | Putative homoserine kinase type II; Identified by MetaGeneAnnotator; putative; protein kinase fold; Belongs to the pseudomonas-type ThrB family. (318 aa) |
| | argA | Acetylglutamate kinase; Identified by MetaGeneAnnotator; putative; Belongs to the acetyltransferase family. ArgA subfamily. (449 aa) |
| | SRAA_0424 | Cobyrinic acid a,c-diamide synthase; Identified by MetaGeneAnnotator; putative. (438 aa) |
| | SRAA_0432 | Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; Identified by MetaGeneAnnotator; putative. (334 aa) |
| | cobQ | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (497 aa) |
| | SRAA_0436 | Fructose-2,6-bisphosphatase; Identified by MetaGeneAnnotator; putative. (219 aa) |
| | ppsA | Phosphoenolpyruvate synthase/pyruvate phosphate dikinase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (797 aa) |
| | cysE | Serine acetyltransferase; Identified by MetaGeneAnnotator; putative. (255 aa) |
| | SRAA_0466 | FAD/FMN-containing dehydrogenase; Identified by MetaGeneAnnotator; putative. (1323 aa) |
| | SRAA_0470 | Uncharacterized protein conserved in bacteria; Identified by MetaGeneAnnotator; putative. (249 aa) |
| | aspS | aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (597 aa) |
| | leuA | Isopropylmalate/homocitrate/citramalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (516 aa) |
| | trpB-2 | Predicted alternative tryptophan synthase beta-subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (457 aa) |
| | SRAA_0538 | Phosphoserine phosphatase; Identified by MetaGeneAnnotator; putative. (242 aa) |
| | ispF | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF). (440 aa) |
| | SRAA_0577 | acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; Identified by MetaGeneAnnotator; putative. (627 aa) |
| | SRAA_0581 | benzoate-CoA ligase family; Identified by MetaGeneAnnotator; putative. (528 aa) |
| | SRAA_0584 | benzoyl-CoA-dihydrodiol lyase; Identified by MetaGeneAnnotator; putative. (560 aa) |
| | boxB | benzoyl-CoA oxygenase, component B; Identified by MetaGeneAnnotator; putative. (475 aa) |
| | SRAA_0589 | Glutathione S-transferase; Identified by MetaGeneAnnotator; putative. (228 aa) |
| | gloB | Zn-dependent hydrolase, including glyoxylase; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid. (311 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa) |
| | kdsA | 3-deoxy-D-manno-octulosonic acid KDO 8-phosphate synthase; Identified by MetaGeneAnnotator; putative; Belongs to the KdsA family. (285 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (551 aa) |
| | dapE | Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (400 aa) |
| | dapD | Tetrahydrodipicolinate N-succinyltransferase; Identified by MetaGeneAnnotator; putative; Belongs to the transferase hexapeptide repeat family. (293 aa) |
| | ispG | Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (420 aa) |
| | hisS | histidyl-tRNA synthetase; Identified by MetaGeneAnnotator; putative. (431 aa) |
| | SRAA_0657 | Enoyl-[acyl-carrier-protein] reductase (NADH); Identified by MetaGeneAnnotator; putative. (269 aa) |
| | SRAA_0665 | acyl-CoA dehydrogenase; Identified by MetaGeneAnnotator; putative. (420 aa) |
| | SRAA_0668 | enoyl-CoA hydratase/carnithine racemase; Identified by MetaGeneAnnotator; putative; Belongs to the enoyl-CoA hydratase/isomerase family. (259 aa) |
| | SRAA_0677 | Glutamate dehydrogenase/leucine dehydrogenase; Identified by MetaGeneAnnotator; putative; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (462 aa) |
| | hisZ | ATP phosphoribosyltransferase involved in histidine biosynthesis; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (405 aa) |
| | SRAA_0682 | Cystathionine beta-lyase/cystathionine gamma-synthase; Identified by MetaGeneAnnotator; putative. (415 aa) |
| | SRAA_0693 | Dihydropteroate synthase and related enzymes; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (298 aa) |
| | SRAA_0701 | FAD/FMN-containing dehydrogenase; Identified by MetaGeneAnnotator; putative. (538 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (391 aa) |
| | fabZ | 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (152 aa) |
| | carA | Carbamoylphosphate synthase small subunit; Identified by MetaGeneAnnotator; putative; Belongs to the CarA family. (390 aa) |
| | carB | Carbamoylphosphate synthase large subunit; Identified by MetaGeneAnnotator; putative; split gene in MJ; Belongs to the CarB family. (1097 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (253 aa) |
| | SRAA_0760 | Glutamate dehydrogenase/leucine dehydrogenase; Identified by MetaGeneAnnotator; putative; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (441 aa) |
| | thrA | Homoserine dehydrogenase; Identified by MetaGeneAnnotator; putative. (453 aa) |
| | thrC | Threonine synthase; Identified by MetaGeneAnnotator; putative. (476 aa) |
| | icd | Isocitrate dehydrogenase; Identified by MetaGeneAnnotator; putative. (417 aa) |
| | SRAA_0813 | acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; Identified by MetaGeneAnnotator; putative. (447 aa) |
| | SRAA_0815 | Acyl carrier protein; Identified by MetaGeneAnnotator; putative. (77 aa) |
| | SRAA_0823 | Acetolactate synthase I/II/III large subunit; Identified by MetaGeneAnnotator; putative; Belongs to the TPP enzyme family. (601 aa) |
| | gpmA | Phosphoglycerate mutase 1; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (247 aa) |
| | panC | Panthothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (299 aa) |
| | panB | Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (291 aa) |
| | ilvD | Dihydroxyacid dehydratase/phosphogluconate dehydratase; Identified by MetaGeneAnnotator; putative; Belongs to the IlvD/Edd family. (641 aa) |
| | SRAA_0862 | Isocitrate lyase; Identified by MetaGeneAnnotator; putative. (443 aa) |
| | thrS | threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). (635 aa) |
| | pheS | phenylalanyl-tRNA synthetase alpha subunit; Identified by MetaGeneAnnotator; putative; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (356 aa) |
| | pheT | phenylalanyl-tRNA synthetase beta subunit; Identified by MetaGeneAnnotator; putative; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (809 aa) |
| | SRAA_0876 | glycine/D-amino acid oxidase (deaminating); Identified by MetaGeneAnnotator; putative. (414 aa) |
| | SRAA_0896 | FAD/FMN-containing dehydrogenase; Identified by MetaGeneAnnotator; putative. (483 aa) |
| | SRAA_0903 | O-acetylhomoserine sulfhydrylase; Identified by MetaGeneAnnotator; putative. (433 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (366 aa) |
| | aroQ | 3-dehydroquinate dehydratase II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (151 aa) |
| | glnS | Glutamyl- and glutaminyl-tRNA synthetase; Identified by MetaGeneAnnotator; putative. (624 aa) |
| | guaA | GMP synthase, PP-ATPase domain/subunit; Catalyzes the synthesis of GMP from XMP. (538 aa) |
| | ppc | Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (918 aa) |
| | pgi | Glucose-6-phosphate isomerase; Identified by MetaGeneAnnotator; putative; Belongs to the GPI family. (544 aa) |
| | edd | Dihydroxyacid dehydratase/phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (612 aa) |
| | glk | Glucokinase; Identified by MetaGeneAnnotator; putative; Belongs to the bacterial glucokinase family. (333 aa) |
| | SRAA_0944 | Transcriptional regulators; Identified by MetaGeneAnnotator; putative. (282 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (279 aa) |
| | SRAA_0952 | L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D; Identified by MetaGeneAnnotator; putative. (357 aa) |
| | SRAA_0974 | acetyl-CoA carboxylase, carboxyltransferase component, subunits alpha and beta; Identified by MetaGeneAnnotator; putative. (510 aa) |
| | sucA | 2-oxoglutarate dehydrogenase complex, dehydrogenase E1 component, and related enzymes; Identified by MetaGeneAnnotator; putative. (959 aa) |
| | sucB | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (420 aa) |
| | SRAA_0982 | Dihydrolipoyl dehydrogenase; Identified by MetaGeneAnnotator; putative. (479 aa) |
| | SRAA_0986 | Predicted thioesterase; Identified by MetaGeneAnnotator; putative. (149 aa) |
| | SRAA_1005 | Isocitrate/isopropylmalate dehydrogenase; Identified by MetaGeneAnnotator; putative. (361 aa) |
| | purL | Phosphoribosylformylglycinamidine FGAM synthase, synthetase domain; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1398 aa) |
| | ldcC | Arginine/lysine/ornithine decarboxylase; Identified by MetaGeneAnnotator; putative. (764 aa) |
| | SRAA_1066 | Hypothetical protein; Identified by MetaGeneAnnotator; putative. (283 aa) |
| | SRAA_1067 | 3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase); Identified by MetaGeneAnnotator; putative. (127 aa) |
| | metE | Methionine synthase II (cobalamin-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (783 aa) |
| | pdhC | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (442 aa) |
| | aceE | Pyruvate dehydrogenase complex, dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (905 aa) |
| | folD | 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (286 aa) |
| | SRAA_1100 | Anthranilate phosphoribosyltransferase; Identified by MetaGeneAnnotator; putative. (316 aa) |
| | ispE | 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (289 aa) |
| | dfp | Phosphopantothenoylcysteine synthetase/decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (405 aa) |
| | SRAA_1154 | Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; Identified by MetaGeneAnnotator; putative. (619 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (126 aa) |
| | nadA | Quinolinate synthase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (380 aa) |
| | acs | Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (664 aa) |
| | SRAA_1178 | glycine/D-amino acid oxidase (deaminating); Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34; In the C-terminal section; belongs to the DAO family. (386 aa) |
| | SRAA_1180 | Sulfite reductase; Beta subunit hemoprotein; identified by MetaGeneAnnotator; putative. (609 aa) |
| | SRAA_1205 | Activator of 2-hydroxyglutaryl-CoA dehydratase; HSP70-class ATPase domain; identified by MetaGeneAnnotator; putative. (732 aa) |
| | SRAA_1208 | 3-hydroxyacyl-CoA dehydrogenase; Identified by MetaGeneAnnotator; putative; Belongs to the enoyl-CoA hydratase/isomerase family. (704 aa) |
| | alkK | acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; Identified by MetaGeneAnnotator; putative. (545 aa) |
| | SRAA_1231 | Lactoylglutathione lyase and related lyase; Identified by MetaGeneAnnotator; putative. (129 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (449 aa) |
| | ispH | Penicillin tolerance protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (312 aa) |
| | lysC | Aspartokinase; Identified by MetaGeneAnnotator; putative; Belongs to the aspartokinase family. (427 aa) |
| | accA | acetyl-CoA carboxylase alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (336 aa) |
| | cysS | cysteinyl-tRNA synthetase; Identified by MetaGeneAnnotator; putative; Belongs to the class-I aminoacyl-tRNA synthetase family. (468 aa) |
| | metG | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (728 aa) |
| | thiO | glycine/D-amino acid oxidase (deaminating); Identified by MetaGeneAnnotator; putative. (375 aa) |
| | aspC | Aspartate/tyrosine/aromatic aminotransferase; Identified by MetaGeneAnnotator; putative. (398 aa) |
| | bioB | Biotin synthase and related enzymes; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (357 aa) |
| | bioD | Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (250 aa) |
| | bioF | 7-keto-8-aminopelargonate synthetase and related enzymes; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (408 aa) |
| | bioA | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Identified by MetaGeneAnnotator; putative; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (477 aa) |
| | prpE | Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; Identified by MetaGeneAnnotator; putative. (639 aa) |
| | SRAA_1317 | acyl-CoA dehydrogenase; Identified by MetaGeneAnnotator; putative. (610 aa) |
| | SRAA_1350 | Hypothetical protein; Identified by MetaGeneAnnotator; putative. (292 aa) |
| | SRAA_1352 | Predicted metal-dependent hydrolase of the TIM-barrel fold; Identified by MetaGeneAnnotator; putative. (309 aa) |
| | SRAA_1353 | Demethylmenaquinone methyltransferase; Identified by MetaGeneAnnotator; putative. (227 aa) |
| | SRAA_1359 | 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase; Identified by MetaGeneAnnotator; putative. (441 aa) |
| | SRAA_1361 | 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase; Identified by MetaGeneAnnotator; putative. (542 aa) |
| | SRAA_1363 | Zn-dependent hydrolase, including glyoxylase; Identified by MetaGeneAnnotator; putative. (321 aa) |
| | SRAA_1418 | Glycine cleavage system T protein; Aminomethyltransferase; identified by MetaGeneAnnotator; putative. (394 aa) |
| | gcvH | Glycine cleavage system H protein (lipoate-binding); The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (121 aa) |
| | gcvP | Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (992 aa) |
| | SRAA_1421 | Acetolactate synthase I/II/III large subunit; Identified by MetaGeneAnnotator; putative. (550 aa) |
| | SRAA_1428 | Prephenate dehydrogenase; Identified by MetaGeneAnnotator; putative. (329 aa) |
| | SRAA_1429 | Prephenate dehydratase; Identified by MetaGeneAnnotator; putative. (362 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (382 aa) |
| | gltX | Glutamyl- and glutaminyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (508 aa) |
| | metZ | Cystathionine beta-lyase/cystathionine gamma-synthase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (410 aa) |
| | purF | Glutamine phosphoribosylpyrophosphate amidotransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (501 aa) |
| | SRAA_1484 | Folylpolyglutamate synthase; Identified by MetaGeneAnnotator; putative; Belongs to the folylpolyglutamate synthase family. (451 aa) |
| | SRAA_1486 | Argininosuccinate synthase; Identified by MetaGeneAnnotator; putative; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (442 aa) |
| | gcdH1 | acyl-CoA dehydrogenase; Identified by MetaGeneAnnotator; putative. (395 aa) |
| | SRAA_1489 | 3-hydroxyacyl-CoA dehydrogenase; Identified by MetaGeneAnnotator; putative. (683 aa) |
| | SRAA_1507 | L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenase; Identified by MetaGeneAnnotator; putative. (384 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (1099 aa) |
| | cysM | Cysteine synthase; Identified by MetaGeneAnnotator; putative; Belongs to the cysteine synthase/cystathionine beta- synthase family. (326 aa) |
| | gluQ | Glutamyl- and glutaminyl-tRNA synthetase; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily. (343 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (898 aa) |
| | SRAA_1556 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (179 aa) |
| | glyA | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (414 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa) |
| | ilvH | Acetolactate synthase, small regulatory subunit; Identified by MetaGeneAnnotator; putative. (163 aa) |
| | ilvB | Acetolactate synthase; Identified by MetaGeneAnnotator; putative. (592 aa) |
| | argD | Ornithine/acetylornithine aminotransferase; Identified by MetaGeneAnnotator; putative; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (403 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (320 aa) |
| | proS | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (581 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (392 aa) |
| | SRAA_1631 | Diadenosine tetraphosphate Ap4A hydrolase and other HIT family hydrolase; Identified by MetaGeneAnnotator; putative. (119 aa) |
| | hisE | phosphoribosyl-ATP pyrophosphohydrolase; Identified by MetaGeneAnnotator; putative. (176 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (143 aa) |
| | accC | Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa) |
| | bccP | Biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (157 aa) |
| | pyrB | Aspartate carbamoyltransferase, catalytic chain; Identified by MetaGeneAnnotator; putative; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (317 aa) |
| | acnB | Identified by MetaGeneAnnotator; putative; Belongs to the aconitase/IPM isomerase family. (863 aa) |
| | mdh | Malate/lactate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (328 aa) |
| | SRAA_1690 | Uncharacterized conserved protein; Identified by MetaGeneAnnotator; putative. (106 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (473 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (216 aa) |
| | leuB | Isocitrate/isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (356 aa) |
| | SRAA_1698 | Aspartate-semialdehyde dehydrogenase; Identified by MetaGeneAnnotator; putative; Belongs to the aspartate-semialdehyde dehydrogenase family. (369 aa) |
| | trpF | Phosphoribosylanthranilate isomerase; Identified by MetaGeneAnnotator; putative; Belongs to the TrpF family. (223 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (413 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (280 aa) |
| | accD | acetyl-CoA carboxylase beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (292 aa) |
| | acpS | Phosphopantetheinyl transferase, holo-ACP synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (136 aa) |
| | fabF1 | 3-oxoacyl-(acyl-carrier-protein) synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (414 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (79 aa) |
| | SRAA_1722 | S-malonyltransferase; Identified by MetaGeneAnnotator; putative. (316 aa) |
| | fabH1 | 3-oxoacyl-[acyl-carrier-protein] synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (339 aa) |
| | plsX | Fatty acid/phospholipid biosynthesis enzyme; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (342 aa) |
| | SRAA_1729 | 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; Identified by MetaGeneAnnotator; putative. (162 aa) |
| | SRAA_1742 | tryptophanyl-tRNA synthetase; Identified by MetaGeneAnnotator; putative; Belongs to the class-I aminoacyl-tRNA synthetase family. (408 aa) |
| | SRAA_1755 | Fructose-2,6-bisphosphatase; Identified by MetaGeneAnnotator; putative. (212 aa) |
| | ileS | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (964 aa) |
| | SRAA_1787 | Dehydrogenase with different specificities related to short-chain alcohol dehydrogenase; Identified by MetaGeneAnnotator; putative. (264 aa) |
| | ilvA | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (525 aa) |
| | SRAA_1817 | acyl-CoA dehydrogenase; Identified by MetaGeneAnnotator; putative. (378 aa) |
| | aceK | Isocitrate dehydrogenase kinase/phosphatase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. (616 aa) |
| | SRAA_1821 | acyl-CoA dehydrogenase; Identified by MetaGeneAnnotator; putative. (401 aa) |
| | glyS | glycyl-tRNA synthetase, beta subunit; Identified by MetaGeneAnnotator; putative. (748 aa) |
| | glyQ | glycyl-tRNA synthetase, alpha subunit; Identified by MetaGeneAnnotator; putative. (348 aa) |
| | SRAA_1832 | acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; Identified by MetaGeneAnnotator; putative. (559 aa) |
| | argC | Acetylglutamate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (306 aa) |
| | SRAA_1839 | Predicted glutamine amidotransferase; Identified by MetaGeneAnnotator; putative. (256 aa) |
| | metX | Homoserine acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. (423 aa) |
| | SRAA_1871 | acyl-CoA hydrolase; Identified by MetaGeneAnnotator; putative. (155 aa) |
| | SRAA_1873 | Isocitrate/isopropylmalate dehydrogenase; Identified by MetaGeneAnnotator; putative. (490 aa) |
| | SRAA_1885 | enoyl-CoA hydratase/carnithine racemase; Identified by MetaGeneAnnotator; putative; Belongs to the enoyl-CoA hydratase/isomerase family. (270 aa) |
| | SRAA_1901 | 3-hydroxyacyl-CoA dehydrogenase; Identified by MetaGeneAnnotator; putative. (810 aa) |
| | SRAA_1903 | acyl-CoA dehydrogenase; Identified by MetaGeneAnnotator; putative. (598 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (300 aa) |
| | SRAA_1916 | Glutamine synthetase; Identified by MetaGeneAnnotator; putative. (471 aa) |
| | SRAA_1918 | Hypothetical protein; Identified by MetaGeneAnnotator; putative. (308 aa) |
| | SRAA_1923 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (270 aa) |
| | argH | Argininosuccinate lyase; Identified by MetaGeneAnnotator; putative. (494 aa) |
| | SRAA_1961 | Methionine synthase I, cobalamin-binding domain; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (900 aa) |
| | tyrS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. (425 aa) |
| | anmK | Predicted molecular chaperone distantly related to HSP70-fold metalloprotease; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (378 aa) |
| | SRAA_1969 | 5,10-methylenetetrahydrofolate reductase; Identified by MetaGeneAnnotator; putative; Belongs to the methylenetetrahydrofolate reductase family. (281 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (291 aa) |
| | SRAA_2022 | Zn-dependent hydrolase, including glyoxylase; Identified by MetaGeneAnnotator; putative. (301 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Identified by MetaGeneAnnotator; putative; Belongs to the TrpC family. (265 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (349 aa) |
| | SRAA_2034 | Chorismate mutase; Identified by MetaGeneAnnotator; putative. (121 aa) |
| | trpE | Anthranilate/para-aminobenzoate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismat [...] (500 aa) |
| | SRAA_2041 | Long-chain acyl-CoA synthetase (AMP-forming); Identified by MetaGeneAnnotator; putative. (648 aa) |
| | SRAA_2047 | Coenzyme F390 synthetase; Identified by MetaGeneAnnotator; putative. (425 aa) |
| | SRAA_2061 | NTP pyrophosphohydrolase including oxidative damage repair enzymes; Identified by MetaGeneAnnotator; putative. (306 aa) |
| | SRAA_2128 | Gluconolactonase; Identified by MetaGeneAnnotator; putative. (320 aa) |
| | SRAA_2129 | FAD/FMN-containing dehydrogenase; Identified by MetaGeneAnnotator; putative. (373 aa) |
| | SRAA_2131 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (389 aa) |
| | SRAA_2138 | glycine/D-amino acid oxidase (deaminating); Identified by MetaGeneAnnotator; putative. (425 aa) |
| | glcB | Malate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (741 aa) |
| | argS | arginyl-tRNA synthetase; Identified by MetaGeneAnnotator; putative. (567 aa) |
| | SRAA_2160 | Predicted metal-sulfur cluster biosynthetic enzyme; Identified by MetaGeneAnnotator; putative. (184 aa) |
| | paaI | Uncharacterized conserved protein; Identified by MetaGeneAnnotator; putative. (265 aa) |
| | SRAA_2162 | Uncharacterized enzyme of phenylacetate metabolism; Identified by MetaGeneAnnotator; putative. (99 aa) |
| | paaA | Uncharacterized conserved protein; Identified by MetaGeneAnnotator; putative. (336 aa) |
| | paaK | Coenzyme F390 synthetase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA). (441 aa) |
| | SRAA_2165 | Uncharacterized protein, possibly involved in aromatic compounds catabolism; Identified by MetaGeneAnnotator; putative. (164 aa) |
| | SRAA_2166 | Phenylacetic acid-responsive transcriptional repressor; Identified by MetaGeneAnnotator; putative. (319 aa) |
| | dld | FAD/FMN-containing dehydrogenase; Identified by MetaGeneAnnotator; putative. (477 aa) |
| | SRAA_2192 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Identified by MetaGeneAnnotator; putative; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (467 aa) |
| | SRAA_2194 | Glutamine synthetase; Identified by MetaGeneAnnotator; putative; Belongs to the glutamine synthetase family. (455 aa) |
| | SRAA_2199 | Arginase/agmatinase/formimionoglutamate hydrolase, arginase family; Identified by MetaGeneAnnotator; putative; Belongs to the arginase family. (318 aa) |
| | fabI | Enoyl-[acyl-carrier-protein] reductase (NADH); Identified by MetaGeneAnnotator; putative. (275 aa) |
| | SRAA_2209 | Phosphoenolpyruvate synthase/pyruvate phosphate dikinase; Identified by MetaGeneAnnotator; putative. (545 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (431 aa) |
| | SRAA_2239 | 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase; Identified by MetaGeneAnnotator; putative. (233 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (371 aa) |
| | SRAA_2257 | 4-hydroxyphenylpyruvate dioxygenase and related hemolysins; Identified by MetaGeneAnnotator; putative. (364 aa) |
| | leuS | leucyl-tRNA synthetase; Identified by MetaGeneAnnotator; putative; Belongs to the class-I aminoacyl-tRNA synthetase family. (941 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (270 aa) |
| | SRAA_2284 | Nucleoside phosphorylase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (251 aa) |
| | SRAA_2285 | acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; Identified by MetaGeneAnnotator; putative. (564 aa) |
| | SRAA_2287 | ATPase involved in DNA replication; Identified by MetaGeneAnnotator; putative. (230 aa) |
| | pyk | Pyruvate kinase; Identified by MetaGeneAnnotator; putative; Belongs to the pyruvate kinase family. (476 aa) |
| | SRAA_2325 | Predicted phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (232 aa) |
| | pgk | 3-phosphoglycerate kinase; Identified by MetaGeneAnnotator; putative; Belongs to the phosphoglycerate kinase family. (446 aa) |
| | fbaA-2 | Fructose/tagatose bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (355 aa) |
| | aroF | 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (366 aa) |
