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SRAA_1901 SRAA_1901 nuoG nuoG nuoH nuoH nuoI nuoI SRAA_0753 SRAA_0753 nuoK nuoK nuoN nuoN SRAA_0760 SRAA_0760 nadD nadD gpsA gpsA guaB guaB ligA ligA SRAA_0982 SRAA_0982 SRAA_1085 SRAA_1085 ppnK ppnK SRAA_1208 SRAA_1208 ahpF-1 ahpF-1 SRAA_1489 SRAA_1489 nadE nadE pdxA pdxA mdh mdh leuB leuB SRAA_1880 SRAA_1880 ahcY ahcY mnmG mnmG fabI fabI dapB dapB SRAA_2326 SRAA_2326 SRAA_2345 SRAA_2345 SRAA_0749 SRAA_0749 nuoD nuoD nuoC nuoC nuoB nuoB nuoA nuoA nnrD nnrD SRAA_0677 SRAA_0677 SRAA_0657 SRAA_0657 hisD hisD aroB aroB SRAA_0079 SRAA_0079
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SRAA_19013-hydroxyacyl-CoA dehydrogenase; Identified by MetaGeneAnnotator; putative. (810 aa)
nuoGNADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit chain G; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (717 aa)
nuoHNADH:ubiquinone oxidoreductase subunit 1 chain H; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone. (358 aa)
nuoIFormate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit chain I; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (169 aa)
SRAA_0753NADH:ubiquinone oxidoreductase subunit 6 chain J); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (222 aa)
nuoKNADH:ubiquinone oxidoreductase subunit 11 or 4L chain K; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 4L family. (104 aa)
nuoNNADH:ubiquinone oxidoreductase subunit 2 chain N; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 2 family. (495 aa)
SRAA_0760Glutamate dehydrogenase/leucine dehydrogenase; Identified by MetaGeneAnnotator; putative; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (441 aa)
nadDNicotinic acid mononucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (229 aa)
gpsAGlycerol-3-phosphate dehydrogenase; Identified by MetaGeneAnnotator; putative; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (341 aa)
guaBIMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (489 aa)
ligANAD-dependent DNA ligase containing BRCT domain type II); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. (714 aa)
SRAA_0982Dihydrolipoyl dehydrogenase; Identified by MetaGeneAnnotator; putative. (479 aa)
SRAA_1085Dihydrolipoyl dehydrogenase; Identified by MetaGeneAnnotator; putative. (611 aa)
ppnKPredicted sugar kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (296 aa)
SRAA_12083-hydroxyacyl-CoA dehydrogenase; Identified by MetaGeneAnnotator; putative; Belongs to the enoyl-CoA hydratase/isomerase family. (704 aa)
ahpF-1Alkyl hydroperoxide reductase, large subunit; Identified by MetaGeneAnnotator; putative. (531 aa)
SRAA_14893-hydroxyacyl-CoA dehydrogenase; Identified by MetaGeneAnnotator; putative. (683 aa)
nadENAD synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (581 aa)
pdxAPyridoxal phosphate biosynthesis protein; Identified by MetaGeneAnnotator; putative; Belongs to the PdxA family. (338 aa)
mdhMalate/lactate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (328 aa)
leuBIsocitrate/isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (356 aa)
SRAA_1880Glutathione reductase (NADPH); Identified by MetaGeneAnnotator; putative. (466 aa)
ahcYS-adenosylhomocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (478 aa)
mnmGNAD/FAD-utilizing enzyme apparently involved in cell division; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34; Belongs to the MnmG family. (667 aa)
fabIEnoyl-[acyl-carrier-protein] reductase (NADH); Identified by MetaGeneAnnotator; putative. (275 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (270 aa)
SRAA_2326Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Identified by MetaGeneAnnotator; putative; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa)
SRAA_2345NAD/NADP transhydrogenase beta subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. (477 aa)
SRAA_0749NADH:ubiquinone oxidoreductase, NADH-binding 51 kD subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. (450 aa)
nuoDNADH:ubiquinone oxidoreductase 49 kD subunit 7; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I 49 kDa subunit family. (417 aa)
nuoCNADH:ubiquinone oxidoreductase 27 kD subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I 30 kDa subunit family. (214 aa)
nuoBNADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductase; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (159 aa)
nuoANADH:ubiquinone oxidoreductase subunit 3 chain A; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 3 family. (131 aa)
nnrDPredicted sugar kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. In the C-terminal section; belongs to the NnrD/CARKD family. (538 aa)
SRAA_0677Glutamate dehydrogenase/leucine dehydrogenase; Identified by MetaGeneAnnotator; putative; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (462 aa)
SRAA_0657Enoyl-[acyl-carrier-protein] reductase (NADH); Identified by MetaGeneAnnotator; putative. (269 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (455 aa)
aroB3-dehydroquinate synthetase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (345 aa)
SRAA_00793-hydroxyacyl-CoA dehydrogenase; Identified by MetaGeneAnnotator; putative. (283 aa)
Your Current Organism:
Serpentinomonas raichei
NCBI taxonomy Id: 1458425
Other names: Comamonadaceae bacterium A1, Comamonadaceae bacterium H1, S. raichei, strain A1
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