STRINGSTRING
asd asd KON89035.1 KON89035.1 KON88999.1 KON88999.1 KON86821.1 KON86821.1 KON86963.1 KON86963.1 gcvT gcvT gcvPA gcvPA gcvPB gcvPB KON87086.1 KON87086.1 KON87116.1 KON87116.1 KON87136.1 KON87136.1 KON87203.1 KON87203.1 KON87502.1 KON87502.1 ilvA ilvA trpB trpB trpA trpA KON87691.1 KON87691.1 KON87735.1 KON87735.1 KON90300.1 KON90300.1 KON87830.1 KON87830.1 KON87831.1 KON87831.1 KON87834.1 KON87834.1 KON87891.1 KON87891.1 KON88049.1 KON88049.1 KON88314.1 KON88314.1 KON88412.1 KON88412.1 KON90361.1 KON90361.1 KON88582.1 KON88582.1 KON88625.1 KON88625.1 KON88635.1 KON88635.1 KON90367.1 KON90367.1 KON88663.1 KON88663.1 KON88741.1 KON88741.1 KON88773.1 KON88773.1 KON86473.1 KON86473.1 thrB thrB KON86758.1 KON86758.1 KON86471.1 KON86471.1 gcvH gcvH KON90209.1 KON90209.1 gpmI gpmI KON86236.1 KON86236.1 glyA glyA KON85704.1 KON85704.1 KON85652.1 KON85652.1 KON85586.1 KON85586.1 KON85574.1 KON85574.1 KON85486.1 KON85486.1 spxA spxA KON86474.1 KON86474.1 KON89997.1 KON89997.1 KON89847.1 KON89847.1 KON89651.1 KON89651.1 dsdA dsdA serC serC spxA-2 spxA-2 KON89263.1 KON89263.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (349 aa)
KON89035.1Aspartate kinase; Catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; diaminopimelate sensitive; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (414 aa)
KON88999.12-hydroxyacid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (316 aa)
KON86821.1Aspartate kinase; Catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (409 aa)
KON86963.1Phosphatidylserine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (179 aa)
gcvTGlycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. (367 aa)
gcvPAGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (448 aa)
gcvPBGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (486 aa)
KON87086.1Xaa-Pro dipeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (353 aa)
KON87116.1Dihydrolipoamide dehydrogenase; E3 component of the branched-chain alpha-keto acid dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology. (473 aa)
KON87136.1Phosphoglycerate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (186 aa)
KON87203.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (210 aa)
KON87502.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (257 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (422 aa)
trpBTryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (401 aa)
trpATryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (261 aa)
KON87691.1CDP-diacylglycerol--serine O-phosphatidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (231 aa)
KON87735.1Serine-pyruvate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (386 aa)
KON90300.13-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (399 aa)
KON87830.1Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (462 aa)
KON87831.1Glycine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (523 aa)
KON87834.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (372 aa)
KON87891.1Amine oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (484 aa)
KON88049.1X-Pro dipeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (376 aa)
KON88314.1Glycerate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glycerate kinase type-1 family. (379 aa)
KON88412.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (99 aa)
KON90361.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (465 aa)
KON88582.1Aminomethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (207 aa)
KON88625.12-amino-3-ketobutyrate CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (396 aa)
KON88635.1Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (480 aa)
KON90367.1Serine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. (291 aa)
KON88663.1Serine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. (220 aa)
KON88741.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (243 aa)
KON88773.1Glycerate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glycerate kinase type-1 family. (393 aa)
KON86473.1Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (432 aa)
thrBSerine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (311 aa)
KON86758.1Metallopeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (365 aa)
KON86471.1Spore coat protein CotS; Derived by automated computational analysis using gene prediction method: Protein Homology. (335 aa)
gcvHGlycine cleavage system protein H; Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate; Belongs to the GcvH family. (127 aa)
KON90209.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ArsC family. (119 aa)
gpmIPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (511 aa)
KON86236.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (295 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (413 aa)
KON85704.1Phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate mutase family. (206 aa)
KON85652.1Peptidase M14; Derived by automated computational analysis using gene prediction method: Protein Homology. (396 aa)
KON85586.12-hydroxyacid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (320 aa)
KON85574.1Aspartate kinase; Catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (455 aa)
KON85486.1Catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology. (375 aa)
spxAArsR family transcriptional regulator; Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development- promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress. Belongs to the ArsC family. Spx subfamily. (131 aa)
KON86474.1Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (353 aa)
KON89997.1Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (331 aa)
KON89847.1Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (378 aa)
KON89651.1Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (404 aa)
dsdASerine ammonia-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the serine/threonine dehydratase family. DsdA subfamily. (446 aa)
serCMFS transporter; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (360 aa)
spxA-2ArsR family transcriptional regulator; Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development- promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress. Belongs to the ArsC family. Spx subfamily. (131 aa)
KON89263.1Dihydrolipoamide dehydrogenase; E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology. (469 aa)
Your Current Organism:
Sporosarcina globispora
NCBI taxonomy Id: 1459
Other names: ATCC 23301, Bacillus globisporus, CCM 2119, CCUG 7419, CIP 103266, DSM 4, HAMBI 471, IFO 16082, JCM 10046, LMG 6928, LMG:6928, NBRC 16082, NCIMB 11434, NRRL B-3396, S. globispora, strain 785, strain W 25, strain W25
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