STRINGSTRING
ldh-2 ldh-2 KON86719.1 KON86719.1 KON86739.1 KON86739.1 KON86775.1 KON86775.1 mdh mdh KON86778.1 KON86778.1 KON89970.1 KON89970.1 kynB kynB KON89909.1 KON89909.1 gcvT gcvT gcvPA gcvPA gcvPB gcvPB KON87116.1 KON87116.1 KON87120.1 KON87120.1 KON87121.1 KON87121.1 KON87129.1 KON87129.1 KON87130.1 KON87130.1 KON87150.1 KON87150.1 KON87532.1 KON87532.1 KON87564.1 KON87564.1 KON87645.1 KON87645.1 KON87646.1 KON87646.1 KON87668.1 KON87668.1 KON87677.1 KON87677.1 glcB glcB KON87735.1 KON87735.1 KON87830.1 KON87830.1 KON87831.1 KON87831.1 KON90314.1 KON90314.1 KON87933.1 KON87933.1 KON88005.1 KON88005.1 KON88218.1 KON88218.1 KON89867.1 KON89867.1 KON89760.1 KON89760.1 spxA-2 spxA-2 KON89370.1 KON89370.1 KON89338.1 KON89338.1 KON89263.1 KON89263.1 KON89224.1 KON89224.1 KON89222.1 KON89222.1 gcvH gcvH KON90209.1 KON90209.1 glyA glyA icmF icmF KON86077.1 KON86077.1 ldh ldh KON85732.1 KON85732.1 KON86472.1 KON86472.1 KON85690.1 KON85690.1 KON90167.1 KON90167.1 KON85586.1 KON85586.1 purU purU spxA spxA mdh-2 mdh-2 KON89200.1 KON89200.1 KON88987.1 KON88987.1 KON88773.1 KON88773.1 KON88767.1 KON88767.1 KON88731.1 KON88731.1 KON88635.1 KON88635.1 KON88626.1 KON88626.1 KON88314.1 KON88314.1 KON88367.1 KON88367.1 KON90348.1 KON90348.1 KON88422.1 KON88422.1 KON90349.1 KON90349.1 KON88457.1 KON88457.1 KON88549.1 KON88549.1 KON88582.1 KON88582.1 KON88583.1 KON88583.1 KON88618.1 KON88618.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ldh-2Lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (316 aa)
KON86719.1acetyl-CoA synthetase; Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (572 aa)
KON86739.1acyl--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (529 aa)
KON86775.1Citrate synthase; Catalyzes the formation of citrate from acetyl-CoA and oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. (373 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (312 aa)
KON86778.1enoyl-CoA hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (158 aa)
KON89970.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (257 aa)
kynBKynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. (208 aa)
KON89909.1Glycolate oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (421 aa)
gcvTGlycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. (367 aa)
gcvPAGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (448 aa)
gcvPBGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (486 aa)
KON87116.1Dihydrolipoamide dehydrogenase; E3 component of the branched-chain alpha-keto acid dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology. (473 aa)
KON87120.1methylmalonyl-CoA mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (617 aa)
KON87121.1methylmalonyl-CoA mutase; MDM; functions in conversion of succinate to propionate; Derived by automated computational analysis using gene prediction method: Protein Homology. (730 aa)
KON87129.1Lactoylglutathione lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (136 aa)
KON87130.1methylmalonyl-CoA carboxyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (516 aa)
KON87150.1acetyl-CoA acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa)
KON87532.1Peptidase S66; Derived by automated computational analysis using gene prediction method: Protein Homology. (325 aa)
KON87564.1Sporulation protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (260 aa)
KON87645.1Nitrite reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (722 aa)
KON87646.1Electron transfer flavoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology. (186 aa)
KON87668.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (988 aa)
KON87677.1Glycolate oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (452 aa)
glcBMalate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (725 aa)
KON87735.1Serine-pyruvate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (386 aa)
KON87830.1Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (462 aa)
KON87831.1Glycine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (523 aa)
KON90314.1enoyl-CoA hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (123 aa)
KON87933.1Glycolate oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (436 aa)
KON88005.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (62 aa)
KON88218.1acetyl-CoA acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (359 aa)
KON89867.1Alcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (331 aa)
KON89760.1acetyl-CoA acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa)
spxA-2ArsR family transcriptional regulator; Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development- promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress. Belongs to the ArsC family. Spx subfamily. (131 aa)
KON89370.1Phosphoglycolate phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (187 aa)
KON89338.1Glycolate oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (443 aa)
KON89263.1Dihydrolipoamide dehydrogenase; E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology. (469 aa)
KON89224.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (213 aa)
KON89222.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (365 aa)
gcvHGlycine cleavage system protein H; Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate; Belongs to the GcvH family. (127 aa)
KON90209.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ArsC family. (119 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (413 aa)
icmFmethylmalonyl-CoA mutase; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. (1088 aa)
KON86077.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa)
ldhLactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (309 aa)
KON85732.1Peptidase S66; Derived by automated computational analysis using gene prediction method: Protein Homology. (306 aa)
KON86472.12-ketogluconate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (320 aa)
KON85690.1Antitoxin endoai; Derived by automated computational analysis using gene prediction method: Protein Homology. (93 aa)
KON90167.1Isocitrate lyase; Catalyzes the reversible formation of glyoxylate and succinate from isocitrate; glyoxylate bypass pathway; Derived by automated computational analysis using gene prediction method: Protein Homology. (429 aa)
KON85586.12-hydroxyacid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (320 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (288 aa)
spxAArsR family transcriptional regulator; Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development- promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress. Belongs to the ArsC family. Spx subfamily. (131 aa)
mdh-2Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (318 aa)
KON89200.1Carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (513 aa)
KON88987.1Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (444 aa)
KON88773.1Glycerate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glycerate kinase type-1 family. (393 aa)
KON88767.1Catalase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the catalase family. (549 aa)
KON88731.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (97 aa)
KON88635.1Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (480 aa)
KON88626.1Catalase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the catalase family. (485 aa)
KON88314.1Glycerate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glycerate kinase type-1 family. (379 aa)
KON88367.1Serine protease; Derived by automated computational analysis using gene prediction method: Protein Homology. (385 aa)
KON90348.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (262 aa)
KON88422.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (184 aa)
KON90349.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (170 aa)
KON88457.13-hydroxyacyl-ACP dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (127 aa)
KON88549.1enoyl-CoA hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (126 aa)
KON88582.1Aminomethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (207 aa)
KON88583.1Cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (227 aa)
KON88618.1Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (902 aa)
Your Current Organism:
Sporosarcina globispora
NCBI taxonomy Id: 1459
Other names: ATCC 23301, Bacillus globisporus, CCM 2119, CCUG 7419, CIP 103266, DSM 4, HAMBI 471, IFO 16082, JCM 10046, LMG 6928, LMG:6928, NBRC 16082, NCIMB 11434, NRRL B-3396, S. globispora, strain 785, strain W 25, strain W25
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