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| | NTE_00521 | PFAM: TFIIB zinc-binding; Transcription factor TFIIB repeat. (292 aa) |
| | NTE_00007 | DNA polymerase elongation subunit (family B); PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain. (749 aa) |
| | pyrB | PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; TIGRFAM: aspartate carbamoyltransferase. (312 aa) |
| | NTE_00016 | Putative nuleotide-utilizing enzyme, moeA; PFAM: Probable molybdopterin binding domain; TIGRFAM: molybdenum cofactor synthesis domain. (266 aa) |
| | tmk | PFAM: Thymidylate kinase; TIGRFAM: thymidylate kinase. (245 aa) |
| | tmk-2 | PFAM: Thymidylate kinase; TIGRFAM: thymidylate kinase. (249 aa) |
| | NTE_00067 | PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit. (238 aa) |
| | NTE_00077 | Dinucleotide-utilizing enzyme possibly involved in molybdopterin or thiamin biosynthesis; PFAM: ThiS family; MoeZ/MoeB domain; ThiF family. (444 aa) |
| | polC | DNA polymerase II large subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. (1137 aa) |
| | polB | Archaeal DNA polymerase II, small subunit/DNA polymerase delta, subunit B; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. (498 aa) |
| | NTE_00089 | PFAM: Cytochrome oxidase assembly protein. (175 aa) |
| | tfe | Transcription initiation factor IIE, alpha subunit; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing [...] (242 aa) |
| | NTE_00110 | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (950 aa) |
| | nadE | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (279 aa) |
| | NTE_00412 | Precorrin-4 C11-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-4 C11-methyltransferase. (270 aa) |
| | NTE_00413 | Precorrin-2 C20-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. (241 aa) |
| | NTE_00434 | DNA polymerase IV (family X); PFAM: PHP domain; DNA polymerase beta thumb; Helix-hairpin-helix domain. (574 aa) |
| | NTE_00436 | Transcription initiation factor TFIIIB, Brf1 subunit/transcription initiation factor TFIIB; PFAM: TFIIB zinc-binding; Transcription factor TFIIB repeat. (334 aa) |
| | NTE_00444 | acyl-CoA synthetase/AMP-acid ligase; PFAM: AMP-binding enzyme; AMP-binding enzyme C-terminal domain. (641 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (225 aa) |
| | tbp | TATA binding protein of transcription factor TFIID; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. (201 aa) |
| | NTE_00642 | Methylthioadenosine phosphorylase; Purine nucleoside phosphorylase involved in purine salvage. (267 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (179 aa) |
| | NTE_00652 | NTP pyrophosphohydrolase; PFAM: NUDIX domain. (147 aa) |
| | NTE_00653 | PFAM: Orotidine 5'-phosphate decarboxylase / HUMPS family; TIGRFAM: orotidine 5'-phosphate decarboxylase, subfamily 1. (251 aa) |
| | purA | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (335 aa) |
| | NTE_00682 | DNA polymerase elongation subunit (family B); PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain. (896 aa) |
| | NTE_00765 | PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (317 aa) |
| | purE | 5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (171 aa) |
| | NTE_00824 | ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligase); PFAM: Domain of unknown function (DUF1297); Protein of unknown function (DUF1246). (366 aa) |
| | NTE_00856 | PFAM: 6-pyruvoyl tetrahydropterin synthase. (278 aa) |
| | NTE_00916 | precorrin-3B C17-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-3B C17-methyltransferase. (269 aa) |
| | NTE_00936 | Phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, C domain. (423 aa) |
| | NTE_00945 | PFAM: Transcription factor S-II (TFIIS); TIGRFAM: transcription factor S, archaeal; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (108 aa) |
| | NTE_00946 | DNA-directed RNA polymerase, subunit L; PFAM: RNA polymerase Rpb3/Rpb11 dimerisation domain. (91 aa) |
| | NTE_00992 | PFAM: Cytochrome oxidase assembly protein. (157 aa) |
| | NTE_01010 | PFAM: Uroporphyrinogen-III synthase HemD. (271 aa) |
| | NTE_01011 | uroporphyrin-III C-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. (266 aa) |
| | hemC | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (315 aa) |
| | hemL | PFAM: Aminotransferase class-III; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase. (431 aa) |
| | pyrH | Uridylate kinase, putative; Catalyzes the reversible phosphorylation of UMP to UDP. (234 aa) |
| | tmk-3 | PFAM: Thymidylate kinase; TIGRFAM: thymidylate kinase. (198 aa) |
| | NTE_01038 | PFAM: Pterin 4 alpha carbinolamine dehydratase. (100 aa) |
| | NTE_01086 | PFAM: Dihydroorotate dehydrogenase. (393 aa) |
| | NTE_01093 | DNA-directed RNA polymerase, subunit F; PFAM: RNA polymerase Rpb4. (110 aa) |
| | NTE_01185 | Putative Fe-S oxidoreductase; PFAM: Radical SAM superfamily; 4Fe-4S single cluster domain. (321 aa) |
| | NTE_01201 | PFAM: Nucleoside diphosphate kinase; Belongs to the NDK family. (134 aa) |
| | pdxT | Pyridoxal phosphate synthase yaaE subunit; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (214 aa) |
| | pdxS | Pyridoxal phosphate synthase yaaD subunit; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (326 aa) |
| | NTE_01245 | Hypothetical protein; PFAM: Chlorite dismutase. (240 aa) |
| | NTE_01338 | DNA-directed RNA polymerase, alpha subunit/40 kD subunit; PFAM: RNA polymerase Rpb3/Rpb11 dimerisation domain; RNA polymerase Rpb3/RpoA insert domain. (250 aa) |
| | nadK | Putative sugar kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (270 aa) |
| | NTE_01381 | Porphobilinogen synthase; PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (337 aa) |
| | hemA | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (442 aa) |
| | NTE_01383 | PFAM: Putative NAD(P)-binding; TIGRFAM: siroheme synthase, N-terminal domain. (222 aa) |
| | NTE_01392 | PFAM: N-terminal domain of ribose phosphate pyrophosphokinase; Phosphoribosyl synthetase-associated domain; TIGRFAM: ribose-phosphate pyrophosphokinase. (297 aa) |
| | NTE_01417 | Putative tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase with PP-loop ATPase domain; PFAM: Domain of unknown function (DUF814); Thiamine biosynthesis protein (ThiI). (377 aa) |
| | NTE_01423 | Cytidyltransferase-related enzyme; PFAM: Cytidylyltransferase; TIGRFAM: cytidyltransferase-like domain. (156 aa) |
| | NTE_01444 | Alternative thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (552 aa) |
| | NTE_01450 | PFAM: Aminotransferase class-III; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (452 aa) |
| | NTE_01469 | Putative Zn-finger containing protein; PFAM: Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27). (127 aa) |
| | tfb | Transcription initiation factor IIB (TFIIB); Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (298 aa) |
| | NTE_01478 | Dihydroorotase-like cyclic amidohydrolase; PFAM: Amidohydrolase; Urease alpha-subunit, N-terminal domain; TIGRFAM: dihydroorotase, multifunctional complex type. (478 aa) |
| | NTE_01512 | Putative phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain. (151 aa) |
| | NTE_01522 | PFAM: Acyl-CoA dehydrogenase, C-terminal domain; Acyl-CoA dehydrogenase, middle domain; Acyl-CoA dehydrogenase, N-terminal domain. (411 aa) |
| | dbh | nucleotidyltransferase/DNA polymerase involved in DNA repair; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. (611 aa) |
| | NTE_01557 | TIGR00303 family protein; PFAM: Phosphoribosyltransferase; TIGRFAM: TIGR00303 family protein; Belongs to the UPF0284 family. (365 aa) |
| | NTE_01633 | Small primase-like protein with Toprim domain; PFAM: Toprim domain. (145 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. (480 aa) |
| | NTE_01635 | CTP-dependent riboflavin kinase; PFAM: Domain of unknown function DUF120. (237 aa) |
| | NTE_01636 | Cytidyltransferase-related enzyme; PFAM: Cytidylyltransferase; TIGRFAM: cytidyltransferase-like domain. (209 aa) |
| | NTE_01648 | Putative Fe-S oxidoreductase; PFAM: Radical SAM superfamily; 4Fe-4S single cluster domain. (387 aa) |
| | ctaB | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (299 aa) |
| | NTE_01666 | Hypothetical protein. (168 aa) |
| | dbh-2 | nucleotidyltransferase/DNA polymerase involved in DNA repair; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. (382 aa) |
| | nadX | Aspartate dehydrogenase; Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate. (276 aa) |
| | nadA | Quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (316 aa) |
| | NTE_01703 | Nicotinate-nucleotide pyrophosphorylase (carboxylating); Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (290 aa) |
| | NTE_01705 | DNA-directed RNA polymerase subunit E; PFAM: S1 RNA binding domain; SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397; TIGRFAM: DNA-directed RNA polymerase (rpoE), archaeal and eukaryotic form. (200 aa) |
| | NTE_01707 | Hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). (168 aa) |
| | cbiD | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (395 aa) |
| | NTE_01732 | Cobalt-precorrin 5A acetaldehyde-lyase; PFAM: Cobalamin synthesis G C-terminus; Cobalamin biosynthesis central region; Cobalamin synthesis G N-terminal. (356 aa) |
| | NTE_01733 | PFAM: Precorrin-8X methylmutase; CbiX. (483 aa) |
| | cbiA | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) /cobyrinate a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (465 aa) |
| | NTE_01736 | cob(I)yrinic acid a,c-diamide adenosyltransferase; PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; TIGRFAM: cob(I)alamin adenosyltransferase. (182 aa) |
| | NTE_01750 | Hypothetical protein. (340 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (425 aa) |
| | NTE_01774 | Putative ATPase; PFAM: D5 N terminal like; Bifunctional DNA primase/polymerase, N-terminal. (780 aa) |
| | NTE_01784 | PFAM: chorismate binding enzyme; Anthranilate synthase component I, N terminal region; TIGRFAM: anthranilate synthase component I, archaeal clade. (453 aa) |
| | NTE_01790 | 7-keto-8-aminopelargonate synthetase-like enzyme; PFAM: Aminotransferase class I and II; TIGRFAM: 8-amino-7-oxononanoate synthase. (387 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (325 aa) |
| | NTE_01809 | PFAM: Aminotransferase class-III; TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (448 aa) |
| | bioD | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (231 aa) |
| | purC | PFAM: SAICAR synthetase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase. (277 aa) |
| | purK | 5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (391 aa) |
| | purE-2 | 5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (182 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (360 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (279 aa) |
| | trpB | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (406 aa) |
| | NTE_01914 | PFAM: Indole-3-glycerol phosphate synthase. (267 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (551 aa) |
| | nadK-2 | Putative sugar kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (333 aa) |
| | NTE_01934 | PFAM: ATP synthase (F/14-kDa) subunit. (98 aa) |
| | priL | DNA primase, large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. (347 aa) |
| | priS | Eukaryotic-type DNA primase, catalytic (small) subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer exten [...] (394 aa) |
| | NTE_01967 | GMP synthase family protein; PFAM: Glutamine amidotransferase class-I. (191 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (478 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (727 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (231 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase, purS protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (92 aa) |
| | NTE_02036 | Hydroxymethylpyrimidine synthase; PFAM: ThiC family; TIGRFAM: thiamine biosynthesis protein ThiC. (444 aa) |
| | NTE_02040 | PFAM: Phosphomethylpyrimidine kinase; Putative aldolase; TIGRFAM: phosphomethylpyrimidine kinase. (450 aa) |
| | NTE_02053 | PFAM: TFIIB zinc-binding; Transcription factor TFIIB repeat. (341 aa) |
| | NTE_02159 | Formyltetrahydrofolate hydrolase; PFAM: ACT domain; Formyl transferase; TIGRFAM: phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent; formyltetrahydrofolate deformylase. (303 aa) |
| | NTE_02160 | Uncharacterized protein, putative amidase; PFAM: Creatinine amidohydrolase. (238 aa) |
| | folD | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa) |
| | NTE_02168 | PFAM: 5-formyltetrahydrofolate cyclo-ligase family; TIGRFAM: 5,10-methenyltetrahydrofolate synthetase. (172 aa) |
| | purD | Phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, C domain; TIGRFAM: phosphoribosylamine--glycine ligase; Belongs to the GARS family. (431 aa) |
| | NTE_02172 | Carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; MGS-like domain; Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Carbamoyl-phosphate synthase L chain, N-terminal domain; TIGRFAM: carbamoyl-phosphate synthase, large subunit. (1029 aa) |
| | carA | PFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I; TIGRFAM: carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (403 aa) |
| | NTE_02189 | Dihydrofolate reductase; PFAM: RibD C-terminal domain. (200 aa) |
| | rpoK | DNA-directed RNA polymerase, subunit K/omega; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family. (137 aa) |
| | lig | ATP-dependent DNA ligase I; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (606 aa) |
| | NTE_02242 | PFAM: Transcription factor TFIIB repeat. (281 aa) |
| | NTE_02247 | Putative Fe-S oxidoreductase; PFAM: Radical SAM superfamily; 4Fe-4S single cluster domain. (347 aa) |
| | thi4 | Thiazole-adenylate synthase; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. (273 aa) |
| | NTE_02277 | NTP pyrophosphohydrolase; PFAM: NUDIX domain. (145 aa) |
| | NTE_02305 | Phosphopantetheine adenylyltransferase. (204 aa) |
| | NTE_02328 | Glutamine phosphoribosylpyrophosphate amidotransferase. (458 aa) |
| | NTE_02371 | Acetyl-coenzyme A synthetase; PFAM: AMP-binding enzyme; AMP-binding enzyme C-terminal domain; TIGRFAM: acetate--CoA ligase. (649 aa) |
| | NTE_02374 | PFAM: Histone-like transcription factor (CBF/NF-Y) and archaeal histone. (63 aa) |
| | NTE_02445 | Transcription initiation factor TFIIIB, Brf1 subunit/transcription initiation factor TFIIB; PFAM: TFIIB zinc-binding; Transcription factor TFIIB repeat. (300 aa) |
| | NTE_02481 | Asparagine synthase, glutamine-hydrolyzing; PFAM: Glutamine amidotransferase domain; Asparagine synthase; TIGRFAM: asparagine synthase (glutamine-hydrolyzing). (546 aa) |
| | NTE_02503 | FO synthase subunit 1; PFAM: Radical SAM superfamily; TIGRFAM: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofG subunit. (395 aa) |
| | rpoN | DNA-directed RNA polymerase, subunit N; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family. (78 aa) |
| | NTE_02599 | Putative kinase, sugar kinase superfamily; PFAM: GHMP kinases N terminal domain. (308 aa) |
| | NTE_02600 | Pantothenate synthetase; PFAM: Protein of unknown function DUF137. (251 aa) |
| | panB | Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (295 aa) |
| | NTE_02602 | PFAM: DNA / pantothenate metabolism flavoprotein; Flavoprotein; TIGRFAM: phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase. (431 aa) |
| | NTE_02606 | Dihydrofolate reductase; PFAM: RibD C-terminal domain. (170 aa) |
| | NTE_02613 | Dihydrofolate reductase; PFAM: RibD C-terminal domain. (222 aa) |
| | NTE_02637 | Transcription initiation factor TFIIIB, Brf1 subunit/transcription initiation factor TFIIB; PFAM: TFIIB zinc-binding; Transcription factor TFIIB repeat. (301 aa) |
| | NTE_02710 | Transcription initiation factor TFIIIB, Brf1 subunit/transcription initiation factor TFIIB; PFAM: Transcription factor TFIIB repeat. (319 aa) |
| | NTE_02718 | PFAM: Cytidylyltransferase; TIGRFAM: nicotinamide-nucleotide adenylyltransferase; cytidyltransferase-like domain. (184 aa) |
| | nusA | NusA family KH domain protein; Participates in transcription termination. Belongs to the NusA family. (161 aa) |
| | rpoA2 | DNA-directed RNA polymerase, subunit A''/DNA-directed RNA polymerase subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1269 aa) |
| | NTE_02750 | DNA-directed RNA polymerase, subunit B; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1117 aa) |
| | rpoH | DNA-directed RNA polymerase, subunit H; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. (83 aa) |
| | queE | Organic radical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (250 aa) |
| | folE | PFAM: GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I. (188 aa) |
| | NTE_02791 | PFAM: Cytidylate kinase-like family; TIGRFAM: cytidylate kinase, putative. (196 aa) |
| | adkA | Archaeal adenylate kinase; PFAM: AAA domain; Belongs to the archaeal adenylate kinase family. (206 aa) |
| | NTE_02799 | NCAIR mutase-like protein; PFAM: AIR carboxylase. (262 aa) |
| | NTE_02804 | PFAM: Cobalamin adenosyltransferase; TIGRFAM: ATP:cob(I)alamin adenosyltransferase. (191 aa) |
| | purP | ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligase); Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. (351 aa) |
| | NTE_02864 | DNA-directed RNA polymerase, subunit RPC10 (contains C4-type Zn-finger); PFAM: DNA directed RNA polymerase, 7 kDa subunit. (54 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: phosphoribosylaminoimidazole synthetase. (345 aa) |
| | NTE_02921 | PFAM: Formyl transferase; TIGRFAM: phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent. (206 aa) |
| | NTE_02931 | PFAM: Lyase; Adenylosuccinate lyase C-terminus; TIGRFAM: adenylosuccinate lyase. (481 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (317 aa) |
| | NTE_02983 | PFAM: Pterin 4 alpha carbinolamine dehydratase. (389 aa) |
| | ctaB-2 | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (301 aa) |
| | cobQ | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (283 aa) |
| | cobD | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (323 aa) |
| | cobS | Cobalamin-5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (256 aa) |
| | NTE_03118 | GTP:adenosylcobinamide-phosphate guanylyltransferase; PFAM: MobA-like NTP transferase domain. (199 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (477 aa) |
| | mptE | Uncharacterized Rossmann fold enzyme; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP). (259 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (517 aa) |
| | NTE_03244 | Metal-dependent hydrolase, beta-lactamase superfamily II; PFAM: Metallo-beta-lactamase superfamily. (335 aa) |
| | cbiT | precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7. (193 aa) |
| | NTE_03272 | PFAM: ATP synthase (C/AC39) subunit. (353 aa) |
| | atpD | H(+)-transporting ATP synthase, vacuolar type, subunit D; Produces ATP from ADP in the presence of a proton gradient across the membrane. (220 aa) |
| | atpB | Archaeal/vacuolar-type H+-ATPase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. (443 aa) |
| | atpA | Archaeal/vacuolar-type H+-ATPase subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (600 aa) |
| | atpE | Archaeal/vacuolar-type H+-ATPase subunit E; Produces ATP from ADP in the presence of a proton gradient across the membrane. (208 aa) |
| | NTE_03285 | Putative Zn-dependent hydrolase of beta-lactamase fold. (417 aa) |
| | pyrI | Aspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (153 aa) |
| | NTE_03303 | Putative nucleoside kinase, CMP and AMP kinase; PFAM: AAA domain. (194 aa) |
| | NTE_03324 | Cytidyltransferase-related enzyme; PFAM: Cytidylyltransferase; TIGRFAM: nicotinamide-nucleotide adenylyltransferase; cytidyltransferase-like domain. (184 aa) |
| | NTE_03373 | Hypothetical protein. (252 aa) |
| | NTE_03545 | 2, 5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 1'-reductase; PFAM: RibD C-terminal domain; TIGRFAM: riboflavin-specific deaminase C-terminal domain; 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 1'-reductase, archaeal. (217 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (154 aa) |
| | NTE_03549 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (229 aa) |
| | NTE_03551 | PFAM: Lumazine binding domain; TIGRFAM: riboflavin synthase, alpha subunit. (205 aa) |
