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| | NTE_00008 | PFAM: O-methyltransferase. (204 aa) |
| | ilvE | Branched-chain amino acid aminotransferase, group I; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (312 aa) |
| | NTE_00019 | PFAM: Amino acid kinase family; TIGRFAM: aspartate kinase. (484 aa) |
| | NTE_00075 | PFAM: Phosphoribosyl-AMP cyclohydrolase. (111 aa) |
| | NTE_00076 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (406 aa) |
| | NTE_00089 | PFAM: Cytochrome oxidase assembly protein. (175 aa) |
| | NTE_00104 | acetyl-CoA acetyltransferase; PFAM: Thiolase, C-terminal domain; Thiolase, N-terminal domain. (388 aa) |
| | NTE_00164 | Hypothetical protein. (148 aa) |
| | NTE_00280 | Mannose-6-phosphate isomerase, type 2; PFAM: Mannose-6-phosphate isomerase. (112 aa) |
| | NTE_00444 | acyl-CoA synthetase/AMP-acid ligase; PFAM: AMP-binding enzyme; AMP-binding enzyme C-terminal domain. (641 aa) |
| | tal | Fructose-6-phosphate aldolase, TalC/MipB family; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (221 aa) |
| | NTE_00601 | Transketolase, alpha subunit; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain. (326 aa) |
| | NTE_00602 | Transketolase, beta subunit; PFAM: Ribulose-phosphate 3 epimerase family; Transketolase, thiamine diphosphate binding domain; TIGRFAM: ribulose-phosphate 3-epimerase. (546 aa) |
| | NTE_00627 | Cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme. (527 aa) |
| | ubiX | Polyprenyl p-hydroxybenzoate/phenylacrylic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (198 aa) |
| | argG | PFAM: Arginosuccinate synthase; TIGRFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (413 aa) |
| | lysY | N-acetyl-gamma-glutamyl-phosphate reductase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (350 aa) |
| | lysZ | N-acetylglutamate kinase; Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis); Belongs to the acetylglutamate kinase family. LysZ subfamily. (267 aa) |
| | NTE_00736 | PFAM: Aminotransferase class-III; TIGRFAM: transaminase, acetylornithine/succinylornithine family; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (393 aa) |
| | NTE_00750 | Phosphoglycerate dehydrogenase-like oxidoreductase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; TIGRFAM: D-3-phosphoglycerate dehydrogenase. (310 aa) |
| | NTE_00762 | PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase. (350 aa) |
| | NTE_00765 | PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (317 aa) |
| | NTE_00786 | PFAM: 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; TIGRFAM: menaquinone biosynthesis decarboxylase, SCO4490 family; UbiD family decarboxylase. (484 aa) |
| | mqnC | De-hypoxanthine futalosine cyclase; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). (375 aa) |
| | NTE_00789 | PFAM: Radical SAM superfamily; TIGRFAM: radical SAM domain protein, CofH subfamily. (372 aa) |
| | purE | 5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (171 aa) |
| | mqnD | 1,4-dihydroxy-6-naphthoate synthase; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnD subfamily. (280 aa) |
| | NTE_00821 | PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like. (220 aa) |
| | NTE_00824 | ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligase); PFAM: Domain of unknown function (DUF1297); Protein of unknown function (DUF1246). (366 aa) |
| | NTE_00858 | PFAM: Asparagine synthase. (265 aa) |
| | NTE_00933 | Aspartate kinase; PFAM: ACT domain; Amino acid kinase family; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; Belongs to the aspartokinase family. (470 aa) |
| | NTE_00936 | Phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, C domain. (423 aa) |
| | NTE_00977 | Arginase family hydrolase, arginase/agmainase/formiminoglutamate hydrolase; PFAM: Arginase family; TIGRFAM: arginase; Belongs to the arginase family. (301 aa) |
| | NTE_00982 | L-alanine aminotransferase apoenzyme; PFAM: Aminotransferase class I and II. (392 aa) |
| | NTE_00987 | Fructose-2,6-bisphosphatase; PFAM: Histidine phosphatase superfamily (branch 1). (201 aa) |
| | NTE_00992 | PFAM: Cytochrome oxidase assembly protein. (157 aa) |
| | NTE_01007 | PFAM: Glucose / Sorbosone dehydrogenase; TIGRFAM: dehydrogenase, PQQ-dependent, s-GDH family. (499 aa) |
| | NTE_01010 | PFAM: Uroporphyrinogen-III synthase HemD. (271 aa) |
| | NTE_01011 | uroporphyrin-III C-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. (266 aa) |
| | hemC | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (315 aa) |
| | hemL | PFAM: Aminotransferase class-III; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase. (431 aa) |
| | NTE_01097 | PFAM: Isocitrate/isopropylmalate dehydrogenase. (342 aa) |
| | NTE_01106 | PFAM: Asparagine synthase. (320 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (333 aa) |
| | NTE_01149 | Dehydrogenase of unknown specificity, short-chain alcohol dehydrogenase like; PFAM: Enoyl-(Acyl carrier protein) reductase. (255 aa) |
| | NTE_01163 | PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase; TIGRFAM: 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase. (355 aa) |
| | NTE_01185 | Putative Fe-S oxidoreductase; PFAM: Radical SAM superfamily; 4Fe-4S single cluster domain. (321 aa) |
| | NTE_01201 | PFAM: Nucleoside diphosphate kinase; Belongs to the NDK family. (134 aa) |
| | NTE_01223 | PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; Phosphoglucomutase/phosphomannomutase, C-terminal domain; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I; TIGRFAM: phosphoglucosamine mutase; Belongs to the phosphohexose mutase family. (454 aa) |
| | NTE_01231 | PFAM: Aconitase C-terminal domain; Aconitase family (aconitate hydratase); TIGRFAM: aconitate hydratase, mitochondrial. (762 aa) |
| | NTE_01233 | 2-oxoacid:acceptor oxidoreductase, alpha subunit; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg; Transketolase, C-terminal domain; Pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, alpha subunit. (650 aa) |
| | NTE_01234 | 2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate family; PFAM: Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate family. (325 aa) |
| | NTE_01254 | PFAM: Aconitase C-terminal domain; TIGRFAM: 3-isopropylmalate dehydratase, small subunit. (166 aa) |
| | leuC | Homoaconitate hydratase family protein/3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (424 aa) |
| | NTE_01293 | PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; TIGRFAM: ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (321 aa) |
| | pckA | ATP-dependent phosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (523 aa) |
| | NTE_01316 | PFAM: Hydroxymethylglutaryl-coenzyme A synthase N terminal; Hydroxymethylglutaryl-coenzyme A synthase C terminal. (466 aa) |
| | NTE_01317 | Threonine ammonia-lyase, medium form; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine ammonia-lyase, medium form. (417 aa) |
| | NTE_01381 | Porphobilinogen synthase; PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (337 aa) |
| | hemA | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (442 aa) |
| | NTE_01383 | PFAM: Putative NAD(P)-binding; TIGRFAM: siroheme synthase, N-terminal domain. (222 aa) |
| | NTE_01392 | PFAM: N-terminal domain of ribose phosphate pyrophosphokinase; Phosphoribosyl synthetase-associated domain; TIGRFAM: ribose-phosphate pyrophosphokinase. (297 aa) |
| | NTE_01450 | PFAM: Aminotransferase class-III; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (452 aa) |
| | NTE_01476 | PFAM: Ribose 5-phosphate isomerase A (phosphoriboisomerase A); TIGRFAM: ribose 5-phosphate isomerase. (225 aa) |
| | argH | PFAM: Lyase; Argininosuccinate lyase C-terminal; TIGRFAM: argininosuccinate lyase. (491 aa) |
| | NTE_01591 | PFAM: 2Fe-2S iron-sulfur cluster binding domain; 4Fe-4S dicluster domain; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein. (280 aa) |
| | NTE_01592 | Succinate dehydrogenase, hydrophobic anchor subunit; PFAM: Succinate dehydrogenase/Fumarate reductase transmembrane subunit. (109 aa) |
| | NTE_01593 | PFAM: Succinate dehydrogenase/Fumarate reductase transmembrane subunit. (150 aa) |
| | NTE_01594 | PFAM: FAD binding domain; Fumarate reductase flavoprotein C-term; TIGRFAM: succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup. (570 aa) |
| | NTE_01636 | Cytidyltransferase-related enzyme; PFAM: Cytidylyltransferase; TIGRFAM: cytidyltransferase-like domain. (209 aa) |
| | NTE_01645 | PFAM: Myo-inositol-1-phosphate synthase. (362 aa) |
| | ctaB | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (299 aa) |
| | pgk | PFAM: Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (402 aa) |
| | NTE_01726 | PFAM: S-adenosylmethionine synthetase, C-terminal domain; S-adenosylmethionine synthetase, central domain; S-adenosylmethionine synthetase, N-terminal domain; TIGRFAM: S-adenosylmethionine synthetase. (380 aa) |
| | NTE_01727 | Dehydrogenase of unknown specificity, short-chain alcohol dehydrogenase like; PFAM: short chain dehydrogenase. (258 aa) |
| | ilvD | PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (559 aa) |
| | NTE_01784 | PFAM: chorismate binding enzyme; Anthranilate synthase component I, N terminal region; TIGRFAM: anthranilate synthase component I, archaeal clade. (453 aa) |
| | NTE_01785 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (446 aa) |
| | NTE_01813 | Nucleoside-diphosphate-sugar pyrophosphorylase family protein; PFAM: Nucleotidyl transferase. (241 aa) |
| | NTE_01815 | acetyl-CoA acetyltransferase; PFAM: Thiolase, C-terminal domain; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III. (365 aa) |
| | purC | PFAM: SAICAR synthetase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase. (277 aa) |
| | purK | 5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (391 aa) |
| | purE-2 | 5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (182 aa) |
| | NTE_01853 | PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain. (338 aa) |
| | NTE_01905 | PFAM: Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type II. (349 aa) |
| | NTE_01906 | Anthranilate synthase, component II; PFAM: Glutamine amidotransferase class-I; TIGRFAM: glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase. (202 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (360 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (279 aa) |
| | trpB | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (406 aa) |
| | NTE_01914 | PFAM: Indole-3-glycerol phosphate synthase. (267 aa) |
| | NTE_01949 | PFAM: Prephenate dehydrogenase. (285 aa) |
| | NTE_01950 | PFAM: Aminotransferase class I and II; Chorismate mutase type II. (465 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (373 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (432 aa) |
| | aroK | PFAM: GHMP kinases C terminal; GHMP kinases N terminal domain; TIGRFAM: shikimate kinase. (284 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (284 aa) |
| | aroD | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (227 aa) |
| | NTE_01959 | PFAM: 3-dehydroquinate synthase. (356 aa) |
| | aroA-2 | 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (260 aa) |
| | NTE_01973 | 1,4-dihydroxy-2-naphthoate octaprenyltransferase; PFAM: UbiA prenyltransferase family. (294 aa) |
| | NTE_01981 | Putative glycerate kinase; PFAM: MOFRL family; Domain of unknown function (DUF4147). (455 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (478 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (727 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (231 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase, purS protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (92 aa) |
| | sucD | succinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (310 aa) |
| | NTE_02034 | PFAM: CoA-ligase; ATP-grasp domain; TIGRFAM: succinyl-CoA synthetase, beta subunit. (369 aa) |
| | NTE_02041 | Nucleoside-diphosphate-sugar pyrophosphorylase family protein; PFAM: Nucleotidyl transferase. (235 aa) |
| | NTE_02042 | PFAM: Sugar nucleotidyl transferase; TIGRFAM: UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase. (419 aa) |
| | NTE_02050 | PFAM: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Metalloenzyme superfamily; TIGRFAM: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, archaeal form. (430 aa) |
| | NTE_02164 | PFAM: Asparagine synthase. (405 aa) |
| | purD | Phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, C domain; TIGRFAM: phosphoribosylamine--glycine ligase; Belongs to the GARS family. (431 aa) |
| | NTE_02175 | PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isopropylmalate/isohomocitrate dehydrogenases. (342 aa) |
| | NTE_02176 | Isopropylmalate/citramalate/homocitrate synthase; PFAM: LeuA allosteric (dimerisation) domain; HMGL-like; TIGRFAM: isopropylmalate/citramalate/homocitrate synthases; Belongs to the alpha-IPM synthase/homocitrate synthase family. (503 aa) |
| | NTE_02177 | PFAM: Small subunit of acetolactate synthase; ACT domain; TIGRFAM: acetolactate synthase, small subunit. (167 aa) |
| | NTE_02178 | Acetolactate synthase, large subunit; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type. (562 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (322 aa) |
| | NTE_02229 | Mg-chelatase subunit ChlI; PFAM: Sigma-54 interaction domain. (550 aa) |
| | NTE_02233 | Phosphoserine phosphatase SerB; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; phosphoserine phosphatase SerB. (218 aa) |
| | NTE_02247 | Putative Fe-S oxidoreductase; PFAM: Radical SAM superfamily; 4Fe-4S single cluster domain. (347 aa) |
| | NTE_02260 | PFAM: Myo-inositol-1-phosphate synthase. (342 aa) |
| | NTE_02263 | Putative archaeal kinase; PFAM: Amino acid kinase family. (260 aa) |
| | fni | Isopentenyl-diphosphate delta-isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (362 aa) |
| | NTE_02265 | Farnesyl-diphosphate synthase; PFAM: Polyprenyl synthetase; Belongs to the FPP/GGPP synthase family. (335 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (594 aa) |
| | NTE_02279 | 4-hydroxybenzoate synthetase (chorismate lyase). (165 aa) |
| | NTE_02281 | Methylase involved in ubiquinone/menaquinone biosynthesis; PFAM: ubiE/COQ5 methyltransferase family. (226 aa) |
| | ilvE-2 | Branched-chain amino acid aminotransferase, group I; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (305 aa) |
| | NTE_02310 | Lactate dehydrogenase-like oxidoreductase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (333 aa) |
| | NTE_02326 | PFAM: Aconitase family (aconitate hydratase); TIGRFAM: 3-isopropylmalate dehydratase, large subunit. (474 aa) |
| | NTE_02327 | PFAM: Aconitase C-terminal domain; TIGRFAM: 3-isopropylmalate dehydratase, small subunit. (196 aa) |
| | NTE_02328 | Glutamine phosphoribosylpyrophosphate amidotransferase. (458 aa) |
| | NTE_02371 | Acetyl-coenzyme A synthetase; PFAM: AMP-binding enzyme; AMP-binding enzyme C-terminal domain; TIGRFAM: acetate--CoA ligase. (649 aa) |
| | pckA-2 | ATP-dependent phosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (508 aa) |
| | NTE_02478 | PFAM: Mannose-6-phosphate isomerase. (120 aa) |
| | NTE_02481 | Asparagine synthase, glutamine-hydrolyzing; PFAM: Glutamine amidotransferase domain; Asparagine synthase; TIGRFAM: asparagine synthase (glutamine-hydrolyzing). (546 aa) |
| | NTE_02548 | Geranylgeranyl pyrophosphate synthase; PFAM: Polyprenyl synthetase; Belongs to the FPP/GGPP synthase family. (287 aa) |
| | NTE_02584 | Dehydrogenase of unknown specificity, short-chain alcohol dehydrogenase like; PFAM: short chain dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (229 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (415 aa) |
| | mvk | Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (333 aa) |
| | panB | Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (295 aa) |
| | sat | Sulfate adenylyltransferase; PFAM: PUA-like domain; ATP-sulfurylase; TIGRFAM: ATP sulphurylase; Belongs to the sulfate adenylyltransferase family. (376 aa) |
| | adkA | Archaeal adenylate kinase; PFAM: AAA domain; Belongs to the archaeal adenylate kinase family. (206 aa) |
| | NTE_02800 | PFAM: lactate/malate dehydrogenase, alpha/beta C-terminal domain; lactate/malate dehydrogenase, NAD binding domain; TIGRFAM: malate dehydrogenase, NAD-dependent; Belongs to the LDH/MDH superfamily. (304 aa) |
| | purP | ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligase); Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. (351 aa) |
| | NTE_02857 | Fructose-bisphosphate aldolase /D-fructose 1,6-bisphosphatase; PFAM: Fructose-1,6-bisphosphatase. (374 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (223 aa) |
| | NTE_02861 | Pyruvate phosphate dikinase; PFAM: PEP-utilising enzyme, TIM barrel domain; PEP-utilising enzyme, mobile domain; Pyruvate phosphate dikinase, PEP/pyruvate binding domain; TIGRFAM: pyruvate, phosphate dikinase. (894 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: phosphoribosylaminoimidazole synthetase. (345 aa) |
| | NTE_02917 | PFAM: Citrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II. (394 aa) |
| | NTE_02921 | PFAM: Formyl transferase; TIGRFAM: phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent. (206 aa) |
| | NTE_02923 | Methylase involved in ubiquinone/menaquinone biosynthesis; PFAM: ubiE/COQ5 methyltransferase family. (233 aa) |
| | NTE_02931 | PFAM: Lyase; Adenylosuccinate lyase C-terminus; TIGRFAM: adenylosuccinate lyase. (481 aa) |
| | NTE_02969 | PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase. (348 aa) |
| | NTE_02979 | Cobalamin-dependent methionine synthase I; PFAM: Homocysteine S-methyltransferase. (320 aa) |
| | NTE_02986 | PFAM: Pterin binding enzyme; Vitamin B12 dependent methionine synthase, activation domain; B12 binding domain; TIGRFAM: 5-methyltetrahydrofolate--homocysteine methyltransferase. (844 aa) |
| | NTE_03017 | PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: phosphoglycolate phosphatase, TA0175-type; HAD-superfamily hydrolase, subfamily IIB; sucrose-phosphate phosphatase subfamily. (238 aa) |
| | NTE_03039 | PFAM: Inositol monophosphatase family. (274 aa) |
| | ctaB-2 | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (301 aa) |
| | NTE_03113 | PFAM: Semialdehyde dehydrogenase, dimerisation domain; Semialdehyde dehydrogenase, NAD binding domain; TIGRFAM: aspartate-semialdehyde dehydrogenase (non-peptidoglycan organisms). (358 aa) |
| | NTE_03194 | PFAM: Hydroxymethylglutaryl-coenzyme A reductase; TIGRFAM: hydroxymethylglutaryl-CoA reductase, degradative; Belongs to the HMG-CoA reductase family. (419 aa) |
| | NTE_03195 | PFAM: HisG, C-terminal domain; ATP phosphoribosyltransferase; TIGRFAM: ATP phosphoribosyltransferase, C-terminal domain; ATP phosphoribosyltransferase. (325 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (437 aa) |
| | NTE_03197 | PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase. (372 aa) |
| | hisB | PFAM: Imidazoleglycerol-phosphate dehydratase. (199 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (217 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (236 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (271 aa) |
| | NTE_03207 | PFAM: Pyridoxal-dependent decarboxylase, C-terminal sheet domain; Pyridoxal-dependent decarboxylase, pyridoxal binding domain; TIGRFAM: diaminopimelate decarboxylase. (447 aa) |
| | NTE_03210 | PFAM: Prephenate dehydratase; ACT domain. (282 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (477 aa) |
| | NTE_03303 | Putative nucleoside kinase, CMP and AMP kinase; PFAM: AAA domain. (194 aa) |
| | NTE_03440 | PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase; TIGRFAM: 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase. (351 aa) |
| | NTE_03474 | Asparagine synthase, glutamine-hydrolyzing; PFAM: Glutamine amidotransferase domain; Asparagine synthase; TIGRFAM: asparagine synthase (glutamine-hydrolyzing). (665 aa) |
| | NTE_03527 | PLP-dependent enzyme, histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase; PFAM: Aminotransferase class I and II. (606 aa) |
| | NTE_03535 | PFAM: Inositol monophosphatase family. (262 aa) |
| | NTE_03538 | PFAM: Proline dehydrogenase. (303 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (154 aa) |
| | NTE_03549 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (229 aa) |
| | NTE_03551 | PFAM: Lumazine binding domain; TIGRFAM: riboflavin synthase, alpha subunit. (205 aa) |
| | glyA | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (443 aa) |
