Your Input: | |
| | ilvE | Branched-chain amino acid aminotransferase, group I; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (312 aa) |
| | NTE_00019 | PFAM: Amino acid kinase family; TIGRFAM: aspartate kinase. (484 aa) |
| | NTE_00075 | PFAM: Phosphoribosyl-AMP cyclohydrolase. (111 aa) |
| | NTE_00076 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (406 aa) |
| | NTE_00424 | PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain; TIGRFAM: glutamine synthetase, type I. (488 aa) |
| | tal | Fructose-6-phosphate aldolase, TalC/MipB family; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (221 aa) |
| | NTE_00601 | Transketolase, alpha subunit; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain. (326 aa) |
| | NTE_00602 | Transketolase, beta subunit; PFAM: Ribulose-phosphate 3 epimerase family; Transketolase, thiamine diphosphate binding domain; TIGRFAM: ribulose-phosphate 3-epimerase. (546 aa) |
| | NTE_00627 | Cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme. (527 aa) |
| | argG | PFAM: Arginosuccinate synthase; TIGRFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (413 aa) |
| | NTE_00733 | PFAM: RimK-like ATP-grasp domain; TIGRFAM: Lysine biosynthesis enzyme LysX; alpha-L-glutamate ligases, RimK family. (287 aa) |
| | lysY | N-acetyl-gamma-glutamyl-phosphate reductase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (350 aa) |
| | lysZ | N-acetylglutamate kinase; Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis); Belongs to the acetylglutamate kinase family. LysZ subfamily. (267 aa) |
| | NTE_00736 | PFAM: Aminotransferase class-III; TIGRFAM: transaminase, acetylornithine/succinylornithine family; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (393 aa) |
| | NTE_00750 | Phosphoglycerate dehydrogenase-like oxidoreductase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; TIGRFAM: D-3-phosphoglycerate dehydrogenase. (310 aa) |
| | NTE_00821 | PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like. (220 aa) |
| | NTE_00858 | PFAM: Asparagine synthase. (265 aa) |
| | NTE_00933 | Aspartate kinase; PFAM: ACT domain; Amino acid kinase family; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; Belongs to the aspartokinase family. (470 aa) |
| | NTE_00977 | Arginase family hydrolase, arginase/agmainase/formiminoglutamate hydrolase; PFAM: Arginase family; TIGRFAM: arginase; Belongs to the arginase family. (301 aa) |
| | NTE_00982 | L-alanine aminotransferase apoenzyme; PFAM: Aminotransferase class I and II. (392 aa) |
| | NTE_00987 | Fructose-2,6-bisphosphatase; PFAM: Histidine phosphatase superfamily (branch 1). (201 aa) |
| | NTE_01097 | PFAM: Isocitrate/isopropylmalate dehydrogenase. (342 aa) |
| | NTE_01106 | PFAM: Asparagine synthase. (320 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (333 aa) |
| | NTE_01231 | PFAM: Aconitase C-terminal domain; Aconitase family (aconitate hydratase); TIGRFAM: aconitate hydratase, mitochondrial. (762 aa) |
| | NTE_01254 | PFAM: Aconitase C-terminal domain; TIGRFAM: 3-isopropylmalate dehydratase, small subunit. (166 aa) |
| | leuC | Homoaconitate hydratase family protein/3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (424 aa) |
| | NTE_01293 | PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; TIGRFAM: ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (321 aa) |
| | NTE_01317 | Threonine ammonia-lyase, medium form; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine ammonia-lyase, medium form. (417 aa) |
| | NTE_01392 | PFAM: N-terminal domain of ribose phosphate pyrophosphokinase; Phosphoribosyl synthetase-associated domain; TIGRFAM: ribose-phosphate pyrophosphokinase. (297 aa) |
| | NTE_01476 | PFAM: Ribose 5-phosphate isomerase A (phosphoriboisomerase A); TIGRFAM: ribose 5-phosphate isomerase. (225 aa) |
| | lysK | Acetylornithine deacetylase; Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine. (380 aa) |
| | NTE_01582 | L-2-aminoadipate N-acetyltransferase; PFAM: RimK-like ATP-grasp domain; TIGRFAM: Lysine biosynthesis enzyme LysX; alpha-L-glutamate ligases, RimK family. (293 aa) |
| | argH | PFAM: Lyase; Argininosuccinate lyase C-terminal; TIGRFAM: argininosuccinate lyase. (491 aa) |
| | pgk | PFAM: Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (402 aa) |
| | NTE_01726 | PFAM: S-adenosylmethionine synthetase, C-terminal domain; S-adenosylmethionine synthetase, central domain; S-adenosylmethionine synthetase, N-terminal domain; TIGRFAM: S-adenosylmethionine synthetase. (380 aa) |
| | ilvD | PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (559 aa) |
| | NTE_01784 | PFAM: chorismate binding enzyme; Anthranilate synthase component I, N terminal region; TIGRFAM: anthranilate synthase component I, archaeal clade. (453 aa) |
| | NTE_01785 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (446 aa) |
| | NTE_01853 | PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain. (338 aa) |
| | NTE_01905 | PFAM: Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type II. (349 aa) |
| | NTE_01906 | Anthranilate synthase, component II; PFAM: Glutamine amidotransferase class-I; TIGRFAM: glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase. (202 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (360 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (279 aa) |
| | trpB | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (406 aa) |
| | NTE_01914 | PFAM: Indole-3-glycerol phosphate synthase. (267 aa) |
| | NTE_01949 | PFAM: Prephenate dehydrogenase. (285 aa) |
| | NTE_01950 | PFAM: Aminotransferase class I and II; Chorismate mutase type II. (465 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (373 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (432 aa) |
| | aroK | PFAM: GHMP kinases C terminal; GHMP kinases N terminal domain; TIGRFAM: shikimate kinase. (284 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (284 aa) |
| | aroD | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (227 aa) |
| | aroA-2 | 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (260 aa) |
| | NTE_02050 | PFAM: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Metalloenzyme superfamily; TIGRFAM: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, archaeal form. (430 aa) |
| | NTE_02164 | PFAM: Asparagine synthase. (405 aa) |
| | NTE_02175 | PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isopropylmalate/isohomocitrate dehydrogenases. (342 aa) |
| | NTE_02176 | Isopropylmalate/citramalate/homocitrate synthase; PFAM: LeuA allosteric (dimerisation) domain; HMGL-like; TIGRFAM: isopropylmalate/citramalate/homocitrate synthases; Belongs to the alpha-IPM synthase/homocitrate synthase family. (503 aa) |
| | NTE_02177 | PFAM: Small subunit of acetolactate synthase; ACT domain; TIGRFAM: acetolactate synthase, small subunit. (167 aa) |
| | NTE_02178 | Acetolactate synthase, large subunit; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type. (562 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (322 aa) |
| | NTE_02233 | Phosphoserine phosphatase SerB; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; phosphoserine phosphatase SerB. (218 aa) |
| | NTE_02238 | Cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme. (336 aa) |
| | ilvE-2 | Branched-chain amino acid aminotransferase, group I; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (305 aa) |
| | NTE_02326 | PFAM: Aconitase family (aconitate hydratase); TIGRFAM: 3-isopropylmalate dehydratase, large subunit. (474 aa) |
| | NTE_02327 | PFAM: Aconitase C-terminal domain; TIGRFAM: 3-isopropylmalate dehydratase, small subunit. (196 aa) |
| | NTE_02448 | Cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme. (334 aa) |
| | NTE_02481 | Asparagine synthase, glutamine-hydrolyzing; PFAM: Glutamine amidotransferase domain; Asparagine synthase; TIGRFAM: asparagine synthase (glutamine-hydrolyzing). (546 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (415 aa) |
| | NTE_02629 | PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain; TIGRFAM: glutamine synthetase, type I. (508 aa) |
| | NTE_02857 | Fructose-bisphosphate aldolase /D-fructose 1,6-bisphosphatase; PFAM: Fructose-1,6-bisphosphatase. (374 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (223 aa) |
| | NTE_02917 | PFAM: Citrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II. (394 aa) |
| | NTE_02979 | Cobalamin-dependent methionine synthase I; PFAM: Homocysteine S-methyltransferase. (320 aa) |
| | NTE_02986 | PFAM: Pterin binding enzyme; Vitamin B12 dependent methionine synthase, activation domain; B12 binding domain; TIGRFAM: 5-methyltetrahydrofolate--homocysteine methyltransferase. (844 aa) |
| | NTE_03113 | PFAM: Semialdehyde dehydrogenase, dimerisation domain; Semialdehyde dehydrogenase, NAD binding domain; TIGRFAM: aspartate-semialdehyde dehydrogenase (non-peptidoglycan organisms). (358 aa) |
| | NTE_03195 | PFAM: HisG, C-terminal domain; ATP phosphoribosyltransferase; TIGRFAM: ATP phosphoribosyltransferase, C-terminal domain; ATP phosphoribosyltransferase. (325 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (437 aa) |
| | NTE_03197 | PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase. (372 aa) |
| | hisB | PFAM: Imidazoleglycerol-phosphate dehydratase. (199 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (217 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (236 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (271 aa) |
| | NTE_03207 | PFAM: Pyridoxal-dependent decarboxylase, C-terminal sheet domain; Pyridoxal-dependent decarboxylase, pyridoxal binding domain; TIGRFAM: diaminopimelate decarboxylase. (447 aa) |
| | NTE_03210 | PFAM: Prephenate dehydratase; ACT domain. (282 aa) |
| | NTE_03474 | Asparagine synthase, glutamine-hydrolyzing; PFAM: Glutamine amidotransferase domain; Asparagine synthase; TIGRFAM: asparagine synthase (glutamine-hydrolyzing). (665 aa) |
| | NTE_03527 | PLP-dependent enzyme, histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase; PFAM: Aminotransferase class I and II. (606 aa) |
| | glyA | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (443 aa) |
