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yfjB yfjB ygaD ygaD sthA sthA nudC nudC nadR nadR nadD nadD pncB pncB cobB cobB pncA pncA nadE nadE pntA pntA pntB pntB yfaY yfaY
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
yfjBNAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (292 aa)
ygaDConserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the CinA family. (162 aa)
sthAPyridine nucleotide transhydrogenase, soluble; Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (466 aa)
nudCNADH pyrophosphatase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the Nudix hydrolase family. NudC subfamily. (257 aa)
nadRBifunctional DNA-binding transcriptional repressor and NMN adenylyltransferase; Function of homologous gene experimentally demonstrated in an other organism; regulator. (410 aa)
nadDNicotinic acid mononucleotide adenylyltransferase, NAD(P)-dependent; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (216 aa)
pncBNicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (412 aa)
cobBDeacetylase of acetyl-CoA synthetase, NAD-dependent; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the sirtuin family. Class III subfamily. (276 aa)
pncANicotinamidase/pyrazinamidase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (213 aa)
nadENAD synthetase, NH3/glutamine-dependent; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (275 aa)
pntAPyridine nucleotide transhydrogenase, alpha subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. (509 aa)
pntBPyridine nucleotide transhydrogenase, beta subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. (462 aa)
yfaYConserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the CinA family. (398 aa)
Your Current Organism:
Klebsiella quasipneumoniae
NCBI taxonomy Id: 1463164
Other names: CCTCC AB 206144 [[Klebsiella alba]], CIP 110770, DSM 28212, K. quasipneumoniae subsp. similipneumoniae, KCTC 12878 [[Klebsiella alba]], Klebsiella alba, Klebsiella alba Xu et al. 2015, Klebsiella quasipneumoniae subsp. similipneumoniae, Klebsiella quasipneumoniae subsp. similipneumoniae Brisse et al. 2014, Klebsiella sp. 07A044, Klebsiella sp. CW-D, LMG 24441 [[Klebsiella alba]], LMG:24441 [[Klebsiella alba]], strain 07A044, strain CW-D 3 [[Klebsiella alba]], strain SB30
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