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guaA guaA cysD cysD rfaE rfaE argG argG trpS trpS uspA uspA trpS-2 trpS-2 nadR nadR ileS ileS valS valS citC citC yadB yadB tilS tilS ibrA ibrA uspG uspG nadD nadD glnS glnS kdpD kdpD phr phr trmU trmU nadE nadE ydaO ydaO ydcF ydcF yecG yecG SBA04646.1 SBA04646.1 metG metG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
guaAGMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. (525 aa)
cysDSulfate adenylyltransferase subunit 2; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (302 aa)
rfaEFused heptose 7-phosphate kinase; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (477 aa)
argGArgininosuccinate synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (447 aa)
trpStryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (334 aa)
uspAUniversal stress global response regulator; Required for resistance to DNA-damaging agents. Belongs to the universal stress protein A family. (145 aa)
trpS-2Tryptophan--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (335 aa)
nadRBifunctional DNA-binding transcriptional repressor and NMN adenylyltransferase; Function of homologous gene experimentally demonstrated in an other organism; regulator. (410 aa)
ileSisoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (950 aa)
valSvalyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (951 aa)
citCCitrate lyase synthetase; Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'- dephosphocoenzyme-A) of the gamma subunit of citrate lyase. (342 aa)
yadBglutamyl-Q tRNA(Asp) synthetase; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily. (293 aa)
tilStRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (437 aa)
ibrAImmunoglobulin-binding regulator; Function of strongly homologous gene; regulator. (407 aa)
uspGUniversal stress protein UP12; Function of homologous gene experimentally demonstrated in an other organism; factor. (142 aa)
nadDNicotinic acid mononucleotide adenylyltransferase, NAD(P)-dependent; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (216 aa)
glnSglutamyl-tRNA synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (555 aa)
kdpDFused sensory histidine kinase in two-component regulatory system with KdpE: signal sensing protein; Function of homologous gene experimentally demonstrated in an other organism; regulator. (895 aa)
phrDeoxyribodipyrimidine photolyase, FAD-binding; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the DNA photolyase family. (480 aa)
trmUtRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis. Sulfur is provided by IscS, via a sulfur-relay system. Binds ATP and its substrate tRNAs; Belongs to the MnmA/TRMU family. (388 aa)
nadENAD synthetase, NH3/glutamine-dependent; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (275 aa)
ydaOPutative C32 tRNA thiolase; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system. (311 aa)
ydcFConserved hypothetical protein; Homologs of previously reported genes of unknown function. (266 aa)
yecGUniversal stress protein; Required for resistance to DNA-damaging agents. Belongs to the universal stress protein A family. (142 aa)
SBA04646.1Universal stress protein; Required for resistance to DNA-damaging agents. Belongs to the universal stress protein A family. (140 aa)
metGmethionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (680 aa)
Your Current Organism:
Klebsiella quasipneumoniae
NCBI taxonomy Id: 1463164
Other names: CCTCC AB 206144 [[Klebsiella alba]], CIP 110770, DSM 28212, K. quasipneumoniae subsp. similipneumoniae, KCTC 12878 [[Klebsiella alba]], Klebsiella alba, Klebsiella alba Xu et al. 2015, Klebsiella quasipneumoniae subsp. similipneumoniae, Klebsiella quasipneumoniae subsp. similipneumoniae Brisse et al. 2014, Klebsiella sp. 07A044, Klebsiella sp. CW-D, LMG 24441 [[Klebsiella alba]], LMG:24441 [[Klebsiella alba]], strain 07A044, strain CW-D 3 [[Klebsiella alba]], strain SB30
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