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cbiD cbiD hemD hemD hemB hemB ABM69555.1 ABM69555.1 cobS cobS cobI cobI cobM cobM hemL hemL hemC hemC cobK cobK cobO cobO hemH hemH hemE hemE ABM69988.1 ABM69988.1 hemA hemA ABM70264.1 ABM70264.1 cobN cobN cobU cobU cobB cobB cobQ cobQ cobL cobL cbiB cbiB cobJ cobJ ABM71060.1 ABM71060.1 hemF hemF cobH cobH cysG cysG
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
cbiDCbiD protein; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (362 aa)
hemDPutative uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (265 aa)
hemBCOG113 Delta-aminolevulinic acid dehydratase [Coenzyme metabolism]; Belongs to the ALAD family. (333 aa)
ABM69555.1COG2109 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]. (193 aa)
cobSCobalamin-5-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (246 aa)
cobIprecorrin-2-C20-methyltransferase; COG2243 Precorrin-2 methylase [Coenzyme metabolism]; Belongs to the precorrin methyltransferase family. (251 aa)
cobMPutative precorrin-4 C11-methyltransferase; COG2875 Precorrin-4 methylase [Coenzyme metabolism]; Belongs to the precorrin methyltransferase family. (251 aa)
hemLCOG1 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. (433 aa)
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. (316 aa)
cobKCOG2099 Precorrin-6x reductase [Coenzyme metabolism]. (265 aa)
cobOPossible cob(I)alamin adenosyltransferase; COG2109 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]. (230 aa)
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (391 aa)
hemEUroporphyrinogen decarboxylase (URO-D); Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (346 aa)
ABM69988.1COG2138 Uncharacterized conserved protein [Function unknown]. (400 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (436 aa)
ABM70264.1COG1981 Predicted membrane protein [Function unknown]. (188 aa)
cobNCOG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases [Coenzyme metabolism]. (1245 aa)
cobUCOG2087 Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase [Coenzyme metabolism]. (186 aa)
cobBCOG1797 Cobyrinic acid a,c-diamide synthase [Coenzyme metabolism]. (463 aa)
cobQCobyric acid synthase CobB; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (495 aa)
cobLPutative precorrin-6y methylase; COG2242 Precorrin-6B methylase 2 [Coenzyme metabolism]. (424 aa)
cbiBPutative cobalamin biosynthetic protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (339 aa)
cobJBifunctional cbiH protein and precorrin-3B C17-methyltransferase; COG1010 Precorrin-3B methylase [Coenzyme metabolism]. (600 aa)
ABM71060.1COG2109 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]. (386 aa)
hemFCoproporphyrinogen III oxidase; Involved in the heme and chlorophyll biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX. (342 aa)
cobHPutative Precorrin-8X methylmutase CobH; COG2082 Precorrin isomerase [Coenzyme metabolism]. (207 aa)
cysGPutative uroporphyrin-III C-methyltransferase; COG7 Uroporphyrinogen-III methylase [Coenzyme metabolism]; Belongs to the precorrin methyltransferase family. (267 aa)
Your Current Organism:
Prochlorococcus marinus AS9601
NCBI taxonomy Id: 146891
Other names: P. marinus str. AS9601, Prochlorococcus marinus str. AS9601, Prochlorococcus sp. AS9601
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