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cbiD cbiD hemD hemD chlM chlM hemB hemB ABM69555.1 ABM69555.1 cobS cobS chlD chlD cobI cobI chlG chlG ctaA ctaA cyoE cyoE cobM cobM gltX gltX hemL hemL hemC hemC cobK cobK cobO cobO hemH hemH ABM69884.1 ABM69884.1 chlL chlL chlB chlB chlN chlN hemE hemE ABM69976.1 ABM69976.1 ABM69988.1 ABM69988.1 pcyA pcyA chlP chlP hemA hemA ABM70264.1 ABM70264.1 cobN cobN cobU cobU pniL34 pniL34 chlH chlH chlI chlI cobB cobB cobQ cobQ cobL cobL cbiB cbiB ABM70847.1 ABM70847.1 cobJ cobJ ABM71060.1 ABM71060.1 hemF hemF pebB pebB pebA pebA ho1 ho1 cobH cobH cysG cysG
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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cbiDCbiD protein; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (362 aa)
hemDPutative uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (265 aa)
chlMMg-protoporphyrin IX methyltransferase; COG2227 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme metabolism]. (233 aa)
hemBCOG113 Delta-aminolevulinic acid dehydratase [Coenzyme metabolism]; Belongs to the ALAD family. (333 aa)
ABM69555.1COG2109 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]. (193 aa)
cobSCobalamin-5-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (246 aa)
chlDProtoporphyrin IX Magnesium chelatase, ChlD subunit; Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX. (727 aa)
cobIprecorrin-2-C20-methyltransferase; COG2243 Precorrin-2 methylase [Coenzyme metabolism]; Belongs to the precorrin methyltransferase family. (251 aa)
chlGChlorophyll synthase 33 kD subunit; COG382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]. (315 aa)
ctaACOG1612 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]. (308 aa)
cyoEPutative protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (333 aa)
cobMPutative precorrin-4 C11-methyltransferase; COG2875 Precorrin-4 methylase [Coenzyme metabolism]; Belongs to the precorrin methyltransferase family. (251 aa)
gltXGlutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (476 aa)
hemLCOG1 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. (433 aa)
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. (316 aa)
cobKCOG2099 Precorrin-6x reductase [Coenzyme metabolism]. (265 aa)
cobOPossible cob(I)alamin adenosyltransferase; COG2109 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]. (230 aa)
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (391 aa)
ABM69884.1Light dependent protochlorophyllide oxido-reductase; Phototransformation of protochlorophyllide (Pchlide) to chlorophyllide (Chlide). (334 aa)
chlLProtochlorophyllide reductase iron-sulfur ATP-binding protein; Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The L component serves as a unique electron donor to the NB-component of the complex, and binds Mg-ATP. (295 aa)
chlBLight-independent protochlorophyllide reductase subunit B; Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein (ChlN-ChlB) is the catalytic component of the complex. (523 aa)
chlNLight-independent protochlorophyllide reductase subunit N; Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein (ChlN-ChlB) is the catalytic component of the complex. (418 aa)
hemEUroporphyrinogen decarboxylase (URO-D); Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (346 aa)
ABM69976.1Possible light-dependent protochlorophyllide oxido-reductase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]. (333 aa)
ABM69988.1COG2138 Uncharacterized conserved protein [Function unknown]. (400 aa)
pcyAFerredoxin-dependent biliverdin reductase; Catalyzes the four-electron reduction of biliverdin IX-alpha (2-electron reduction at both the A and D rings); the reaction proceeds via an isolatable 2-electron intermediate, 181,182-dihydrobiliverdin. Belongs to the HY2 family. (241 aa)
chlPAromatic-ring hydroxylase (flavoprotein monooxygenase); COG644 Dehydrogenases (flavoproteins) [Energy production and conversion]. (446 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (436 aa)
ABM70264.1COG1981 Predicted membrane protein [Function unknown]. (188 aa)
cobNCOG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases [Coenzyme metabolism]. (1245 aa)
cobUCOG2087 Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase [Coenzyme metabolism]. (186 aa)
pniL34Phytochrome-regulated protein; Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME); Belongs to the AcsF family. (390 aa)
chlHProtoporphyrin IX magnesium chelatase, subunit chlH; COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases [Coenzyme metabolism]. (1336 aa)
chlIProtoporphyrin IX Magnesium chelatase, ChlI subunit; Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX. (362 aa)
cobBCOG1797 Cobyrinic acid a,c-diamide synthase [Coenzyme metabolism]. (463 aa)
cobQCobyric acid synthase CobB; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (495 aa)
cobLPutative precorrin-6y methylase; COG2242 Precorrin-6B methylase 2 [Coenzyme metabolism]. (424 aa)
cbiBPutative cobalamin biosynthetic protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (339 aa)
ABM70847.1Short-chain dehydrogenase/reductase (SDR) superfamily; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]. (309 aa)
cobJBifunctional cbiH protein and precorrin-3B C17-methyltransferase; COG1010 Precorrin-3B methylase [Coenzyme metabolism]. (600 aa)
ABM71060.1COG2109 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]. (386 aa)
hemFCoproporphyrinogen III oxidase; Involved in the heme and chlorophyll biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX. (342 aa)
pebBPhycoerythrobilin:ferredoxin oxidoreductase; Catalyzes the two-electron reduction of the C2 and C3(1) diene system of 15,16-dihydrobiliverdin; Belongs to the HY2 family. (253 aa)
pebAPhycoerythrobilin:ferredoxin oxidoreductase; Catalyzes the two-electron reduction of biliverdin IX-alpha at the C15 methine bridge; Belongs to the HY2 family. (236 aa)
ho1COG5398 Heme oxygenase [Inorganic ion transport and metabolism]. (236 aa)
cobHPutative Precorrin-8X methylmutase CobH; COG2082 Precorrin isomerase [Coenzyme metabolism]. (207 aa)
cysGPutative uroporphyrin-III C-methyltransferase; COG7 Uroporphyrinogen-III methylase [Coenzyme metabolism]; Belongs to the precorrin methyltransferase family. (267 aa)
Your Current Organism:
Prochlorococcus marinus AS9601
NCBI taxonomy Id: 146891
Other names: P. marinus str. AS9601, Prochlorococcus marinus str. AS9601, Prochlorococcus sp. AS9601
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