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gap2 gap2 accB accB tas tas accC accC pgm pgm cysH cysH hemD hemD ABM69429.1 ABM69429.1 metF metF gltA gltA cysC cysC pgk pgk eno eno hemB hemB eda eda met3 met3 glyA glyA ABM69645.1 ABM69645.1 pdhC pdhC ABM69745.1 ABM69745.1 mqo mqo gltX gltX hemL hemL hemC hemC gpmB gpmB tal tal accA accA rbcL rbcL rbcS rbcS thrB thrB glk glk comB comB acs acs met17 met17 sir sir rpe rpe glpX glpX hemA hemA gnd gnd pgl pgl cbbA cbbA ABM70129.1 ABM70129.1 accD accD prkB prkB ABM70156.1 ABM70156.1 ureA ureA ureB ureB ureC ureC pdhB pdhB glnA glnA spt spt gadB gadB pykF pykF pgi pgi dapF dapF apa2 apa2 dapB dapB tpi tpi thrA thrA folD folD zwf zwf prsA prsA cad cad lysA lysA sdhA sdhA cysQ cysQ adhC adhC ABM70737.1 ABM70737.1 ABM70738.1 ABM70738.1 acoA acoA lpd lpd argD argD serA serA ABM70842.1 ABM70842.1 gpmI gpmI fumC fumC rpiA rpiA gltB gltB ppc ppc icd icd tktA tktA cysE cysE lysC lysC dapA dapA asd asd cysG cysG acnB acnB thrC thrC
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gap2COG57 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (340 aa)
accBBiotin / Lipoyl attachment:Acetyl-CoA biotin carboxyl carrier subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (168 aa)
tasAldo/keto reductase family; COG667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]. (320 aa)
accCacetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa)
pgmCOG33 Phosphoglucomutase [Carbohydrate transport and metabolism]. (545 aa)
cysHPhosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (240 aa)
hemDPutative uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (265 aa)
ABM69429.1O-acetylserine (thiol)-lyase A; COG31 Cysteine synthase [Amino acid transport and metabolism]; Belongs to the cysteine synthase/cystathionine beta- synthase family. (322 aa)
metFCOG685 5,10-methylenetetrahydrofolate reductase [Amino acid transport and metabolism]; Belongs to the methylenetetrahydrofolate reductase family. (296 aa)
gltACOG372 Citrate synthase [Energy production and conversion]; Belongs to the citrate synthase family. (381 aa)
cysCAdenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. (207 aa)
pgkCOG126 3-phosphoglycerate kinase [Carbohydrate transport and metabolism]; Belongs to the phosphoglycerate kinase family. (402 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (430 aa)
hemBCOG113 Delta-aminolevulinic acid dehydratase [Coenzyme metabolism]; Belongs to the ALAD family. (333 aa)
edaCOG800 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]. (208 aa)
met3ATP-sulfurylase; COG2046 ATP sulfurylase (sulfate adenylyltransferase) [Inorganic ion transport and metabolism]. (391 aa)
glyASerine hydroxymethyltransferase (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (423 aa)
ABM69645.1COG1012 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Belongs to the aldehyde dehydrogenase family. (463 aa)
pdhCDihydrolipoamide acetyltransferase; COG508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]. (455 aa)
ABM69745.1O-acetylserine (thiol)-lyase A; COG31 Cysteine synthase [Amino acid transport and metabolism]; Belongs to the cysteine synthase/cystathionine beta- synthase family. (328 aa)
mqoPutative malate/quinone oxidoreductase; COG579 Predicted dehydrogenase [General function prediction only]. (498 aa)
gltXGlutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (476 aa)
hemLCOG1 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. (433 aa)
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. (316 aa)
gpmBPossible alpha-ribazole-5'-P phosphatase; COG406 Fructose-2,6-bisphosphatase [Carbohydrate transport and metabolism]; Belongs to the phosphoglycerate mutase family. (442 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (341 aa)
accAacetyl-CoA carboxylase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (335 aa)
rbcLRibulose bisphosphate carboxylase, large chain; RuBisCO catalyzes two reactions: the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site. Belongs to the RuBisCO large chain family. Type I subfamily. (471 aa)
rbcSCOG4451 Ribulose bisphosphate carboxylase small subunit [Energy production and conversion]. (113 aa)
thrBHomoserine kinase:GHMP kinases putative ATP-binding domain-containing protein; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (302 aa)
glkCOG837 Glucokinase [Carbohydrate transport and metabolism]; Belongs to the bacterial glucokinase family. (344 aa)
comBProbable 2-phosphosulfolactate phosphatase; COG2045 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Belongs to the ComB family. (249 aa)
acsAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (660 aa)
met17COG2873 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]. (442 aa)
sirCOG155 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (595 aa)
rpeCOG36 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Belongs to the ribulose-phosphate 3-epimerase family. (251 aa)
glpXFructose-1,6-bisphosphatase/sedoheptulose-1, 7-bis phosphatase; Catalyzes the hydrolysis of fructose 1,6-bisphosphate (Fru 1,6-P2) and sedoheptulose 1,7-bisphosphate (Sed 1,7-P2) to fructose 6- phosphate and sedoheptulose 7-phosphate, respectively; Belongs to the FBPase class 2 family. (333 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (436 aa)
gnd6-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (472 aa)
pglPutative 6-phosphogluconolactonase (DevB, Pgl); Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (245 aa)
cbbAFructose-bisphosphate/sedoheptulose-1, 7-bisphosph ate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (357 aa)
ABM70129.1COG3588 Fructose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]. (355 aa)
accDacetyl-CoA carboxylase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (293 aa)
prkBCOG3954 Phosphoribulokinase [Energy production and conversion]. (298 aa)
ABM70156.1Rieske iron-sulfur protein 2Fe-2S subunit; COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]. (440 aa)
ureAUrease gamma subunit; COG831 Urea amidohydrolase (urease) gamma subunit [Amino acid transport and metabolism]; Belongs to the urease gamma subunit family. (100 aa)
ureBUrease beta subunit; COG832 Urea amidohydrolase (urease) beta subunit [Amino acid transport and metabolism]; Belongs to the urease beta subunit family. (106 aa)
ureCUrease alpha subunit; COG804 Urea amidohydrolase (urease) alpha subunit [Amino acid transport and metabolism]; Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family. (569 aa)
pdhBPyruvate dehydrogenase E1 beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (327 aa)
glnAGlutamine synthetase, glutamate--ammonia ligase; COG174 Glutamine synthetase [Amino acid transport and metabolism]. (473 aa)
sptCOG75 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]. (394 aa)
gadBCOG76 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]. (461 aa)
pykFCOG469 Pyruvate kinase [Carbohydrate transport and metabolism]; Belongs to the pyruvate kinase family. (596 aa)
pgiPhosphoglucose isomerase (PGI); COG166 Glucose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Belongs to the GPI family. (527 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (286 aa)
apa2COG4360 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]. (276 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (282 aa)
tpiTriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (241 aa)
thrAHomoserine dehydrogenase:ACT domain-containing protein; COG460 Homoserine dehydrogenase [Amino acid transport and metabolism]. (433 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (298 aa)
zwfGlucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (507 aa)
prsARibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (331 aa)
cadCOG1982 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]. (465 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (457 aa)
sdhACOG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]. (584 aa)
cysQCysQ; COG1218 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase [Inorganic ion transport and metabolism]. (300 aa)
adhCCOG1062 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]. (355 aa)
ABM70737.1COG3959 Transketolase, N-terminal subunit [Carbohydrate transport and metabolism]. (288 aa)
ABM70738.1COG3958 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]. (304 aa)
acoAPyruvate dehydrogenase E1 alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (357 aa)
lpdCOG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]. (479 aa)
argDCOG4992 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (391 aa)
serAPutative D-3-phosphoglycerate dehydrogenase (PGDH); COG111 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (528 aa)
ABM70842.1COG5135 Uncharacterized conserved protein [Function unknown]. (183 aa)
gpmIPhosphoglycerate mutase, co-factor-independent (iPGM); Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (540 aa)
fumCFumarate lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa)
rpiARibose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (231 aa)
gltBFerredoxin-dependent glutamate synthase, Fd-GOGAT; COG69 Glutamate synthase domain 2 [Amino acid transport and metabolism]. (1524 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (989 aa)
icdCOG538 Isocitrate dehydrogenases [Energy production and conversion]. (474 aa)
tktATransketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (668 aa)
cysECOG1045 Serine acetyltransferase [Amino acid transport and metabolism]. (244 aa)
lysCCOG527 Aspartokinases [Amino acid transport and metabolism]. (586 aa)
dapADihydrodipicolinate synthetase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (300 aa)
asdAspartate Semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (343 aa)
cysGPutative uroporphyrin-III C-methyltransferase; COG7 Uroporphyrinogen-III methylase [Coenzyme metabolism]; Belongs to the precorrin methyltransferase family. (267 aa)
acnBAconitate hydratase B; COG1049 Aconitase B [Energy production and conversion]; Belongs to the aconitase/IPM isomerase family. (857 aa)
thrCThreonine synthase: Pyridoxal-5'-phosphate-dependent enzymes, beta family; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (367 aa)
Your Current Organism:
Prochlorococcus marinus AS9601
NCBI taxonomy Id: 146891
Other names: P. marinus str. AS9601, Prochlorococcus marinus str. AS9601, Prochlorococcus sp. AS9601
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