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argH argH gap2 gap2 argJ argJ aroK aroK ABM69429.1 ABM69429.1 gltA gltA trpB trpB ABM69492.1 ABM69492.1 pgk pgk eno eno aroC aroC leuD leuD leuC leuC glyA glyA hisB hisB metK metK aroQ aroQ proC proC ABM69745.1 ABM69745.1 ABM69746.1 ABM69746.1 metB metB hisF hisF argB argB gpmB gpmB tal tal ilvB ilvB trpF trpF hisG hisG trpA trpA hisI hisI proA proA thrB thrB aroA aroA met17 met17 metA metA aspC aspC aroB aroB rpe rpe ilvD ilvD cbbA cbbA ABM70129.1 ABM70129.1 leuB leuB proB proB hisA hisA trpD trpD glnA glnA pykF pykF ilvA ilvA hisZ hisZ argC argC dapF dapF ilvE ilvE metH metH dapB dapB tpi tpi thrA thrA hisH hisH leuA leuA prsA prsA lysA lysA ilvN ilvN aroH aroH ABM70700.1 ABM70700.1 ABM70701.1 ABM70701.1 ABM70737.1 ABM70737.1 ABM70738.1 ABM70738.1 argF argF trpC trpC argD argD ilvC ilvC serA serA gpmI gpmI hisD hisD rpiA rpiA dapL dapL pheA pheA ABM71067.1 ABM71067.1 icd icd tktA tktA cysE cysE lysC lysC dapA dapA asd asd ABM71186.1 ABM71186.1 aroG aroG acnB acnB aroE aroE argG argG thrC thrC
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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from curated databases
experimentally determined
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gene neighborhood
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argHFumarate lyase:Delta crystallin; COG165 Argininosuccinate lyase [Amino acid transport and metabolism]. (459 aa)
gap2COG57 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (340 aa)
argJArgJ family; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (412 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (185 aa)
ABM69429.1O-acetylserine (thiol)-lyase A; COG31 Cysteine synthase [Amino acid transport and metabolism]; Belongs to the cysteine synthase/cystathionine beta- synthase family. (322 aa)
gltACOG372 Citrate synthase [Energy production and conversion]; Belongs to the citrate synthase family. (381 aa)
trpBTryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (414 aa)
ABM69492.1Aminotransferases class-I; COG79 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]. (369 aa)
pgkCOG126 3-phosphoglycerate kinase [Carbohydrate transport and metabolism]; Belongs to the phosphoglycerate kinase family. (402 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (430 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (365 aa)
leuDCOG66 3-isopropylmalate dehydratase small subunit [Amino acid transport and metabolism]; Belongs to the LeuD family. (207 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (468 aa)
glyASerine hydroxymethyltransferase (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (423 aa)
hisBCOG131 Imidazoleglycerol-phosphate dehydratase [Amino acid transport and metabolism]. (201 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (413 aa)
aroQDehydroquinase class II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (147 aa)
proCDelta 1-pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (270 aa)
ABM69745.1O-acetylserine (thiol)-lyase A; COG31 Cysteine synthase [Amino acid transport and metabolism]; Belongs to the cysteine synthase/cystathionine beta- synthase family. (328 aa)
ABM69746.1COG626 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]. (489 aa)
metBCOG626 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]. (387 aa)
hisFImidazole glycerol phosphate synthase subunit HisF (cyclase); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (256 aa)
argBAspartokinase superfamily:Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (283 aa)
gpmBPossible alpha-ribazole-5'-P phosphatase; COG406 Fructose-2,6-bisphosphatase [Carbohydrate transport and metabolism]; Belongs to the phosphoglycerate mutase family. (442 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (341 aa)
ilvBCOG28 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]. (587 aa)
trpFCOG135 Phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; Belongs to the TrpF family. (218 aa)
hisGPossible ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (212 aa)
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (261 aa)
hisICOG139 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; In the N-terminal section; belongs to the PRA-CH family. (219 aa)
proAGamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (436 aa)
thrBHomoserine kinase:GHMP kinases putative ATP-binding domain-containing protein; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (302 aa)
aroAEPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (436 aa)
met17COG2873 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]. (442 aa)
metAPutative homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (296 aa)
aspCAminotransferases class-I; COG436 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]. (392 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (363 aa)
rpeCOG36 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Belongs to the ribulose-phosphate 3-epimerase family. (251 aa)
ilvDCOG129 Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism / Carbohydrate transport and metabolism]; Belongs to the IlvD/Edd family. (557 aa)
cbbAFructose-bisphosphate/sedoheptulose-1, 7-bisphosph ate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (357 aa)
ABM70129.1COG3588 Fructose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]. (355 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (357 aa)
proBPutative glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (360 aa)
hisACOG106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]. (255 aa)
trpDPutative Anthranilate synthase component II; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (344 aa)
glnAGlutamine synthetase, glutamate--ammonia ligase; COG174 Glutamine synthetase [Amino acid transport and metabolism]. (473 aa)
pykFCOG469 Pyruvate kinase [Carbohydrate transport and metabolism]; Belongs to the pyruvate kinase family. (596 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (513 aa)
hisZCOG124 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]. (383 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (351 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (286 aa)
ilvEPutative Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (304 aa)
metHPutative methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1188 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (282 aa)
tpiTriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (241 aa)
thrAHomoserine dehydrogenase:ACT domain-containing protein; COG460 Homoserine dehydrogenase [Amino acid transport and metabolism]. (433 aa)
hisHGlutamine amidotransferase class-I; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (205 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (546 aa)
prsARibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (331 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (457 aa)
ilvNCOG440 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]. (174 aa)
aroHChorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis. (127 aa)
ABM70700.1Hypothetical protein; COG107 Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Belongs to the HisA/HisF family. (254 aa)
ABM70701.1Hypothetical protein; COG118 Glutamine amidotransferase [Amino acid transport and metabolism]. (195 aa)
ABM70737.1COG3959 Transketolase, N-terminal subunit [Carbohydrate transport and metabolism]. (288 aa)
ABM70738.1COG3958 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]. (304 aa)
argFOrnithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (308 aa)
trpCCOG134 Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Belongs to the TrpC family. (295 aa)
argDCOG4992 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (391 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (329 aa)
serAPutative D-3-phosphoglycerate dehydrogenase (PGDH); COG111 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (528 aa)
gpmIPhosphoglycerate mutase, co-factor-independent (iPGM); Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (540 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (428 aa)
rpiARibose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (231 aa)
dapLPutative aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (408 aa)
pheAChorismate mutase-Prephenate dehydratase; COG77 Prephenate dehydratase [Amino acid transport and metabolism]. (281 aa)
ABM71067.1COG147 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]. (506 aa)
icdCOG538 Isocitrate dehydrogenases [Energy production and conversion]. (474 aa)
tktATransketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (668 aa)
cysECOG1045 Serine acetyltransferase [Amino acid transport and metabolism]. (244 aa)
lysCCOG527 Aspartokinases [Amino acid transport and metabolism]. (586 aa)
dapADihydrodipicolinate synthetase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (300 aa)
asdAspartate Semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (343 aa)
ABM71186.1Aminotransferases class-IV; COG115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]. (275 aa)
aroGDAHP synthetase class I; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (355 aa)
acnBAconitate hydratase B; COG1049 Aconitase B [Energy production and conversion]; Belongs to the aconitase/IPM isomerase family. (857 aa)
aroEShikimate / quinate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (286 aa)
argGCOG137 Argininosuccinate synthase [Amino acid transport and metabolism]; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (404 aa)
thrCThreonine synthase: Pyridoxal-5'-phosphate-dependent enzymes, beta family; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (367 aa)
Your Current Organism:
Prochlorococcus marinus AS9601
NCBI taxonomy Id: 146891
Other names: P. marinus str. AS9601, Prochlorococcus marinus str. AS9601, Prochlorococcus sp. AS9601
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