STRINGSTRING
EO98_19390 EO98_19390 EO98_00040 EO98_00040 rfcS rfcS rpoK rpoK rpoN rpoN EO98_00455 EO98_00455 EO98_00530 EO98_00530 EO98_00850 EO98_00850 EO98_00860 EO98_00860 EO98_01545 EO98_01545 EO98_01730 EO98_01730 EO98_01775 EO98_01775 EO98_01855 EO98_01855 EO98_01880 EO98_01880 cdc6 cdc6 mutS2 mutS2 EO98_01955 EO98_01955 EO98_01990 EO98_01990 polB polB EO98_02165 EO98_02165 EO98_02195 EO98_02195 gyrA gyrA gyrB gyrB top6A top6A top6B top6B EO98_02735 EO98_02735 dbh dbh EO98_02975 EO98_02975 EO98_03025 EO98_03025 EO98_03030 EO98_03030 EO98_03360 EO98_03360 EO98_03375 EO98_03375 EO98_03540 EO98_03540 EO98_03850 EO98_03850 EO98_03860 EO98_03860 EO98_03865 EO98_03865 EO98_03965 EO98_03965 pcn pcn EO98_04305 EO98_04305 EO98_04695 EO98_04695 EO98_04705 EO98_04705 EO98_04760 EO98_04760 EO98_04765 EO98_04765 EO98_04785 EO98_04785 EO98_04845 EO98_04845 EO98_05095 EO98_05095 EO98_05460 EO98_05460 EO98_05660 EO98_05660 EO98_05725 EO98_05725 nth nth polC polC EO98_06690 EO98_06690 EO98_06930 EO98_06930 EO98_06950 EO98_06950 EO98_07145 EO98_07145 EO98_07165 EO98_07165 EO98_07175 EO98_07175 EO98_07265 EO98_07265 mre11 mre11 rpoD rpoD EO98_08140 EO98_08140 EO98_08190 EO98_08190 EO98_08225 EO98_08225 EO98_08325 EO98_08325 EO98_08425 EO98_08425 EO98_08485 EO98_08485 EO98_08620 EO98_08620 rpoH rpoH EO98_08825 EO98_08825 EO98_08830 EO98_08830 EO98_08835 EO98_08835 rpoA2 rpoA2 rpoL rpoL EO98_09330 EO98_09330 EO98_09350 EO98_09350 EO98_09405 EO98_09405 EO98_09415 EO98_09415 EO98_09440 EO98_09440 EO98_09490 EO98_09490 EO98_09595 EO98_09595 EO98_09635 EO98_09635 dbh-2 dbh-2 nth-2 nth-2 fen fen EO98_09850 EO98_09850 EO98_09885 EO98_09885 EO98_09910 EO98_09910 EO98_10060 EO98_10060 tfe tfe EO98_10775 EO98_10775 EO98_11020 EO98_11020 EO98_11095 EO98_11095 lon lon EO98_11255 EO98_11255 EO98_11535 EO98_11535 EO98_11795 EO98_11795 EO98_12305 EO98_12305 EO98_12470 EO98_12470 EO98_12480 EO98_12480 mutL mutL mutS mutS EO98_13410 EO98_13410 EO98_13710 EO98_13710 EO98_13730 EO98_13730 EO98_13740 EO98_13740 EO98_13965 EO98_13965 EO98_13990 EO98_13990 tbp tbp EO98_14220 EO98_14220 uvrA uvrA uvrC uvrC uvrB uvrB EO98_15185 EO98_15185 EO98_15280 EO98_15280 topA topA EO98_15350 EO98_15350 EO98_15610 EO98_15610 hel308 hel308 EO98_15760 EO98_15760 radA radA EO98_15855 EO98_15855 EO98_15925 EO98_15925 EO98_15990 EO98_15990 EO98_16010 EO98_16010 EO98_16025 EO98_16025 cas1 cas1 EO98_16490 EO98_16490 EO98_16635 EO98_16635 EO98_16675 EO98_16675 EO98_16715 EO98_16715 EO98_17375 EO98_17375 EO98_17385 EO98_17385 EO98_17505 EO98_17505 EO98_17515 EO98_17515 EO98_17535 EO98_17535 EO98_17855 EO98_17855 EO98_17875 EO98_17875 EO98_18020 EO98_18020 EO98_18025 EO98_18025 EO98_18030 EO98_18030 EO98_18180 EO98_18180 EO98_18295 EO98_18295 EO98_18325 EO98_18325 lig lig EO98_18925 EO98_18925 cas1-2 cas1-2 cas1-3 cas1-3 EO98_19240 EO98_19240 EO98_19290 EO98_19290
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EO98_19390Cro/Cl family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (65 aa)
EO98_00040Histone; Derived by automated computational analysis using gene prediction method: Protein Homology. (70 aa)
rfcSReplication factor C small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. (329 aa)
rpoKDNA-directed RNA polymerase subunit K; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family. (60 aa)
rpoNDNA-directed RNA polymerase subunit N; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family. (62 aa)
EO98_00455Replication protein A; Derived by automated computational analysis using gene prediction method: Protein Homology. (453 aa)
EO98_00530Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (187 aa)
EO98_00850Universal stress protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (149 aa)
EO98_00860Universal stress protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (152 aa)
EO98_01545Methanogenesis marker protein 11; Derived by automated computational analysis using gene prediction method: Protein Homology. (300 aa)
EO98_01730Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (153 aa)
EO98_01775DNA topoisomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (833 aa)
EO98_01855Hef nuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (849 aa)
EO98_01880Haloacid dehalogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (210 aa)
cdc6Cell division control protein 6; Involved in regulation of DNA replication. (373 aa)
mutS2DNA mismatch repair protein MutS; Has ATPase and non-specific DNA-binding activities. Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily. (707 aa)
EO98_01955DNA repair protein RadB; Derived by automated computational analysis using gene prediction method: Protein Homology. (178 aa)
EO98_01990XRE family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (173 aa)
polBDNA polymerase II; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. (679 aa)
EO98_02165DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (162 aa)
EO98_02195Response regulator receiver protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (130 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (937 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (634 aa)
top6ADNA topoisomerase VI subunit A; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. (369 aa)
top6BDNA topoisomerase; Relaxes both positive and negative superturns and exhibits a strong decatenase activity. (621 aa)
EO98_027353'-phosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (152 aa)
dbhDNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. (361 aa)
EO98_02975Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (645 aa)
EO98_03025Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (100 aa)
EO98_03030XRE family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (68 aa)
EO98_03360Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (72 aa)
EO98_03375Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (63 aa)
EO98_03540DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (192 aa)
EO98_03850Universal stress protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (150 aa)
EO98_03860Universal stress protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (153 aa)
EO98_03865Universal stress protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (145 aa)
EO98_03965Replication protein C; Derived by automated computational analysis using gene prediction method: Protein Homology. (341 aa)
pcnDNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. (245 aa)
EO98_04305Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (624 aa)
EO98_04695Integrase; Derived by automated computational analysis using gene prediction method: Protein Homology. (205 aa)
EO98_04705Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (297 aa)
EO98_04760Integrase; Derived by automated computational analysis using gene prediction method: Protein Homology. (189 aa)
EO98_04765Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the MCM family. (689 aa)
EO98_04785Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (396 aa)
EO98_04845Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (351 aa)
EO98_05095Universal stress protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (150 aa)
EO98_05460NrpR transcriptional repressor; Derived by automated computational analysis using gene prediction method: Protein Homology. (252 aa)
EO98_05660Phosphate regulatory protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (317 aa)
EO98_05725DNA polymerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (935 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (204 aa)
polCDNA polymerase II large subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. (1150 aa)
EO98_06690DNA-directed RNA polymerase subunit E; Participates in both the initiation and recycling phases of transcription; Derived by automated computational analysis using gene prediction method: Protein Homology. (195 aa)
EO98_06930Crp/Fnr family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (262 aa)
EO98_06950Replication protein A; Derived by automated computational analysis using gene prediction method: Protein Homology. (417 aa)
EO98_07145Restriction endonuclease subunit R; Derived by automated computational analysis using gene prediction method: Protein Homology. (917 aa)
EO98_07165Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (488 aa)
EO98_07175DNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (500 aa)
EO98_07265Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (119 aa)
mre11Double-stranded DNA repair protein Mre11; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. (643 aa)
rpoDDNA-directed RNA polymerase subunit D; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (266 aa)
EO98_08140Replication protein A protects and stabilize the intermediate ssDNA that is generated by the unwinding action of a DNA helicase at the replication fork. In addition, SSBs prevent the formation of secondary structures by single-stranded template DNA; Derived by automated computational analysis using gene prediction method: Protein Homology. (484 aa)
EO98_08190Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (134 aa)
EO98_08225Cell division control protein Cdc6; Involved in regulation of DNA replication. (414 aa)
EO98_08325Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology. (260 aa)
EO98_08425MerR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (284 aa)
EO98_08485Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (184 aa)
EO98_08620Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (267 aa)
rpoHDNA-directed RNA polymerase subunit H; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. (78 aa)
EO98_08825DNA-directed RNA polymerase subunit B; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; Derived by automated computational analysis using gene prediction method: Protein Homology. (531 aa)
EO98_08830DNA-directed RNA polymerase subunit B; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (604 aa)
EO98_08835DNA-directed RNA polymerase subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (880 aa)
rpoA2DNA-directed RNA polymerase subunit A'; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (399 aa)
rpoLDNA-directed RNA polymerase subunit L; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family. (92 aa)
EO98_09330Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (115 aa)
EO98_09350Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (287 aa)
EO98_09405Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (79 aa)
EO98_09415Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (119 aa)
EO98_09440Deoxyribodipyrimidine photolyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (462 aa)
EO98_09490Nickel-responsive regulator; Transcriptional regulator; Belongs to the transcriptional regulatory CopG/NikR family. (140 aa)
EO98_09595XRE family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (246 aa)
EO98_09635Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (173 aa)
dbh-2DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. (365 aa)
nth-2Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (234 aa)
fenFlap endonuclease-1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] (338 aa)
EO98_09850Peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (219 aa)
EO98_09885XRE family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (72 aa)
EO98_09910Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (154 aa)
EO98_10060Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (163 aa)
tfeTranscription factor; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to [...] (164 aa)
EO98_10775Universal stress protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (150 aa)
EO98_11020Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PDCD5 family. (122 aa)
EO98_11095Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (119 aa)
lonATPase AAA; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (797 aa)
EO98_11255AsnC family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (163 aa)
EO98_11535Helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (495 aa)
EO98_11795HxlR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (118 aa)
EO98_12305Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (259 aa)
EO98_12470HxlR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (118 aa)
EO98_12480Damage-inducible protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (774 aa)
mutLDNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (732 aa)
mutSDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (900 aa)
EO98_13410ATPase AAA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the MCM family. (701 aa)
EO98_13710TrmB family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (119 aa)
EO98_13730NrpR transcriptional repressor; Derived by automated computational analysis using gene prediction method: Protein Homology. (324 aa)
EO98_13740Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (177 aa)
EO98_13965Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (79 aa)
EO98_13990Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (63 aa)
tbpTranscription factor; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. (183 aa)
EO98_14220XRE family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (161 aa)
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (993 aa)
uvrCExcinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (516 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (670 aa)
EO98_15185Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (93 aa)
EO98_15280Universal stress protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (150 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (751 aa)
EO98_15350Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (113 aa)
EO98_15610Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (109 aa)
hel308Extensin; DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks. (730 aa)
EO98_15760Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (328 aa)
radADNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. (325 aa)
EO98_15855Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (277 aa)
EO98_159258-oxoguanine DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (282 aa)
EO98_15990N-6 DNA methylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (520 aa)
EO98_16010Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (440 aa)
EO98_16025DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1054 aa)
cas1CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (333 aa)
EO98_16490Nickel-responsive regulator; Transcriptional regulator; Belongs to the transcriptional regulatory CopG/NikR family. (152 aa)
EO98_16635Toxin-antitoxin system, toxin component; Derived by automated computational analysis using gene prediction method: Protein Homology. (331 aa)
EO98_16675Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (291 aa)
EO98_16715Nickel-responsive regulator; Transcriptional regulator. (140 aa)
EO98_17375TetR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (220 aa)
EO98_17385Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (201 aa)
EO98_17505Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (224 aa)
EO98_17515Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (214 aa)
EO98_17535RNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (734 aa)
EO98_17855Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (75 aa)
EO98_17875Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (187 aa)
EO98_18020Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (1013 aa)
EO98_18025Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (428 aa)
EO98_18030Derived by automated computational analysis using gene prediction method: Protein Homology. (504 aa)
EO98_18180Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (212 aa)
EO98_18295Chemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology. (132 aa)
EO98_18325Universal stress protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (146 aa)
ligDNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (568 aa)
EO98_18925Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (119 aa)
cas1-2CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (405 aa)
cas1-3CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (405 aa)
EO98_19240Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (118 aa)
EO98_19290Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (365 aa)
Your Current Organism:
Methanosarcina sp. 2HT1A6
NCBI taxonomy Id: 1483599
Other names: M. sp. 2.H.T.1A.6, Methanosarcina sp. 2.H.T.1A.6
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