STRINGSTRING
ilvD-2 ilvD-2 GY26_19945 GY26_19945 GY26_19125 GY26_19125 GY26_18040 GY26_18040 GY26_17550 GY26_17550 GY26_15890 GY26_15890 GY26_14210 GY26_14210 GY26_13580 GY26_13580 GY26_13015 GY26_13015 GY26_11730 GY26_11730 GY26_11250 GY26_11250 argJ argJ GY26_10510 GY26_10510 GY26_10205 GY26_10205 GY26_09910 GY26_09910 GY26_09280 GY26_09280 argC argC GY26_08885 GY26_08885 GY26_08785 GY26_08785 GY26_08730 GY26_08730 GY26_08670 GY26_08670 GY26_08485 GY26_08485 GY26_08285 GY26_08285 argB argB GY26_06350 GY26_06350 GY26_06125 GY26_06125 GY26_05865 GY26_05865 GY26_05640 GY26_05640 argA argA GY26_05380 GY26_05380 leuB leuB asd asd GY26_04220 GY26_04220 GY26_03860 GY26_03860 gltA gltA ilvC ilvC ilvH ilvH GY26_03255 GY26_03255 GY26_02520 GY26_02520 GY26_02495 GY26_02495 ilvD ilvD GY26_01290 GY26_01290 GY26_00675 GY26_00675 leuC leuC leuD leuD GY26_18735 GY26_18735 pqqC pqqC argD argD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ilvD-2Dihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (570 aa)
GY26_19945Tartrate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (358 aa)
GY26_19125Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (431 aa)
GY26_18040Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (389 aa)
GY26_17550Aminotransferase class I/II; Derived by automated computational analysis using gene prediction method: Protein Homology. (401 aa)
GY26_15890Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (414 aa)
GY26_14210Pyruvate dehydrogenase; Catalyzes the formation of acetate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (574 aa)
GY26_13580MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (413 aa)
GY26_13015Isocitrate dehydrogenase; NADP-specific, catalyzes the formation of 2-oxoglutarate from isocitrate or oxalosuccinate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the monomeric-type IDH family. (745 aa)
GY26_11730GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (501 aa)
GY26_11250Catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; Derived by automated computational analysis using gene prediction method: Protein Homology. (366 aa)
argJOrnithine acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (402 aa)
GY26_10510Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (169 aa)
GY26_10205GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (480 aa)
GY26_09910Diaminobutyrate--2-oxoglutarate aminotransferase; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (421 aa)
GY26_09280Pyruvate dehydrogenase; Catalyzes the formation of acetate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (569 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (314 aa)
GY26_08885GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (464 aa)
GY26_08785Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (295 aa)
GY26_08730Acetylornithine deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (374 aa)
GY26_08670Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (243 aa)
GY26_08485GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (235 aa)
GY26_08285GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (245 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (298 aa)
GY26_06350Bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aconitase/IPM isomerase family. (867 aa)
GY26_06125Dihydroxy-acid dehydratase; Catalyzes the formation of 3-methyl-2-oxobutanoate from 2,3,-dihydroxy-3-methylbutanoate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (584 aa)
GY26_05865Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (473 aa)
GY26_05640Aminotransferase; Broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; Derived by automated computational analysis using gene prediction method: Protein Homology. (408 aa)
argAN-acetylglutamate synthase; Catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the acetyltransferase family. ArgA subfamily. (436 aa)
GY26_05380Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (154 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (359 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (371 aa)
GY26_04220GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (468 aa)
GY26_03860GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (244 aa)
gltAType II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (429 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa)
ilvHAcetolactate synthase 3 regulatory subunit; With IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (163 aa)
GY26_03255Acetolactate synthase 3 catalytic subunit; Catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; Derived by automated computational analysis using gene prediction method: Protein Homology. (574 aa)
GY26_02520Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (151 aa)
GY26_02495Pyruvate dehydrogenase; Catalyzes the formation of acetate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (577 aa)
ilvDDihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (616 aa)
GY26_01290Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (308 aa)
GY26_00675Acetylornithine deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (377 aa)
leuCIsopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (486 aa)
leuD3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (214 aa)
GY26_18735Dihydroxy-acid dehydratase; Catalyzes the formation of 3-methyl-2-oxobutanoate from 2,3,-dihydroxy-3-methylbutanoate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (599 aa)
pqqCPyrroloquinoline quinone biosynthesis protein PqqC; Ring cyclization and eight-electron oxidation of 3a-(2-amino- 2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9- dicarboxylic-acid to PQQ. (244 aa)
argDAcetylornithine aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (405 aa)
Your Current Organism:
Gammaproteobacteria bacterium MFB021
NCBI taxonomy Id: 1492922
Other names: G. bacterium MFB021, bacterium MFB021
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.