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| | ART_0026 | 2-methylcitrate synthase; COG0372; Belongs to the citrate synthase family. (379 aa) |
| | ART_0027 | Methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. (309 aa) |
| | ART_0028 | 2-methylcitrate dehydratase; COG2079. (506 aa) |
| | ART_0029 | Hypothetical protein; COG1802. (223 aa) |
| | ART_0030 | Acyl-coenzyme A synthetase; COG0365. (644 aa) |
| | gcvH | Putative glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (128 aa) |
| | ART_0086 | Hypothetical protein; COG1716. (160 aa) |
| | gcvP | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (924 aa) |
| | ART_0092 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1131 aa) |
| | panB | Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (306 aa) |
| | ART_0138 | L-glutamine synthetase; COG0174; Belongs to the glutamine synthetase family. (448 aa) |
| | ART_0139 | Glutamine-synthetase adenylyltransferase/deadenyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds t [...] (1053 aa) |
| | glsA | Glutaminase; COG2066; Belongs to the glutaminase family. (304 aa) |
| | ART_0205 | Glutamine synthetase; COG0174. (474 aa) |
| | lipA | Lipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (338 aa) |
| | lipB | Hypothetical protein; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (238 aa) |
| | ART_0214 | 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; COG0508. (591 aa) |
| | ART_0215 | Dihydrolipoamide dehydrogenase; COG1249. (460 aa) |
| | ART_0217 | Aminomethyltransferase; COG0404. (377 aa) |
| | ART_0251 | Aconitase; COG1048. (941 aa) |
| | ART_0266 | L-threonine aldolase; COG2008. (355 aa) |
| | ART_0300 | Glutamate synthase large chain; COG0069. (1540 aa) |
| | ART_0301 | Glutamate synthase [NADPH] small chain; COG0493. (484 aa) |
| | ART_0338 | Dihydrolipoyllysine-residue acetyltransferase; COG0508. (421 aa) |
| | ART_0339 | Pyruvate dehydrogenase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (341 aa) |
| | pdhA | Pyruvate dehydrogenase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa) |
| | ART_0343 | Succinate dehydrogenase/fumarate reductase iron-sulfur subunit; COG0479. (249 aa) |
| | ART_0344 | Hypothetical protein; COG1053. (648 aa) |
| | ART_0345 | Succinate dehydrogenase, cytochrome b subunit. (238 aa) |
| | ART_0402 | Succinate dehydrogenase, flavoprotein subunit; COG1053. (85 aa) |
| | ART_0403 | Hypothetical protein; COG1053. (154 aa) |
| | ART_0448 | Succinate dehydrogenase, flavoprotein subunit; COG1053. (579 aa) |
| | ART_0593 | Dimethylmenaquinone methyltransferase; COG0684. (204 aa) |
| | ART_0647 | Aconitate hydratase; COG1048. (934 aa) |
| | ART_0699 | Biotin/lipoate A/B protein ligase; COG0095. (353 aa) |
| | ART_0705 | Phosphoserine phosphatase; COG0560. (304 aa) |
| | ART_0781 | Aminotransferase; COG0436. (411 aa) |
| | ART_0807 | Threonine dehydratase; COG1171. (310 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (606 aa) |
| | ART_0917 | Pyruvate decarboxylase; COG0028; Belongs to the TPP enzyme family. (607 aa) |
| | ART_0974 | GCN5-related N-acetyltransferase; COG0456. (269 aa) |
| | ART_0990 | Asparagine synthetase; COG0367. (894 aa) |
| | ART_1006 | Hypothetical protein; COG0095. (232 aa) |
| | ART_1021 | Aldehyde dehydrogenase; COG1012; Belongs to the aldehyde dehydrogenase family. (477 aa) |
| | proA | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (426 aa) |
| | proB | Gamma-glutamyl kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (383 aa) |
| | ART_1101 | Hypothetical protein; COG2513. (247 aa) |
| | ART_1112 | Glutamate decarboxylase; COG0076; Belongs to the group II decarboxylase family. (455 aa) |
| | ART_1148 | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (915 aa) |
| | ART_1179 | Nitrogen regulatory protein P-II; COG0347. (112 aa) |
| | ART_1180 | Ammonium transporter; COG0004. (452 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (199 aa) |
| | leuC | Isopropylmalate isomerase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (505 aa) |
| | ART_1330 | Branched-chain amino acid aminotransferase; COG0115. (370 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (355 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (341 aa) |
| | ART_1369 | Acetolactate synthase, regulatory subunit; COG0440. (170 aa) |
| | ART_1370 | Acetolactate synthase, catalytic subunit; COG0028. (629 aa) |
| | ilvD | Dihydroxy-acid dehydratase; COG0129; Belongs to the IlvD/Edd family. (580 aa) |
| | mqo | Malate:quinone oxidoreductase; COG0579. (499 aa) |
| | murI | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (346 aa) |
| | ART_1482 | Creatine amidinohydrolase; COG0006. (418 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (441 aa) |
| | ART_1485 | Sarcosine oxidase subunit beta; COG0665. (406 aa) |
| | ART_1486 | Sarcosine oxidase subunit delta; COG4311. (119 aa) |
| | ART_1487 | Sarcosine oxidase subunit alpha; COG0404. (982 aa) |
| | ART_1488 | Sarcosine oxidase subunit gamma; COG4583. (215 aa) |
| | ART_1489 | L-serine dehydratase SdaA; COG1760; Belongs to the iron-sulfur dependent L-serine dehydratase family. (457 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (303 aa) |
| | ART_1540 | 2-oxoglutarate decarboxylase; COG0567. (1264 aa) |
| | ART_1556 | Acetyl-coenzyme A synthetase; COG0365. (576 aa) |
| | ART_1564 | L-serine dehydratase. (165 aa) |
| | ART_1565 | L-serine ammonia-lyase; COG1760. (71 aa) |
| | ART_1566 | Putative L-serine ammonia-lyase; COG1760. (57 aa) |
| | ART_1567 | L-serine ammonia-lyase; COG1760. (132 aa) |
| | ART_1690 | NAD-specific glutamate dehydrogenase; COG2902. (1624 aa) |
| | ART_1825 | Serine-pyruvate aminotransferase; COG0075. (365 aa) |
| | lipA-2 | Lipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (338 aa) |
| | ART_1854 | L-serine dehydratase; COG1760; Belongs to the iron-sulfur dependent L-serine dehydratase family. (465 aa) |
| | glyA-2 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (438 aa) |
| | gcvH-2 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (127 aa) |
| | gcvT | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (377 aa) |
| | gcvP-2 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (956 aa) |
| | purU-2 | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (305 aa) |
| | ART_1897 | Putative citrate synthase; COG0372; Belongs to the citrate synthase family. (427 aa) |
| | leuA-2 | Putative 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (604 aa) |
| | ART_1946 | Putative alanine aminotransferase; COG0436. (405 aa) |
| | mdh | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa) |
| | ART_1987 | Putative oxidoreductase; COG1304. (429 aa) |
| | ART_2148 | Aspartate aminotransferase; COG0436. (411 aa) |
| | ART_2211 | Proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; COG4230; Belongs to the aldehyde dehydrogenase family. (1150 aa) |
| | ART_2256 | 4-aminobutyrate aminotransferase; COG0160; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (453 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (377 aa) |
| | ART_2333 | Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (700 aa) |
| | ilvD-2 | Dihydroxy-acid dehydratase; COG0129; Belongs to the IlvD/Edd family. (617 aa) |
| | ART_2401 | Hypothetical protein; COG0160; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (461 aa) |
| | ART_2402 | Methylmalonate-semialdehyde dehydrogenase; COG1012. (495 aa) |
| | ART_2469 | Acetyl-coenzyme A synthetase; COG0365. (590 aa) |
| | ART_2557 | N-acetylglutamate synthase; COG1246; Belongs to the acetyltransferase family. (174 aa) |
| | panC | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (328 aa) |
| | ART_2657 | Acetolactate synthase, large subunit; COG0028; Belongs to the TPP enzyme family. (538 aa) |
| | ART_2661 | Demethylmenaquinone methyltransferase; COG0684. (202 aa) |
| | ART_2841 | Pyruvate dehydrogenase; COG0028; Belongs to the TPP enzyme family. (582 aa) |
| | ART_2857 | Pyruvate dehydrogenase E1 component, alpha subunit; COG1071. (421 aa) |
| | ART_2858 | Pyruvate dehydrogenase E1 component, beta subunit; COG0022. (321 aa) |
| | ART_2859 | Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase component; COG0508. (488 aa) |
| | ART_2887 | Hypothetical protein; COG1249. (476 aa) |
| | panD | Aspartate alpha-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (134 aa) |
| | ldh | Lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (317 aa) |
| | ART_2979 | Aminodeoxychorismate lyase; COG0115. (330 aa) |
| | ART_2980 | Hypothetical protein; COG3247. (202 aa) |
| | acsA | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (658 aa) |
| | ART_3073 | Hypothetical protein; COG1285. (249 aa) |
| | ART_3085 | Glutamate dehydrogenase; COG0334; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (446 aa) |
| | ART_3157 | Malate synthase A; COG2225; Belongs to the malate synthase family. (549 aa) |
| | ART_3158 | Isocitrate lyase; COG2224. (440 aa) |
| | ART_3159 | Hypothetical protein; COG3800. (488 aa) |
| | ART_3160 | Hypothetical protein. (39 aa) |
| | ppc | Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (939 aa) |
| | pckG | Phosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (609 aa) |
| | ART_3450 | acetyl-CoA acetyltransferase; COG0183; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa) |
| | ART_3458 | Fumarate reductase flavoprotein subunit; COG1053. (471 aa) |
| | ART_3498 | acyl-CoA carboxylase subunit alpha; COG4770. (587 aa) |
| | ART_3576 | Glycine dehydrogenase subunit 2; COG1003. (505 aa) |
| | ART_3577 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (470 aa) |
| | ART_3581 | Acetolactate synthase, large subunit; COG0028; Belongs to the TPP enzyme family. (569 aa) |
| | ART_3675 | 3-hydroxyisobutyrate dehydrogenase; COG2084. (305 aa) |
| | ART_3676 | Hypothetical protein; COG1012; Belongs to the aldehyde dehydrogenase family. (497 aa) |
| | sucC | succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (389 aa) |
| | sucD | succinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (300 aa) |
| | ART_3759 | Hypothetical protein; COG0508. (96 aa) |
| | ART_3769 | Acetolactate synthase, large subunit; COG0028; Belongs to the TPP enzyme family. (557 aa) |
| | ART_3789 | Aspartate ammonia-lyase; COG1027. (483 aa) |
| | ART_3835 | succinyl-CoA:coenzyme A transferase; COG0427. (503 aa) |
| | ART_3866 | Isocitrate dehydrogenase; COG2838; Belongs to the monomeric-type IDH family. (739 aa) |
| | purU-3 | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (294 aa) |
| | glyA-3 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (428 aa) |
| | folD | Bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (294 aa) |
| | ART_3897 | Succinate dehydrogenase iron-sulfur protein; COG0479; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (263 aa) |
| | ART_3898 | Succinate dehydrogenase, flavoprotein subunit; COG1053. (599 aa) |
| | ART_3899 | Succinate dehydrogenase hydrophobic membrane anchor protein; COG2142. (155 aa) |
| | ART_3900 | Succinate dehydrogenase cytochrome, b-556 subunit; COG2009. (111 aa) |
| | ART_3930 | Threonine dehydratase; COG1171. (412 aa) |
| | fumC | Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (476 aa) |
| | ART_3985 | Succinate-semialdehyde dehydrogenase; COG1012; Belongs to the aldehyde dehydrogenase family. (495 aa) |
| | ART_4066 | Hypothetical protein; COG1249. (475 aa) |
| | ART_4071 | acetyl/propionyl-CoA carboxylase subunit alpha; COG4770. (600 aa) |
| | ART_4154 | L-threonine 3-dehydrogenase; COG1063. (349 aa) |
| | kbl | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (402 aa) |
| | ART_4159 | Hypothetical protein; COG0665. (385 aa) |
| | ART_4222 | Pyruvate dehydrogenase (acetyl-transferring); COG1071. (380 aa) |
| | ART_4223 | Pyruvate dehydrogenase E1 component, beta subunit; COG0022. (336 aa) |
| | ART_4224 | Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase component; COG0508. (451 aa) |
| | ART_4246 | 2,4-dienoyl-CoA reductase; COG1902. (675 aa) |
