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| | ART_0026 | 2-methylcitrate synthase; COG0372; Belongs to the citrate synthase family. (379 aa) |
| | ART_0027 | Methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. (309 aa) |
| | ART_0028 | 2-methylcitrate dehydratase; COG2079. (506 aa) |
| | ART_0029 | Hypothetical protein; COG1802. (223 aa) |
| | ART_0030 | Acyl-coenzyme A synthetase; COG0365. (644 aa) |
| | ART_0086 | Hypothetical protein; COG1716. (160 aa) |
| | ART_0092 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1131 aa) |
| | panB | Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (306 aa) |
| | lipA | Lipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (338 aa) |
| | lipB | Hypothetical protein; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (238 aa) |
| | ART_0214 | 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; COG0508. (591 aa) |
| | ART_0215 | Dihydrolipoamide dehydrogenase; COG1249. (460 aa) |
| | ART_0251 | Aconitase; COG1048. (941 aa) |
| | ART_0338 | Dihydrolipoyllysine-residue acetyltransferase; COG0508. (421 aa) |
| | ART_0339 | Pyruvate dehydrogenase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (341 aa) |
| | pdhA | Pyruvate dehydrogenase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa) |
| | ART_0343 | Succinate dehydrogenase/fumarate reductase iron-sulfur subunit; COG0479. (249 aa) |
| | ART_0344 | Hypothetical protein; COG1053. (648 aa) |
| | ART_0345 | Succinate dehydrogenase, cytochrome b subunit. (238 aa) |
| | ART_0402 | Succinate dehydrogenase, flavoprotein subunit; COG1053. (85 aa) |
| | ART_0403 | Hypothetical protein; COG1053. (154 aa) |
| | ART_0448 | Succinate dehydrogenase, flavoprotein subunit; COG1053. (579 aa) |
| | ART_0593 | Dimethylmenaquinone methyltransferase; COG0684. (204 aa) |
| | ART_0647 | Aconitate hydratase; COG1048. (934 aa) |
| | ART_0699 | Biotin/lipoate A/B protein ligase; COG0095. (353 aa) |
| | ART_0807 | Threonine dehydratase; COG1171. (310 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (606 aa) |
| | ART_0917 | Pyruvate decarboxylase; COG0028; Belongs to the TPP enzyme family. (607 aa) |
| | ART_0990 | Asparagine synthetase; COG0367. (894 aa) |
| | ART_1006 | Hypothetical protein; COG0095. (232 aa) |
| | ART_1021 | Aldehyde dehydrogenase; COG1012; Belongs to the aldehyde dehydrogenase family. (477 aa) |
| | ART_1101 | Hypothetical protein; COG2513. (247 aa) |
| | ART_1112 | Glutamate decarboxylase; COG0076; Belongs to the group II decarboxylase family. (455 aa) |
| | ART_1148 | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (915 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (199 aa) |
| | leuC | Isopropylmalate isomerase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (505 aa) |
| | ART_1330 | Branched-chain amino acid aminotransferase; COG0115. (370 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (355 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (341 aa) |
| | ART_1369 | Acetolactate synthase, regulatory subunit; COG0440. (170 aa) |
| | ART_1370 | Acetolactate synthase, catalytic subunit; COG0028. (629 aa) |
| | ilvD | Dihydroxy-acid dehydratase; COG0129; Belongs to the IlvD/Edd family. (580 aa) |
| | mqo | Malate:quinone oxidoreductase; COG0579. (499 aa) |
| | ART_1540 | 2-oxoglutarate decarboxylase; COG0567. (1264 aa) |
| | ART_1556 | Acetyl-coenzyme A synthetase; COG0365. (576 aa) |
| | lipA-2 | Lipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (338 aa) |
| | ART_1897 | Putative citrate synthase; COG0372; Belongs to the citrate synthase family. (427 aa) |
| | leuA-2 | Putative 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (604 aa) |
| | mdh | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa) |
| | ART_1987 | Putative oxidoreductase; COG1304. (429 aa) |
| | ART_2148 | Aspartate aminotransferase; COG0436. (411 aa) |
| | ART_2256 | 4-aminobutyrate aminotransferase; COG0160; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (453 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (377 aa) |
| | ART_2333 | Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (700 aa) |
| | ilvD-2 | Dihydroxy-acid dehydratase; COG0129; Belongs to the IlvD/Edd family. (617 aa) |
| | ART_2401 | Hypothetical protein; COG0160; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (461 aa) |
| | ART_2402 | Methylmalonate-semialdehyde dehydrogenase; COG1012. (495 aa) |
| | ART_2469 | Acetyl-coenzyme A synthetase; COG0365. (590 aa) |
| | panC | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (328 aa) |
| | ART_2657 | Acetolactate synthase, large subunit; COG0028; Belongs to the TPP enzyme family. (538 aa) |
| | ART_2661 | Demethylmenaquinone methyltransferase; COG0684. (202 aa) |
| | ART_2841 | Pyruvate dehydrogenase; COG0028; Belongs to the TPP enzyme family. (582 aa) |
| | ART_2857 | Pyruvate dehydrogenase E1 component, alpha subunit; COG1071. (421 aa) |
| | ART_2858 | Pyruvate dehydrogenase E1 component, beta subunit; COG0022. (321 aa) |
| | ART_2859 | Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase component; COG0508. (488 aa) |
| | ART_2887 | Hypothetical protein; COG1249. (476 aa) |
| | panD | Aspartate alpha-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (134 aa) |
| | ldh | Lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (317 aa) |
| | ART_2979 | Aminodeoxychorismate lyase; COG0115. (330 aa) |
| | ART_2980 | Hypothetical protein; COG3247. (202 aa) |
| | acsA | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (658 aa) |
| | ART_3073 | Hypothetical protein; COG1285. (249 aa) |
| | ART_3157 | Malate synthase A; COG2225; Belongs to the malate synthase family. (549 aa) |
| | ART_3158 | Isocitrate lyase; COG2224. (440 aa) |
| | ART_3159 | Hypothetical protein; COG3800. (488 aa) |
| | ART_3160 | Hypothetical protein. (39 aa) |
| | ppc | Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (939 aa) |
| | pckG | Phosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (609 aa) |
| | ART_3450 | acetyl-CoA acetyltransferase; COG0183; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa) |
| | ART_3458 | Fumarate reductase flavoprotein subunit; COG1053. (471 aa) |
| | ART_3498 | acyl-CoA carboxylase subunit alpha; COG4770. (587 aa) |
| | ART_3581 | Acetolactate synthase, large subunit; COG0028; Belongs to the TPP enzyme family. (569 aa) |
| | ART_3675 | 3-hydroxyisobutyrate dehydrogenase; COG2084. (305 aa) |
| | ART_3676 | Hypothetical protein; COG1012; Belongs to the aldehyde dehydrogenase family. (497 aa) |
| | sucC | succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (389 aa) |
| | sucD | succinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (300 aa) |
| | ART_3759 | Hypothetical protein; COG0508. (96 aa) |
| | ART_3769 | Acetolactate synthase, large subunit; COG0028; Belongs to the TPP enzyme family. (557 aa) |
| | ART_3789 | Aspartate ammonia-lyase; COG1027. (483 aa) |
| | ART_3835 | succinyl-CoA:coenzyme A transferase; COG0427. (503 aa) |
| | ART_3866 | Isocitrate dehydrogenase; COG2838; Belongs to the monomeric-type IDH family. (739 aa) |
| | ART_3897 | Succinate dehydrogenase iron-sulfur protein; COG0479; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (263 aa) |
| | ART_3898 | Succinate dehydrogenase, flavoprotein subunit; COG1053. (599 aa) |
| | ART_3899 | Succinate dehydrogenase hydrophobic membrane anchor protein; COG2142. (155 aa) |
| | ART_3900 | Succinate dehydrogenase cytochrome, b-556 subunit; COG2009. (111 aa) |
| | ART_3930 | Threonine dehydratase; COG1171. (412 aa) |
| | fumC | Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (476 aa) |
| | ART_3985 | Succinate-semialdehyde dehydrogenase; COG1012; Belongs to the aldehyde dehydrogenase family. (495 aa) |
| | ART_4066 | Hypothetical protein; COG1249. (475 aa) |
| | ART_4071 | acetyl/propionyl-CoA carboxylase subunit alpha; COG4770. (600 aa) |
| | ART_4222 | Pyruvate dehydrogenase (acetyl-transferring); COG1071. (380 aa) |
| | ART_4223 | Pyruvate dehydrogenase E1 component, beta subunit; COG0022. (336 aa) |
| | ART_4224 | Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase component; COG0508. (451 aa) |
