STRINGSTRING
gcvH gcvH gcvP gcvP ART_0138 ART_0138 ART_0139 ART_0139 glsA glsA ART_0205 ART_0205 ART_0217 ART_0217 ART_0266 ART_0266 ART_0300 ART_0300 ART_0301 ART_0301 ART_0705 ART_0705 ART_0781 ART_0781 ART_0974 ART_0974 proA proA proB proB ART_1179 ART_1179 ART_1180 ART_1180 murI murI ART_1482 ART_1482 glyA glyA ART_1485 ART_1485 ART_1486 ART_1486 ART_1487 ART_1487 ART_1488 ART_1488 ART_1489 ART_1489 purU purU ART_1690 ART_1690 ART_1825 ART_1825 ART_1854 ART_1854 glyA-2 glyA-2 gcvH-2 gcvH-2 gcvT gcvT gcvP-2 gcvP-2 purU-2 purU-2 ART_1946 ART_1946 ART_2211 ART_2211 ART_2557 ART_2557 ART_3085 ART_3085 ART_3576 ART_3576 ART_3577 ART_3577 purU-3 purU-3 glyA-3 glyA-3 folD folD ART_4154 ART_4154 kbl kbl ART_4159 ART_4159 ART_4246 ART_4246
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gcvHPutative glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (128 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (924 aa)
ART_0138L-glutamine synthetase; COG0174; Belongs to the glutamine synthetase family. (448 aa)
ART_0139Glutamine-synthetase adenylyltransferase/deadenyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds t [...] (1053 aa)
glsAGlutaminase; COG2066; Belongs to the glutaminase family. (304 aa)
ART_0205Glutamine synthetase; COG0174. (474 aa)
ART_0217Aminomethyltransferase; COG0404. (377 aa)
ART_0266L-threonine aldolase; COG2008. (355 aa)
ART_0300Glutamate synthase large chain; COG0069. (1540 aa)
ART_0301Glutamate synthase [NADPH] small chain; COG0493. (484 aa)
ART_0705Phosphoserine phosphatase; COG0560. (304 aa)
ART_0781Aminotransferase; COG0436. (411 aa)
ART_0974GCN5-related N-acetyltransferase; COG0456. (269 aa)
proAGlutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (426 aa)
proBGamma-glutamyl kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (383 aa)
ART_1179Nitrogen regulatory protein P-II; COG0347. (112 aa)
ART_1180Ammonium transporter; COG0004. (452 aa)
murIGlutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (346 aa)
ART_1482Creatine amidinohydrolase; COG0006. (418 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (441 aa)
ART_1485Sarcosine oxidase subunit beta; COG0665. (406 aa)
ART_1486Sarcosine oxidase subunit delta; COG4311. (119 aa)
ART_1487Sarcosine oxidase subunit alpha; COG0404. (982 aa)
ART_1488Sarcosine oxidase subunit gamma; COG4583. (215 aa)
ART_1489L-serine dehydratase SdaA; COG1760; Belongs to the iron-sulfur dependent L-serine dehydratase family. (457 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (303 aa)
ART_1690NAD-specific glutamate dehydrogenase; COG2902. (1624 aa)
ART_1825Serine-pyruvate aminotransferase; COG0075. (365 aa)
ART_1854L-serine dehydratase; COG1760; Belongs to the iron-sulfur dependent L-serine dehydratase family. (465 aa)
glyA-2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (438 aa)
gcvH-2Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (127 aa)
gcvTAminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (377 aa)
gcvP-2Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (956 aa)
purU-2Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (305 aa)
ART_1946Putative alanine aminotransferase; COG0436. (405 aa)
ART_2211Proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; COG4230; Belongs to the aldehyde dehydrogenase family. (1150 aa)
ART_2557N-acetylglutamate synthase; COG1246; Belongs to the acetyltransferase family. (174 aa)
ART_3085Glutamate dehydrogenase; COG0334; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (446 aa)
ART_3576Glycine dehydrogenase subunit 2; COG1003. (505 aa)
ART_3577Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (470 aa)
purU-3Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (294 aa)
glyA-3Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (428 aa)
folDBifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (294 aa)
ART_4154L-threonine 3-dehydrogenase; COG1063. (349 aa)
kbl2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (402 aa)
ART_4159Hypothetical protein; COG0665. (385 aa)
ART_42462,4-dienoyl-CoA reductase; COG1902. (675 aa)
Your Current Organism:
Arthrobacter sp. PAMC25486
NCBI taxonomy Id: 1494608
Other names: A. sp. PAMC 25486, Arthrobacter sp. PAMC 25486
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