(20 nodes) Aromatic amino acid family biosynthetic process network (Arthrobacter sp. PAMC25486)

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Your Input:
	ART_0061	Prephenate dehydrogenase; COG0287. (358 aa)
	ART_0098	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; COG3200; Belongs to the class-II DAHP synthase family. (465 aa)
	trpE	Anthranilate synthase, component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...] (522 aa)
	trpC	Indole-3-glycerol phosphate synthase; COG0134; Belongs to the TrpC family. (271 aa)
	trpB	Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (483 aa)
	trpA	Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (280 aa)
	trpF	Phosphoribosylanthranilate isomerase; COG0135; Belongs to the TrpF family. (204 aa)
	trpD	Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (354 aa)
	aroB	3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (366 aa)
	aroK	Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (192 aa)
	aroC	Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (399 aa)
	ART_0965	Shikimate 5-dehydrogenase; COG0169. (294 aa)
	aroA	3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (449 aa)
	ART_1712	Putative chorismate mutase; COG1605. (157 aa)
	ART_2055	Shikimate 5-dehydrogenase; COG0169. (264 aa)
	pheA	Prephenate dehydratase; COG0077. (312 aa)
	ART_2789	Anthranilate synthase, amidotransferase component; COG0512. (206 aa)
	ART_2982	Para-aminobenzoate synthase subunit I; COG0147. (722 aa)
	aroQ	3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (152 aa)
	ART_3105	Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (381 aa)

Your Current Organism:

Arthrobacter sp. PAMC25486

NCBI taxonomy Id: 1494608
Other names: A. sp. PAMC 25486, Arthrobacter sp. PAMC 25486

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ART_0061	ART_1712	ART_0061	ART_1712	Prephenate dehydrogenase; COG0287.	Putative chorismate mutase; COG1605.	0.953
ART_0061	ART_3105	ART_0061	ART_3105	Prephenate dehydrogenase; COG0287.	Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP).	0.689
ART_0061	aroA	ART_0061	ART_1549	Prephenate dehydrogenase; COG0287.	3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.	0.794
ART_0061	aroB	ART_0061	ART_0962	Prephenate dehydrogenase; COG0287.	3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).	0.902
ART_0061	aroC	ART_0061	ART_0964	Prephenate dehydrogenase; COG0287.	Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.	0.907
ART_0061	aroK	ART_0061	ART_0963	Prephenate dehydrogenase; COG0287.	Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.	0.763
ART_0061	pheA	ART_0061	ART_2588	Prephenate dehydrogenase; COG0287.	Prephenate dehydratase; COG0077.	0.989
ART_0061	trpA	ART_0061	ART_0298	Prephenate dehydrogenase; COG0287.	Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	0.820
ART_0061	trpC	ART_0061	ART_0296	Prephenate dehydrogenase; COG0287.	Indole-3-glycerol phosphate synthase; COG0134; Belongs to the TrpC family.	0.429
ART_0061	trpD	ART_0061	ART_0872	Prephenate dehydrogenase; COG0287.	Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).	0.444
ART_0061	trpE	ART_0061	ART_0293	Prephenate dehydrogenase; COG0287.	Anthranilate synthase, component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...]	0.563
ART_0098	ART_0965	ART_0098	ART_0965	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; COG3200; Belongs to the class-II DAHP synthase family.	Shikimate 5-dehydrogenase; COG0169.	0.542
ART_0098	ART_1712	ART_0098	ART_1712	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; COG3200; Belongs to the class-II DAHP synthase family.	Putative chorismate mutase; COG1605.	0.919
ART_0098	ART_3105	ART_0098	ART_3105	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; COG3200; Belongs to the class-II DAHP synthase family.	Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP).	0.913
ART_0098	aroA	ART_0098	ART_1549	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; COG3200; Belongs to the class-II DAHP synthase family.	3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.	0.426
ART_0098	aroB	ART_0098	ART_0962	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; COG3200; Belongs to the class-II DAHP synthase family.	3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).	0.973
ART_0098	aroC	ART_0098	ART_0964	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; COG3200; Belongs to the class-II DAHP synthase family.	Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.	0.461
ART_0098	aroQ	ART_0098	ART_3054	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; COG3200; Belongs to the class-II DAHP synthase family.	3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family.	0.415
ART_0965	ART_0098	ART_0965	ART_0098	Shikimate 5-dehydrogenase; COG0169.	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; COG3200; Belongs to the class-II DAHP synthase family.	0.542
ART_0965	ART_2055	ART_0965	ART_2055	Shikimate 5-dehydrogenase; COG0169.	Shikimate 5-dehydrogenase; COG0169.	0.931