(5 nodes) Mixed, incl. Monosaccharide binding, and dTTP biosynthetic process network (Arthrobacter sp. PAMC25486)

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Your Input:
	ART_2166	Hypothetical protein; COG3491; Belongs to the iron/ascorbate-dependent oxidoreductase family. (338 aa)
	ART_2167	Hypothetical protein. (549 aa)
	ART_2168	Hypothetical protein; COG1725. (147 aa)
	thyA	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (263 aa)
	ART_2170	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (193 aa)

Your Current Organism:

Arthrobacter sp. PAMC25486

NCBI taxonomy Id: 1494608
Other names: A. sp. PAMC 25486, Arthrobacter sp. PAMC 25486

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ART_2166	ART_2167	ART_2166	ART_2167	Hypothetical protein; COG3491; Belongs to the iron/ascorbate-dependent oxidoreductase family.	Hypothetical protein.	0.570
ART_2166	ART_2168	ART_2166	ART_2168	Hypothetical protein; COG3491; Belongs to the iron/ascorbate-dependent oxidoreductase family.	Hypothetical protein; COG1725.	0.570
ART_2166	ART_2170	ART_2166	ART_2170	Hypothetical protein; COG3491; Belongs to the iron/ascorbate-dependent oxidoreductase family.	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.	0.487
ART_2166	thyA	ART_2166	ART_2169	Hypothetical protein; COG3491; Belongs to the iron/ascorbate-dependent oxidoreductase family.	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.487
ART_2167	ART_2166	ART_2167	ART_2166	Hypothetical protein.	Hypothetical protein; COG3491; Belongs to the iron/ascorbate-dependent oxidoreductase family.	0.570
ART_2167	ART_2168	ART_2167	ART_2168	Hypothetical protein.	Hypothetical protein; COG1725.	0.773
ART_2167	ART_2170	ART_2167	ART_2170	Hypothetical protein.	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.	0.651
ART_2167	thyA	ART_2167	ART_2169	Hypothetical protein.	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.651
ART_2168	ART_2166	ART_2168	ART_2166	Hypothetical protein; COG1725.	Hypothetical protein; COG3491; Belongs to the iron/ascorbate-dependent oxidoreductase family.	0.570
ART_2168	ART_2167	ART_2168	ART_2167	Hypothetical protein; COG1725.	Hypothetical protein.	0.773
ART_2168	ART_2170	ART_2168	ART_2170	Hypothetical protein; COG1725.	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.	0.661
ART_2168	thyA	ART_2168	ART_2169	Hypothetical protein; COG1725.	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.654
ART_2170	ART_2166	ART_2170	ART_2166	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.	Hypothetical protein; COG3491; Belongs to the iron/ascorbate-dependent oxidoreductase family.	0.487
ART_2170	ART_2167	ART_2170	ART_2167	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.	Hypothetical protein.	0.651
ART_2170	ART_2168	ART_2170	ART_2168	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.	Hypothetical protein; COG1725.	0.661
ART_2170	thyA	ART_2170	ART_2169	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.999
thyA	ART_2166	ART_2169	ART_2166	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	Hypothetical protein; COG3491; Belongs to the iron/ascorbate-dependent oxidoreductase family.	0.487
thyA	ART_2167	ART_2169	ART_2167	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	Hypothetical protein.	0.651
thyA	ART_2168	ART_2169	ART_2168	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	Hypothetical protein; COG1725.	0.654
thyA	ART_2170	ART_2169	ART_2170	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.	0.999