STRINGSTRING
ART_3688 ART_3688 ART_3963 ART_3963 folD folD ART_0030 ART_0030 lipA lipA dxs dxs pdhA pdhA ART_0389 ART_0389 ART_0416 ART_0416 ART_0432 ART_0432 bioD bioD ART_0529 ART_0529 ART_0530 ART_0530 bioB bioB kbl kbl mshC mshC metK metK metE metE ART_1023 ART_1023 ART_1045 ART_1045 ART_1132 ART_1132 ART_1133 ART_1133 thiL thiL ART_1463 ART_1463 ART_1506 ART_1506 ART_1556 ART_1556 ART_1711 ART_1711 ART_1812 ART_1812 thiG thiG ART_1821 ART_1821 ART_4222 ART_4222 ART_1822 ART_1822 thiE thiE lipA-2 lipA-2 ART_2068 ART_2068 mshD mshD ART_2173 ART_2173 metXA metXA ART_2206 ART_2206 ART_2207 ART_2207 ART_2272 ART_2272 ART_2279 ART_2279 ackA ackA ART_2333 ART_2333 ART_2431 ART_2431 ART_2469 ART_2469 ART_2526 ART_2526 ART_2830 ART_2830 ART_2857 ART_2857 ART_2925 ART_2925 metZ metZ acsA acsA ART_3218 ART_3218 ART_3311 ART_3311
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ART_3688Hypothetical protein; COG2314. (180 aa)
ART_3963Hypothetical protein. (247 aa)
folDBifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (294 aa)
ART_0030Acyl-coenzyme A synthetase; COG0365. (644 aa)
lipALipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (338 aa)
dxs1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (663 aa)
pdhAPyruvate dehydrogenase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
ART_0389Cysteine synthase; COG0031. (331 aa)
ART_0416Hypothetical protein; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (278 aa)
ART_0432Glyoxalase/bleomycin resistance protein; COG2764. (136 aa)
bioDDethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (234 aa)
ART_05298-amino-7-oxononanoate synthase; COG0156. (381 aa)
ART_0530Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; COG0161; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (453 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (358 aa)
kbl2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (402 aa)
mshCcysteinyl-tRNA synthetase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily. (428 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (400 aa)
metE5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (771 aa)
ART_10235,10-methylenetetrahydrofolate reductase; COG0685; Belongs to the methylenetetrahydrofolate reductase family. (322 aa)
ART_1045Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase multifunctional protein; COG0351. (529 aa)
ART_1132Cysteine synthase; COG0031; Belongs to the cysteine synthase/cystathionine beta- synthase family. (311 aa)
ART_1133Serine O-acetyltransferase; COG1045. (195 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (338 aa)
ART_1463Homoserine dehydrogenase; COG0460. (455 aa)
ART_1506Cysteine synthase; COG0031. (369 aa)
ART_1556Acetyl-coenzyme A synthetase; COG0365. (576 aa)
ART_1711Hypothetical protein. (379 aa)
ART_1812UBA/THIF-type NAD/FAD binding protein; COG0476. (400 aa)
thiGThiazole biosynthesis protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (266 aa)
ART_1821Thiamine biosynthesis protein ThiS; COG2104. (79 aa)
ART_4222Pyruvate dehydrogenase (acetyl-transferring); COG1071. (380 aa)
ART_1822Glycine oxidase ThiO; COG0665. (416 aa)
thiEThiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (229 aa)
lipA-2Lipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (338 aa)
ART_2068Glycosyl transferase family protein; COG0438. (430 aa)
mshDGNAT family acetyltransferase; Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol. (326 aa)
ART_2173Aspartate-semialdehyde dehydrogenase; COG0136; Belongs to the aspartate-semialdehyde dehydrogenase family. (377 aa)
metXAHomoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (396 aa)
ART_2206Cystathionine gamma-synthase; COG0626. (391 aa)
ART_2207Cystathionine beta-synthase; COG0031. (461 aa)
ART_2272Hypothetical protein; COG2764. (170 aa)
ART_2279Sulfate adenylyltransferase subunit 2; COG0175. (316 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (377 aa)
ART_2333Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (700 aa)
ART_2431Hypothetical protein; COG0620. (401 aa)
ART_2469Acetyl-coenzyme A synthetase; COG0365. (590 aa)
ART_2526Phosphomethylpyrimidine kinase; COG0351. (277 aa)
ART_2830ThiS family protein; COG1977. (95 aa)
ART_2857Pyruvate dehydrogenase E1 component, alpha subunit; COG1071. (421 aa)
ART_2925Hypothetical protein; COG2764. (136 aa)
metZO-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (412 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (658 aa)
ART_3218Putative cystathionine gamma-synthase; COG0626. (421 aa)
ART_3311Cystathionine gamma-synthase; COG0626. (397 aa)
Your Current Organism:
Arthrobacter sp. PAMC25486
NCBI taxonomy Id: 1494608
Other names: A. sp. PAMC 25486, Arthrobacter sp. PAMC 25486
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