STRINGSTRING
U27_06465 U27_06465 U27_00063 U27_00063 U27_00099 U27_00099 U27_00117 U27_00117 U27_00118 U27_00118 recG recG U27_00358 U27_00358 uvrB uvrB U27_00662 U27_00662 U27_00684 U27_00684 mfd mfd U27_00836 U27_00836 U27_07030 U27_07030 U27_01049 U27_01049 U27_01116 U27_01116 recA recA radA radA polA polA recO recO U27_01372 U27_01372 U27_01398 U27_01398 U27_01843 U27_01843 U27_01888 U27_01888 U27_01951 U27_01951 U27_02165 U27_02165 recF recF U27_02306 U27_02306 U27_02344 U27_02344 U27_02480 U27_02480 U27_02583 U27_02583 nfo nfo U27_02709 U27_02709 U27_03037 U27_03037 U27_03164 U27_03164 uvrC uvrC ligA ligA dinB dinB U27_03720 U27_03720 U27_03723 U27_03723 U27_03827 U27_03827 U27_03878 U27_03878 U27_03953 U27_03953 U27_03965 U27_03965 U27_03991 U27_03991 mutS mutS ruvB ruvB ruvA ruvA ruvC ruvC mutS2 mutS2 U27_04455 U27_04455 mutL mutL U27_04664 U27_04664 U27_04672 U27_04672 recR recR U27_04997 U27_04997 U27_05173 U27_05173 U27_05954 U27_05954 U27_06014 U27_06014 uvrA uvrA U27_06343 U27_06343 U27_06428 U27_06428
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
U27_06465Putative endonuclease V. (173 aa)
U27_00063Helix-hairpin-helix motif protein. (131 aa)
U27_00099DNA polymerase IV, Family X. (168 aa)
U27_00117DNA mismatch repair protein MutS domain protein. (506 aa)
U27_00118DNA mismatch repair protein MutS domain protein. (519 aa)
recGATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (881 aa)
U27_00358Hypothetical protein. (407 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (664 aa)
U27_00662DNA mismatch repair protein MutS domain protein. (602 aa)
U27_00684LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response). (212 aa)
mfdTranscription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1191 aa)
U27_008366-O-methylguanine DNA methyltransferase, DNA binding domain. (113 aa)
U27_07030Hypothetical protein. (74 aa)
U27_01049DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. (565 aa)
U27_01116Hypothetical protein. (297 aa)
recAProtein recA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (365 aa)
radADNA repair protein radA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (458 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (907 aa)
recODNA repair protein recO; Involved in DNA repair and RecF pathway recombination. (279 aa)
U27_01372Hypothetical protein. (493 aa)
U27_01398DEAD/DEAH box helicase-like protein. (699 aa)
U27_01843A/G-specific adenine glycosylase. (222 aa)
U27_01888Putative DNA glycosylase. (224 aa)
U27_01951ATP-dependent DNA helicase. (458 aa)
U27_02165Hypothetical protein. (337 aa)
recFDNA replication and repair protein recF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (404 aa)
U27_02306Exodeoxyribonuclease. (257 aa)
U27_02344ATP-dependent DNA helicase, RecQ family. (994 aa)
U27_02480Smr protein/MutS2. (109 aa)
U27_02583DNA-directed DNA polymerase I. (803 aa)
nfoProbable endonuclease 4; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (287 aa)
U27_02709Excinuclease ABC, protein A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (976 aa)
U27_03037DNA-3-methyladenine glycosylase I. (212 aa)
U27_03164ATP-dependent DNA ligase. (348 aa)
uvrCUvrABC system protein C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (636 aa)
ligADNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. (680 aa)
dinBDNA polymerase IV 2; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (369 aa)
U27_03720Hypothetical cytosolic protein. (322 aa)
U27_03723Hypothetical protein. (124 aa)
U27_03827NurA protein. (393 aa)
U27_03878Putative comE operon protein 1. (117 aa)
U27_03953HhH-GPD family protein. (225 aa)
U27_03965Hypothetical protein. (268 aa)
U27_03991Radical SAM domain-containing protein. (366 aa)
mutSDNA mismatch repair protein mutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (900 aa)
ruvBHolliday junction ATP-dependent DNA helicase ruvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (349 aa)
ruvAHolliday junction ATP-dependent DNA helicase ruvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (198 aa)
ruvCCrossover junction endodeoxyribonuclease ruvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (165 aa)
mutS2MutS2 family protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (794 aa)
U27_04455Helix-hairpin-helix motif protein. (380 aa)
mutLDNA mismatch repair protein mutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (629 aa)
U27_04664single-stranded-DNA-specific exonuclease RecJ. (560 aa)
U27_04672Putative helicase. (1277 aa)
recRRecombination protein recR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (201 aa)
U27_04997Helicase-like protein; Type III restriction enzyme, res subunit:DEAD/DEAH box helicase-like. (1757 aa)
U27_05173Radical SAM domain protein. (269 aa)
U27_05954formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (276 aa)
U27_06014Phage SPO1 DNA polymerase-related protein. (240 aa)
uvrAExcinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (939 aa)
U27_06343Nuclease subunit B homolog. (1219 aa)
U27_06428Hypothetical protein GobsU_26601. (93 aa)
Your Current Organism:
Vecturithrix granuli
NCBI taxonomy Id: 1499967
Other names: C. Vecturithrix granuli, Candidatus Vecturithrix granuli, bacterium UASB270
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