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| | U27_05674 | Pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (214 aa) |
| | U27_00021 | UvrD/REP helicase family protein. (877 aa) |
| | U27_00043 | Hypothetical protein. (384 aa) |
| | U27_00084 | Hypothetical protein. (155 aa) |
| | U27_00099 | DNA polymerase IV, Family X. (168 aa) |
| | fmt | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (314 aa) |
| | U27_00117 | DNA mismatch repair protein MutS domain protein. (506 aa) |
| | U27_00118 | DNA mismatch repair protein MutS domain protein. (519 aa) |
| | ileS | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (928 aa) |
| | U27_00151 | Transposase, IS4 family. (332 aa) |
| | tyrS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (423 aa) |
| | vapC | PilT protein domain protein; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (127 aa) |
| | U27_00182 | TatD-related deoxyribonuclease. (256 aa) |
| | U27_00206 | Putative RNA methylase family protein; Belongs to the methyltransferase superfamily. (379 aa) |
| | U27_00244 | Hypothetical protein. (357 aa) |
| | U27_00246 | Hypothetical protein. (173 aa) |
| | hisS | histidyl-tRNA synthetase. (418 aa) |
| | recG | ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (881 aa) |
| | xseB | Exodeoxyribonuclease 7 small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (78 aa) |
| | xseA | Exodeoxyribonuclease 7 large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (401 aa) |
| | U27_00344 | Hypothetical protein. (324 aa) |
| | rtcA | RNA 3'-terminal phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. (340 aa) |
| | asnS | asparaginyl-tRNA synthetase. (460 aa) |
| | trpS | tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (321 aa) |
| | U27_00358 | Hypothetical protein. (407 aa) |
| | U27_00421 | DNA topoisomerase. (692 aa) |
| | U27_00460 | Transposase of ISCARN10, IS200/IS605 family IS200 group. (125 aa) |
| | rlmH | Ribosomal RNA large subunit methyltransferase H; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. (158 aa) |
| | uvrB | Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (664 aa) |
| | U27_00662 | DNA mismatch repair protein MutS domain protein. (602 aa) |
| | U27_00712 | Putative type I restriction enzyme R protein. (992 aa) |
| | mfd | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1191 aa) |
| | U27_00751 | RNA methyltransferase, TrmA family; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (451 aa) |
| | dtd | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (145 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (468 aa) |
| | U27_00820 | Hypothetical protein. (846 aa) |
| | U27_00826 | Deoxyribonuclease; Subunit R is required for both nuclease and ATPase activities, but not for modification. (1101 aa) |
| | U27_00827 | Transposase. (150 aa) |
| | priA | Pprimosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (820 aa) |
| | U27_00855 | PilT-like protein. (135 aa) |
| | U27_00864 | YbaK/prolyl-tRNA synthetase associated region. (159 aa) |
| | U27_00913 | Hypothetical protein. (306 aa) |
| | U27_00921 | Hypothetical protein. (613 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (434 aa) |
| | U27_00931 | Pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (326 aa) |
| | U27_00976 | Transposase. (240 aa) |
| | U27_00979 | Hypothetical protein. (118 aa) |
| | U27_01002 | Hypothetical protein. (394 aa) |
| | U27_01056 | Ribonuclease Z. (321 aa) |
| | U27_01081 | DNA polymerase III, alpha subunit. (409 aa) |
| | rlmN | Ribosomal RNA large subunit methyltransferase N; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (345 aa) |
| | truA | tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (247 aa) |
| | U27_01148 | Putative tRNA/rRNA methyltransferase. (285 aa) |
| | U27_01151 | DNA polymerase III, delta subunit. (337 aa) |
| | leuS | leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (831 aa) |
| | U27_01194 | Hypothetical protein. (356 aa) |
| | U27_01196 | Hypothetical protein. (233 aa) |
| | U27_01206 | Hypothetical protein. (91 aa) |
| | recA | Protein recA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (365 aa) |
| | glyQS | glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. (433 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (909 aa) |
| | radA | DNA repair protein radA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (458 aa) |
| | U27_01279 | Hypothetical protein Psyrpo1_00862. (147 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (907 aa) |
| | U27_01370 | Restriction endonuclease. (902 aa) |
| | U27_01398 | DEAD/DEAH box helicase-like protein. (699 aa) |
| | cas1 | CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (335 aa) |
| | cas2 | CRISPR-associated protein, Cas2 family; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (91 aa) |
| | U27_01461 | Transposase and inactivated derivatives. (94 aa) |
| | cas1-2 | CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (334 aa) |
| | cas2-2 | CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (95 aa) |
| | U27_01535 | RNA-directed DNA polymerase. (476 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (1079 aa) |
| | U27_01650 | ATP-dependent helicase, DEAD/DEAH box family. (1510 aa) |
| | U27_01651 | ATP-dependent DNA helicase, RecQ family. (1739 aa) |
| | rny | Metal dependent phosphohydrolase; Endoribonuclease that initiates mRNA decay. (520 aa) |
| | pheT | phenylalanyl-tRNA synthetase, beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (809 aa) |
| | pheS | phenylalanyl-tRNA synthetase alpha chain; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (341 aa) |
| | thrS | Putative tRNA synthetase class II with core domain (G, H, P, S and T); Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). (637 aa) |
| | U27_01671 | phenylalanyl-tRNA synthetase alpha chain. (520 aa) |
| | U27_01672 | phenylalanyl-tRNA synthetase beta chain. (561 aa) |
| | U27_01684 | Hypothetical protein. (569 aa) |
| | U27_01704 | Helicase domain protein. (656 aa) |
| | U27_01721 | Type III restriction protein res subunit. (502 aa) |
| | U27_01746 | PilT protein domain protein. (129 aa) |
| | rph | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (245 aa) |
| | U27_01756 | Pseudouridine synthase; Belongs to the pseudouridine synthase RsuA family. (253 aa) |
| | miaA | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (313 aa) |
| | U27_01795 | PIN domain protein. (129 aa) |
| | U27_01828 | Transposase IS4 family protein. (198 aa) |
| | U27_01843 | A/G-specific adenine glycosylase. (222 aa) |
| | U27_01846 | DNA polymerase III, alpha subunit. (1162 aa) |
| | U27_01850 | Modification methylase NspV. (489 aa) |
| | rtcB | Hypothetical protein; Fragment; Belongs to the RtcB family. (484 aa) |
| | U27_01888 | Putative DNA glycosylase. (224 aa) |
| | U27_01911 | Helicase domain protein. (1133 aa) |
| | U27_01931 | Putative hydrolase. (279 aa) |
| | U27_01951 | ATP-dependent DNA helicase. (458 aa) |
| | U27_01955 | Hypothetical protein. (141 aa) |
| | U27_02032 | Methyltransferase. (67 aa) |
| | U27_02040 | Type III restriction protein res subunit. (78 aa) |
| | U27_02167 | Glucose-inhibited division protein A. (424 aa) |
| | gyrA | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (817 aa) |
| | gyrB | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (802 aa) |
| | U27_02205 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (369 aa) |
| | rpoA | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (340 aa) |
| | U27_02306 | Exodeoxyribonuclease. (257 aa) |
| | U27_02317 | DNA deoxyribo-dipyrimidine photolyase family protein. (458 aa) |
| | U27_02338 | Transposase IS4 family protein. (261 aa) |
| | U27_02343 | Hypothetical protein. (932 aa) |
| | U27_02344 | ATP-dependent DNA helicase, RecQ family. (994 aa) |
| | U27_02374 | YicC domain protein. (350 aa) |
| | U27_02420 | Hypothetical protein. (77 aa) |
| | U27_02421 | PilT protein domain protein. (49 aa) |
| | U27_02476 | Hypothetical protein. (910 aa) |
| | U27_02480 | Smr protein/MutS2. (109 aa) |
| | argS | arginyl-tRNA synthetase. (589 aa) |
| | U27_02582 | Gp9 protein. (105 aa) |
| | U27_02583 | DNA-directed DNA polymerase I. (803 aa) |
| | U27_02592 | Putative helicase. (488 aa) |
| | nfo | Probable endonuclease 4; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (287 aa) |
| | U27_02709 | Excinuclease ABC, protein A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (976 aa) |
| | rsmH | Ribosomal RNA small subunit methyltransferase H; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (344 aa) |
| | U27_02802 | DNA damage inducible protein. (89 aa) |
| | U27_02877 | Helicase c2. (734 aa) |
| | trmD | tRNA (guanine-N(1)-)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. (230 aa) |
| | U27_02917 | Hypothetical protein. (181 aa) |
| | rnhB | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (228 aa) |
| | U27_02920 | Hypothetical protein. (42 aa) |
| | U27_02921 | Hypothetical protein. (106 aa) |
| | dnaX | DNA polymerase III, gamma and tau subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (567 aa) |
| | U27_02974 | Superfamily II DNA/RNA helicase. (1052 aa) |
| | U27_03004 | Ribonuclease G. (527 aa) |
| | U27_03031 | Hypothetical protein Despr_1156. (490 aa) |
| | selA | L-seryl-tRNA(Sec) selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. (470 aa) |
| | U27_03037 | DNA-3-methyladenine glycosylase I. (212 aa) |
| | U27_03047 | Type I site-specific deoxyribonuclease HsdR; Subunit R is required for both nuclease and ATPase activities, but not for modification. (1146 aa) |
| | U27_03088 | Putative N6-adenine-specific DNA methylase. (399 aa) |
| | U27_03098 | Hypothetical protein. (346 aa) |
| | U27_03099 | Hypothetical protein. (1227 aa) |
| | U27_03103 | ANL34 protein. (135 aa) |
| | U27_03105 | Twitching motility protein PilT. (130 aa) |
| | U27_03108 | Hypothetical protein. (225 aa) |
| | U27_03133 | Hypothetical protein; Belongs to the DEAD box helicase family. (582 aa) |
| | U27_03162 | Exoribonuclease II. (491 aa) |
| | U27_03164 | ATP-dependent DNA ligase. (348 aa) |
| | U27_03192 | Twitching motility protein PilT. (130 aa) |
| | U27_03194 | Type IIS restriction enzyme R and M protein. (1051 aa) |
| | U27_03197 | Hypothetical protein. (298 aa) |
| | uvrC | UvrABC system protein C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (636 aa) |
| | ligA | DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. (680 aa) |
| | U27_03273 | EcoEI R domain protein. (780 aa) |
| | U27_03318 | PilT protein-like protein. (124 aa) |
| | U27_03320 | Toxin-antitoxin system, toxin component, PIN family. (138 aa) |
| | U27_03340 | Hypothetical protein. (156 aa) |
| | U27_03347 | Hypothetical protein. (177 aa) |
| | U27_03348 | Type I restriction endonuclease. (121 aa) |
| | U27_03366 | Hypothetical protein. (1216 aa) |
| | dinB | DNA polymerase IV 2; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (369 aa) |
| | U27_03392 | Helicase. (941 aa) |
| | U27_03403 | Putative helicase. (926 aa) |
| | U27_03407 | Amidase. (436 aa) |
| | U27_03422 | Guanine-specific ribonuclease N1 and T1. (133 aa) |
| | U27_03485 | DNA adenine methylase subfamily. (339 aa) |
| | U27_03527 | RNA-directed DNA polymerase. (337 aa) |
| | U27_03528 | Putative group II intron reverse transcriptase/maturase. (281 aa) |
| | U27_03564 | Hypothetical protein. (221 aa) |
| | U27_03586 | Transposase IS200-family protein. (150 aa) |
| | U27_03734 | HD domain protein. (202 aa) |
| | rnc | Ribonuclease 3 2; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. (285 aa) |
| | metG | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (688 aa) |
| | U27_03772 | DNA polymerase III, delta prime subunit. (335 aa) |
| | aspS | aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (591 aa) |
| | ybeY | Probable rRNA maturation factor; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (154 aa) |
| | U27_03946 | McrC protein. (362 aa) |
| | U27_03953 | HhH-GPD family protein. (225 aa) |
| | U27_03969 | Hypothetical protein. (363 aa) |
| | U27_04037 | RNA-directed DNA polymerase; Reverse transcriptase. (330 aa) |
| | U27_04067 | tRNA-dihydrouridine synthase; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (324 aa) |
| | mutS | DNA mismatch repair protein mutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (900 aa) |
| | rsmA | Ribosomal RNA small subunit methyltransferase A; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (275 aa) |
| | U27_04190 | Predicted HD domain containing protein. (181 aa) |
| | ruvB | Holliday junction ATP-dependent DNA helicase ruvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (349 aa) |
| | ruvA | Holliday junction ATP-dependent DNA helicase ruvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (198 aa) |
| | ruvC | Crossover junction endodeoxyribonuclease ruvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (165 aa) |
| | U27_04267 | Pseudouridine synthase; Belongs to the pseudouridine synthase RsuA family. (247 aa) |
| | proS | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (478 aa) |
| | mutS2 | MutS2 family protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (794 aa) |
| | U27_04433 | 23S rRNA m(5)U-1939 methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (456 aa) |
| | U27_04436 | Putative NAD(+) diphosphatase. (272 aa) |
| | tgt | Queuine tRNA-ribosyltransferase 1; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form [...] (377 aa) |
| | U27_04586 | PilT protein domain protein. (150 aa) |
| | U27_04649 | Toxin of toxin-antitoxin system VapC. (133 aa) |
| | rnr | Ribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. (704 aa) |
| | U27_04672 | Putative helicase. (1277 aa) |
| | U27_04714 | DNA adenine methylase subfamily. (311 aa) |
| | truB | tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. (346 aa) |
| | U27_04735 | Hypothetical protein. (247 aa) |
| | U27_04783 | Beta-lactamase domain protein. (270 aa) |
| | U27_04810 | seryl-tRNA synthetase 2. (427 aa) |
| | dnaX-2 | DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (433 aa) |
| | U27_04822 | Transposase IS200-family protein. (150 aa) |
| | lysS | lysyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (523 aa) |
| | U27_04947 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (456 aa) |
| | thrS-2 | threonyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (596 aa) |
| | U27_04997 | Helicase-like protein; Type III restriction enzyme, res subunit:DEAD/DEAH box helicase-like. (1757 aa) |
| | U27_04998 | Hypothetical protein. (181 aa) |
| | U27_04999 | Helicase-like. (988 aa) |
| | U27_05000 | Hypothetical protein. (1485 aa) |
| | U27_05055 | ATP-dependent DNA helicase recQ. (730 aa) |
| | U27_05075 | Integral membrane protein. (328 aa) |
| | U27_05126 | D12 class N6 adenine-specific DNA methyltransferase. (295 aa) |
| | U27_05138 | Transposase of ISCARN10, IS200/IS605 family IS200 group. (159 aa) |
| | queA | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (343 aa) |
| | U27_05281 | Hypothetical protein. (1119 aa) |
| | U27_05282 | Hypothetical protein. (1149 aa) |
| | U27_05343 | Queuine tRNA-ribosyltransferase 1; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form [...] (367 aa) |
| | U27_05344 | SAM-dependent methyltransferase. (290 aa) |
| | U27_05369 | PilT protein domain protein. (145 aa) |
| | U27_05396 | Hypothetical protein. (304 aa) |
| | U27_05418 | Hypothetical protein; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. (162 aa) |
| | U27_05420 | YbaK/prolyl-tRNA synthetase associated region. (167 aa) |
| | U27_05455 | Hypothetical protein. (1181 aa) |
| | topA | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (826 aa) |
| | U27_05532 | Hypothetical protein. (333 aa) |
| | U27_05561 | RNA-directed DNA polymerase. (150 aa) |
| | trmJ | RNA methyltransferase, TrmH family, group 1; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. (256 aa) |
| | U27_05576 | PilT protein domain protein. (156 aa) |
| | U27_05608 | YbaK/prolyl-tRNA synthetase associated region. (155 aa) |
| | U27_05612 | PUA domain containing protein. (395 aa) |
| | glnS | glutaminyl-tRNA synthetase. (599 aa) |
| | U27_05676 | Truncated alanyl-tRNA synthetase. (403 aa) |
| | U27_05705 | Hypothetical protein. (149 aa) |
| | U27_05785 | Type I site-specific deoxyribonuclease. (918 aa) |
| | U27_05786 | Hypothetical protein. (116 aa) |
| | U27_05804 | Hypothetical protein. (307 aa) |
| | U27_05811 | Beta-lactamase domain protein. (259 aa) |
| | U27_05828 | Transposase IS4 family protein. (233 aa) |
| | U27_05829 | Transposase. (131 aa) |
| | U27_05862 | PilT protein-like. (120 aa) |
| | rnpA | Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (125 aa) |
| | U27_05876 | Ribosomal RNA small subunit methyltransferase G. (169 aa) |
| | U27_05898 | Putative DNA helicase. (539 aa) |
| | U27_05954 | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (276 aa) |
| | rpoB | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1506 aa) |
| | rpoC | DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1472 aa) |
| | rpoA-2 | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (345 aa) |
| | U27_06014 | Phage SPO1 DNA polymerase-related protein. (240 aa) |
| | uvrA | Excinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (939 aa) |
| | U27_06099 | Transposase and inactivated derivatives. (217 aa) |
| | rsmI | Ribosomal RNA small subunit methyltransferase I; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (283 aa) |
| | U27_06197 | PilT protein domain protein. (138 aa) |
| | U27_06206 | Transposase, IS4 family protein. (383 aa) |
| | U27_06262 | Hypothetical protein. (477 aa) |
| | U27_06265 | Slr0569 protein. (481 aa) |
| | U27_06323 | CRISPR-associated protein Cas1. (185 aa) |
| | cas2-3 | CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (97 aa) |
| | U27_06343 | Nuclease subunit B homolog. (1219 aa) |
| | U27_06375 | Transposase. (286 aa) |
| | U27_06380 | Hypothetical protein. (114 aa) |
| | U27_06415 | Hypothetical protein. (668 aa) |
| | gatB | aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (481 aa) |
| | gatA | glutamyl-tRNA(gln) amidotransferase subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (493 aa) |
| | gatC | glutamyl-tRNA(gln) amidotransferase subunit C; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (95 aa) |
| | U27_06428 | Hypothetical protein GobsU_26601. (93 aa) |
| | U27_06465 | Putative endonuclease V. (173 aa) |
| | U27_06488 | RNA-directed DNA polymerase; Reverse transcriptase. (374 aa) |
| | U27_06497 | PilT protein domain protein. (72 aa) |
| | U27_06599 | DNA adenine methylase. (308 aa) |
| | U27_06610 | Insertion element protein. (107 aa) |
| | U27_06665 | SAM-dependent methyltransferase. (246 aa) |
| | rnhA | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (157 aa) |
| | U27_06766 | Metal dependent phosphohydrolase. (179 aa) |
| | trmB | tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (206 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (593 aa) |
| | U27_06810 | Hypothetical protein. (208 aa) |
| | rsmH-2 | Ribosomal RNA small subunit methyltransferase H 2; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (358 aa) |
| | U27_06877 | Type I site-specific deoxyribonuclease. (100 aa) |
| | U27_06878 | Type I site-specific deoxyribonuclease. (211 aa) |
| | U27_06893 | Hypothetical protein. (444 aa) |
| | mutL | DNA mismatch repair protein mutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (629 aa) |
| | cysS | cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (506 aa) |
| | U27_06997 | RNA methyltransferase, TrmH family, group 3; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (249 aa) |
| | U27_07025 | Type-2 restriction enzyme AvaI. (324 aa) |
| | U27_07029 | D12 class N6 adenine-specific DNA methyltransferase. (304 aa) |
