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EW14_0950 EW14_0950 EW14_2064 EW14_2064 secA secA EW14_1989 EW14_1989 EW14_1988 EW14_1988 EW14_1957 EW14_1957 secY secY EW14_1798 EW14_1798 atpB atpB atpE atpE atpG-2 atpG-2 atpF atpF atpH atpH atpA atpA atpG atpG atpC atpC atpD atpD EW14_1775 EW14_1775 EW14_1754 EW14_1754 EW14_1752 EW14_1752 EW14_1677 EW14_1677 EW14_1641 EW14_1641 EW14_1626 EW14_1626 cobD cobD EW14_1598 EW14_1598 EW14_1580 EW14_1580 EW14_1549 EW14_1549 EW14_1535 EW14_1535 EW14_1532 EW14_1532 EW14_1464 EW14_1464 EW14_1428 EW14_1428 EW14_1422 EW14_1422 EW14_1411 EW14_1411 cobQ cobQ EW14_1371 EW14_1371 EW14_1351 EW14_1351 EW14_1345 EW14_1345 EW14_1293 EW14_1293 EW14_1280 EW14_1280 EW14_1261 EW14_1261 EW14_1239 EW14_1239 EW14_1188 EW14_1188 EW14_1187 EW14_1187 EW14_1185 EW14_1185 EW14_1076 EW14_1076 EW14_1055 EW14_1055 EW14_1054 EW14_1054 EW14_1027 EW14_1027 EW14_0979 EW14_0979 EW14_0978 EW14_0978 EW14_0964 EW14_0964 EW14_0962 EW14_0962 secD secD EW14_2071 EW14_2071 EW14_0936 EW14_0936 EW14_0916 EW14_0916 EW14_0915 EW14_0915 EW14_0895 EW14_0895 EW14_0837 EW14_0837 pstB pstB EW14_0804 EW14_0804 EW14_0803 EW14_0803 EW14_0799 EW14_0799 EW14_0745 EW14_0745 EW14_0691 EW14_0691 EW14_0682 EW14_0682 EW14_0675 EW14_0675 EW14_0640 EW14_0640 EW14_0614 EW14_0614 EW14_0607 EW14_0607 EW14_0534 EW14_0534 EW14_0515 EW14_0515 tatC tatC petC petC EW14_0488 EW14_0488 EW14_0487 EW14_0487 EW14_0486 EW14_0486 ndhB ndhB EW14_0459 EW14_0459 EW14_0430 EW14_0430 tatA tatA EW14_0383 EW14_0383 ndhC ndhC ndhK ndhK ndhJ ndhJ EW14_0307 EW14_0307 EW14_0305 EW14_0305 EW14_0257 EW14_0257 secE secE ndhI ndhI EW14_0201 EW14_0201 ndhD ndhD EW14_0191 EW14_0191 EW14_0173 EW14_0173 EW14_0120 EW14_0120 EW14_0106 EW14_0106 EW14_0105 EW14_0105 EW14_0103 EW14_0103 EW14_0084 EW14_0084
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EW14_0950Integral membrane protein; Alternative locus ID: PMIT0604_0950; DUF6. (296 aa)
EW14_2064Multidrug efflux transporter; Alternative locus ID: PMIT0604_2065; MFS family. (428 aa)
secAProtein export cytoplasm protein SecA ATPase RNA helicase; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane; Belongs to the SecA family. (943 aa)
EW14_1989Hypothetical protein; Important for reducing fluoride concentration in the cell, thus reducing its toxicity. (109 aa)
EW14_1988Magnesium transporter; Acts as a magnesium transporter. (468 aa)
EW14_1957Na+/H+ antiporter; Alternative locus ID: PMIT0604_1958. (455 aa)
secYPreprotein translocase secY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (439 aa)
EW14_1798Cell division protein FtsW; Alternative locus ID: PMIT0604_1798; Belongs to the SEDS family. (411 aa)
atpBATP synthase A chain; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (241 aa)
atpEATP synthase C chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (81 aa)
atpG-2ATP synthase B' chain; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria. Belongs to the ATPase B chain family. (153 aa)
atpFATP synthase B chain; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (170 aa)
atpHATP synthase delta chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (180 aa)
atpAATP synthase alpha chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (505 aa)
atpGATP synthase gamma chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (315 aa)
atpCATP synthase epsilon chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. (134 aa)
atpDATP synthase beta chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (486 aa)
EW14_1775Preprotein translocase subunit SecG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. (46 aa)
EW14_1754Hypothetical protein; Alternative locus ID: PMIT0604_1754. (384 aa)
EW14_1752Potassium voltage-gated channel subfamily KQT; Alternative locus ID: PMIT0604_1752; VIC family; possible potassium channel. (260 aa)
EW14_1677Hypothetical protein; Alternative locus ID: PMIT0604_1677. (290 aa)
EW14_1641Outer membrane protein/protective antigen OMA87; Alternative locus ID: PMIT0604_1641. (710 aa)
EW14_1626Hypothetical protein; Alternative locus ID: PMIT0604_1626; FIG019731: Sugar transporter. (465 aa)
cobDAdenosylcobinamide-phosphate synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (342 aa)
EW14_1598Nickel transporter UreH; Alternative locus ID: PMIT0604_1598. (223 aa)
EW14_1580Polysaccharide export-related periplasmic protein; Alternative locus ID: PMIT0604_1580. (409 aa)
EW14_1549Nitrate/nitrite transporter; Alternative locus ID: PMIT0604_1549. (517 aa)
EW14_1535HupE-UreJ family cobalt transporter; Alternative locus ID: PMIT0604_1535. (210 aa)
EW14_1532Hypothetical protein; Alternative locus ID: PMIT0604_1532. (211 aa)
EW14_1464Phospholipid-lipopolysaccharide ABC transporter; Alternative locus ID: PMIT0604_1464. (584 aa)
EW14_1428Permease of the drug/metabolite transporter (DMT); Alternative locus ID: PMIT0604_1428. (304 aa)
EW14_1422Hypothetical protein; Alternative locus ID: PMIT0604_1422; FIG00941872: hypothetical protein. (85 aa)
EW14_1411Putative porin precursor; Alternative locus ID: PMIT0604_1411; Belongs to the OprB family. (433 aa)
cobQCobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (509 aa)
EW14_1371Putative membrane fusion protein; Alternative locus ID: PMIT0604_1371; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (353 aa)
EW14_1351Na+-dependent transporter of the SNF family; Alternative locus ID: PMIT0604_1351. (447 aa)
EW14_1345Mn2+ and Fe2+ transporter; Alternative locus ID: PMIT0604_1345; NRAMP family. (434 aa)
EW14_1293Permease of the major facilitator; Alternative locus ID: PMIT0604_1293. (418 aa)
EW14_1280Nitrate/nitrite transporter; Alternative locus ID: PMIT0604_1280. (517 aa)
EW14_1261Putative porin; Alternative locus ID: PMIT0604_1261; Belongs to the OprB family. (364 aa)
EW14_1239ABC transporter; Alternative locus ID: PMIT0604_1239; multidrug efflux family. (590 aa)
EW14_1188ABC transporter; Alternative locus ID: PMIT0604_1188; substrate binding protein, possibly oligopeptides. (523 aa)
EW14_1187Dipeptide transport system permease protein DppB; Alternative locus ID: PMIT0604_1187; TCDB 3.A.1.5.2. (340 aa)
EW14_1185Putative multidrug efflux transporter; Alternative locus ID: PMIT0604_1185; MFS family. (409 aa)
EW14_1076ABC transporter; Alternative locus ID: PMIT0604_1076; possibly multidrug efflux. (547 aa)
EW14_1055Hypothetical protein; Alternative locus ID: PMIT0604_1055; FIG00941530: hypothetical protein. (103 aa)
EW14_1054Hypothetical protein; Alternative locus ID: PMIT0604_1054; FIG00940821: hypothetical protein. (108 aa)
EW14_1027Putative SMC domain N terminal domain; Alternative locus ID: PMIT0604_1027. (207 aa)
EW14_0979Cell division protein FtsX; Alternative locus ID: PMIT0604_0979. (410 aa)
EW14_0978Substrate-specific component BioY of biotin ECF transporter; Alternative locus ID: PMIT0604_0978. (189 aa)
EW14_0964Hypothetical protein; Alternative locus ID: PMIT0604_0964; FIG00941373: hypothetical protein. (292 aa)
EW14_0962Protein-export membrane protein SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (304 aa)
secDProtein-export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily. (461 aa)
EW14_2071Chloride channel protein; Alternative locus ID: PMIT0604_2072. (452 aa)
EW14_0936ATP-binding protein of ABC transporter; Alternative locus ID: PMIT0604_0936. (581 aa)
EW14_0916Urea ABC transporter; Alternative locus ID: PMIT0604_0916; permease protein UrtB; Belongs to the binding-protein-dependent transport system permease family. (384 aa)
EW14_0915Urea ABC transporter; Alternative locus ID: PMIT0604_0915; permease protein UrtC; Belongs to the binding-protein-dependent transport system permease family. (332 aa)
EW14_0895ABC transporter; Alternative locus ID: PMIT0604_0895; ATP binding component, possibly iron transporter; Belongs to the ABC transporter superfamily. (352 aa)
EW14_0837Putative ABC transporter component; Alternative locus ID: PMIT0604_0837. (304 aa)
pstBPhosphate transport ATP-binding protein PstB; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (269 aa)
EW14_0804Phosphate transport system permease protein PstA; Alternative locus ID: PMIT0604_0804; TCDB 3.A.1.7.1. (297 aa)
EW14_0803Phosphate transport system permease protein PstC; Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (315 aa)
EW14_0799Putative potassium channel; Alternative locus ID: PMIT0604_0799; VIC family. (351 aa)
EW14_0745Phosphonate ABC transporter permease protein phnE; Alternative locus ID: PMIT0604_0745; TCDB 3.A.1.9.1. (500 aa)
EW14_0691Sulfate permease; Alternative locus ID: PMIT0604_0691. (521 aa)
EW14_0682Small mechanosensitive ion channel; Alternative locus ID: PMIT0604_0682; MscS family. (343 aa)
EW14_0675Putative sodium:solute symporter; Alternative locus ID: PMIT0604_0675; ESS family. (441 aa)
EW14_0640NADH dehydrogenase I subunit 4; Alternative locus ID: PMIT0604_0640; Involved in photosystem-1 cyclic electron flow. (513 aa)
EW14_0614Inner membrane protein YrbG; Alternative locus ID: PMIT0604_0614; predicted calcium/sodium:proton antiporter. (359 aa)
EW14_0607ABC transporter; Alternative locus ID: PMIT0604_0607; ATP-binding/permease protein. (598 aa)
EW14_0534Ferric iron ABC transporter; Alternative locus ID: PMIT0604_0534; permease protein. (512 aa)
EW14_0515Putative Na+/H+ antiporter; Alternative locus ID: PMIT0604_0515; CPA1 family. (399 aa)
tatCTwin-arginine translocation protein TatC; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. (252 aa)
petCCytochrome b6-f complex iron-sulfur subunit PetC1; Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions. (178 aa)
EW14_0488Cytochrome c oxidase polypeptide II; Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). (267 aa)
EW14_0487Cytochrome c oxidase polypeptide I; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. (541 aa)
EW14_0486Cytochrome c oxidase polypeptide III; Alternative locus ID: PMIT0604_0486. (200 aa)
ndhBNADH dehydrogenase subunit 2; NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration. (506 aa)
EW14_0459Dipeptide transport system permease protein DppC; Alternative locus ID: PMIT0604_0459; TCDB 3.A.1.5.2. (281 aa)
EW14_0430Transmembrane component of energizing module of ECF transporters in Cyanobacteria; Alternative locus ID: PMIT0604_0430. (304 aa)
tatATwin-arginine translocation protein TatA; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. (88 aa)
EW14_0383NADH-plastoquinone oxidoreductase chain 5-like protein; Alternative locus ID: PMIT0604_0383. (144 aa)
ndhCNAD(P)H-quinone oxidoreductase subunit 3; NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration. (120 aa)
ndhKNAD(P)H-quinone oxidoreductase chain K; NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration; Belongs to the complex I 20 kDa subunit family. (244 aa)
ndhJNAD(P)H-quinone oxidoreductase chain J; NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration. (176 aa)
EW14_0307Ammonium transporter family; Alternative locus ID: PMIT0604_0307. (446 aa)
EW14_0305Putative membrane protein; Alternative locus ID: PMIT0604_0305; putative virulence factor. (540 aa)
EW14_0257Sulfate permease; Alternative locus ID: PMIT0604_0257. (550 aa)
secEPreprotein translocase subunit SecE; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. (80 aa)
ndhINAD(P)H-quinone oxidoreductase chain I; NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient; Belongs to the complex I 23 kDa subunit family. (208 aa)
EW14_0201NAD(P)H-quinone oxidoreductase chain J; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I subunit 6 family. (199 aa)
ndhDNADH dehydrogenase subunit 4; NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 4 family. (534 aa)
EW14_0191NADH dehydrogenase subunit 5; Alternative locus ID: PMIT0604_0191; Involved in CO2 fixation. (673 aa)
EW14_0173Lead; Alternative locus ID: PMIT0604_0173; cadmium, zinc and mercury transporting ATPase; Copper-translocating P-type ATPase. (754 aa)
EW14_0120Outer membrane efflux protein precursor; Alternative locus ID: PMIT0604_0120. (475 aa)
EW14_0106Trk system potassium uptake protein TrkA; Alternative locus ID: PMIT0604_0106. (234 aa)
EW14_0105Potassium uptake protein TrkH; Alternative locus ID: PMIT0604_0105. (373 aa)
EW14_0103Sulfate permease; Alternative locus ID: PMIT0604_0103; Trk-type. (602 aa)
EW14_0084ATP-binding protein of ABC transporter; Alternative locus ID: PMIT0604_0084. (660 aa)
Your Current Organism:
Prochlorococcus sp. MIT0604
NCBI taxonomy Id: 1501268
Other names: P. sp. MIT 0604, Prochlorococcus sp. MIT 0604
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