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| | AJY48523.1 | Nucleoside-triphosphatase rdgB; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (202 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (344 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (221 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (145 aa) |
| | AJY48666.1 | KEGG: shikimate dehydrogenase; PFAM: Shikimate dehydrogenase substrate binding domain protein; Shikimate/quinate 5-dehydrogenase. (292 aa) |
| | aroK | Transcriptional regulator, XRE family with shikimate kinase activity; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (307 aa) |
| | AJY48721.1 | SMART: flavin reductase domain protein FMN-binding protein; PFAM: flavin reductase domain protein FMN-binding protein; KEGG: hypothetical protein. (310 aa) |
| | AJY48723.1 | 2-dehydropantoate 2-reductase; PFAM: Ketopantoate reductase ApbA/PanE domain protein; KEGG: apbA2; 2-dehydropantoate 2-reductase. (351 aa) |
| | argH | KEGG: argH; argininosuccinate lyase; PFAM: Lyase 1, N-terminal; HAMAP : Argininosuccinate lyase; TIGRFAM: argininosuccinate lyase. (467 aa) |
| | AJY48772.1 | KEGG: HAD family hydrolase; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; HAD-superfamily hydrolase, subfamily IA, variant 1. (257 aa) |
| | AJY48796.1 | KEGG: argE; acetylornithine deacetylase; PFAM: peptidase M20; peptidase dimerization domain protein; TIGRFAM: acetylornithine deacetylase (ArgE). (395 aa) |
| | ribA | GTP cyclohydrolase-2; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. (211 aa) |
| | AJY48855.1 | TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; KEGG: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. (148 aa) |
| | AJY49062.1 | NAD(P) transhydrogenase, alpha subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. (523 aa) |
| | AJY49063.1 | NAD(P)(+) transhydrogenase (AB-specific); The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. (480 aa) |
| | AJY49112.1 | SMART: Asparaginase/glutaminase; KEGG: ansA; L-asparaginase; PFAM: Asparaginase/glutaminase. (331 aa) |
| | AJY49129.1 | Serine 3-dehydrogenase; PFAM: short-chain dehydrogenase/reductase SDR; KEGG: short-chain dehydrogenase. (253 aa) |
| | AJY49130.1 | Acetylornithine transaminase; PFAM: aminotransferase class-III; KEGG: hypothetical protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (449 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. (165 aa) |
| | AJY49398.1 | PFAM: FAD synthetase; Riboflavin kinase; KEGG: ribF; bifunctional riboflavin kinase/FMN adenylyltransferase; SMART: Riboflavin kinase; TIGRFAM: riboflavin biosynthesis protein RibF; cytidyltransferase-related domain protein; Belongs to the ribF family. (345 aa) |
| | nadE | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (544 aa) |
| | hisC | TIGRFAM: histidinol-phosphate aminotransferase; HAMAP : Histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: hisC; histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (353 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (257 aa) |
| | hisA | KEGG: hisA; 1-(5-phosphoribosyl)-5-; PFAM: histidine biosynthesis protein; HAMAP : 1-(5-phosphoribosyl)-5-(5- phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (248 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (213 aa) |
| | hisB | KEGG: hisB; imidazoleglycerol-phosphate dehydratase; PFAM: imidazoleglycerol-phosphate dehydratase; HAMAP : Imidazoleglycerol-phosphate dehydratase. (197 aa) |
| | AJY49485.1 | KEGG: ectD; ectoine hydroxylase; PFAM: Phytanoyl-CoA dioxygenase; TIGRFAM: ectoine hydroxylase. (343 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (164 aa) |
| | hisE | KEGG: hisE; phosphoribosyl-ATP pyrophosphatase; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase-like protein; TIGRFAM: phosphoribosyl-ATP diphosphatase; HAMAP : Phosphoribosyl-ATP pyrophosphatase. (130 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1320 aa) |
| | AJY49563.1 | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (342 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa) |
| | purC | PFAM: SAICAR synthetase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; HAMAP : Phosphoribosylaminoimidazole-succinocarboxamide synthase; KEGG: purC; phosphoribosylaminoimidazole-succinocarboxamide synthase. (238 aa) |
| | AJY49573.1 | TIGRFAM: nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; Quinolinate phosphoribosyl transferase domain-containing protein; KEGG: nadC; nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. (284 aa) |
| | AJY49693.1 | KEGG: hypothetical protein; PFAM: protein of unknown function DUF340 membrane. (310 aa) |
| | AJY49694.1 | KEGG: hypothetical protein. (243 aa) |
| | AJY49696.1 | KEGG: peptidase M24; TIGRFAM: ectoine utilization protein EutD; PFAM: peptidase M24; creatinase. (399 aa) |
| | AJY49697.1 | Ectoine utilization protein EutE; PFAM: Succinylglutamate desuccinylase/aspartoacylase; TIGRFAM: ectoine utilization protein EutE; KEGG: doeB; N-acetyl diamonbutyric acid acylase. (343 aa) |
| | AJY49698.1 | KEGG: doeX; DoeX, transcriptional regulator AsnC family; PFAM: Transcription regulator, AsnC-type; SMART: Transcription regulator, AsnC-type. (158 aa) |
| | AJY49699.1 | PFAM: Aldehyde Dehydrogenase; KEGG: gabD2; succinate-semialdehyde dehydrogenase (NAD(P)(+)); Belongs to the aldehyde dehydrogenase family. (498 aa) |
| | AJY49700.1 | Acetylornithine transaminase; KEGG: hypothetical protein; PFAM: aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (477 aa) |
| | AJY49760.1 | TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; KEGG: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. (182 aa) |
| | AJY49761.1 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (126 aa) |
| | AJY49872.1 | KEGG: Short chain dehydrogenase/reductase; PFAM: short-chain dehydrogenase/reductase SDR. (264 aa) |
| | argD | Acetylornithine/succinyldiaminopimelate aminotransferase; KEGG: argD; bifunctionalN-succinyldiaminopimelate-aminotransf erase/acetylornithine transaminase protein; TIGRFAM: succinylornithine transaminase family; acetylornithine and succinylornithine aminotransferase; HAMAP : Acetylornithine/succinyldiaminopimelate aminotransferase; PFAM: aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (404 aa) |
| | AJY49874.1 | KEGG: arginine succinyltransferase; PFAM: arginine N-succinyltransferase beta subunit; TIGRFAM: arginine/ornithine succinyltransferase subunit. (368 aa) |
| | AJY49875.1 | KEGG: arginine succinyltransferase; PFAM: arginine N-succinyltransferase beta subunit; TIGRFAM: arginine N-succinyltransferase; arginine/ornithine succinyltransferase subunit. (343 aa) |
| | astD | N-succinylglutamate 5-semialdehyde dehydrogenase; Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate. (490 aa) |
| | astB | N-succinylarginine dihydrolase; Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)- succinylornithine, ammonia and CO(2). (455 aa) |
| | AJY49878.1 | TIGRFAM: carbamate kinase; PFAM: aspartate/glutamate/uridylate kinase; KEGG: carbamate kinase; Belongs to the carbamate kinase family. (301 aa) |
| | AJY49879.1 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (333 aa) |
| | arcA | HAMAP : Arginine deiminase; PFAM: amidinotransferase; KEGG: arcA; arginine deiminase. (409 aa) |
| | AJY49881.1 | PFAM: C4-dicarboxylate anaerobic carrier-like protein; KEGG: arginine repressor. (481 aa) |
| | AJY49966.1 | PFAM: dihydrodipicolinate synthetase; KEGG: dihydrodipicolinate synthase; Belongs to the DapA family. (302 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (409 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (279 aa) |
| | pncB | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (393 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (171 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (373 aa) |
| | astE | Succinylglutamate desuccinylase; Transforms N(2)-succinylglutamate into succinate and glutamate; Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily. (325 aa) |
| | purD | KEGG: phosphoribosylamine--glycine ligase; HAMAP : Phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine/glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain-containing protein; Phosphoribosylglycinamide synthetase, C-domain-containing protein; Phosphoribosylglycinamide synthetase, N-domain-containing protein; Belongs to the GARS family. (428 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (363 aa) |
| | nadK | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (330 aa) |
| | nadD | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (219 aa) |
| | sthA | Soluble pyridine nucleotide transhydrogenase; Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (463 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (370 aa) |
| | AJY50461.1 | KEGG: FimV N-terminal domain-containing protein; TIGRFAM: FimV N-terminal domain-containing protein. (698 aa) |
| | truA | tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (312 aa) |
| | trpF | KEGG: trpF; N-(5'-phosphoribosyl)anthranilate isomerase; PFAM: N-(5 phosphoribosyl)anthranilate isomerase; HAMAP : N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (212 aa) |
| | trpB-2 | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (416 aa) |
| | trpA-2 | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (267 aa) |
| | AJY50467.1 | TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; KEGG: bifunctional folylpolyglutamate synthase/dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. (416 aa) |
| | AJY50468.1 | Sporulation domain-containing protein; KEGG: acetyl-CoA carboxylase subunit beta; PFAM: Sporulation domain-containing protein. (227 aa) |
| | AJY50469.1 | KEGG: membrane protein required for colicin V production; PFAM: Colicin V production protein. (191 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (506 aa) |
| | AJY50472.1 | KEGG: cytochrome b561; PFAM: Di-heme cytochrome, transmembrane. (193 aa) |
| | AJY50473.1 | PFAM: YceI family protein; SMART: YceI family protein; KEGG: yceI; hypothetical protein; Belongs to the UPF0312 family. (194 aa) |
| | AJY50474.1 | MATE efflux family protein; KEGG: hypothetical protein; PFAM: multi antimicrobial extrusion protein MatE; TIGRFAM: MATE efflux family protein. (448 aa) |
| | AJY50480.1 | Hypothetical protein; KEGG: kinesin K39. (429 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (255 aa) |
| | purM | HAMAP : phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein; KEGG: purM; phosphoribosylaminoimidazole synthetase. (355 aa) |
| | AJY50494.1 | TIGRFAM: riboflavin synthase, alpha subunit; KEGG: ribE; riboflavin synthase subunit alpha; PFAM: Lumazine-binding domain. (213 aa) |
| | AJY50495.1 | PFAM: Xanthine/uracil/vitamin C permease; KEGG: NCS2 family transporter. (432 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (181 aa) |
| | gpt | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (159 aa) |
| | ung | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (227 aa) |
| | upp | Uracil phosphoribosyl transferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa) |
| | AJY50500.1 | Uracil-xanthine permease; KEGG: NCS2 family transporter; TIGRFAM: uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease. (410 aa) |
| | AJY50526.1 | 1-alkyl-2-acetylglycerophosphocholine esterase; PFAM: Asparaginase/glutaminase; SMART: Asparaginase/glutaminase; KEGG: ansA; asparaginase. (356 aa) |
| | AJY50622.1 | NAD(+) diphosphatase; PFAM: NUDIX hydrolase; Zinc ribbon NADH pyrophosphatase; KEGG: nudC; NUDIX hydrolase. (259 aa) |
| | hisI | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (156 aa) |
| | ectC | L-ectoine synthase; Catalyzes the circularization of gamma-N-acetyl-alpha,gamma- diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4- pyrimidine carboxylic acid), which is an excellent osmoprotectant. (130 aa) |
| | AJY50717.1 | Diaminobutyrate/2-oxoglutarate aminotransferase; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (422 aa) |
| | ectA | L-2,4-diaminobutyric acid acetyltransferase; Catalyzes the acetylation of L-2,4-diaminobutyrate (DABA) to gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) with acetyl coenzyme A. (192 aa) |
| | AJY50746.1 | Cytidyltransferase-related domain protein; PFAM: NUDIX hydrolase; cytidylyltransferase; TIGRFAM: cytidyltransferase-related domain protein; KEGG: nadR; nicotinamide-nucleotide adenylyltransferase. (364 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (345 aa) |
| | coaE | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (200 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (759 aa) |
| | AJY50858.1 | KEGG: pheA; chorismate mutase; SMART: Chorismate mutase; TIGRFAM: chorismate mutase; PFAM: prephenate dehydratase; Chorismate mutase, type II; amino acid-binding ACT domain-containing protein. (363 aa) |
| | argG | TIGRFAM: argininosuccinate synthase; HAMAP : Argininosuccinate synthase; PFAM: argininosuccinate synthase; KEGG: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (406 aa) |
| | purH | Bifunctional purine biosynthesis protein purH; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; KEGG: purH; phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; HAMAP : Bifunctional purine biosynthesis protein purH; PFAM: AICARFT/IMPCHase bienzyme; MGS domain protein; SMART: AICARFT/IMPCHase bienzyme; MGS domain protein. (538 aa) |
| | folE | HAMAP : GTP cyclohydrolase 1; TIGRFAM: GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase; KEGG: folE; GTP cyclohydrolase I. (183 aa) |
| | AJY51025.1 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (306 aa) |
| | AJY51047.1 | KEGG: anthranilate synthase; PFAM: Chorismate binding domain-containing protein; Anthranilate synthase component I domain protein. (472 aa) |
| | AJY51048.1 | TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: Glutamine amidotransferase type 1; KEGG: glutamine amidotransferase of anthranilate synthase. (226 aa) |
| | AJY51049.1 | KEGG: hypothetical protein; PFAM: protein of unknown function DUF1294. (91 aa) |
| | AJY51050.1 | KEGG: pseudouridine synthase Rsu; SMART: RNA-binding S4 domain protein; TIGRFAM: pseudouridine synthase Rsu; PFAM: pseudouridine synthase; RNA-binding S4 domain protein; Belongs to the pseudouridine synthase RsuA family. (347 aa) |
| | AJY51051.1 | PFAM: protein of unknown function DUF924; KEGG: hypothetical protein. (181 aa) |
| | AJY51053.1 | MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; TIGRFAM: MazG family protein; KEGG: mazG; nucleoside triphosphate pyrophosphohydrolase. (284 aa) |
| | AJY51054.1 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (758 aa) |
| | rlmD | 23S rRNA (uracil-5-)-methyltransferase rumA; Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily. (467 aa) |
| | acpS | Holo-(acyl-carrier-protein) synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (126 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (409 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (438 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (217 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (431 aa) |
| | hisZ | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (398 aa) |
| | AJY51299.1 | KEGG: hypothetical protein; PFAM: Acyl carrier protein phosphodiesterase. (191 aa) |
| | AJY51306.1 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (306 aa) |
| | AJY51310.1 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (535 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase subfamily 1 core; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (233 aa) |
| | AJY51324.1 | Para-aminobenzoate synthase, subunit I; PFAM: Chorismate binding domain-containing protein; Anthranilate synthase component I domain protein; KEGG: pabB; para-aminobenzoate synthase component I; TIGRFAM: para-aminobenzoate synthase, subunit I. (451 aa) |
| | trpC | HAMAP : Indole-3-glycerol phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; KEGG: trpC; indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (267 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (339 aa) |
| | AJY51340.1 | TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: Glutamine amidotransferase type 1; KEGG: trpG; glutamine amidotransferase. (211 aa) |
| | nusB | NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (164 aa) |
| | ribH-2 | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. (162 aa) |
| | ribB | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (388 aa) |
| | AJY51463.1 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (388 aa) |
| | nrdR | Transcriptional regulator, NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (167 aa) |
| | pyrD | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (338 aa) |
| | AJY51583.1 | TIGRFAM: adenylosuccinate lyase; KEGG: adenylosuccinate lyase; PFAM: Lyase 1, N-terminal; Adenylosuccinate lyase domain-containing protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (461 aa) |
| | AJY51693.1 | TIGRFAM: aspartate racemase; PFAM: Asp/Glu/hydantoin racemase; KEGG: aspartate racemase. (229 aa) |
| | ribA-2 | GTP cyclohydrolase-2; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. (367 aa) |
| | AJY51791.1 | KEGG: guaA; glutamine amidotransferase; PFAM: Glutamine amidotransferase type 1. (238 aa) |
| | AJY51957.1 | KEGG: guaA; GMP synthase; PFAM: GMP synthase domain protein. (103 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (525 aa) |
| | guaB | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (489 aa) |
| | argA | Amino-acid acetyltransferase; PFAM: aspartate/glutamate/uridylate kinase; GCN5-related N-acetyltransferase; KEGG: argA; N-acetylglutamate synthase; TIGRFAM: amino-acid N-acetyltransferase; HAMAP : Amino-acid acetyltransferase; Belongs to the acetyltransferase family. ArgA subfamily. (438 aa) |
| | AJY52044.1 | Aspartate kinase, monofunctional class; KEGG: lysC; aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain-containing protein; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; Belongs to the aspartokinase family. (416 aa) |
| | AJY52048.1 | KEGG: damage-inducible protein CinA; TIGRFAM: CinA domain protein; PFAM: CinA domain protein; Belongs to the CinA family. (174 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (368 aa) |
| | aroK-2 | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (195 aa) |
| | AJY52107.1 | Histidinol-phosphate transaminase; PFAM: aminotransferase class I and II; KEGG: hisC; histidinol-phosphate aminotransferase. (374 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (273 aa) |
| | cobB | HAMAP : NAD-dependent deacetylase; PFAM: Silent information regulator protein Sir2; KEGG: npdA; NAD-dependent deacetylase; Belongs to the sirtuin family. Class III subfamily. (237 aa) |
| | AJY52238.1 | PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; KEGG: CDP-6-deoxy-delta-3,4-glucoseen reductase. (246 aa) |
| | AJY52277.1 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (445 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (299 aa) |
| | AJY52455.1 | PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; KEGG: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. (182 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (263 aa) |
| | panC | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (290 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (126 aa) |
| | AJY52477.1 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (304 aa) |
| | carB | Carbamoyl-phosphate synthase large subunit glutamine-dependent; SMART: Carbamoyl-phosphate synthetase large chain oligomerisation; MGS domain protein; PFAM: Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; Carbamoyl-phosphate synthase L chain ATP-binding protein; MGS domain protein; KEGG: carB; carbamoyl phosphate synthase, large subunit; TIGRFAM: carbamoyl-phosphate synthase, large subunit; HAMAP : Carbamoyl-phosphate synthase large subunit glutamine-dependent; Belongs to the CarB family. (1076 aa) |
| | carA | PFAM: Carbamoyl-phosphate synthase small chain; Glutamine amidotransferase type 1; SMART: Carbamoyl-phosphate synthase small chain; TIGRFAM: carbamoyl-phosphate synthase, small subunit; KEGG: carA; carbamoyl phosphate synthase small subunit; HAMAP : Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (386 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (268 aa) |
| | AJY52562.1 | TIGRFAM: acetylornithine deacetylase (ArgE); PFAM: peptidase M20; peptidase dimerization domain protein; KEGG: argE; acetylornithine deacetylase. (387 aa) |
| | coaX | Putative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (279 aa) |
| | birA | BirA bifunctional protein, biotin operon repressor and biotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. (331 aa) |
| | AJY52658.1 | KEGG: typA; GTP-binding protein; TIGRFAM: GTP-binding protein TypA; small GTP-binding protein; PFAM: protein synthesis factor GTP-binding protein; elongation factor Tu domain 2 protein; elongation factor G domain-containing protein. (616 aa) |
| | AJY52659.1 | KEGG: sodium symporter; PFAM: sodium:neurotransmitter symporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (481 aa) |
| | AJY52718.1 | TIGRFAM: aspartate carbamoyltransferase; KEGG: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain-containing protein; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (341 aa) |
