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| | AJY52759.1 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (367 aa) |
| | AJY48522.1 | Oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (394 aa) |
| | hemL | KEGG: hemL; glutamate-1-semialdehyde-2,1-aminomutase; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; HAMAP : Glutamate-1-semialdehyde 2,1-aminomutase; PFAM: aminotransferase class-III. (426 aa) |
| | AJY48526.1 | PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: thiD; phosphomethylpyrimidine kinase. (269 aa) |
| | AJY48527.1 | PFAM: Uncharacterized protein family UPF0093; TIGRFAM: Conserved hypothetical protein CHP00701; KEGG: hypothetical protein. (143 aa) |
| | atpB | ATP synthase subunit a; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (275 aa) |
| | atpE | ATP synthase subunit c; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (75 aa) |
| | atpF | ATP synthase subunit b; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (156 aa) |
| | atpH | ATP synthase subunit delta; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (178 aa) |
| | atpA | ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (514 aa) |
| | atpG | ATP synthase gamma chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (295 aa) |
| | atpD | ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (459 aa) |
| | atpC | ATP synthase epsilon chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. (142 aa) |
| | glmU | Bifunctional protein glmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (456 aa) |
| | AJY48559.1 | KEGG: hypothetical protein. (230 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (221 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (210 aa) |
| | rpoZ | DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (85 aa) |
| | AJY48760.1 | TIGRFAM: HemY protein; PFAM: HemY domain protein; KEGG: hemY; porphoryin biosynthesis protein HemY. (425 aa) |
| | AJY48763.1 | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (259 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (314 aa) |
| | AJY48780.1 | TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: thiD; phosphomethylpyrimidine kinase. (276 aa) |
| | thiG | Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (269 aa) |
| | AJY48803.1 | TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamine S protein; KEGG: thiS; thiamine biosynthesis protein ThiS. (68 aa) |
| | AJY48806.1 | PFAM: MobA-like NTP transferase domain; KEGG: hypothetical protein. (205 aa) |
| | AJY48810.1 | Xanthine dehydrogenase; KEGG: molybdopterin binding aldehyde oxidase and xanthine dehydrogenase; SMART: aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; PFAM: aldehyde oxidase and xanthine dehydrogenase molybdopterin binding protein; aldehyde oxidase and xanthine dehydrogenase a/b hammerhead. (729 aa) |
| | hemE | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (371 aa) |
| | ribA | GTP cyclohydrolase-2; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. (211 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (641 aa) |
| | AJY48855.1 | TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; KEGG: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. (148 aa) |
| | AJY48857.1 | Hypothetical protein; KEGG: ssuA; putative periplasmic-binding protein. (362 aa) |
| | AJY48919.1 | KEGG: RNA-directed DNA polymerase; PFAM: RNA-directed DNA polymerase (Reverse transcriptase); Group II intron maturase-specific domain protein. (508 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (288 aa) |
| | purU-2 | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (288 aa) |
| | AJY48996.1 | KEGG: hypothetical protein. (435 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (276 aa) |
| | purU-3 | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (288 aa) |
| | pqqE | Coenzyme PQQ synthesis protein E; Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ). (406 aa) |
| | pqqD | Coenzyme PQQ synthesis protein D; Functions as a PqqA binding protein and presents PqqA to PqqE, in the pyrroloquinoline quinone (PQQ) biosynthetic pathway. (94 aa) |
| | pqqC | Pyrroloquinoline-quinone synthase; Ring cyclization and eight-electron oxidation of 3a-(2-amino- 2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9- dicarboxylic-acid to PQQ. (262 aa) |
| | pqqB | Coenzyme PQQ synthesis protein B; May be involved in the transport of PQQ or its precursor to the periplasm; Belongs to the PqqB family. (307 aa) |
| | AJY49123.1 | KEGG: NAD-dependent epimerase/dehydratase; PFAM: NAD-dependent epimerase/dehydratase. (320 aa) |
| | AJY49141.1 | PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein; KEGG: cobalamin (vitamin B12) biosynthesis CbiX protein. (284 aa) |
| | AJY49144.1 | PFAM: TspO/MBR family protein; KEGG: TspO/MBR family protein. (99 aa) |
| | AJY49184.1 | Beta-alanine--pyruvate transaminase; PFAM: aminotransferase class-III; KEGG: beta alanine--pyruvate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (457 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. (165 aa) |
| | AJY49221.1 | Dihydroorotate dehydrogenase family protein; PFAM: dihydroorotate oxidase; 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein; KEGG: dihydropyrimidine dehydrogenase; TIGRFAM: dihydroorotate dehydrogenase family protein. (447 aa) |
| | AJY49223.1 | Dihydropyrimidinase; PFAM: amidohydrolase; KEGG: dihydropyrimidinase; TIGRFAM: dihydropyrimidinase. (479 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (346 aa) |
| | AJY49231.1 | Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (423 aa) |
| | mobA | Molybdopterin-guanine dinucleotide biosynthesis protein A; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (203 aa) |
| | fdhD | Formate dehydrogenase subunit FdhD; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (289 aa) |
| | AJY49234.1 | KEGG: hypothetical protein; PFAM: Protein of unknown function DUF3305. (145 aa) |
| | AJY49243.1 | Molybdenum cofactor biosynthesis protein B; May be involved in the biosynthesis of molybdopterin. Belongs to the MoaB/Mog family. (173 aa) |
| | AJY49244.1 | Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (401 aa) |
| | AJY49323.1 | 4-hydroxythreonine-4-phosphate dehydrogenase; PFAM: Pyridoxal phosphate biosynthetic protein PdxA; TIGRFAM: 4-hydroxythreonine-4-phosphate dehydrogenase; HAMAP : 4-hydroxythreonine-4-phosphate dehydrogenase; KEGG: pdxA1; 4-hydroxythreonine-4-phosphate dehydrogenase; Belongs to the PdxA family. (333 aa) |
| | AJY49378.1 | Nucleotide sugar dehydrogenase; KEGG: UDP-glucose dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase dimerization; UDP-glucose/GDP-mannose dehydrogenase; TIGRFAM: nucleotide sugar dehydrogenase; SMART: UDP-glucose/GDP-mannose dehydrogenase. (442 aa) |
| | AJY49398.1 | PFAM: FAD synthetase; Riboflavin kinase; KEGG: ribF; bifunctional riboflavin kinase/FMN adenylyltransferase; SMART: Riboflavin kinase; TIGRFAM: riboflavin biosynthesis protein RibF; cytidyltransferase-related domain protein; Belongs to the ribF family. (345 aa) |
| | nadE | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (544 aa) |
| | AJY49441.1 | Benzoate--CoA ligase; PFAM: AMP-dependent synthetase and ligase; Domain of unknown function DUF4009; KEGG: badA-2; benzoate-coenzyme A ligase. (572 aa) |
| | AJY49480.1 | KEGG: hypothetical protein. (119 aa) |
| | AJY49482.1 | KEGG: hypothetical protein. (104 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (927 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (164 aa) |
| | AJY49538.1 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; SMART: delta-aminolevulinic acid dehydratase; KEGG: hemB; delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (336 aa) |
| | priA | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (748 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1320 aa) |
| | AJY49563.1 | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (342 aa) |
| | purC | PFAM: SAICAR synthetase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; HAMAP : Phosphoribosylaminoimidazole-succinocarboxamide synthase; KEGG: purC; phosphoribosylaminoimidazole-succinocarboxamide synthase. (238 aa) |
| | AJY49573.1 | TIGRFAM: nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; Quinolinate phosphoribosyl transferase domain-containing protein; KEGG: nadC; nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. (284 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa) |
| | acsA | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (649 aa) |
| | AJY49594.1 | TIGRFAM: oxygen-independent coproporphyrinogen III oxidase; SMART: Elongator protein 3/MiaB/NifB; KEGG: hemN; coproporphyrinogen III oxidase; PFAM: HemN domain protein; Radical SAM domain protein; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (477 aa) |
| | AJY49605.1 | PFAM: protein of unknown function DUF336; KEGG: glcG; GlcG protein. (133 aa) |
| | AJY49613.1 | PFAM: protein of unknown function DUF336; KEGG: hypothetical protein. (153 aa) |
| | AJY49710.1 | RNA polymerase, sigma-24 subunit, RpoE, ECF subfamily; KEGG: sigX; ECF subfamily RNA polymerase sigma-70 factor; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; TIGRFAM: RNA polymerase sigma-70 factor; RNA polymerase sigma factor, sigma-70 family. (188 aa) |
| | rpoS | RNA polymerase, sigma 38 subunit, RpoS; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. (322 aa) |
| | pdxA | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (354 aa) |
| | AJY49756.1 | PFAM: ApaG domain protein; KEGG: apaG; ApaG protein. (125 aa) |
| | AJY49760.1 | TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; KEGG: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. (182 aa) |
| | AJY49761.1 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (126 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (617 aa) |
| | rpoD | RNA polymerase, sigma 70 subunit, RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (616 aa) |
| | AJY49886.1 | TIGRFAM: cob(II)yrinic acid a,c-diamide reductase; PFAM: nitroreductase; KEGG: cob(II)yrinic acid a,c-diamide reductase. (233 aa) |
| | AJY49926.1 | PFAM: Protein of unknown function DUF3820; KEGG: hypothetical protein. (77 aa) |
| | AJY49933.1 | Putative signal transduction protein with CBS domain; SMART: transporter-associated region; PFAM: transporter-associated region; CBS domain containing protein; KEGG: tlyC; magnesium and cobalt transporter. (299 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (313 aa) |
| | hemA | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (437 aa) |
| | AJY49951.1 | PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; KEGG: thiF; adenylyltransferase. (251 aa) |
| | AJY49994.1 | KEGG: DNA-directed DNA polymerase; PFAM: UMUC domain protein DNA-repair protein. (49 aa) |
| | AJY49995.1 | PFAM: Domain of unknown function DUF4113; KEGG: rumB; DNA-directed DNA polymerase. (82 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (409 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (279 aa) |
| | AJY50024.1 | KEGG: hypothetical protein; PFAM: protein of unknown function DUF1486. (108 aa) |
| | pncB | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (393 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (171 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (373 aa) |
| | hemH | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (359 aa) |
| | purD | KEGG: phosphoribosylamine--glycine ligase; HAMAP : Phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine/glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain-containing protein; Phosphoribosylglycinamide synthetase, C-domain-containing protein; Phosphoribosylglycinamide synthetase, N-domain-containing protein; Belongs to the GARS family. (428 aa) |
| | AJY50196.1 | KEGG: hypothetical protein. (407 aa) |
| | AJY50222.1 | RNA polymerase, sigma-24 subunit, RpoE, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; KEGG: RNA polymerase, sigma-24 subunit, ECF subfamily. (192 aa) |
| | AJY50232.1 | Acetate--CoA ligase; KEGG: acyl-CoA synthetase; PFAM: AMP-dependent synthetase and ligase; Domain of unknown function DUF4009. (556 aa) |
| | nadK | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (330 aa) |
| | AJY50287.1 | Putative protein family UPF0093; KEGG: hypothetical protein; PFAM: Uncharacterized protein family UPF0093. (141 aa) |
| | AJY50306.1 | RNA polymerase, sigma-24 subunit, RpoE, ECF subfamily; KEGG: RNA polymerase sigma factor; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; Belongs to the sigma-70 factor family. ECF subfamily. (187 aa) |
| | AJY50321.1 | PFAM: SMP-30/Gluconolaconase/LRE-like region-containing protein; KEGG: SMP-30/gluconolaconase/LRE-like region-containing protein. (298 aa) |
| | cobT | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (349 aa) |
| | cobD | Cobalamin biosynthesis protein cbiB; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (334 aa) |
| | AJY50332.1 | KEGG: cobD; threonine-phosphate decarboxylase; TIGRFAM: L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II. (367 aa) |
| | AJY50333.1 | Cobalbumin biosynthesis protein; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (183 aa) |
| | cobS | Cobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (256 aa) |
| | AJY50336.1 | PFAM: cobalbumin biosynthesis protein; KEGG: hypothetical protein. (141 aa) |
| | AJY50341.1 | KEGG: NAD-dependent epimerase/dehydratase; PFAM: NAD-dependent epimerase/dehydratase. (296 aa) |
| | AJY50342.1 | PFAM: CobB/CobQ domain protein glutamine amidotransferase; Cobyrinic acid ac-diamide synthase; KEGG: glutamine amidotransferase. (437 aa) |
| | AJY50344.1 | cob(I)alamin adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (203 aa) |
| | rho | H+transporting two-sector ATPase alpha/beta subunit central region; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (318 aa) |
| | cobQ | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (488 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (435 aa) |
| | nadD | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (219 aa) |
| | lipA | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (352 aa) |
| | AJY50423.1 | KEGG: holA; DNA polymerase III subunit delta; PFAM: DNA polymerase III delta; TIGRFAM: DNA polymerase III, delta subunit. (355 aa) |
| | trpF | KEGG: trpF; N-(5'-phosphoribosyl)anthranilate isomerase; PFAM: N-(5 phosphoribosyl)anthranilate isomerase; HAMAP : N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (212 aa) |
| | trpB-2 | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (416 aa) |
| | trpA-2 | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (267 aa) |
| | accD | Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (340 aa) |
| | AJY50467.1 | TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; KEGG: bifunctional folylpolyglutamate synthase/dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. (416 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (506 aa) |
| | AJY50477.1 | PFAM: transcriptional coactivator/pterin dehydratase; HAMAP : pterin-4-alpha-carbinolamine dehydratase; KEGG: phhB; pterin-4-alpha-carbinolamine dehydratase. (112 aa) |
| | AJY50479.1 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: cysG; siroheme synthase; Belongs to the precorrin methyltransferase family. (273 aa) |
| | dcd | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (177 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (255 aa) |
| | purM | HAMAP : phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein; KEGG: purM; phosphoribosylaminoimidazole synthetase. (355 aa) |
| | AJY50494.1 | TIGRFAM: riboflavin synthase, alpha subunit; KEGG: ribE; riboflavin synthase subunit alpha; PFAM: Lumazine-binding domain. (213 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (181 aa) |
| | gpt | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (159 aa) |
| | upp | Uracil phosphoribosyl transferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa) |
| | AJY50501.1 | KEGG: mobB; molybdopterin-guanine dinucleotide biosynthesis protein MobB; TIGRFAM: molybdopterin-guanine dinucleotide biosynthesis protein B. (187 aa) |
| | moaC | Molybdenum cofactor biosynthesis C, bacterial-type; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (265 aa) |
| | AJY50503.1 | PFAM: molybdopterin biosynthesis MoaE protein; KEGG: moaE; molybdenum cofactor biosynthesis protein E. (138 aa) |
| | purU-4 | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (284 aa) |
| | AJY50521.1 | KEGG: hypothetical protein; PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein. (281 aa) |
| | AJY50511.1 | Phosphoribosyltransferase; KEGG: hpt; hypoxanthine-guanine phosphoribosyltransferase; PFAM: phosphoribosyltransferase. (192 aa) |
| | queE | 7-carboxy-7-deazaguanine synthase-like; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (218 aa) |
| | queC | 7-cyano-7-deazaguanine synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (235 aa) |
| | AJY50539.1 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. (330 aa) |
| | AJY50556.1 | KEGG: ctaA; cytochrome oxidase assembly; PFAM: cytochrome oxidase assembly. (349 aa) |
| | cyoE | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (305 aa) |
| | dnaQ | DNA polymerase III, epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (245 aa) |
| | AJY50626.1 | Acetate--CoA ligase; KEGG: prpE; Propionyl-CoA synthetase; PFAM: AMP-dependent synthetase and ligase; Domain of unknown function DUF4009; Acyl-CoA synthase, domain of unknown function DUF3448. (637 aa) |
| | AJY50627.1 | Protein of unknown function DUF165; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (222 aa) |
| | AJY50629.1 | TIGRFAM: DNA polymerase III, epsilon subunit; SMART: Exonuclease; Excinuclease ABC C subunit domain protein; KEGG: cho; excinuclease Cho; PFAM: Exonuclease RNase T and DNA polymerase III; Excinuclease ABC C subunit domain protein. (462 aa) |
| | AJY50630.1 | Hypothetical protein; KEGG: ABC transporter periplasmic protein. (381 aa) |
| | AJY50640.1 | KEGG: hypothetical protein. (175 aa) |
| | AJY50641.1 | KEGG: hypothetical protein; PFAM: Protein of unknown function DUF3987. (511 aa) |
| | pdxH | Pyridoxine/pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (214 aa) |
| | ectC | L-ectoine synthase; Catalyzes the circularization of gamma-N-acetyl-alpha,gamma- diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4- pyrimidine carboxylic acid), which is an excellent osmoprotectant. (130 aa) |
| | AJY50717.1 | Diaminobutyrate/2-oxoglutarate aminotransferase; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (422 aa) |
| | ectA | L-2,4-diaminobutyric acid acetyltransferase; Catalyzes the acetylation of L-2,4-diaminobutyrate (DABA) to gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) with acetyl coenzyme A. (192 aa) |
| | AJY50726.1 | Nucleotide sugar dehydrogenase; SMART: UDP-glucose/GDP-mannose dehydrogenase; TIGRFAM: nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase dimerization; UDP-glucose/GDP-mannose dehydrogenase; KEGG: ugd2; UDP-glucose 6-dehydrogenase. (430 aa) |
| | folD | Bifunctional protein folD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (290 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (345 aa) |
| | moaA-2 | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (323 aa) |
| | AJY50795.1 | Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (420 aa) |
| | AJY50796.1 | Molybdenum cofactor biosynthesis protein B; May be involved in the biosynthesis of molybdopterin. Belongs to the MoaB/Mog family. (192 aa) |
| | coaE | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (200 aa) |
| | cmk | PFAM: cytidylate kinase region; HAMAP : Cytidylate kinase; TIGRFAM: cytidylate kinase; KEGG: cmk; cytidylate kinase. (232 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (367 aa) |
| | AJY50877.1 | TIGRFAM: DNA polymerase III, epsilon subunit; SMART: Exonuclease; KEGG: DNA polymerase III subunit epsilon; PFAM: Exonuclease RNase T and DNA polymerase III. (687 aa) |
| | AJY50889.1 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (446 aa) |
| | purH | Bifunctional purine biosynthesis protein purH; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; KEGG: purH; phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; HAMAP : Bifunctional purine biosynthesis protein purH; PFAM: AICARFT/IMPCHase bienzyme; MGS domain protein; SMART: AICARFT/IMPCHase bienzyme; MGS domain protein. (538 aa) |
| | folE | HAMAP : GTP cyclohydrolase 1; TIGRFAM: GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase; KEGG: folE; GTP cyclohydrolase I. (183 aa) |
| | AJY51047.1 | KEGG: anthranilate synthase; PFAM: Chorismate binding domain-containing protein; Anthranilate synthase component I domain protein. (472 aa) |
| | pdxJ | Pyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (278 aa) |
| | AJY51070.1 | RNA polymerase, sigma-24 subunit, RpoE, ECF subfamily; KEGG: rpoE; RNA polymerase sigma factor AlgU; TIGRFAM: RNA polymerase sigma factor RpoE; RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; Belongs to the sigma-70 factor family. ECF subfamily. (199 aa) |
| | AJY51076.1 | KEGG: hypothetical protein. (353 aa) |
| | AJY51083.1 | Ribonucleotide reductase, class 1b, subunit NrdF; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (323 aa) |
| | AJY51095.1 | KEGG: holB; DNA polymerase III subunit delta'; TIGRFAM: DNA polymerase III, delta prime subunit. (328 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (217 aa) |
| | AJY51098.1 | Aminodeoxychorismate lyase; PFAM: aminotransferase class IV; KEGG: aminodeoxychorismate lyase apoprotein; TIGRFAM: aminodeoxychorismate lyase. (270 aa) |
| | kdsB | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (258 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (420 aa) |
| | AJY51173.1 | RNA polymerase, sigma 54 subunit, RpoN; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (471 aa) |
| | AJY51201.1 | cob(I)alamin adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (199 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (431 aa) |
| | queG | 4Fe-4S cluster binding protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (377 aa) |
| | dnaX | DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (651 aa) |
| | AJY51310.1 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (535 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase subfamily 1 core; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (233 aa) |
| | AJY51324.1 | Para-aminobenzoate synthase, subunit I; PFAM: Chorismate binding domain-containing protein; Anthranilate synthase component I domain protein; KEGG: pabB; para-aminobenzoate synthase component I; TIGRFAM: para-aminobenzoate synthase, subunit I. (451 aa) |
| | trpC | HAMAP : Indole-3-glycerol phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; KEGG: trpC; indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (267 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (339 aa) |
| | AJY51351.1 | PFAM: hydroxyneurosporene synthase; KEGG: hypothetical protein. (395 aa) |
| | AJY51383.1 | 8-amino-7-oxononanoate synthase; PFAM: aminotransferase class I and II; KEGG: wcbT; 8-amino-7-oxononanoate synthase. (441 aa) |
| | AJY51413.1 | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (182 aa) |
| | AJY51415.1 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (296 aa) |
| | AJY51420.1 | KEGG: nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase dimerization; UDP-glucose/GDP-mannose dehydrogenase; TIGRFAM: nucleotide sugar dehydrogenase; SMART: UDP-glucose/GDP-mannose dehydrogenase. (388 aa) |
| | AJY51439.1 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (185 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (272 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (333 aa) |
| | nusB | NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (164 aa) |
| | ribH-2 | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. (162 aa) |
| | ribB | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (388 aa) |
| | AJY51463.1 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (388 aa) |
| | AJY51479.1 | DNA-directed DNA polymerase; PFAM: UMUC domain protein DNA-repair protein; Domain of unknown function DUF4113; DNA polymerase, Y-family, little finger domain-containing protein; KEGG: umuC; DNA-directed DNA polymerase. (433 aa) |
| | AJY51503.1 | Hypothetical protein. (138 aa) |
| | AJY51518.1 | KEGG: ATP-binding protein. (472 aa) |
| | AJY51520.1 | KEGG: hypothetical protein; PFAM: Protein of unknown function DUF3987. (486 aa) |
| | queF | NADPH-dependent 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). (277 aa) |
| | pdxB | Erythronate-4-phosphate dehydrogenase; Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate. (385 aa) |
| | pyrD | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (338 aa) |
| | AJY51583.1 | TIGRFAM: adenylosuccinate lyase; KEGG: adenylosuccinate lyase; PFAM: Lyase 1, N-terminal; Adenylosuccinate lyase domain-containing protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (461 aa) |
| | AJY51585.1 | PFAM: GCN5-related N-acetyltransferase; KEGG: hypothetical protein. (141 aa) |
| | AJY51611.1 | TIGRFAM: Cof-like hydrolase; HAD-superfamily hydrolase, subfamily IIB; PFAM: Haloacid dehalogenase domain protein hydrolase type 3; KEGG: cof; hypothetical protein. (265 aa) |
| | AJY51712.1 | KEGG: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; PFAM: Nucleotidyl transferase; mannose-6-phosphate isomerase type II; TIGRFAM: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Belongs to the mannose-6-phosphate isomerase type 2 family. (469 aa) |
| | AJY51716.1 | PFAM: Creatininase; KEGG: creatininase. (257 aa) |
| | ribA-2 | GTP cyclohydrolase-2; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. (367 aa) |
| | AJY51720.1 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: hypothetical protein. (132 aa) |
| | AJY51741.1 | KEGG: oxidoreductase protein; PFAM: NADP-dependent oxidoreductase domain. (311 aa) |
| | thiC | Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (629 aa) |
| | AJY51753.1 | KEGG: thiC; thiamine biosynthesis protein ThiC; PFAM: thiamine biosynthesis protein ThiC. (272 aa) |
| | cyoE-2 | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (307 aa) |
| | AJY51820.1 | PFAM: NADP-dependent oxidoreductase domain; KEGG: dkgB; 2,5-diketo-D-gluconate reductase B. (270 aa) |
| | AJY51823.1 | KEGG: cysG; uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; TIGRFAM: uroporphyrin-III C-methyltransferase. (298 aa) |
| | AJY51855.1 | RNA polymerase, sigma-24 subunit, RpoE, ECF subfamily; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; KEGG: ECF subfamily RNA polymerase sigma-24 subunit. (187 aa) |
| | AJY51874.1 | RNA polymerase, sigma-24 subunit, RpoE, ECF subfamily; KEGG: pfrI; ferric regulator sigma-24 subunit; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; Belongs to the sigma-70 factor family. ECF subfamily. (175 aa) |
| | AJY51924.1 | RNA polymerase, sigma-24 subunit, RpoE, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein; KEGG: fecI; RNA polymerase, sigma 19 factor; Belongs to the sigma-70 factor family. ECF subfamily. (174 aa) |
| | AJY51957.1 | KEGG: guaA; GMP synthase; PFAM: GMP synthase domain protein. (103 aa) |
| | AJY51992.1 | Hypothetical protein; KEGG: adenylate kinase. (178 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (525 aa) |
| | guaB | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (489 aa) |
| | AJY52006.1 | Acetylornithine transaminase; KEGG: putative class III aminotransferase; PFAM: aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (441 aa) |
| | AJY52048.1 | KEGG: damage-inducible protein CinA; TIGRFAM: CinA domain protein; PFAM: CinA domain protein; Belongs to the CinA family. (174 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (551 aa) |
| | dinB | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (348 aa) |
| | queA | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (343 aa) |
| | tgt | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (378 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa) |
| | hemF | Coproporphyrinogen-III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (317 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (364 aa) |
| | bioF | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (385 aa) |
| | AJY52178.1 | Hypothetical protein; KEGG: alpha/beta hydrolase. (246 aa) |
| | bioC | Biotin biosynthesis protein BioC; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (260 aa) |
| | bioD | Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (229 aa) |
| | AJY52181.1 | TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate aminotransferase; PFAM: aminotransferase class-III; KEGG: aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (423 aa) |
| | AJY52217.1 | PFAM: DNA polymerase III chi subunit HolC; KEGG: holC; DNA polymerase III subunit chi. (143 aa) |
| | rho-2 | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (419 aa) |
| | accA | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (318 aa) |
| | AJY52244.1 | KEGG: dnaE; DNA polymerase III subunit alpha; PFAM: DNA polymerase III alpha subunit; PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type; TIGRFAM: DNA polymerase III, alpha subunit; SMART: phosphoesterase PHP domain protein. (1168 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (257 aa) |
| | AJY52277.1 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (445 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (152 aa) |
| | rpoH | RNA polymerase, sigma 32 subunit, RpoH; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. (288 aa) |
| | AJY52290.1 | KEGG: bolA; BolA protein; PFAM: BolA family protein; Belongs to the BolA/IbaG family. (102 aa) |
| | AJY52326.1 | PFAM: RNA-directed DNA polymerase (Reverse transcriptase); KEGG: RNA-directed DNA polymerase. (310 aa) |
| | AJY52339.1 | PFAM: NAD-dependent epimerase/dehydratase; KEGG: nad-dependent epimerase dehydratase. (315 aa) |
| | AJY52409.1 | KEGG: hypothetical protein. (421 aa) |
| | proC-2 | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (274 aa) |
| | AJY52455.1 | PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; KEGG: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. (182 aa) |
| | nusA | NusA antitermination factor; Participates in both transcription termination and antitermination. (504 aa) |
| | AJY52477.1 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (304 aa) |
| | carA | PFAM: Carbamoyl-phosphate synthase small chain; Glutamine amidotransferase type 1; SMART: Carbamoyl-phosphate synthase small chain; TIGRFAM: carbamoyl-phosphate synthase, small subunit; KEGG: carA; carbamoyl phosphate synthase small subunit; HAMAP : Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (386 aa) |
| | AJY52510.1 | KEGG: rumB; DNA-directed DNA polymerase; PFAM: UMUC domain protein DNA-repair protein. (75 aa) |
| | AJY52511.1 | Protein of unknown function DUF4113; KEGG: rumB; DNA-directed DNA polymerase; PFAM: Domain of unknown function DUF4113; UMUC domain protein DNA-repair protein; DNA polymerase type-Y, HhH motif; DNA polymerase, Y-family, little finger domain-containing protein. (346 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (379 aa) |
| | AJY52567.1 | Putative RNA polymerase, sigma-24 subunit, ECF subfamily; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; KEGG: RNA polymerase ECF-subfamily sigma factor. (414 aa) |
| | thiM | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (269 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (207 aa) |
| | rpoA | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (331 aa) |
| | rpoC | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1404 aa) |
| | rpoB | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1358 aa) |
| | nusG | NusG antitermination factor; Participates in transcription elongation, termination and antitermination. (177 aa) |
| | coaX | Putative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (279 aa) |
| | AJY52672.1 | PFAM: protein of unknown function DUF1486; KEGG: hypothetical protein. (143 aa) |
| | AJY52682.1 | PFAM: dTDP-4-dehydrorhamnose reductase; KEGG: dTDP-4-dehydrorhamnose reductase. (296 aa) |
| | AJY52718.1 | TIGRFAM: aspartate carbamoyltransferase; KEGG: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain-containing protein; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (341 aa) |
| | AJY52720.1 | UPF0301 protein yqgE; PFAM: protein of unknown function DUF179; HAMAP : UPF0301 protein yqgE; KEGG: algH; transcriptional regulator; Belongs to the UPF0301 (AlgH) family. (185 aa) |
| | AJY52736.1 | PFAM: 5-formyltetrahydrofolate cyclo-ligase; TIGRFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (211 aa) |
| | hldE | Bifunctional protein hldE; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (476 aa) |
| | hldD | ADP-L-glycero-D-manno-heptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. (318 aa) |
