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JMA_05010 JMA_05010 JMA_06260 JMA_06260 JMA_09020 JMA_09020 JMA_09030 JMA_09030 JMA_09040 JMA_09040 JMA_09050 JMA_09050 lipA lipA JMA_12470 JMA_12470 fumC fumC JMA_13560 JMA_13560 JMA_14470 JMA_14470 pdhA pdhA JMA_15220 JMA_15220 JMA_15230 JMA_15230 JMA_15240 JMA_15240 ilvE ilvE JMA_15370 JMA_15370 JMA_15380 JMA_15380 ilvC ilvC leuA leuA leuB leuB leuC leuC leuD leuD JMA_15440 JMA_15440 JMA_15500 JMA_15500 sucC sucC sucD sucD JMA_17570 JMA_17570 JMA_17580 JMA_17580 JMA_18040 JMA_18040 JMA_18280 JMA_18280 JMA_18290 JMA_18290 thrB thrB JMA_18720 JMA_18720 odhA odhA JMA_20760 JMA_20760 JMA_20770 JMA_20770 JMA_20780 JMA_20780 JMA_20790 JMA_20790 buk buk JMA_20810 JMA_20810 JMA_20820 JMA_20820 JMA_20830 JMA_20830 JMA_23760 JMA_23760 JMA_23770 JMA_23770 JMA_23780 JMA_23780 mdh mdh JMA_24230 JMA_24230 JMA_24240 JMA_24240 JMA_24330 JMA_24330 pckA pckA ilvD ilvD JMA_28590 JMA_28590 JMA_29730 JMA_29730 serC serC lipL lipL ldh ldh JMA_33590 JMA_33590 glcB glcB JMA_34670 JMA_34670 mqo mqo JMA_36140 JMA_36140
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
JMA_05010Threonine aldolase. (340 aa)
JMA_06260Succinate-semialdehyde dehdyrogenase; Belongs to the aldehyde dehydrogenase family. (474 aa)
JMA_09020Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha. (327 aa)
JMA_09030TPP-dependent acetoin dehydrogenase complex, E1 protein subunit beta. (326 aa)
JMA_09040Branched-chain alpha-keto acid dehydrogenase subunit E2. (452 aa)
JMA_09050Dihydrolipoamide dehydrogenase. (456 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (313 aa)
JMA_12470Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (511 aa)
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (462 aa)
JMA_13560Lipoate-protein ligase A. (330 aa)
JMA_14470Aldehyde dehydrogenase A; Belongs to the aldehyde dehydrogenase family. (481 aa)
pdhAPyruvate dehydrogenase E1 subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (370 aa)
JMA_152202-oxoisovalerate dehydrogenase subunit beta. (325 aa)
JMA_15230Branched-chain alpha-keto acid dehydrogenase subunit E2. (440 aa)
JMA_15240Dihydrolipoamide dehydrogenase. (469 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (299 aa)
JMA_15370Acetolactate synthase. (579 aa)
JMA_15380Acetolactate synthase. (170 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (342 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (513 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (366 aa)
leuCIsopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (467 aa)
leuD3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (190 aa)
JMA_15440Threonine ammonia-lyase. (291 aa)
JMA_15500Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1147 aa)
sucCmalate--CoA ligase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa)
sucDsuccinyl-CoA synthetase subsunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (300 aa)
JMA_175702-oxoglutarate ferredoxin oxidoreductase subunit alpha. (581 aa)
JMA_175802-oxoacid ferredoxin oxidoreductase subunit beta. (288 aa)
JMA_18040Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (903 aa)
JMA_18280Homoserine dehydrogenase. (432 aa)
JMA_18290Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (353 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (306 aa)
JMA_18720Dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (422 aa)
odhA2-oxoglutarate dehydrogenase E1; E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). (937 aa)
JMA_20760Branched-chain alpha-keto acid dehydrogenase subunit E2. (429 aa)
JMA_207702-oxoisovalerate dehydrogenase subunit beta. (327 aa)
JMA_207802-oxoisovalerate dehydrogenase subunit alpha. (332 aa)
JMA_20790Dihydrolipoamide dehydrogenase. (473 aa)
bukButyrate kinase; Belongs to the acetokinase family. (361 aa)
JMA_20810Leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (365 aa)
JMA_20820Phosphate butyryltransferase. (300 aa)
JMA_20830ATPase AAA. (671 aa)
JMA_23760Succinate dehydrogenase. (257 aa)
JMA_23770Succinate dehydrogenase flavoprotein subunit. (586 aa)
JMA_23780Succinate dehydrogenase cytochrome B558. (202 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (314 aa)
JMA_24230Isocitrate dehydrogenase. (422 aa)
JMA_24240Citrate synthase; Belongs to the citrate synthase family. (371 aa)
JMA_24330NAD-dependent malic enzyme 4. (412 aa)
pckAPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (530 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (565 aa)
JMA_28590Acetamidase. (433 aa)
JMA_297303-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (394 aa)
serCMFS transporter; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (359 aa)
lipLOctanoyltransferase; Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes; Belongs to the octanoyltransferase LipL family. (280 aa)
ldhLactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (313 aa)
JMA_33590Isocitrate lyase. (428 aa)
glcBMalate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (720 aa)
JMA_34670Branched-chain amino acid aminotransferase. (356 aa)
mqoMalate:quinone oxidoreductase. (511 aa)
JMA_36140Malate dehydrogenase. (395 aa)
Your Current Organism:
Jeotgalibacillus malaysiensis
NCBI taxonomy Id: 1508404
Other names: DSM 28777, J. malaysiensis, Jeotgalibacillus malaysiensis Yaakop et al. 2015, Jeotgalibacillus sp. D5, KCTC 33550, strain D5
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