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asd asd astC astC argB argB argJ argJ argC argC argH argH argG argG CBH20274.1 CBH20274.1 ilvE ilvE CBH20525.1 CBH20525.1 leuA leuA leuC leuC leuD leuD leuB leuB lysA lysA hisG hisG hisD hisD CBH20648.1 CBH20648.1 hisB hisB hisH hisH hisA hisA hisF hisF hisI hisI hisE hisE CBH20655.1 CBH20655.1 ltaE ltaE CBH20775.1 CBH20775.1 CBH20776.1 CBH20776.1 aroA aroA pheA pheA CBH20918.1 CBH20918.1 CBH21026.1 CBH21026.1 arcA arcA arcB arcB arcC arcC CBH21102.1 CBH21102.1 CBH21285.1 CBH21285.1 CBH21533.1 CBH21533.1 ilvC ilvC ilvD ilvD ilvB ilvB aroK aroK aroD aroD aapP aapP yecS yecS CBH21727.1 CBH21727.1 CBH21870.1 CBH21870.1 CBH21872.1 CBH21872.1 CBH21873.1 CBH21873.1 yqfN yqfN sigA sigA dnaG dnaG CBH21877.1 CBH21877.1 folK folK folB folB folP folP mtrA mtrA CBH21882.1 CBH21882.1 pabB pabB pabA pabA pheB pheB CBH21932.1 CBH21932.1 CBH21933.1 CBH21933.1 dapH dapH dapB dapB dapA dapA dapF dapF trpB trpB trpA trpA trpB-2 trpB-2 CBH22110.1 CBH22110.1 trpF trpF trpC trpC trpD trpD pabA-2 pabA-2 trpE trpE megL megL metAA metAA CBH22269.1 CBH22269.1 metK metK CBH22487.1 CBH22487.1 aroE aroE aroC aroC aroA-2 aroA-2 aroB aroB thrC thrC thrB thrB fliY-2 fliY-2 yecS-2 yecS-2 yecC yecC
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (327 aa)
astCSuccinylornithine transaminase, PLP-dependent; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (404 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (286 aa)
argJArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (417 aa)
argCN-acetyl-gamma-glutamylphosphate reductase, NAD(P)-binding; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (348 aa)
argHArgininosuccinate lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (438 aa)
argGArgininosuccinate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (421 aa)
CBH20274.1Putative 5-methyltetrahydrofolate--homocysteine methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (770 aa)
ilvEBranched-chain-amino-acid aminotransferase (BCAT). (340 aa)
CBH20525.1Threonine dehydratase. (413 aa)
leuA2-isopropylmalate synthase (Alpha-isopropylmalate synthase) (Alpha-IPM synthetase); Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (567 aa)
leuC3-isopropylmalate isomerase subunit, dehydratase component; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (422 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (169 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (383 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (421 aa)
hisGATP phosphoribosyltransferase (ATP-PRTase) (ATP-PRT); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (207 aa)
hisDBifunctional histidinal dehydrogenase and histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (424 aa)
CBH20648.1Putative Histidinol-phosphate aminotransferase 1 (Imidazole acetol-phosphate transaminase 1); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (340 aa)
hisBImidazoleglycerol-phosphate dehydratase (IGPD). (194 aa)
hisHImidazole glycerol phosphate synthase, glutamine amidotransferase subunit with HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (208 aa)
hisA1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylideneamino] imidazole-4-carboxamide isomerase (Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase). (244 aa)
hisFImidazole glycerol phosphate synthase, catalytic subunit with HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (252 aa)
hisIPhosphoribosyl-AMP cyclohydrolase (PRA-CH); Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. (110 aa)
hisEPhosphoribosyl-ATP pyrophosphatase (PRA-PH). (92 aa)
CBH20655.1Homologs of previously reported genes of unknown function. (187 aa)
ltaEL-allo-threonine aldolase, PLP-dependent; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (342 aa)
CBH20775.1Bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase. (339 aa)
CBH20776.1Prephenate dehydrogenase. (288 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (428 aa)
pheAPheA. (369 aa)
CBH20918.1Putative GCN5-related N-acetyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (424 aa)
CBH21026.1Homoserine dehydrogenase. (403 aa)
arcAArginine deiminase (ADI) (Arginine dihydrolase) (AD). (410 aa)
arcBOrnithine carbamoyltransferase 1; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (332 aa)
arcCCarbamate kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the carbamate kinase family. (311 aa)
CBH21102.1Putative phosphoserine phosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (242 aa)
CBH21285.1Methylenetetrahydrofolate reductase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the methylenetetrahydrofolate reductase family. (302 aa)
CBH21533.1Aspartokinase; Belongs to the aspartokinase family. (442 aa)
ilvCKetol-acid reductoisomerase (NADP(+)); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (328 aa)
ilvDDihydroxyacid dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the IlvD/Edd family. (552 aa)
ilvBAcetolactate synthase 3 catalytic subunit. (547 aa)
aroKPutative shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (166 aa)
aroDPutative 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (254 aa)
aapPAmino-acid transporter subunit; Function of strongly homologous gene; transporter. (240 aa)
yecSPutative transporter subunit: permease component of ABC superfamily transporter; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (212 aa)
CBH21727.1Amino acid abc transporter, amino acid-binding protein. (266 aa)
CBH21870.1Homologs of previously reported genes of unknown function; Belongs to the methyltransferase superfamily. (376 aa)
CBH21872.1Protein of unknown function; No homology to any previously reported sequences. (241 aa)
CBH21873.1Homologs of previously reported genes of unknown function. (261 aa)
yqfNYqfN. (242 aa)
sigARNA polymerase sigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (376 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (580 aa)
CBH21877.13-deoxy-7-phosphoheptulonate synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (257 aa)
folK2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (151 aa)
folBDihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (123 aa)
folP7,8-dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (266 aa)
mtrAGTP cyclohydrolase I. (197 aa)
CBH21882.1Putative Aminodeoxychorismate lyase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (368 aa)
pabBPara-aminobenzoate synthase component I. (451 aa)
pabAAminodeoxychorismate synthase, subunit II; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (192 aa)
pheBACT domain-containing protein pheB; Belongs to the UPF0735 family. (144 aa)
CBH21932.1Aminotransferase. (353 aa)
CBH21933.1Predicted phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (303 aa)
dapHTetrahydrodipicolinate N-acetyltransferase; Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate. (238 aa)
dapBDihydrodipicolinate reductase (DHPR); Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (253 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (297 aa)
dapFDiaminopimelate epimerase (DAP epimerase); Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (281 aa)
trpBTryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (395 aa)
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (256 aa)
trpB-2Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (396 aa)
CBH22110.1Bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase (fragment). (269 aa)
trpFN-(5'-phosphoribosyl)anthranilate isomerase (PRAI); Belongs to the TrpF family. (201 aa)
trpCIndol-3-glycerol phosphate synthase; Belongs to the TrpC family. (262 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (338 aa)
pabA-2Aminodeoxychorismate synthase, subunit II; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (195 aa)
trpEAnthranilate synthase component I. (484 aa)
megLMethionine gamma-lyase. (399 aa)
metAAHomoserine O-succinyltransferase (Homoserine O-transsuccinylase) (HTS) (modular protein); Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (589 aa)
CBH22269.1O-acetylhomoserine aminocarboxypropyltransferase. (425 aa)
metKMethionine adenosyltransferase 1; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (394 aa)
CBH22487.1Histidinol phosphate phosphatase HisJ family; Belongs to the PHP hydrolase family. HisK subfamily. (269 aa)
aroEShikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (278 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (370 aa)
aroA-23-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (468 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (352 aa)
thrCThrC; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (353 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (298 aa)
fliY-2Cystine transporter subunit; Function of homologous gene experimentally demonstrated in an other organism; transporter. (269 aa)
yecS-2Putative transporter subunit: permease component of ABC superfamily transporter; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (223 aa)
yecCPutative transporter subunit: ATP-binding component of ABC superfamily transporter; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (242 aa)
Your Current Organism:
Acetoanaerobium sticklandii
NCBI taxonomy Id: 1511
Other names: A. sticklandii, ATCC 12662, BCRC 14485, CCRC 14485, CCRC:14485, CCUG 9281, Clostridium sticklandii, DSM 519, NCIMB 10654, strain StadtmanHF
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