STRINGSTRING
pycA pycA pepA pepA CBH20326.1 CBH20326.1 CBH20334.1 CBH20334.1 buk buk CBH20381.1 CBH20381.1 asnB asnB yhdR yhdR buk-2 buk-2 yqiS yqiS buk-3 buk-3 CBH20615.1 CBH20615.1 CBH20616.1 CBH20616.1 vorB vorB CBH20618.1 CBH20618.1 CBH20619.1 CBH20619.1 CBH21001.1 CBH21001.1 accB accB accC accC accD accD accA accA CBH21018.1 CBH21018.1 fabH fabH CBH21021.1 CBH21021.1 fabD fabD fabG fabG fabF fabF fabZ fabZ CBH21063.1 CBH21063.1 CBH21064.1 CBH21064.1 argK argK yqjC yqjC yqjD yqjD CBH21068.1 CBH21068.1 gcdC gcdC oadB oadB birA birA CBH21072.1 CBH21072.1 CBH21079.1 CBH21079.1 CBH21189.1 CBH21189.1 CBH21190.1 CBH21190.1 atoD atoD atoA atoA paaF paaF CBH21253.1 CBH21253.1 atoB atoB CBH21255.1 CBH21255.1 etfB etfB etfA etfA CBH21275.1 CBH21275.1 CBH21276.1 CBH21276.1 vorB-2 vorB-2 CBH21278.1 CBH21278.1 CBH21279.1 CBH21279.1 CBH21342.1 CBH21342.1 CBH21359.1 CBH21359.1 icd icd CBH21364.1 CBH21364.1 ackA ackA CBH21562.1 CBH21562.1 ansA ansA CBH21587.1 CBH21587.1 cmk cmk CBH21589.1 CBH21589.1 CBH21590.1 CBH21590.1 korC korC korB korB korA korA CBH21594.1 CBH21594.1 CBH21595.1 CBH21595.1 CBH21596.1 CBH21596.1 rluB rluB CBH21598.1 CBH21598.1 codY codY CBH21711.1 CBH21711.1 ppdK ppdK CBH21935.1 CBH21935.1 pepD pepD CBH22033.1 CBH22033.1 CBH22035.1 CBH22035.1 ybhJ ybhJ rex rex CBH22516.1 CBH22516.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pycAPyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1144 aa)
pepAPutative cytosol aminopeptidase (Leucine aminopeptidase) (LAP) (Leucyl aminopeptidase); Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. (498 aa)
CBH20326.13-hydroxyacyl-CoA dehydrogenase precursor. (319 aa)
CBH20334.1Phosphate butyryltransferase. (301 aa)
bukBranched-chain fatty-acid kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the acetokinase family. (355 aa)
CBH20381.1Acetaldehyde dehydrogenase / alcohol dehydrogenase-like protein. (494 aa)
asnBAsparagine synthase (Glutamine-hydrolyzing). (605 aa)
yhdRPutative aspartate aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (394 aa)
buk-2Branched-chain fatty-acid kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the acetokinase family. (359 aa)
yqiSPhosphate butyryltransferase. (301 aa)
buk-3Putative butyrate kinase (BK) (Branched-chain carboxylic acid kinase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the acetokinase family. (362 aa)
CBH20615.1Putative ATP/GTP-binding protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (225 aa)
CBH20616.14Fe-4S ferredoxin, iron-sulfur binding domain protein. (72 aa)
vorBKetoisovalerate oxidoreductase subunit vorB (VOR) (2-oxoisovalerate oxidoreductase beta chain) (2-oxoisovalerate ferredoxin reductase subunit beta). (351 aa)
CBH20618.1Putative subunit of oxidoreductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (249 aa)
CBH20619.1Putative subunit of oxidoreductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (184 aa)
CBH21001.1Homologs of previously reported genes of unknown function. (562 aa)
accBAcetyl CoA carboxylase, BCCP subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (142 aa)
accCacetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (448 aa)
accDacetyl-CoA carboxylase, beta (carboxyltranferase) subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (264 aa)
accAAcetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (265 aa)
CBH21018.1Putative transcriptional regulator; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (151 aa)
fabH3-oxoacyl-[acyl-carrier-protein] synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (324 aa)
CBH21021.1Dioxygenase related to 2-nitropropane dioxygenase. (316 aa)
fabDmalonyl-CoA-[acyl-carrier-protein] transacylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (328 aa)
fabG3-oxoacyl-[acyl-carrier-protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (244 aa)
fabF3-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (413 aa)
fabZ(3R)-hydroxymyristol acyl carrier protein dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (140 aa)
CBH21063.1Methylmalonyl-CoA mutase, large subunit. (559 aa)
CBH21064.1Cobalamin B12-binding domain protein. (134 aa)
argKMembrane ATPase/protein kinase; Function of homologous gene experimentally demonstrated in an other organism; transporter. (310 aa)
yqjCPutative lyase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (135 aa)
yqjDCarboxyl transferase YqjD. (513 aa)
CBH21068.1Sodium pump decarboxylase, gamma subunit; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation; Belongs to the OadG family. (134 aa)
gcdCGlutaconyl-CoA decarboxylase subunit gamma (Biotin carrier). (129 aa)
oadBOxaloacetate decarboxylase beta chain; Tunnel subunit of the primary sodium pump glutaconyl-CoA decarboxylase (GCD). (403 aa)
birABifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. (317 aa)
CBH21072.1Homologs of previously reported genes of unknown function. (319 aa)
CBH21079.1Aspartate aminotransferase. (385 aa)
CBH21189.1Putative fumarate hydratase subunit beta (Fumarase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (184 aa)
CBH21190.1Putative fumarate hydratase subunit alpha (Fumarase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (280 aa)
atoDacetyl-CoA:acetoacetyl-CoA transferase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; carrier. (216 aa)
atoAacetyl-CoA:acetoacetyl-CoA transferase, beta subunit; Function of homologous gene experimentally demonstrated in an other organism; carrier. (215 aa)
paaFenoyl-CoA hydratase-isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the enoyl-CoA hydratase/isomerase family. (257 aa)
CBH21253.13-hydroxybutyryl-CoA dehydrogenase. (279 aa)
atoBacetyl-CoA acetyltransferase; Function of homologous gene experimentally demonstrated in an other organism; carrier; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa)
CBH21255.1Acyl-CoA dehydrogenase, short-chain specific. (379 aa)
etfBElectron transfer flavoprotein (beta subunit). (260 aa)
etfAElectron transfer flavoprotein (alpha subunit). (336 aa)
CBH21275.1Phosphate butyryltransferase. (303 aa)
CBH21276.14Fe-4S ferredoxin, iron-sulfur binding domain protein. (79 aa)
vorB-2Ketoisovalerate oxidoreductase subunit vorB (VOR) (2-oxoisovalerate oxidoreductase beta chain) (2-oxoisovalerate ferredoxin reductase subunit beta). (356 aa)
CBH21278.1Thiamine pyrophosphate protein domain protein TPP-binding. (251 aa)
CBH21279.1Pyruvate ferredoxin/flavodoxin oxidoreductase. (176 aa)
CBH21342.1Aminotransferase class I and II. (438 aa)
CBH21359.1Aspartate aminotransferase. (393 aa)
icdIsocitrate dehydrogenase, specific for NADP+; Function of homologous gene experimentally demonstrated in an other organism; extrachromosomal origin. (334 aa)
CBH21364.1Methylcitrate synthase. (446 aa)
ackAAcetate kinase A and propionate kinase 2; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (399 aa)
CBH21562.1Aminoacyl-histidine dipeptidase. (482 aa)
ansAL-asparaginase. (325 aa)
CBH21587.1Putative acyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (193 aa)
cmkCytidylate kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (220 aa)
CBH21589.1Putative phosphoglycerate mutase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (199 aa)
CBH21590.1Transcriptional regulator, RpiR family. (289 aa)
korC2-oxoglutarate synthase subunit korC (2-ketoglutarate oxidoreductase gamma chain) (KOR) (2-oxoglutarate-ferredoxin oxidoreductase subunit gamma). (176 aa)
korB2-oxoglutarate synthase subunit korB (2-ketoglutarate oxidoreductase beta chain) (KOR) (2-oxoglutarate-ferredoxin oxidoreductase subunit beta). (266 aa)
korA2-oxoglutarate synthase subunit korA (2-ketoglutarate oxidoreductase alpha chain) (KOR) (2-oxoglutarate-ferredoxin oxidoreductase subunit alpha). (382 aa)
CBH21594.1Ferredoxin. (62 aa)
CBH21595.1Conserved carboxylase region. (465 aa)
CBH21596.1Protein of unknown function; No homology to any previously reported sequences. (139 aa)
rluBRluB; Belongs to the pseudouridine synthase RsuA family. (235 aa)
CBH21598.1Transcriptional regulator, XRE family. (179 aa)
codYGTP-sensing transcriptional pleiotropic repressor codY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. (259 aa)
CBH21711.1Aspartate racemase. (246 aa)
ppdKPyruvate, phosphate dikinase (Pyruvate, orthophosphate dikinase); Belongs to the PEP-utilizing enzyme family. (881 aa)
CBH21935.12-nitropropane dioxygenase, NPD. (336 aa)
pepDAminoacyl-histidine dipeptidase. (489 aa)
CBH22033.1Homologs of previously reported genes of unknown function. (1178 aa)
CBH22035.1Putative propanediol utilization protein; Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. (190 aa)
ybhJPutative enzyme; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (773 aa)
rexRedox regulator Rex; Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. (209 aa)
CBH22516.1Putative malate dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (392 aa)
Your Current Organism:
Acetoanaerobium sticklandii
NCBI taxonomy Id: 1511
Other names: A. sticklandii, ATCC 12662, BCRC 14485, CCRC 14485, CCRC:14485, CCUG 9281, Clostridium sticklandii, DSM 519, NCIMB 10654, strain StadtmanHF
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