STRINGSTRING
CBH20134.1 CBH20134.1 CBH20135.1 CBH20135.1 recF recF gyrB gyrB gyrA gyrA uvrX uvrX dnaX dnaX radA radA uvrB uvrB uvrA uvrA uvrC uvrC pcrA pcrA ligA ligA CBH20850.1 CBH20850.1 CBH20950.1 CBH20950.1 recX recX CBH21299.1 CBH21299.1 mutS mutS mutL mutL lexA lexA recJ recJ polA polA topA topA ssb ssb dnaE dnaE recA recA polC polC CBH21925.1 CBH21925.1 CBH22030.1 CBH22030.1 CBH22266.1 CBH22266.1 CBH22404.1 CBH22404.1 CBH22622.1 CBH22622.1 ssb-2 ssb-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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CBH20134.1DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (363 aa)
CBH20135.1Homologs of previously reported genes of unknown function. (68 aa)
recFDNA replication and repair protein recF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (361 aa)
gyrBDNA gyrase (subunit B); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (641 aa)
gyrADNA gyrase (type II topoisomerase), subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP [...] (817 aa)
uvrXLesion bypass phage DNA polymerase; Function of strongly homologous gene; enzyme. (435 aa)
dnaXDNA polymerase III subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (552 aa)
radARepair protein radA homolog; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (453 aa)
uvrBExcinulease of nucleotide excision repair, DNA damage recognition component; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. I [...] (654 aa)
uvrAATPase and DNA damage recognition protein of nucleotide excision repair excinuclease UvrABC; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (942 aa)
uvrCUvrABC system protein C (Protein uvrC) (Excinuclease ABC subunit C); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (587 aa)
pcrAATP-dependent DNA helicase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (720 aa)
ligADNA ligase, NAD(+)-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. (683 aa)
CBH20850.1Excinuclease ABC C subunit domain protein. (302 aa)
CBH20950.1DNA topoisomerase. (702 aa)
recXProtein of unknown function; Modulates RecA activity; Belongs to the RecX family. (213 aa)
CBH21299.1Putative ATP-dependent DNA helicase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (599 aa)
mutSDNA mismatch repair recognition factor; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (853 aa)
mutLDNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (634 aa)
lexALexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (208 aa)
recJPutative single-stranded-DNA-specific exonuclease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (777 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. (888 aa)
topATopA; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally [...] (684 aa)
ssbSingle-stranded DNA-binding protein 3 (SSB 3) (Helix-destabilizing protein 3). (138 aa)
dnaEDNA polymerase III DnaE. (1150 aa)
recADNA strand exchange and recombination protein with protease and nuclease activity; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (350 aa)
polCDNA polymerase III PolC; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (1417 aa)
CBH21925.1Homologs of previously reported genes of unknown function. (353 aa)
CBH22030.1Putative Helicase, UvrD/REP/exonuclease family protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (828 aa)
CBH22266.1Putative DNA polymerase III, delta' subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (277 aa)
CBH22404.1Putative HRDC domain protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (388 aa)
CBH22622.1ATP-dependent DNA helicase. (600 aa)
ssb-2Single-stranded DNA-binding protein (SSB) (Helix-destabilizing protein). (149 aa)
Your Current Organism:
Acetoanaerobium sticklandii
NCBI taxonomy Id: 1511
Other names: A. sticklandii, ATCC 12662, BCRC 14485, CCRC 14485, CCRC:14485, CCUG 9281, Clostridium sticklandii, DSM 519, NCIMB 10654, strain StadtmanHF
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