Your Input: | |
| | hutH | Histidine ammonia-lyase (Histidase). (511 aa) |
| | hutU | Urocanase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (676 aa) |
| | pdxT | Glutamine amidotransferase subunit pdxT (Glutamine amidotransferase glutaminase subunit pdxT); Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (191 aa) |
| | pdxS | Pyridoxal biosynthesis lyase pdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (292 aa) |
| | ptsI | Phosphotransferase system (PTS) enzyme I; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (564 aa) |
| | hcp | Hybrid-cluster [4Fe-2S-2O] protein in anaerobic terminal reductases; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. (543 aa) |
| | CBH20362.1 | Homologs of previously reported genes of unknown function. (519 aa) |
| | pyrB | Aspartate carbamoyltransferase, catalytic subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (357 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (408 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) (OMPdecase); Belongs to the OMP decarboxylase family. Type 2 subfamily. (278 aa) |
| | pyrK | Dihydroorotate dehydrogenase (electron transfer subunit). (223 aa) |
| | pyrD | PyrD; Catalyzes the conversion of dihydroorotate to orotate. (311 aa) |
| | pyrE | Orotate phosphoribosyltransferase (OPRT) (OPRTase); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (184 aa) |
| | CBH20411.1 | 5'-Nucleotidase domain protein precursor; Belongs to the 5'-nucleotidase family. (592 aa) |
| | guaB | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (487 aa) |
| | guaA | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. (509 aa) |
| | CBH20462.1 | Homologs of previously reported genes of unknown function. (443 aa) |
| | purE | N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (162 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the SAICAR synthetase family. (231 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (447 aa) |
| | purM | Phosphoribosylaminoimidazole synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (352 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (188 aa) |
| | purH | Fused IMP cyclohydrolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (504 aa) |
| | purD | Phosphoribosylamine--glycine ligase (modular protein); Belongs to the GARS family. (1669 aa) |
| | CBH20510.1 | Putative FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (438 aa) |
| | CBH20511.1 | Purine or other phosphorylase family 1. (247 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa) |
| | gcvT | Aminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. (365 aa) |
| | gcvH | Glycine cleavage complex lipoylprotein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa) |
| | gcvPA | Probable glycine dehydrogenase (decarboxylating) subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (447 aa) |
| | gcvPB | GcvPB; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (485 aa) |
| | fsaB | Fructose-6-phosphate aldolase 2; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (215 aa) |
| | glmU | Fused N-acetyl glucosamine-1-phosphate uridyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (451 aa) |
| | prsA | Phosphoribosylpyrophosphate synthase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (318 aa) |
| | glmM | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (452 aa) |
| | glmS | L-glutamine:D-fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (608 aa) |
| | folD | Bifunctional protein folD [Includes: Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (294 aa) |
| | hprK | HPr kinase/phosphorylase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon [...] (322 aa) |
| | glcK | Glucokinase. (318 aa) |
| | pgi | Glucose-6-phosphate isomerase (GPI) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI); Belongs to the GPI family. (453 aa) |
| | folC | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. (435 aa) |
| | gapA | Glyceraldehyde-3-phosphate dehydrogenase A; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (339 aa) |
| | pgk | Phosphoglycerate kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the phosphoglycerate kinase family. (398 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (248 aa) |
| | gpmI | Phosphoglycero mutase III, cofactor-independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (507 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (430 aa) |
| | hppA | Putative K(+)-stimulated pyrophosphate-energized sodium pump; Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane. Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily. (679 aa) |
| | iadA | Isoaspartyl dipeptidase; Catalyzes the hydrolytic cleavage of a subset of L- isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation. Belongs to the peptidase M38 family. (390 aa) |
| | deoD | Purine-nucleoside phosphorylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (237 aa) |
| | nagBA | N-acetylglucosamine-6-phosphate isomerase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. (248 aa) |
| | pfp | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (406 aa) |
| | CBH21048.1 | Indigoidine synthase A like protein. (306 aa) |
| | CBH21081.1 | Anaerobic ribonucleoside triphosphate reductase. (782 aa) |
| | nrdG | Anaerobic ribonucleotide reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (170 aa) |
| | CBH21083.1 | Protein of unknown function; No homology to any previously reported sequences. (47 aa) |
| | adeC | AdeC; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. (581 aa) |
| | CBH21217.1 | Phosphoribulokinase/uridine kinase. (554 aa) |
| | fhs | Formate-tetrahydrofolate ligase (Formyltetrahydrofolate synthetase) (FHS) (FTHFS); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the formate--tetrahydrofolate ligase family. (558 aa) |
| | CBH21283.1 | Methenyltetrahydrofolate cyclohydrolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (218 aa) |
| | acoL | Dihydrolipoamide dehydrogenase. (457 aa) |
| | gcvH-2 | Glycine cleavage complex lipoylprotein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (123 aa) |
| | gatY | D-tagatose 1,6-bisphosphate aldolase 2, catalytic subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (311 aa) |
| | CBH21354.1 | Glutamine synthetase, catalytic region. (638 aa) |
| | ADSL | Adenylosuccinate lyase (Adenylosuccinase) (ASL) (ASASE); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (477 aa) |
| | CBH21402.1 | Glutamate formiminotransferase. (298 aa) |
| | CBH21403.1 | Putative methenyl tetrahydrofolate cyclohydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (214 aa) |
| | hutI-2 | Imidazolonepropionase (Imidazolone-5-propionate hydrolase). (421 aa) |
| | glyA-2 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (413 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (170 aa) |
| | deoA | Thymidine phosphorylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (441 aa) |
| | nudF | ADP-ribose pyrophosphatase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (178 aa) |
| | yosS | SPbeta phage deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (144 aa) |
| | udk | Uridine/cytidine kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (210 aa) |
| | pykF | Pyruvate kinase I; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the pyruvate kinase family. (583 aa) |
| | pfkA | 6-phosphofructokinase I; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (319 aa) |
| | ptsH | Phosphocarrier protein HPr. (88 aa) |
| | whiA | Conserved protein of unknown function; Involved in cell division and chromosome segregation. (320 aa) |
| | CBH21775.1 | Putative DNA repair protein (Nucleotide pyrophosphatase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the Nudix hydrolase family. (144 aa) |
| | CBH21776.1 | Conserved protein of unknown function; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. (332 aa) |
| | yvcJ | Putative ATPase/kinase; Displays ATPase and GTPase activities. (285 aa) |
| | CBH21778.1 | Putative phosphoesterase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (244 aa) |
| | CBH21785.1 | Phosphoglucomutase. (576 aa) |
| | tktB | Transketolase 2, thiamin-binding; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (661 aa) |
| | cdd | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (130 aa) |
| | glsA | Glutaminase 1; Belongs to the glutaminase family. (305 aa) |
| | rpe | D-ribulose-5-phosphate 3-epimerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ribulose-phosphate 3-epimerase family. (218 aa) |
| | CBH21988.1 | Uracil permease. (415 aa) |
| | pyrR | Transcriptional attenuator and uracil phosphoribosyltransferase activity (minor); Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. (177 aa) |
| | deoC | DeoC; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (223 aa) |
| | hpt-2 | Hypoxanthine phosphoribosyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (172 aa) |
| | CBH22054.1 | Catabolite control protein A. (331 aa) |
| | trmB | tRNA (guanine-N(7)-)-methyltransferase (tRNA(m7G46)-methyltransferase); Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (222 aa) |
| | psuG | Conserved protein of unknown function; Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway; Belongs to the pseudouridine-5'-phosphate glycosidase family. (304 aa) |
| | yeiI | Putative kinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (372 aa) |
| | hutG | Formimidoylglutamase (Formiminoglutamase) (Formiminoglutamate hydrolase); Catalyzes the conversion of N-formimidoyl-L-glutamate to L- glutamate and formamide; Belongs to the arginase family. (327 aa) |
| | SurE | Predicted acid phosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (253 aa) |
| | CBH22209.1 | Putative 5-formyltetrahydrofolate cyclo-ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (192 aa) |
| | CBH22247.1 | CMP/dCMP deaminase, zinc-binding. (162 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa) |
| | rpiB | Ribose 5-phosphate isomerase B/allose 6-phosphate isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (151 aa) |
| | tdk | Thymidine kinase. (191 aa) |
| | glpX | Fructose 1,6-bisphosphatase II; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (323 aa) |
| | glpX-2 | Fructose 1,6-bisphosphatase II; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (331 aa) |
| | CBH22267.1 | Putative thymidylate kinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (231 aa) |
| | thyX | Thymidylate synthase thyX (TS) (TSase); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (256 aa) |
| | CBH22375.1 | Ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent. (783 aa) |
| | gdhA | Glutamate dehydrogenase, NADP-specific; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (448 aa) |
| | yrpC | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (274 aa) |
| | CBH22525.1 | Homologs of previously reported genes of unknown function. (275 aa) |
| | carA | Carbamoyl phosphate synthetase small subunit, glutamine amidotransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the CarA family. (360 aa) |
| | carB | Carbamoyl-phosphate synthase large subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (1067 aa) |
| | thyA | Thymidylate synthase (TS) (TSase); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (277 aa) |
| | CBH22591.1 | Dihydrofolate reductase. (166 aa) |
| | CBH22598.1 | Putative Ribose-phosphate pyrophosphokinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (269 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (427 aa) |
