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hutH hutH hutU hutU hcp hcp CBH20362.1 CBH20362.1 pyrB pyrB pyrC pyrC pyrF pyrF pyrK pyrK pyrD pyrD pyrE pyrE CBH20411.1 CBH20411.1 guaB guaB guaA guaA CBH20462.1 CBH20462.1 purE purE purC purC purF purF purM purM purN purN purH purH purD purD CBH20510.1 CBH20510.1 CBH20511.1 CBH20511.1 glyA glyA gcvT gcvT gcvH gcvH gcvPA gcvPA gcvPB gcvPB folD folD folC folC deoD deoD CBH21048.1 CBH21048.1 CBH21081.1 CBH21081.1 nrdG nrdG CBH21083.1 CBH21083.1 adeC adeC CBH21217.1 CBH21217.1 fhs fhs CBH21283.1 CBH21283.1 acoL acoL gcvH-2 gcvH-2 CBH21354.1 CBH21354.1 ADSL ADSL CBH21402.1 CBH21402.1 CBH21403.1 CBH21403.1 hutI-2 hutI-2 glyA-2 glyA-2 apt apt deoA deoA yosS yosS udk udk cdd cdd glsA glsA CBH21988.1 CBH21988.1 pyrR pyrR hpt-2 hpt-2 psuG psuG yeiI yeiI hutG hutG SurE SurE CBH22209.1 CBH22209.1 CBH22247.1 CBH22247.1 upp upp tdk tdk CBH22267.1 CBH22267.1 thyX thyX CBH22375.1 CBH22375.1 gdhA gdhA yrpC yrpC carA carA carB carB thyA thyA CBH22591.1 CBH22591.1 purA purA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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hutHHistidine ammonia-lyase (Histidase). (511 aa)
hutUUrocanase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (676 aa)
hcpHybrid-cluster [4Fe-2S-2O] protein in anaerobic terminal reductases; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. (543 aa)
CBH20362.1Homologs of previously reported genes of unknown function. (519 aa)
pyrBAspartate carbamoyltransferase, catalytic subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (357 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (408 aa)
pyrFOrotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) (OMPdecase); Belongs to the OMP decarboxylase family. Type 2 subfamily. (278 aa)
pyrKDihydroorotate dehydrogenase (electron transfer subunit). (223 aa)
pyrDPyrD; Catalyzes the conversion of dihydroorotate to orotate. (311 aa)
pyrEOrotate phosphoribosyltransferase (OPRT) (OPRTase); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (184 aa)
CBH20411.15'-Nucleotidase domain protein precursor; Belongs to the 5'-nucleotidase family. (592 aa)
guaBIMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (487 aa)
guaAGMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. (509 aa)
CBH20462.1Homologs of previously reported genes of unknown function. (443 aa)
purEN5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (162 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the SAICAR synthetase family. (231 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (447 aa)
purMPhosphoribosylaminoimidazole synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (352 aa)
purNPhosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (188 aa)
purHFused IMP cyclohydrolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (504 aa)
purDPhosphoribosylamine--glycine ligase (modular protein); Belongs to the GARS family. (1669 aa)
CBH20510.1Putative FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (438 aa)
CBH20511.1Purine or other phosphorylase family 1. (247 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
gcvTAminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. (365 aa)
gcvHGlycine cleavage complex lipoylprotein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa)
gcvPAProbable glycine dehydrogenase (decarboxylating) subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (447 aa)
gcvPBGcvPB; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (485 aa)
folDBifunctional protein folD [Includes: Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (294 aa)
folCFolylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. (435 aa)
deoDPurine-nucleoside phosphorylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (237 aa)
CBH21048.1Indigoidine synthase A like protein. (306 aa)
CBH21081.1Anaerobic ribonucleoside triphosphate reductase. (782 aa)
nrdGAnaerobic ribonucleotide reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (170 aa)
CBH21083.1Protein of unknown function; No homology to any previously reported sequences. (47 aa)
adeCAdeC; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. (581 aa)
CBH21217.1Phosphoribulokinase/uridine kinase. (554 aa)
fhsFormate-tetrahydrofolate ligase (Formyltetrahydrofolate synthetase) (FHS) (FTHFS); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the formate--tetrahydrofolate ligase family. (558 aa)
CBH21283.1Methenyltetrahydrofolate cyclohydrolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (218 aa)
acoLDihydrolipoamide dehydrogenase. (457 aa)
gcvH-2Glycine cleavage complex lipoylprotein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (123 aa)
CBH21354.1Glutamine synthetase, catalytic region. (638 aa)
ADSLAdenylosuccinate lyase (Adenylosuccinase) (ASL) (ASASE); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (477 aa)
CBH21402.1Glutamate formiminotransferase. (298 aa)
CBH21403.1Putative methenyl tetrahydrofolate cyclohydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (214 aa)
hutI-2Imidazolonepropionase (Imidazolone-5-propionate hydrolase). (421 aa)
glyA-2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (413 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (170 aa)
deoAThymidine phosphorylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (441 aa)
yosSSPbeta phage deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (144 aa)
udkUridine/cytidine kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (210 aa)
cddCytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (130 aa)
glsAGlutaminase 1; Belongs to the glutaminase family. (305 aa)
CBH21988.1Uracil permease. (415 aa)
pyrRTranscriptional attenuator and uracil phosphoribosyltransferase activity (minor); Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. (177 aa)
hpt-2Hypoxanthine phosphoribosyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (172 aa)
psuGConserved protein of unknown function; Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway; Belongs to the pseudouridine-5'-phosphate glycosidase family. (304 aa)
yeiIPutative kinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (372 aa)
hutGFormimidoylglutamase (Formiminoglutamase) (Formiminoglutamate hydrolase); Catalyzes the conversion of N-formimidoyl-L-glutamate to L- glutamate and formamide; Belongs to the arginase family. (327 aa)
SurEPredicted acid phosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (253 aa)
CBH22209.1Putative 5-formyltetrahydrofolate cyclo-ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (192 aa)
CBH22247.1CMP/dCMP deaminase, zinc-binding. (162 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa)
tdkThymidine kinase. (191 aa)
CBH22267.1Putative thymidylate kinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (231 aa)
thyXThymidylate synthase thyX (TS) (TSase); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (256 aa)
CBH22375.1Ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent. (783 aa)
gdhAGlutamate dehydrogenase, NADP-specific; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (448 aa)
yrpCGlutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (274 aa)
carACarbamoyl phosphate synthetase small subunit, glutamine amidotransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the CarA family. (360 aa)
carBCarbamoyl-phosphate synthase large subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (1067 aa)
thyAThymidylate synthase (TS) (TSase); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (277 aa)
CBH22591.1Dihydrofolate reductase. (166 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (427 aa)
Your Current Organism:
Acetoanaerobium sticklandii
NCBI taxonomy Id: 1511
Other names: A. sticklandii, ATCC 12662, BCRC 14485, CCRC 14485, CCRC:14485, CCUG 9281, Clostridium sticklandii, DSM 519, NCIMB 10654, strain StadtmanHF
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