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| | pdxT | Glutamine amidotransferase subunit pdxT (Glutamine amidotransferase glutaminase subunit pdxT); Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (191 aa) |
| | astC | Succinylornithine transaminase, PLP-dependent; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (404 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (286 aa) |
| | argJ | ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (417 aa) |
| | argC | N-acetyl-gamma-glutamylphosphate reductase, NAD(P)-binding; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (348 aa) |
| | argH | Argininosuccinate lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (438 aa) |
| | argG | Argininosuccinate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (421 aa) |
| | CBH20274.1 | Putative 5-methyltetrahydrofolate--homocysteine methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (770 aa) |
| | CBH20275.1 | Homologs of previously reported genes of unknown function. (211 aa) |
| | ilvE | Branched-chain-amino-acid aminotransferase (BCAT). (340 aa) |
| | CBH20326.1 | 3-hydroxyacyl-CoA dehydrogenase precursor. (319 aa) |
| | CBH20327.1 | Homologs of previously reported genes of unknown function. (312 aa) |
| | CBH20328.1 | Homologs of previously reported genes of unknown function. (277 aa) |
| | buk | Branched-chain fatty-acid kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the acetokinase family. (355 aa) |
| | ykfB | Putative muconate cycloisomerase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (367 aa) |
| | eutB | Ethanolamine ammonia-lyase, large subunit, heavy chain; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (455 aa) |
| | eutC | Ethanolamine ammonia-lyase light chain (Ethanolamine ammonia-lyase small subunit); Belongs to the EutC family. (294 aa) |
| | tyrS | Tyrosyl-tRNA synthetase 1 (Tyrosine--tRNA ligase 1) (TyrRS 1); Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (408 aa) |
| | pyrB | Aspartate carbamoyltransferase, catalytic subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (357 aa) |
| | CBH20425.1 | B3/4 domain protein. (235 aa) |
| | guaA | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. (509 aa) |
| | CBH20456.1 | Metallo-beta-lactamase superfamily protein. (269 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (447 aa) |
| | asnB | Asparagine synthase (Glutamine-hydrolyzing). (605 aa) |
| | CBH20516.1 | Putative translation initiation factor EIF-2B subunit 1; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the eIF-2B alpha/beta/delta subunits family. (350 aa) |
| | CBH20755.1 | Putative amidohydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (380 aa) |
| | mtnK | 5-methylribose kinase; Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate. (406 aa) |
| | glmS | L-glutamine:D-fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (608 aa) |
| | dsdA | D-serine ammonia-lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the serine/threonine dehydratase family. DsdA subfamily. (451 aa) |
| | CBH20638.1 | Alanine dehydrogenase-like protein. (376 aa) |
| | hisG | ATP phosphoribosyltransferase (ATP-PRTase) (ATP-PRT); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (207 aa) |
| | hisD | Bifunctional histidinal dehydrogenase and histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (424 aa) |
| | CBH20648.1 | Putative Histidinol-phosphate aminotransferase 1 (Imidazole acetol-phosphate transaminase 1); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (340 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase (IGPD). (194 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit with HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (208 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylideneamino] imidazole-4-carboxamide isomerase (Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase). (244 aa) |
| | hisF | Imidazole glycerol phosphate synthase, catalytic subunit with HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (252 aa) |
| | hisI | Phosphoribosyl-AMP cyclohydrolase (PRA-CH); Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. (110 aa) |
| | hisE | Phosphoribosyl-ATP pyrophosphatase (PRA-PH). (92 aa) |
| | CBH22693.1 | Cysteine desulfurase family protein. (380 aa) |
| | CBH22593.1 | Putative glutamine amidotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (241 aa) |
| | CBH22591.1 | Dihydrofolate reductase. (166 aa) |
| | CBH22588.1 | Amidohydrolase 3. (536 aa) |
| | ygeX | 2,3-diaminopropionate ammonia-lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (406 aa) |
| | CBH22548.1 | Homologs of previously reported genes of unknown function. (311 aa) |
| | carB | Carbamoyl-phosphate synthase large subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (1067 aa) |
| | carA | Carbamoyl phosphate synthetase small subunit, glutamine amidotransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the CarA family. (360 aa) |
| | CBH22541.1 | Putative thiosulfate sulfurtransferase ynjE precursor (fragment); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (339 aa) |
| | aspC | aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily. (429 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (298 aa) |
| | thrC | ThrC; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (353 aa) |
| | ytkL | YtkL; Belongs to the UPF0173 family. (223 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (352 aa) |
| | aroA-2 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (468 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (370 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (278 aa) |
| | CBH22488.1 | Homologs of previously reported genes of unknown function; Belongs to the UPF0597 family. (450 aa) |
| | CBH22487.1 | Histidinol phosphate phosphatase HisJ family; Belongs to the PHP hydrolase family. HisK subfamily. (269 aa) |
| | asnS | Asparaginyl tRNA synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (464 aa) |
| | gdhA | Glutamate dehydrogenase, NADP-specific; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (448 aa) |
| | CBH22409.1 | Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (56 aa) |
| | ispD | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (233 aa) |
| | ispF | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (157 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (495 aa) |
| | cysK | Cysteine synthase A, O-acetylserine sulfhydrolase A subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the cysteine synthase/cystathionine beta- synthase family. (304 aa) |
| | CBH22360.1 | Serine acetyltransferase (SAT); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (191 aa) |
| | cysS | cysteinyl-tRNA synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-I aminoacyl-tRNA synthetase family. (466 aa) |
| | proS | Prolyl-tRNA synthetase 2 (Proline--tRNA ligase 2) (ProRS 2); Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). Can inadvertently accommodate and process cysteine. Misacylated Cys-tRNA(Pro) is not edited by ProRS; this function may be provided by ProX; Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily. (481 aa) |
| | CBH22349.1 | Putative uncharacterized protein (PrdE); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (158 aa) |
| | CBH22269.1 | O-acetylhomoserine aminocarboxypropyltransferase. (425 aa) |
| | metAA | Homoserine O-succinyltransferase (Homoserine O-transsuccinylase) (HTS) (modular protein); Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (589 aa) |
| | acpS | Holo-acyl carrier protein synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (122 aa) |
| | CBH22232.1 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (384 aa) |
| | lipA | Lipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (282 aa) |
| | yhfJ-2 | Putative lipoate-protein ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (330 aa) |
| | yhfJ | Putative Lipoyltransferase and lipoate-protein ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (325 aa) |
| | leuS | leucyl-tRNA synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-I aminoacyl-tRNA synthetase family. (800 aa) |
| | megL | Methionine gamma-lyase. (399 aa) |
| | CBH22145.1 | Alanyl-tRNA synthetase related protein. (402 aa) |
| | CBH22140.1 | Homologs of previously reported genes of unknown function. (514 aa) |
| | CBH22133.1 | Homologs of previously reported genes of unknown function. (384 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (338 aa) |
| | trpC | Indol-3-glycerol phosphate synthase; Belongs to the TrpC family. (262 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase (PRAI); Belongs to the TrpF family. (201 aa) |
| | CBH22110.1 | Bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase (fragment). (269 aa) |
| | trpB-2 | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (396 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (256 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (395 aa) |
| | CBH22098.1 | D-cysteine desulfhydrase. (329 aa) |
| | CBH22097.1 | Cyclase family protein. (210 aa) |
| | proC | Pyrroline-5-carboxylate reductase, NAD(P)-binding; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (266 aa) |
| | CRYZ | Quinone oxidoreductase (NADPH:quinone reductase) (Zeta-crystallin). (326 aa) |
| | CBH22065.1 | Malate/lactate dehydrogenase-like protein. (421 aa) |
| | acpP-2 | Acyl carrier protein (ACP); Carrier of the growing fatty acid chain in fatty acid biosynthesis. (75 aa) |
| | hisC | Putative histidinol-phosphate aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (360 aa) |
| | ileS | Isoleucyl-tRNA synthetase 2 (Isoleucine--tRNA ligase 2) (IleRS 2); Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 [...] (1034 aa) |
| | pfs | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (230 aa) |
| | trpS | tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (339 aa) |
| | dapF | Diaminopimelate epimerase (DAP epimerase); Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (281 aa) |
| | dfp | Fused 4'-phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (398 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (297 aa) |
| | dapB | Dihydrodipicolinate reductase (DHPR); Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (253 aa) |
| | dapH | Tetrahydrodipicolinate N-acetyltransferase; Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate. (238 aa) |
| | glsA | Glutaminase 1; Belongs to the glutaminase family. (305 aa) |
| | CBH21933.1 | Predicted phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (303 aa) |
| | nadA | Quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (305 aa) |
| | nadC | Quinolinate phosphoribosyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the NadC/ModD family. (265 aa) |
| | CBH21901.1 | Predicted hydrolase. (238 aa) |
| | glyQ | Glycine tRNA synthetase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (294 aa) |
| | glyS | Glycine tRNA synthetase, beta subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (687 aa) |
| | ppdK | Pyruvate, phosphate dikinase (Pyruvate, orthophosphate dikinase); Belongs to the PEP-utilizing enzyme family. (881 aa) |
| | CBH21882.1 | Putative Aminodeoxychorismate lyase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (368 aa) |
| | folP | 7,8-dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (266 aa) |
| | folB | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (123 aa) |
| | folK | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (151 aa) |
| | CBH21877.1 | 3-deoxy-7-phosphoheptulonate synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (257 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (389 aa) |
| | ispG | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (348 aa) |
| | pfkA | 6-phosphofructokinase I; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (319 aa) |
| | pykF | Pyruvate kinase I; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the pyruvate kinase family. (583 aa) |
| | kbl | Glycine C-acetyltransferase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (395 aa) |
| | aroD | Putative 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (254 aa) |
| | aroK | Putative shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (166 aa) |
| | iscS-2 | Cysteine desulfurase (tRNA sulfurtransferase), PLP-dependent; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (398 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (882 aa) |
| | CBH21596.1 | Protein of unknown function; No homology to any previously reported sequences. (139 aa) |
| | korB | 2-oxoglutarate synthase subunit korB (2-ketoglutarate oxidoreductase beta chain) (KOR) (2-oxoglutarate-ferredoxin oxidoreductase subunit beta). (266 aa) |
| | ispH | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (278 aa) |
| | CBH21579.1 | Rhodanese-like domain protein. (275 aa) |
| | CBH21572.1 | P-protein [includes: chorismate mutase and prephenate dehydratase] (fragment). (92 aa) |
| | CBH21570.1 | Homologs of previously reported genes of unknown function. (397 aa) |
| | yjiM | Putative 2-hydroxyglutaryl-CoA dehydratase (hgdB-like); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (384 aa) |
| | hgdC | ATPase, activator of (R)-hydroxyglutaryl-CoA dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (256 aa) |
| | ansA | L-asparaginase. (325 aa) |
| | CBH21566.1 | Homologs of previously reported genes of unknown function. (201 aa) |
| | iscS | Cysteine desulfurase (tRNA sulfurtransferase), PLP-dependent; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (383 aa) |
| | CBH21550.1 | Protein of unknown function; No homology to any previously reported sequences. (408 aa) |
| | rdlA | Rhodanese. (323 aa) |
| | ilvB | Acetolactate synthase 3 catalytic subunit. (547 aa) |
| | ilvD | Dihydroxyacid dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the IlvD/Edd family. (552 aa) |
| | ilvC | Ketol-acid reductoisomerase (NADP(+)); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (328 aa) |
| | CBH21533.1 | Aspartokinase; Belongs to the aspartokinase family. (442 aa) |
| | kal | 3-aminobutyryl-CoA ammonia lyase; Involved in the anaerobic fermentation of lysine. Catalyzes the deamination of L-3-aminobutyryl-CoA to produce crotonoyl-CoA. Belongs to the KAL family. (126 aa) |
| | kce | 3-keto-5-aminohexanoate cleavage enzyme; Involved in the anaerobic fermentation of lysine. Catalyzes the reversible reaction between 3-keto-5-aminohexanoate (KAH) and acetyl-CoA to form 3-aminobutyryl-CoA and acetoacetate. The reaction involves the deprotonation of KAH, the nucleophilic addition onto acetyl-CoA and the intramolecular transfer of the CoA moiety. Belongs to the KCE family. (273 aa) |
| | kdd | 3,5-diaminohexanoate dehydrogenase; Involved in the anaerobic fermentation of lysine. Catalyzes the oxidative deamination of L-erythro-3,5-diaminohexanoate (3,5-DAH) to 3-keto-5-aminohexanoate (KAH); Belongs to the KDD family. (344 aa) |
| | kamA | L-lysine 2,3-aminomutase; Catalyzes the interconversion of L-alpha-lysine and L-beta- lysine. (414 aa) |
| | kamD | D-lysine 5,6-aminomutase alpha subunit; Catalyzes the migration of the L-beta-lysine and D-lysine epsilon amino group to the delta carbon to produce 3,5-diaminohexanoate and 2,5-diaminohexanoate, respectively. (519 aa) |
| | selD | Selenophosphate synthase; Synthesizes selenophosphate from selenide and ATP. (324 aa) |
| | plsX | Fatty acid/phospholipid synthesis protein; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (336 aa) |
| | ahrC | Transcriptional regulator; Regulates arginine biosynthesis genes. (148 aa) |
| | dtd | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (154 aa) |
| | hisS-2 | Histidyl tRNA synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (420 aa) |
| | aspS-2 | aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (586 aa) |
| | glyA-2 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (413 aa) |
| | ord | (2R,4S)-2,4-diaminopentanoate dehydrogenase (DAPDH); Involved in the ornithine fermentation pathway. Catalyzes the oxidative deamination of (2R,4S)-2,4-diaminopentanoate (DAP) to yield 2-amino-4-ketopentanoate (AKP). (353 aa) |
| | pgk | Phosphoglycerate kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the phosphoglycerate kinase family. (398 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (248 aa) |
| | gpmI | Phosphoglycero mutase III, cofactor-independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (507 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (430 aa) |
| | CBH20775.1 | Bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase. (339 aa) |
| | CBH20776.1 | Prephenate dehydrogenase. (288 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (428 aa) |
| | pheA | PheA. (369 aa) |
| | CBH20809.1 | Putative Coenzyme A transferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (278 aa) |
| | CBH20810.1 | Putative glutaconate CoA-transferase, subunit B; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (249 aa) |
| | mtrK | 5-methylribose kinase; Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate. (401 aa) |
| | mtnA | Putative Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (354 aa) |
| | CBH20829.1 | Acyl-CoA hydrolase. (139 aa) |
| | CBH20869.1 | Putative glutamine amidotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (242 aa) |
| | CBH20880.1 | Pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit (modular protein). (86 aa) |
| | CBH20882.1 | NADH dependant phenylglyoxylate (fragment). (299 aa) |
| | buk-4 | Branched-chain fatty-acid kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the acetokinase family. (355 aa) |
| | ydjJ | Putative iditol dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (346 aa) |
| | hutI | Putative imidazolonepropionase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (385 aa) |
| | fdhA | Formate dehydrogenase alpha chain; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (699 aa) |
| | hydE | Iron-only hydrogenase maturation protein; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (348 aa) |
| | nagBA | N-acetylglucosamine-6-phosphate isomerase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. (248 aa) |
| | accB | Acetyl CoA carboxylase, BCCP subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (142 aa) |
| | accC | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (448 aa) |
| | accD | acetyl-CoA carboxylase, beta (carboxyltranferase) subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (264 aa) |
| | accA | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (265 aa) |
| | fabH | 3-oxoacyl-[acyl-carrier-protein] synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (324 aa) |
| | acpP | Acyl carrier protein (ACP); Carrier of the growing fatty acid chain in fatty acid biosynthesis. (75 aa) |
| | fabD | malonyl-CoA-[acyl-carrier-protein] transacylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (328 aa) |
| | fabF | 3-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (413 aa) |
| | fabZ | (3R)-hydroxymyristol acyl carrier protein dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (140 aa) |
| | CBH21026.1 | Homoserine dehydrogenase. (403 aa) |
| | pfp | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (406 aa) |
| | arcA | Arginine deiminase (ADI) (Arginine dihydrolase) (AD). (410 aa) |
| | arcB | Ornithine carbamoyltransferase 1; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (332 aa) |
| | arcC | Carbamate kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the carbamate kinase family. (311 aa) |
| | ispE | 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (309 aa) |
| | CBH21064.1 | Cobalamin B12-binding domain protein. (134 aa) |
| | yqjC | Putative lyase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (135 aa) |
| | yqjD | Carboxyl transferase YqjD. (513 aa) |
| | CBH21068.1 | Sodium pump decarboxylase, gamma subunit; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation; Belongs to the OadG family. (134 aa) |
| | gcdC | Glutaconyl-CoA decarboxylase subunit gamma (Biotin carrier). (129 aa) |
| | lysU | Lysine tRNA synthetase, inducible; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-II aminoacyl-tRNA synthetase family. (506 aa) |
| | cobQ | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (506 aa) |
| | CBH21102.1 | Putative phosphoserine phosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (242 aa) |
| | cobB | Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (456 aa) |
| | cobD-2 | Putative threonine-phosphate decarboxylase (L-threonine-O-3-phosphate decarboxylase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (363 aa) |
| | CBH21145.1 | Homologs of previously reported genes of unknown function. (219 aa) |
| | CBH21148.1 | Amidohydrolase. (296 aa) |
| | CBH21149.1 | Putative membrane protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (222 aa) |
| | hisS | Histidyl-tRNA synthetase (Histidine--tRNA ligase) (HisRS). (430 aa) |
| | yvdE | Putative glutamine amidotransferase-like protein yvdE; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (240 aa) |
| | glnS | glutamyl-tRNA synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (559 aa) |
| | CBH21202.1 | Homologs of previously reported genes of unknown function. (215 aa) |
| | grdC | Glycine reductase component C subunit beta; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (511 aa) |
| | grdD | Glycine reductase component C subunit alpha; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (388 aa) |
| | atoD | acetyl-CoA:acetoacetyl-CoA transferase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; carrier. (216 aa) |
| | atoA | acetyl-CoA:acetoacetyl-CoA transferase, beta subunit; Function of homologous gene experimentally demonstrated in an other organism; carrier. (215 aa) |
| | thrS | threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). (637 aa) |
| | paaF | enoyl-CoA hydratase-isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the enoyl-CoA hydratase/isomerase family. (257 aa) |
| | CBH21253.1 | 3-hydroxybutyryl-CoA dehydrogenase. (279 aa) |
| | atoB | acetyl-CoA acetyltransferase; Function of homologous gene experimentally demonstrated in an other organism; carrier; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa) |
| | CBH21255.1 | Acyl-CoA dehydrogenase, short-chain specific. (379 aa) |
| | pheS | Phenylalanine tRNA synthetase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (339 aa) |
| | pheT | Phenylalanine tRNA synthetase, beta subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (788 aa) |
| | CBH21267.1 | FMN-dependent alpha-hydroxy acid dehydrogenase. (342 aa) |
| | argS | Arginyl-tRNA synthetase 2 (Arginine--tRNA ligase 2) (ArgRS 2). (566 aa) |
| | CBH21278.1 | Thiamine pyrophosphate protein domain protein TPP-binding. (251 aa) |
| | CBH21285.1 | Methylenetetrahydrofolate reductase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the methylenetetrahydrofolate reductase family. (302 aa) |
| | CBH21290.1 | 5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (261 aa) |
| | gcvH-2 | Glycine cleavage complex lipoylprotein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (123 aa) |
| | hutI-2 | Imidazolonepropionase (Imidazolone-5-propionate hydrolase). (421 aa) |
| | orr | Ornithine racemase; Involved in the ornithine fermentation pathway. Catalyzes the conversion of L-ornithine to D-ornithine. OR could also racemize basic amino acids such as lysine and arginine. Serine, asparagine and alanine could be also converted by OR, but at a lower rate. (353 aa) |
| | ortB | 2-amino-4-ketopentanoate thiolase (AKPT) beta subunit; Involved in the ornithine fermentation pathway. Catalyzes the thiolytic cleavage of 2-amino-4-ketopentanoate (AKP) with coenzyme A (CoA) to form acetyl-CoA and alanine. It is strictly specific for AKP. (469 aa) |
| | ortA | 2-amino-4-ketopentanoate thiolase (AKPT), alpha subunit; Involved in the ornithine fermentation pathway. Catalyzes the thiolytic cleavage of 2-amino-4-ketopentanoate (AKP) with coenzyme A (CoA) to form acetyl-CoA and alanine. It is strictly specific for AKP. Belongs to the OrtA family. (101 aa) |
| | folD | Bifunctional protein folD [Includes: Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (294 aa) |
| | ltaE | L-allo-threonine aldolase, PLP-dependent; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (342 aa) |
| | pgi | Glucose-6-phosphate isomerase (GPI) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI); Belongs to the GPI family. (453 aa) |
| | CBH20742.1 | Cysteine desulfurase family protein. (382 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (884 aa) |
| | CBH21402.1 | Glutamate formiminotransferase. (298 aa) |
| | icd | Isocitrate dehydrogenase, specific for NADP+; Function of homologous gene experimentally demonstrated in an other organism; extrachromosomal origin. (334 aa) |
| | CBH21293.1 | Ferredoxin; Function of strongly homologous gene; transporter. (643 aa) |
| | CBH20525.1 | Threonine dehydratase. (413 aa) |
| | leuA | 2-isopropylmalate synthase (Alpha-isopropylmalate synthase) (Alpha-IPM synthetase); Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (567 aa) |
| | leuC | 3-isopropylmalate isomerase subunit, dehydratase component; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (422 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (169 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (383 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa) |
| | gcvT | Aminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. (365 aa) |
| | gcvH | Glycine cleavage complex lipoylprotein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa) |
| | gcvPA | Probable glycine dehydrogenase (decarboxylating) subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (447 aa) |
| | gcvPB | GcvPB; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (485 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (421 aa) |
| | metS | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (651 aa) |
| | buk-2 | Branched-chain fatty-acid kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the acetokinase family. (359 aa) |
| | buk-3 | Putative butyrate kinase (BK) (Branched-chain carboxylic acid kinase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the acetokinase family. (362 aa) |
| | CBH20618.1 | Putative subunit of oxidoreductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (249 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (327 aa) |
| | aspS | aspartyl-tRNA synthetase; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (700 aa) |
| | pycA | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1144 aa) |
| | CBH20154.1 | Peptidase M20. (549 aa) |
| | hutH | Histidine ammonia-lyase (Histidase). (511 aa) |
| | hutU | Urocanase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (676 aa) |
| | CBH20175.1 | Alanine racemase domain protein. (364 aa) |
| | serS | seryl-tRNA synthetase, also charges selenocysteinyl-tRNA with serine; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (425 aa) |
| | CBH20211.1 | Homologs of previously reported genes of unknown function. (595 aa) |
