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atpD atpD atpC atpC CBH22179.1 CBH22179.1 asrB asrB hpt-2 hpt-2 dfp dfp coaD coaD fliI fliI pyrH pyrH CBH21806.1 CBH21806.1 purA purA CBH22598.1 CBH22598.1 carB carB carA carA CBH22436.1 CBH22436.1 udk udk CBH21550.1 CBH21550.1 coaE coaE ackA ackA apt apt relA relA ADSL ADSL pyrB pyrB yacB yacB CBH21068.1 CBH21068.1 yqjD yqjD CBH21045.1 CBH21045.1 accA accA accD accD accC accC CBH20848.1 CBH20848.1 hpt hpt dacA dacA prsA prsA CBH20511.1 CBH20511.1 purH purH purN purN purM purM purF purF purC purC purE purE guaA guaA guaB guaB CBH20417.1 CBH20417.1 pyrE pyrE pyrD pyrD pyrK pyrK pyrF pyrF pyrC pyrC CBH22434.1 CBH22434.1 atpB-2 atpB-2 atpD-2 atpD-2 adk adk upp upp atpB atpB atpE atpE atpF atpF atpA-2 atpA-2 atpH atpH atpA atpA atpG atpG
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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atpDF1 sector of membrane-bound ATP synthase, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (465 aa)
atpCAtpC; Produces ATP from ADP in the presence of a proton gradient across the membrane. (133 aa)
CBH22179.1Homologs of previously reported genes of unknown function. (448 aa)
asrBAnaerobic sulfite reductase subunit B. (262 aa)
hpt-2Hypoxanthine phosphoribosyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (172 aa)
dfpFused 4'-phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (398 aa)
coaDPantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (162 aa)
fliIFlagellum-specific ATP synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (436 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (237 aa)
CBH21806.1Bifunctional riboflavin kinase/FMN adenylyltransferase; Belongs to the ribF family. (310 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (427 aa)
CBH22598.1Putative Ribose-phosphate pyrophosphokinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (269 aa)
carBCarbamoyl-phosphate synthase large subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (1067 aa)
carACarbamoyl phosphate synthetase small subunit, glutamine amidotransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the CarA family. (360 aa)
CBH22436.1Putative ATPase related protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (140 aa)
udkUridine/cytidine kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (210 aa)
CBH21550.1Protein of unknown function; No homology to any previously reported sequences. (408 aa)
coaEDephosphocoenzyme A kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (200 aa)
ackAAcetate kinase A and propionate kinase 2; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (399 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (170 aa)
relAGTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (729 aa)
ADSLAdenylosuccinate lyase (Adenylosuccinase) (ASL) (ASASE); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (477 aa)
pyrBAspartate carbamoyltransferase, catalytic subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (357 aa)
yacBYacB; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (256 aa)
CBH21068.1Sodium pump decarboxylase, gamma subunit; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation; Belongs to the OadG family. (134 aa)
yqjDCarboxyl transferase YqjD. (513 aa)
CBH21045.1Putative guanosine 3',5'-bis-pyrophosphate (PpGpp) synthesis/degradation protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (264 aa)
accAAcetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (265 aa)
accDacetyl-CoA carboxylase, beta (carboxyltranferase) subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (264 aa)
accCacetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (448 aa)
CBH20848.1RelA/SpoT domain protein. (251 aa)
hptHypoxanthine phosphoribosyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (180 aa)
dacAConserved protein of unknown function; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (271 aa)
prsAPhosphoribosylpyrophosphate synthase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (318 aa)
CBH20511.1Purine or other phosphorylase family 1. (247 aa)
purHFused IMP cyclohydrolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (504 aa)
purNPhosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (188 aa)
purMPhosphoribosylaminoimidazole synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (352 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (447 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the SAICAR synthetase family. (231 aa)
purEN5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (162 aa)
guaAGMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. (509 aa)
guaBIMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (487 aa)
CBH20417.1Homologs of previously reported genes of unknown function. (249 aa)
pyrEOrotate phosphoribosyltransferase (OPRT) (OPRTase); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (184 aa)
pyrDPyrD; Catalyzes the conversion of dihydroorotate to orotate. (311 aa)
pyrKDihydroorotate dehydrogenase (electron transfer subunit). (223 aa)
pyrFOrotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) (OMPdecase); Belongs to the OMP decarboxylase family. Type 2 subfamily. (278 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (408 aa)
CBH22434.1Protein of unknown function; No homology to any previously reported sequences. (209 aa)
atpB-2V-type ATP synthase beta chain (V-type ATPase subunit B); Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit. (457 aa)
atpD-2V-type sodium ATP synthase subunit D; Produces ATP from ADP in the presence of a proton gradient across the membrane. (203 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (226 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa)
atpBF0 sector of membrane-bound ATP synthase, subunit a; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (237 aa)
atpEAtpE; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (84 aa)
atpFF0F1 ATP synthase subunit B; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (169 aa)
atpA-2V-type ATP synthase alpha chain (V-type ATPase subunit A); Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (594 aa)
atpHF0F1 ATP synthase subunit delta; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (180 aa)
atpAF1 sector of membrane-bound ATP synthase, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (504 aa)
atpGF1 sector of membrane-bound ATP synthase, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (284 aa)
Your Current Organism:
Acetoanaerobium sticklandii
NCBI taxonomy Id: 1511
Other names: A. sticklandii, ATCC 12662, BCRC 14485, CCRC 14485, CCRC:14485, CCUG 9281, Clostridium sticklandii, DSM 519, NCIMB 10654, strain StadtmanHF
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