(44 nodes) S-adenosyl-L-methionine-dependent methyltransferase superfamily network (Acetoanaerobium sticklandii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ksgA	Ribosomal RNA small subunit methyltransferase A; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (289 aa)
	gidB	Methyltransferase, SAM-dependent methyltransferase, glucose-inhibited cell-division protein; Specifically methylates the N7 position of a guanine in 16S rRNA; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family. (240 aa)
	CBH22650.1	Methyltransferase. (406 aa)
	CBH22647.1	Putative Modification methylase PstI (Adenine-specific methyltransferase PstI) (M.PstI); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (509 aa)
	CBH22388.1	Putative Cyclopropane-fatty-acyl-phospholipid synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (276 aa)
	yabB	Putative methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (252 aa)
	prmC	Methyltransferase; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. (283 aa)
	CBH22137.1	Methyltransferase type 11 (modular protein). (332 aa)
	hsdM	Type I restriction modification system protein HsdMI. (515 aa)
	trmB	tRNA (guanine-N(7)-)-methyltransferase (tRNA(m7G46)-methyltransferase); Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (222 aa)
	mraW	S-adenosyl-dependent methyltransferase activity on membrane-located substrates; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (310 aa)
	rsmB	RsmB; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. (444 aa)
	CBH21960.1	Putative methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (188 aa)
	prmA	Ribosomal protein L11 methyltransferase; Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family. (312 aa)
	yqfN	YqfN. (242 aa)
	CBH21870.1	Homologs of previously reported genes of unknown function; Belongs to the methyltransferase superfamily. (376 aa)
	CBH21763.1	Uncharacterized RNA methyltransferase BCE_0363; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (475 aa)
	CBH21667.1	Phage modification methylase. (269 aa)
	CBH21662.1	C-5 cytosine-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (466 aa)
	cheR	CheR. (258 aa)
	CBH21462.1	Putative cell adhesion protein (contact hemolysin TlyA-related); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (266 aa)
	CBH21450.1	Putative O-methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (219 aa)
	CBH21385.1	N-6 DNA methylase. (597 aa)
	CBH21315.1	Uncharacterized RNA methyltransferase CTC_01941; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (449 aa)
	CBH21313.1	Putative RNA methylase, NOL1/NOP2/sun family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (455 aa)
	CBH21308.1	SAM dependent methyltransferase. (381 aa)
	CBH21157.1	Predicted type II restriction enzyme, methylase subunit. (1227 aa)
	cobL	Putative Precorrin-6B methylase 2; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (193 aa)
	CBH21036.1	Homologs of previously reported genes of unknown function. (289 aa)
	CBH21012.1	Putative RNA methylase (modular protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (331 aa)
	CBH20979.1	Putative Methyltransferase type 11; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (197 aa)
	rsmH	Methyltransferase; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (348 aa)
	CBH20938.1	Modification methylase Sau3AI (Cytosine-specific methyltransferase Sau3AI) (M.Sau3AI) (fragment). (49 aa)
	CBH20937.1	Modification methylase Sau3AI (Cytosine-specific methyltransferase Sau3AI) (M.Sau3AI) (fragment). (219 aa)
	CBH20842.1	Homologs of previously reported genes of unknown function. (197 aa)
	ybaJ	Putative methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (251 aa)
	CBH20824.1	Putative Methyltransferase type 12; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (205 aa)
	CBH20763.1	Putative methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (250 aa)
	CBH20752.1	Protein of unknown function; No homology to any previously reported sequences. (192 aa)
	CBH20706.1	Homologs of previously reported genes of unknown function. (570 aa)
	CBH20440.1	Cytosine-specific methyltransferase. (326 aa)
	CBH20438.1	Cytosine-specific methyltransferase. (344 aa)
	CBH20191.1	Putative S-adenosylmethionine-dependent methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (201 aa)
	speE	Spermidine synthase (putrescine aminopropyltransferase); Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. (282 aa)

Your Current Organism:

Acetoanaerobium sticklandii

NCBI taxonomy Id: 1511
Other names: A. sticklandii, ATCC 12662, BCRC 14485, CCRC 14485, CCRC:14485, CCUG 9281, Clostridium sticklandii, DSM 519, NCIMB 10654, strain StadtmanHF

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBH20438.1	CBH20440.1	CLOST_0308	CLOST_0310	Cytosine-specific methyltransferase.	Cytosine-specific methyltransferase.	0.981
CBH20438.1	CBH20937.1	CLOST_0308	CLOST_0811	Cytosine-specific methyltransferase.	Modification methylase Sau3AI (Cytosine-specific methyltransferase Sau3AI) (M.Sau3AI) (fragment).	0.954
CBH20438.1	CBH20938.1	CLOST_0308	CLOST_0812	Cytosine-specific methyltransferase.	Modification methylase Sau3AI (Cytosine-specific methyltransferase Sau3AI) (M.Sau3AI) (fragment).	0.573
CBH20438.1	CBH21662.1	CLOST_0308	CLOST_1542	Cytosine-specific methyltransferase.	C-5 cytosine-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.929
CBH20440.1	CBH20438.1	CLOST_0310	CLOST_0308	Cytosine-specific methyltransferase.	Cytosine-specific methyltransferase.	0.981
CBH20440.1	CBH20937.1	CLOST_0310	CLOST_0811	Cytosine-specific methyltransferase.	Modification methylase Sau3AI (Cytosine-specific methyltransferase Sau3AI) (M.Sau3AI) (fragment).	0.995
CBH20440.1	CBH20938.1	CLOST_0310	CLOST_0812	Cytosine-specific methyltransferase.	Modification methylase Sau3AI (Cytosine-specific methyltransferase Sau3AI) (M.Sau3AI) (fragment).	0.578
CBH20440.1	CBH21662.1	CLOST_0310	CLOST_1542	Cytosine-specific methyltransferase.	C-5 cytosine-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.974
CBH20824.1	ybaJ	CLOST_0698	CLOST_0702	Putative Methyltransferase type 12; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.	Putative methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	0.596
CBH20842.1	CBH20979.1	CLOST_0716	CLOST_0854	Homologs of previously reported genes of unknown function.	Putative Methyltransferase type 11; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.	0.608
CBH20937.1	CBH20438.1	CLOST_0811	CLOST_0308	Modification methylase Sau3AI (Cytosine-specific methyltransferase Sau3AI) (M.Sau3AI) (fragment).	Cytosine-specific methyltransferase.	0.954
CBH20937.1	CBH20440.1	CLOST_0811	CLOST_0310	Modification methylase Sau3AI (Cytosine-specific methyltransferase Sau3AI) (M.Sau3AI) (fragment).	Cytosine-specific methyltransferase.	0.995
CBH20937.1	CBH20938.1	CLOST_0811	CLOST_0812	Modification methylase Sau3AI (Cytosine-specific methyltransferase Sau3AI) (M.Sau3AI) (fragment).	Modification methylase Sau3AI (Cytosine-specific methyltransferase Sau3AI) (M.Sau3AI) (fragment).	0.919
CBH20937.1	CBH21662.1	CLOST_0811	CLOST_1542	Modification methylase Sau3AI (Cytosine-specific methyltransferase Sau3AI) (M.Sau3AI) (fragment).	C-5 cytosine-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.931
CBH20938.1	CBH20438.1	CLOST_0812	CLOST_0308	Modification methylase Sau3AI (Cytosine-specific methyltransferase Sau3AI) (M.Sau3AI) (fragment).	Cytosine-specific methyltransferase.	0.573
CBH20938.1	CBH20440.1	CLOST_0812	CLOST_0310	Modification methylase Sau3AI (Cytosine-specific methyltransferase Sau3AI) (M.Sau3AI) (fragment).	Cytosine-specific methyltransferase.	0.578
CBH20938.1	CBH20937.1	CLOST_0812	CLOST_0811	Modification methylase Sau3AI (Cytosine-specific methyltransferase Sau3AI) (M.Sau3AI) (fragment).	Modification methylase Sau3AI (Cytosine-specific methyltransferase Sau3AI) (M.Sau3AI) (fragment).	0.919
CBH20979.1	CBH20842.1	CLOST_0854	CLOST_0716	Putative Methyltransferase type 11; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.	Homologs of previously reported genes of unknown function.	0.608
CBH21012.1	rsmB	CLOST_0887	CLOST_1852	Putative RNA methylase (modular protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.	RsmB; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.	0.404
CBH21036.1	CBH21313.1	CLOST_0911	CLOST_1193	Homologs of previously reported genes of unknown function.	Putative RNA methylase, NOL1/NOP2/sun family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.	0.403

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