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guaD guaD CBH20411.1 CBH20411.1 guaB guaB guaA guaA purE purE purC purC purF purF purM purM purN purN purH purH purD purD CBH20475.1 CBH20475.1 prsA prsA rph rph hpt hpt CBH20848.1 CBH20848.1 deoD deoD CBH21029.1 CBH21029.1 ppx ppx CBH21045.1 CBH21045.1 arcC arcC CBH21081.1 CBH21081.1 adeC adeC ADSL ADSL relA relA apt apt nudF nudF pykF pykF CBH21785.1 CBH21785.1 gmk gmk hpt-2 hpt-2 SurE SurE adk adk CBH22375.1 CBH22375.1 CBH22598.1 CBH22598.1 purA purA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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guaDGuanine deaminase. (154 aa)
CBH20411.15'-Nucleotidase domain protein precursor; Belongs to the 5'-nucleotidase family. (592 aa)
guaBIMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (487 aa)
guaAGMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. (509 aa)
purEN5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (162 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the SAICAR synthetase family. (231 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (447 aa)
purMPhosphoribosylaminoimidazole synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (352 aa)
purNPhosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (188 aa)
purHFused IMP cyclohydrolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (504 aa)
purDPhosphoribosylamine--glycine ligase (modular protein); Belongs to the GARS family. (1669 aa)
CBH20475.1Putative exopolyphosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (304 aa)
prsAPhosphoribosylpyrophosphate synthase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (318 aa)
rphNucleoside-triphosphatase; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (443 aa)
hptHypoxanthine phosphoribosyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (180 aa)
CBH20848.1RelA/SpoT domain protein. (251 aa)
deoDPurine-nucleoside phosphorylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (237 aa)
CBH21029.1Putative Exopolyphosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (500 aa)
ppxPpx1. (513 aa)
CBH21045.1Putative guanosine 3',5'-bis-pyrophosphate (PpGpp) synthesis/degradation protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (264 aa)
arcCCarbamate kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the carbamate kinase family. (311 aa)
CBH21081.1Anaerobic ribonucleoside triphosphate reductase. (782 aa)
adeCAdeC; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. (581 aa)
ADSLAdenylosuccinate lyase (Adenylosuccinase) (ASL) (ASASE); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (477 aa)
relAGTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (729 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (170 aa)
nudFADP-ribose pyrophosphatase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (178 aa)
pykFPyruvate kinase I; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the pyruvate kinase family. (583 aa)
CBH21785.1Phosphoglucomutase. (576 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (204 aa)
hpt-2Hypoxanthine phosphoribosyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (172 aa)
SurEPredicted acid phosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (253 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (226 aa)
CBH22375.1Ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent. (783 aa)
CBH22598.1Putative Ribose-phosphate pyrophosphokinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (269 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (427 aa)
Your Current Organism:
Acetoanaerobium sticklandii
NCBI taxonomy Id: 1511
Other names: A. sticklandii, ATCC 12662, BCRC 14485, CCRC 14485, CCRC:14485, CCUG 9281, Clostridium sticklandii, DSM 519, NCIMB 10654, strain StadtmanHF
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