(22 nodes) 2-Oxocarboxylic acid metabolism network (Acetoanaerobium sticklandii)

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Your Input:
	asd	Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (327 aa)
	astC	Succinylornithine transaminase, PLP-dependent; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (404 aa)
	argB	Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (286 aa)
	argJ	ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (417 aa)
	argC	N-acetyl-gamma-glutamylphosphate reductase, NAD(P)-binding; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (348 aa)
	ilvE	Branched-chain-amino-acid aminotransferase (BCAT). (340 aa)
	leuA	2-isopropylmalate synthase (Alpha-isopropylmalate synthase) (Alpha-IPM synthetase); Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (567 aa)
	leuC	3-isopropylmalate isomerase subunit, dehydratase component; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (422 aa)
	leuD	3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (169 aa)
	leuB	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (383 aa)
	yhdR	Putative aspartate aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (394 aa)
	CBH21079.1	Aspartate aminotransferase. (385 aa)
	CBH21342.1	Aminotransferase class I and II. (438 aa)
	CBH21359.1	Aspartate aminotransferase. (393 aa)
	icd	Isocitrate dehydrogenase, specific for NADP+; Function of homologous gene experimentally demonstrated in an other organism; extrachromosomal origin. (334 aa)
	CBH21364.1	Methylcitrate synthase. (446 aa)
	CBH21533.1	Aspartokinase; Belongs to the aspartokinase family. (442 aa)
	ilvC	Ketol-acid reductoisomerase (NADP(+)); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (328 aa)
	ilvD	Dihydroxyacid dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the IlvD/Edd family. (552 aa)
	ilvB	Acetolactate synthase 3 catalytic subunit. (547 aa)
	CBH22052.1	Putative aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (475 aa)
	ybhJ	Putative enzyme; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (773 aa)

Your Current Organism:

Acetoanaerobium sticklandii

NCBI taxonomy Id: 1511
Other names: A. sticklandii, ATCC 12662, BCRC 14485, CCRC 14485, CCRC:14485, CCUG 9281, Clostridium sticklandii, DSM 519, NCIMB 10654, strain StadtmanHF

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBH21079.1	CBH21342.1	CLOST_0954	CLOST_1222	Aspartate aminotransferase.	Aminotransferase class I and II.	0.900
CBH21079.1	CBH21359.1	CLOST_0954	CLOST_1239	Aspartate aminotransferase.	Aspartate aminotransferase.	0.906
CBH21079.1	CBH21364.1	CLOST_0954	CLOST_1244	Aspartate aminotransferase.	Methylcitrate synthase.	0.847
CBH21079.1	CBH21533.1	CLOST_0954	CLOST_1413	Aspartate aminotransferase.	Aspartokinase; Belongs to the aspartokinase family.	0.831
CBH21079.1	argJ	CLOST_0954	CLOST_0138	Aspartate aminotransferase.	ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family.	0.909
CBH21079.1	icd	CLOST_0954	CLOST_1243	Aspartate aminotransferase.	Isocitrate dehydrogenase, specific for NADP+; Function of homologous gene experimentally demonstrated in an other organism; extrachromosomal origin.	0.811
CBH21079.1	yhdR	CLOST_0954	CLOST_0430	Aspartate aminotransferase.	Putative aspartate aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	0.914
CBH21342.1	CBH21079.1	CLOST_1222	CLOST_0954	Aminotransferase class I and II.	Aspartate aminotransferase.	0.900
CBH21342.1	CBH21359.1	CLOST_1222	CLOST_1239	Aminotransferase class I and II.	Aspartate aminotransferase.	0.900
CBH21342.1	CBH21364.1	CLOST_1222	CLOST_1244	Aminotransferase class I and II.	Methylcitrate synthase.	0.847
CBH21342.1	CBH21533.1	CLOST_1222	CLOST_1413	Aminotransferase class I and II.	Aspartokinase; Belongs to the aspartokinase family.	0.831
CBH21342.1	argJ	CLOST_1222	CLOST_0138	Aminotransferase class I and II.	ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family.	0.909
CBH21342.1	icd	CLOST_1222	CLOST_1243	Aminotransferase class I and II.	Isocitrate dehydrogenase, specific for NADP+; Function of homologous gene experimentally demonstrated in an other organism; extrachromosomal origin.	0.811
CBH21342.1	yhdR	CLOST_1222	CLOST_0430	Aminotransferase class I and II.	Putative aspartate aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	0.900
CBH21359.1	CBH21079.1	CLOST_1239	CLOST_0954	Aspartate aminotransferase.	Aspartate aminotransferase.	0.906
CBH21359.1	CBH21342.1	CLOST_1239	CLOST_1222	Aspartate aminotransferase.	Aminotransferase class I and II.	0.900
CBH21359.1	CBH21364.1	CLOST_1239	CLOST_1244	Aspartate aminotransferase.	Methylcitrate synthase.	0.847
CBH21359.1	CBH21533.1	CLOST_1239	CLOST_1413	Aspartate aminotransferase.	Aspartokinase; Belongs to the aspartokinase family.	0.831
CBH21359.1	argJ	CLOST_1239	CLOST_0138	Aspartate aminotransferase.	ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family.	0.909
CBH21359.1	icd	CLOST_1239	CLOST_1243	Aspartate aminotransferase.	Isocitrate dehydrogenase, specific for NADP+; Function of homologous gene experimentally demonstrated in an other organism; extrachromosomal origin.	0.811

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