STRINGSTRING
AJA10461.1 AJA10461.1 adk adk gpmA gpmA coaE coaE AJA11023.1 AJA11023.1 AJA10994.1 AJA10994.1 AJA10906.1 AJA10906.1 AJA10868.1 AJA10868.1 phaA phaA AJA10769.1 AJA10769.1 argB argB AJA10713.1 AJA10713.1 AJA10680.1 AJA10680.1 AJA10671.1 AJA10671.1 AJA10553.1 AJA10553.1 AJA10551.1 AJA10551.1 AJA10550.1 AJA10550.1 AJA10513.1 AJA10513.1 AJA10463.1 AJA10463.1 tdk tdk AJA10324.1 AJA10324.1 AJA10199.1 AJA10199.1 AJA10165.1 AJA10165.1 aroK aroK AJA10085.1 AJA10085.1 AJA10062.1 AJA10062.1 AJA10039.1 AJA10039.1 ppnK ppnK pyrH pyrH glpK glpK AJA09776.1 AJA09776.1 lysC lysC anmK anmK anmK2 anmK2 AJA09600.1 AJA09600.1 AJA09596.1 AJA09596.1 AJA09559.1 AJA09559.1 AJA09534.1 AJA09534.1 pcaF pcaF AJA09486.1 AJA09486.1 AJA09462.1 AJA09462.1 AJA09461.1 AJA09461.1 AJA09450.1 AJA09450.1 AJA09449.1 AJA09449.1 ndk ndk ppk ppk AJA09404.1 AJA09404.1 AJA09399.1 AJA09399.1 AJA09398.1 AJA09398.1 AJA09383.1 AJA09383.1 AJA09196.1 AJA09196.1 AJA09194.1 AJA09194.1 AJA09187.1 AJA09187.1 cmk cmk AJA09155.1 AJA09155.1 thlA thlA ppdK ppdK AJA09023.1 AJA09023.1 AJA08985.1 AJA08985.1 nodQ nodQ AJA08857.1 AJA08857.1 AJA08843.1 AJA08843.1 glk glk AJA08813.1 AJA08813.1 thrB thrB AJA08768.1 AJA08768.1 tpiA tpiA AJA08752.1 AJA08752.1 ispE ispE nnrE nnrE pgi pgi AJA08682.1 AJA08682.1 lpd lpd AJA08672.1 AJA08672.1 tmk tmk AJA08652.1 AJA08652.1 AJA08650.1 AJA08650.1 AJA08634.1 AJA08634.1 AJA08631.1 AJA08631.1 coaX coaX fda fda pgk pgk gap gap tklB tklB bkdA1 bkdA1 AJA08569.1 AJA08569.1 AJA08526.1 AJA08526.1 AJA08442.1 AJA08442.1 AJA08421.1 AJA08421.1 AJA08407.1 AJA08407.1 AJA08385.1 AJA08385.1 pdhB pdhB pdhA pdhA eno2 eno2 AJA08345.1 AJA08345.1 AJA08192.1 AJA08192.1 AJA08174.1 AJA08174.1 eno1 eno1 AJA08136.1 AJA08136.1 AJA08128.1 AJA08128.1 AJA08078.1 AJA08078.1 AJA08060.1 AJA08060.1 thiL thiL pyk pyk AJA07771.1 AJA07771.1 AJA07753.1 AJA07753.1 AJA07735.1 AJA07735.1 AJA07668.1 AJA07668.1 AJA07631.1 AJA07631.1 proB proB sucA sucA AJA07582.1 AJA07582.1 AJA07579.1 AJA07579.1 fadA2 fadA2 AJA07369.1 AJA07369.1 gmk gmk fadA1 fadA1 AJA07320.1 AJA07320.1 AJA07286.1 AJA07286.1 AJA07155.1 AJA07155.1 paaJ paaJ AJA07059.1 AJA07059.1 AJA07024.1 AJA07024.1 AJA11535.1 AJA11535.1 AJA11530.1 AJA11530.1 AJA11469.1 AJA11469.1 AJA11456.1 AJA11456.1 AJA11352.1 AJA11352.1 AJA11327.1 AJA11327.1 AJA11300.1 AJA11300.1 AJA11297.1 AJA11297.1 AJA11293.1 AJA11293.1 AJA11258.1 AJA11258.1 AJA11152.1 AJA11152.1 prs prs
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AJA10461.1Aminoglycoside phosphotransferase. (327 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa)
gpmA2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (228 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (207 aa)
AJA11023.1Putative pyruvate, phosphate dikinase regulatory protein; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation. (270 aa)
AJA10994.1PfkB protein. (332 aa)
AJA10906.1HipA N-terminal domain-containing protein. (413 aa)
AJA10868.1Hypothetical protein. (350 aa)
phaAAcetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (404 aa)
AJA10769.1PfkB protein. (334 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (299 aa)
AJA10713.1Histidine triad (HIT) protein. (125 aa)
AJA10680.1Putative membrane protein. (67 aa)
AJA10671.1Riboflavin biosynthesis protein RibF; Belongs to the ribF family. (313 aa)
AJA10553.1PTS system fructose subfamily transporter subunit IIA. (142 aa)
AJA10551.1HPr kinase. (148 aa)
AJA10550.1Sensor signal transduction histidine kinase. (534 aa)
AJA10513.1Diguanylate cyclase/phosphodiesterase. (543 aa)
AJA10463.1PAS/PAC sensor signal transduction histidine kinase. (787 aa)
tdkThymidine kinase. (211 aa)
AJA10324.1Diguanylate cyclase/phosphodiesterase. (569 aa)
AJA10199.1Diguanylate phosphodiesterase. (763 aa)
AJA10165.1Signal transduction histidine kinase. (505 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (186 aa)
AJA10085.1Osmosensitive K+ channel histidine kinase. (889 aa)
AJA10062.1Hypothetical protein. (722 aa)
AJA10039.1Aspartate kinase. (480 aa)
ppnKPutative inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (256 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (241 aa)
glpKGlycerol kinase; Belongs to the FGGY kinase family. (495 aa)
AJA09776.1Phosphoenolpyruvate-protein phosphotransferase PtsP; Belongs to the PEP-utilizing enzyme family. (766 aa)
lysCAspartokinase; Belongs to the aspartokinase family. (410 aa)
anmKAnhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (377 aa)
anmK2Anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (365 aa)
AJA09600.1Hypothetical protein. (330 aa)
AJA09596.1acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (381 aa)
AJA09559.1Putative nonspecific lipid-transfer protein. (396 aa)
AJA09534.1PAS domain S-box. (506 aa)
pcaFBeta-ketoadipyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (402 aa)
AJA09486.1Putative lipid kinase. (308 aa)
AJA09462.1PTS system, N-acetylglucosamine-specific IIBC component. (560 aa)
AJA09461.1Phosphoenolpyruvate-protein phosphotransferase. (829 aa)
AJA09450.1Acetyl-CoA C-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (384 aa)
AJA09449.1acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (409 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa)
ppkPolyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (722 aa)
AJA09404.1Hypothetical protein. (261 aa)
AJA09399.1Hypothetical protein. (218 aa)
AJA09398.1CheA signal transduction histidine kinase. (810 aa)
AJA09383.1Periplasmic sensor hybrid histidine kinase. (814 aa)
AJA09196.1Phosphoglycerate/bisphosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. (253 aa)
AJA09194.1Sensor/response regulator hybrid. (873 aa)
AJA09187.1Sensor signal transduction histidine kinase. (435 aa)
cmkCytidylate kinase. (209 aa)
AJA09155.1Sensor signal transduction histidine kinase. (451 aa)
thlAAcetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa)
ppdKPyruvate, phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (887 aa)
AJA09023.1Non-specific protein-tyrosine kinase. (762 aa)
AJA08985.12-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. (173 aa)
nodQBifunctional enzyme NodQ; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (633 aa)
AJA08857.1Hypothetical protein. (1689 aa)
AJA08843.1Putative PAS/PAC sensor protein. (297 aa)
glkGlucokinase; Belongs to the bacterial glucokinase family. (323 aa)
AJA08813.1Sensor signal transduction histidine kinase. (409 aa)
thrBHomoserine kinase; Belongs to the pseudomonas-type ThrB family. (320 aa)
AJA08768.1Histidine kinase. (455 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (250 aa)
AJA08752.1Crp/FNR family transcriptional regulator. (227 aa)
ispE4-diphosphocytidyl-2-C-methyl-D- erythritolkinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (282 aa)
nnrEYjeF-related protein-like protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. In the C-terminal section; belongs to the NnrD/CARKD family. (450 aa)
pgiGlucose-6-phosphate isomerase; Belongs to the GPI family. (502 aa)
AJA08682.1Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (430 aa)
lpdDihydrolipoyl dehydrogenase. (465 aa)
AJA08672.1acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (416 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (219 aa)
AJA08652.1Multi-sensor signal transduction histidine kinase. (763 aa)
AJA08650.1Signal transduction histidine kinase, nitrogen specific, NtrB. (363 aa)
AJA08634.1Histidine kinase A-like protein. (541 aa)
AJA08631.1Hypothetical protein. (98 aa)
coaXType III pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (261 aa)
fdaFructose-bisphosphate aldolase class 1. (296 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (398 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa)
tklBTransketolase; Belongs to the transketolase family. (655 aa)
bkdA12-oxoisovalerate dehydrogenase subunit alpha. (436 aa)
AJA08569.1ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein. (343 aa)
AJA08526.1Hypothetical protein. (728 aa)
AJA08442.1HPr kinase. (288 aa)
AJA08421.1Phosphomethylpyrimidine kinase. (385 aa)
AJA08407.1Sensor signal transduction histidine kinase. (704 aa)
AJA08385.1Signal transduction histidine kinase LytS. (390 aa)
pdhBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (462 aa)
pdhAPyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (356 aa)
eno2Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (424 aa)
AJA08345.1Sensor signal transduction histidine kinase. (468 aa)
AJA08192.1Hypothetical protein. (692 aa)
AJA08174.1Sensor signal transduction histidine kinase. (598 aa)
eno1Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (432 aa)
AJA08136.1Aminoglycoside phosphotransferase. (326 aa)
AJA08128.1Diguanylate cyclase domain protein. (785 aa)
AJA08078.1ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein. (340 aa)
AJA08060.1Two-component system sensor histidine kinase. (621 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (309 aa)
pykPyruvate kinase; Belongs to the pyruvate kinase family. (484 aa)
AJA07771.1PfkB protein. (339 aa)
AJA07753.1Hypothetical protein; Belongs to the FGGY kinase family. (472 aa)
AJA07735.1Transcriptional regulator/sugar kinase. (309 aa)
AJA07668.1Diacylglycerol kinase catalytic subunit. (324 aa)
AJA07631.1Hypothetical protein. (134 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (367 aa)
sucA2-oxoglutarate dehydrogenase E1 component. (940 aa)
AJA07582.1Sphingosine kinase. (276 aa)
AJA07579.1Hypothetical protein. (346 aa)
fadA23-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa)
AJA07369.1Hypothetical protein. (160 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (220 aa)
fadA13-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (389 aa)
AJA07320.12-dehydro-3-deoxygalactonokinase. (290 aa)
AJA07286.1Hypothetical protein. (371 aa)
AJA07155.1Hypothetical protein. (135 aa)
paaJ3-oxoadipyl-CoA/3-oxo-5, 6-dehydrosuberyl-CoAthiolase; Belongs to the thiolase-like superfamily. Thiolase family. (400 aa)
AJA07059.1Hypothetical protein. (448 aa)
AJA07024.1Integral membrane sensor signal transduction histidine kinase. (754 aa)
AJA11535.1Phosphoglycerate/bisphosphoglycerate mutase. (189 aa)
AJA11530.1Cobalbumin biosynthesis enzyme; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (173 aa)
AJA11469.1Putative lipid kinase. (308 aa)
AJA11456.1Hypothetical protein. (344 aa)
AJA11352.1Two-component system sensor histidine kinase. (624 aa)
AJA11327.1Signal transduction histidine kinase. (356 aa)
AJA11300.1Hypothetical protein. (310 aa)
AJA11297.1Hypothetical protein. (88 aa)
AJA11293.1Hypothetical protein. (750 aa)
AJA11258.1Signal transduction histidine kinase LytS. (374 aa)
AJA11152.1Transketolase, central region. (733 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (311 aa)
Your Current Organism:
Sphingopyxis fribergensis
NCBI taxonomy Id: 1515612
Other names: DSM 28731, LMG 28478, LMG:28478, S. fribergensis, Sphingopyxis fribergensis Oelschlagel et al. 2015, Sphingopyxis sp. Kp5.2, strain Kp5.2
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