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aksA aksA AJG96904.1 AJG96904.1 AJG96905.1 AJG96905.1 AJG96918.1 AJG96918.1 buk buk AJG96927.1 AJG96927.1 leuA_2 leuA_2 leuC leuC leuD leuD leuB leuB AJG96932.1 AJG96932.1 ilvC_2 ilvC_2 AJG96997.1 AJG96997.1 AJG97024.1 AJG97024.1 AJG97025.1 AJG97025.1 mmgB mmgB AJG97113.1 AJG97113.1 AJG97393.1 AJG97393.1 AJG97427.1 AJG97427.1 AJG97429.2 AJG97429.2 AJG97553.1 AJG97553.1 AJG97682.1 AJG97682.1 ldh-3 ldh-3 AJG97714.1 AJG97714.1 eutD eutD ackA ackA garR garR AJG98159.1 AJG98159.1 AJG98259.1 AJG98259.1 ilvD ilvD AJG98611.1 AJG98611.1 AJG98768.1 AJG98768.1 AJG98769.2 AJG98769.2 AJG98792.1 AJG98792.1 acdA_1 acdA_1 phaJ_2 phaJ_2 AJG98798.1 AJG98798.1 leuA_4 leuA_4 AJG99160.1 AJG99160.1 AJG99323.1 AJG99323.1 AJG99404.1 AJG99404.1 AJG99405.2 AJG99405.2 ilvN ilvN AJG99416.1 AJG99416.1 AJG99880.1 AJG99880.1 camK_1 camK_1 AJH00318.1 AJH00318.1 phaJ phaJ AJH00389.1 AJH00389.1 atoB atoB AJH00647.1 AJH00647.1 korB_1 korB_1 ydiF_4 ydiF_4 AJH00844.2 AJH00844.2 AJH00857.1 AJH00857.1 ctfA ctfA AJH00859.1 AJH00859.1 adc adc buk-2 buk-2 AJH01048.1 AJH01048.1 korB_2 korB_2 korA_2 korA_2 AJH01087.1 AJH01087.1 pduL pduL bssA_1 bssA_1 ldh ldh ilvD_2 ilvD_2 AJH01282.1 AJH01282.1 AJH01366.2 AJH01366.2 nifJ_3 nifJ_3 AJH01598.1 AJH01598.1 AJH01599.1 AJH01599.1 AJH01600.1 AJH01600.1 AJH01659.1 AJH01659.1 buk2_3 buk2_3 AJH02086.1 AJH02086.1 AJH02257.1 AJH02257.1 AMK50376.1 AMK50376.1 ldh-2 ldh-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
aksAHomoaconitate hydratase; In Methanococcus jannaschii this protein catalyzes the condensation of alpha-ketoglutarate and acetyl-CoA to form trans-homoaconitate; functions in alphaketosuberate synthesis which is a precursor in coenzyme B and biotin synthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the alpha-IPM synthase/homocitrate synthase family. (389 aa)
AJG96904.1Fumarate hydratase; Catalyzes the reversible hydration of fumaric acid to yield I-malic acid; Derived by automated computational analysis using gene prediction method: Protein Homology. (280 aa)
AJG96905.1Fumarate hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (185 aa)
AJG96918.1Phosphate butyryltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (302 aa)
bukButyrate kinase; Catalyzes the phosphorylation of 2-butanoate to butanoyl phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the acetokinase family. (355 aa)
AJG96927.1Acetolactate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (169 aa)
leuA_2Transferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the alpha-IPM synthase/homocitrate synthase family. (531 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (419 aa)
leuD3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (161 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (360 aa)
AJG96932.1Acetolactate synthase catalytic subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (557 aa)
ilvC_2Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (334 aa)
AJG96997.1Bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (860 aa)
AJG97024.1Crotonase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the enoyl-CoA hydratase/isomerase family. (261 aa)
AJG97025.1acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (379 aa)
mmgB3-hydroxybutyryl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (282 aa)
AJG97113.1acetyl-CoA acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa)
AJG97393.1Glycyl radical enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology. (801 aa)
AJG97427.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (484 aa)
AJG97429.2Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (493 aa)
AJG97553.1Pyruvate, phosphate dikinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PEP-utilizing enzyme family. (875 aa)
AJG97682.1Formate acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (743 aa)
ldh-3L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (316 aa)
AJG97714.1Branched chain amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (342 aa)
eutDPhosphate acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (333 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa)
garROxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (291 aa)
AJG98159.1Pyruvate-flavodoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1172 aa)
AJG98259.1Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (543 aa)
ilvDDihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (556 aa)
AJG98611.1Pyruvate-flavodoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1171 aa)
AJG98768.1Isopropylmalate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (304 aa)
AJG98769.2Homocitrate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the alpha-IPM synthase/homocitrate synthase family. (250 aa)
AJG98792.1Crotonase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the enoyl-CoA hydratase/isomerase family. (261 aa)
acdA_1acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (379 aa)
phaJ_2enoyl-CoA hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (141 aa)
AJG98798.1CoA-transferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 3-oxoacid CoA-transferase family. (518 aa)
leuA_42-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (667 aa)
AJG99160.1Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (556 aa)
AJG99323.1Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (543 aa)
AJG99404.1Branched-chain amino acid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (238 aa)
AJG99405.2Acetate CoA-transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (217 aa)
ilvNAcetolactate synthase isozyme 1 small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (101 aa)
AJG99416.1Acetolactate synthase catalytic subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (560 aa)
AJG99880.1Crotonase; Derived by automated computational analysis using gene prediction method: Protein Homology. (278 aa)
camK_1Crotonase; Derived by automated computational analysis using gene prediction method: Protein Homology. (276 aa)
AJH00318.13-oxoacid CoA-transferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 3-oxoacid CoA-transferase family. (515 aa)
phaJenoyl-CoA hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (138 aa)
AJH00389.1CoA-transferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 3-oxoacid CoA-transferase family. (514 aa)
atoBacetyl-CoA acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
AJH00647.12-oxoacid:ferredoxin oxidoreductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (555 aa)
korB_12-oxoacid ferredoxin oxidoreductase; Catalyzes the coenzyme A-dependent decarboxylation of 2-oxoacids, such as pyruvate and 2-oxoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. (282 aa)
ydiF_4CoA-transferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 3-oxoacid CoA-transferase family. (508 aa)
AJH00844.23-hydroxybutyryl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (312 aa)
AJH00857.1Aldehyde dehydrogenase EutE; Derived by automated computational analysis using gene prediction method: Protein Homology. (468 aa)
ctfABranched-chain amino acid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (217 aa)
AJH00859.1Acetate CoA-transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (221 aa)
adcAcetoacetate decarboxylase; Catalyzes the conversion of acetoacetate to acetone and carbon dioxide; Belongs to the ADC family. (246 aa)
buk-2Butyrate kinase; Catalyzes the phosphorylation of 2-butanoate to butanoyl phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the acetokinase family. (356 aa)
AJH01048.1Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (390 aa)
korB_22-oxoacid ferredoxin oxidoreductase; Catalyzes the coenzyme A-dependent decarboxylation of 2-oxoacids, such as pyruvate and 2-oxoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. (283 aa)
korA_22-oxoacid:ferredoxin oxidoreductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (561 aa)
AJH01087.1Aldehyde dehydrogenase EutE; Derived by automated computational analysis using gene prediction method: Protein Homology. (472 aa)
pduLPhosphate propanoyltransferase; Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. (212 aa)
bssA_1Glycyl radical enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology. (844 aa)
ldhL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (316 aa)
ilvD_2Dihydroxy-acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (571 aa)
AJH01282.1Acylphosphatase; Catalyzes the hydrolysis of acylphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (90 aa)
AJH01366.2Aminotransferase class IV; Derived by automated computational analysis using gene prediction method: Protein Homology. (244 aa)
nifJ_3Pyruvate-flavodoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1169 aa)
AJH01598.1acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (379 aa)
AJH01599.13-oxoacid CoA-transferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 3-oxoacid CoA-transferase family. (517 aa)
AJH01600.1Crotonase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the enoyl-CoA hydratase/isomerase family. (258 aa)
AJH01659.13-oxoacid CoA-transferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 3-oxoacid CoA-transferase family. (516 aa)
buk2_3Butyrate kinase; Catalyzes the phosphorylation of 2-butanoate to butanoyl phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the acetokinase family. (356 aa)
AJH02086.1Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1146 aa)
AJH02257.1Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (391 aa)
AMK50376.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (466 aa)
ldh-2L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. (315 aa)
Your Current Organism:
Clostridium beijerinckii
NCBI taxonomy Id: 1520
Other names: ATCC 25752, BCRC 14488, C. beijerinckii, CCUG 56442, CIP 104308, Clostridium rubrum, Clostridium sp. H18, DSM 791, LMG 5716, LMG:5716, NCIMB 9362, NCTC 13035
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