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AJG97225.1 AJG97225.1 asd_1 asd_1 AJG96932.1 AJG96932.1 leuB leuB AJG98768.1 AJG98768.1 AJG98769.2 AJG98769.2 leuA_4 leuA_4 AJG99160.1 AJG99160.1 ilvN ilvN AJG99416.1 AJG99416.1 ilvD_2 ilvD_2 AJH01162.1 AJH01162.1 leuD leuD leuC leuC leuA_2 leuA_2 AJG96927.1 AJG96927.1 aksA aksA AJG98368.1 AJG98368.1 ilvD ilvD AJG97714.1 AJG97714.1 ilvC_2 ilvC_2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AJG97225.1Aspartate-semialdehyde dehydrogenase; Catalyzes the formation of aspartate semialdehyde from aspartyl phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate-semialdehyde dehydrogenase family. (361 aa)
asd_1Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (330 aa)
AJG96932.1Acetolactate synthase catalytic subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (557 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (360 aa)
AJG98768.1Isopropylmalate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (304 aa)
AJG98769.2Homocitrate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the alpha-IPM synthase/homocitrate synthase family. (250 aa)
leuA_42-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (667 aa)
AJG99160.1Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (556 aa)
ilvNAcetolactate synthase isozyme 1 small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (101 aa)
AJG99416.1Acetolactate synthase catalytic subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (560 aa)
ilvD_2Dihydroxy-acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (571 aa)
AJH01162.14-amino-4-deoxychorismate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (243 aa)
leuD3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (161 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (419 aa)
leuA_2Transferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the alpha-IPM synthase/homocitrate synthase family. (531 aa)
AJG96927.1Acetolactate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (169 aa)
aksAHomoaconitate hydratase; In Methanococcus jannaschii this protein catalyzes the condensation of alpha-ketoglutarate and acetyl-CoA to form trans-homoaconitate; functions in alphaketosuberate synthesis which is a precursor in coenzyme B and biotin synthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the alpha-IPM synthase/homocitrate synthase family. (389 aa)
AJG98368.1Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (431 aa)
ilvDDihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (556 aa)
AJG97714.1Branched chain amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (342 aa)
ilvC_2Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (334 aa)
Your Current Organism:
Clostridium beijerinckii
NCBI taxonomy Id: 1520
Other names: ATCC 25752, BCRC 14488, C. beijerinckii, CCUG 56442, CIP 104308, Clostridium rubrum, Clostridium sp. H18, DSM 791, LMG 5716, LMG:5716, NCIMB 9362, NCTC 13035
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