(52 nodes) Pyridoxal phosphate binding network (Clostridium beijerinckii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	lysN_2	GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (505 aa)
	AJH01156.1	Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (387 aa)
	patA_3	Catalyzes the transamination of the aromatic amino acid forming a ketoacid; first step in aromatic amino acid degradation in lactococci; Derived by automated computational analysis using gene prediction method: Protein Homology. (390 aa)
	AJH01273.1	GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (480 aa)
	AJH01332.1	Acylneuraminate cytidylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (244 aa)
	AJH01338.2	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (265 aa)
	AJH01366.2	Aminotransferase class IV; Derived by automated computational analysis using gene prediction method: Protein Homology. (244 aa)
	AJH01368.1	Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (397 aa)
	AJH01400.1	4-aminobutyrate--2-oxoglutarate transaminase; Catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (446 aa)
	AJH01409.1	Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family. (311 aa)
	argD	Acetylornithine aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (393 aa)
	lysA	Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (431 aa)
	aspC	Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (396 aa)
	AMK50521.1	Glycogen phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (811 aa)
	AJG97311.1	O-acetylhomoserine aminocarboxypropyltransferase; Catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol; Derived by automated computational analysis using gene prediction method: Protein Homology. (429 aa)
	cysK	Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family. (303 aa)
	AJG96977.1	Maltose phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (753 aa)
	AJG96955.1	Catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology. (378 aa)
	AJG96954.1	Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (382 aa)
	serC	3-phosphoserine/phosphohydroxythreonine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (360 aa)
	AJG98379.1	Threonine dehydratase; Catalyzes the formation of 2-oxobutanoate from L-threonine; Derived by automated computational analysis using gene prediction method: Protein Homology. (406 aa)
	AJG98405.1	Alanine racemase; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. (226 aa)
	AJG98522.1	Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (396 aa)
	AJG98533.1	Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
	hisC	Histidinol-phosphate aminotransferase; Catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (354 aa)
	glyA	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (411 aa)
	AJG98683.1	Aspartate 4-decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (544 aa)
	AJG98695.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (441 aa)
	AJG98734.1	Diaminopropionate ammonia-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (400 aa)
	AJG98748.2	Molybdenum cofactor sulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology. (143 aa)
	AJG98978.1	GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (491 aa)
	AJG99076.1	GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (474 aa)
	AJG99173.1	Pyridoxal-5'-phosphate-dependent protein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (320 aa)
	AJG99252.1	Cysteine desulfurase DndA; Derived by automated computational analysis using gene prediction method: Protein Homology. (383 aa)
	AJG99286.1	D-amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (282 aa)
	alr_1	Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (376 aa)
	AJG99873.1	Cystathionine beta-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (396 aa)
	AJH00201.1	Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (144 aa)
	AJH00530.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (371 aa)
	AJH00539.1	O-acetylhomoserine aminocarboxypropyltransferase; Catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol; Derived by automated computational analysis using gene prediction method: Protein Homology. (434 aa)
	AJH00664.1	Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (444 aa)
	AJH00815.1	Molybdenum cofactor sulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology. (143 aa)
	AJH01076.1	GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (450 aa)
	mdeA_1	O-acetylhomoserine aminocarboxypropyltransferase; Catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol; Derived by automated computational analysis using gene prediction method: Protein Homology. (432 aa)
	metC_1	Catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology. (386 aa)
	AJG97469.1	O-acetylhomoserine aminocarboxypropyltransferase; Catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol; Derived by automated computational analysis using gene prediction method: Protein Homology. (429 aa)
	AJG97574.1	Glycogen phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (786 aa)
	iscS	Cysteine desulfurase NifS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (393 aa)
	AJG98013.1	Threonine-phosphate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (361 aa)
	hemL	Glutamate-1-semialdehyde aminotransferase; Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate; Derived by automated computational analysis using gene prediction method: Protein Homology. (431 aa)
	iscS_2	Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology. (382 aa)
	AJG98063.1	Aminotransferase class I/II; Derived by automated computational analysis using gene prediction method: Protein Homology. (346 aa)

Your Current Organism:

Clostridium beijerinckii

NCBI taxonomy Id: 1520
Other names: ATCC 25752, BCRC 14488, C. beijerinckii, CCUG 56442, CIP 104308, Clostridium rubrum, Clostridium sp. H18, DSM 791, LMG 5716, LMG:5716, NCIMB 9362, NCTC 13035

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AJG96954.1	AJG96955.1	LF65_00279	LF65_00280	Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.966
AJG96954.1	AJG97311.1	LF65_00279	LF65_00680	Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	O-acetylhomoserine aminocarboxypropyltransferase; Catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.933
AJG96954.1	AJG97469.1	LF65_00279	LF65_00844	Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	O-acetylhomoserine aminocarboxypropyltransferase; Catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.933
AJG96954.1	AJG98379.1	LF65_00279	LF65_01776	Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Threonine dehydratase; Catalyzes the formation of 2-oxobutanoate from L-threonine; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.842
AJG96954.1	AJG98522.1	LF65_00279	LF65_01923	Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.930
AJG96954.1	AJG99173.1	LF65_00279	LF65_02600	Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyridoxal-5'-phosphate-dependent protein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.842
AJG96954.1	AJG99873.1	LF65_00279	LF65_03310	Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Cystathionine beta-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.930
AJG96954.1	AJH00530.1	LF65_00279	LF65_03982	Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.927
AJG96954.1	AJH00539.1	LF65_00279	LF65_03991	Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	O-acetylhomoserine aminocarboxypropyltransferase; Catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.933
AJG96954.1	AJH01366.2	LF65_00279	LF65_04837	Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Aminotransferase class IV; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.920
AJG96954.1	AJH01409.1	LF65_00279	LF65_04880	Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family.	0.967
AJG96954.1	cysK	LF65_00279	LF65_00648	Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family.	0.967
AJG96954.1	mdeA_1	LF65_00279	LF65_00693	Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	O-acetylhomoserine aminocarboxypropyltransferase; Catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.935
AJG96954.1	metC_1	LF65_00279	LF65_00700	Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.904
AJG96955.1	AJG96954.1	LF65_00280	LF65_00279	Catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology.	Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.966
AJG96955.1	AJG97311.1	LF65_00280	LF65_00680	Catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology.	O-acetylhomoserine aminocarboxypropyltransferase; Catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.774
AJG96955.1	AJG97469.1	LF65_00280	LF65_00844	Catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology.	O-acetylhomoserine aminocarboxypropyltransferase; Catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.773
AJG96955.1	AJG98379.1	LF65_00280	LF65_01776	Catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology.	Threonine dehydratase; Catalyzes the formation of 2-oxobutanoate from L-threonine; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.842
AJG96955.1	AJG98522.1	LF65_00280	LF65_01923	Catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology.	Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.929
AJG96955.1	AJG99173.1	LF65_00280	LF65_02600	Catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyridoxal-5'-phosphate-dependent protein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.842

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