STRINGSTRING
AJG97427.1 AJG97427.1 spoVG spoVG ctsR ctsR clpC clpC sigH sigH buk buk AJG96997.1 AJG96997.1 AJG97024.1 AJG97024.1 AJG97025.1 AJG97025.1 mmgB mmgB groS groS groEL groEL pgi pgi spoIIQ spoIIQ spoIIID spoIIID pyk_2 pyk_2 spoIVFB spoIVFB tpiA tpiA gpmI gpmI eno eno AJG97429.2 AJG97429.2 cheV cheV spoIIAA spoIIAA spoIIAB spoIIAB hrcA hrcA grpE grpE dnaK dnaK dnaJ dnaJ pfkA_1 pfkA_1 ftsZ ftsZ sigG sigG nrdR nrdR spoIVA spoIVA eutD eutD ackA ackA acp acp ftsY ftsY murE murE clpP_2 clpP_2 clpX clpX AJG98117.1 AJG98117.1 AJG98216.1 AJG98216.1 mraZ mraZ murE-2 murE-2 murF murF spoVE spoVE spo0A spo0A dapB dapB dapA dapA asd_1 asd_1 fba fba AJG98792.1 AJG98792.1 acdA_1 acdA_1 AJG98798.1 AJG98798.1 AJG99351.1 AJG99351.1 gapN gapN AJG99576.1 AJG99576.1 AJG99880.1 AJG99880.1 camK_1 camK_1 ftsE ftsE AJH00302.2 AJH00302.2 AJH00389.1 AJH00389.1 AJH00834.1 AJH00834.1 ydiF_4 ydiF_4 ctfA ctfA adc adc clpP clpP buk-2 buk-2 fliE fliE AJH01322.1 AJH01322.1 AJH01341.1 AJH01341.1 AJH01598.1 AJH01598.1 AJH01600.1 AJH01600.1 fbaA fbaA AJH01617.2 AJH01617.2 pheA pheA buk2_3 buk2_3 dapA_2 dapA_2 pyk_3 pyk_3 pfkA_2 pfkA_2 ftsX_2 ftsX_2 ftsE-2 ftsE-2 glcK_2 glcK_2 dapA-2 dapA-2 AMK50376.1 AMK50376.1 glgC glgC glgA glgA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AJG97427.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (484 aa)
spoVGTranscriptional regulator; Could be involved in septation. (91 aa)
ctsRCtsR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CtsR family. (151 aa)
clpCATP-dependent Clp protease ATP-binding subunit ClpC; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ClpA/ClpB family. (824 aa)
sigHDNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. (215 aa)
bukButyrate kinase; Catalyzes the phosphorylation of 2-butanoate to butanoyl phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the acetokinase family. (355 aa)
AJG96997.1Bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (860 aa)
AJG97024.1Crotonase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the enoyl-CoA hydratase/isomerase family. (261 aa)
AJG97025.1acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (379 aa)
mmgB3-hydroxybutyryl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (282 aa)
groSCo-chaperone GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (94 aa)
groELMolecular chaperone GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (541 aa)
pgiGlucose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GPI family. (449 aa)
spoIIQPeptidase M23; Derived by automated computational analysis using gene prediction method: Protein Homology. (245 aa)
spoIIIDStage III sporulation protein D; Derived by automated computational analysis using gene prediction method: Protein Homology. (84 aa)
pyk_2Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (472 aa)
spoIVFBPeptidase M50; Derived by automated computational analysis using gene prediction method: Protein Homology. (285 aa)
tpiATriose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (248 aa)
gpmI2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (512 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (430 aa)
AJG97429.2Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (493 aa)
cheVChemotaxis protein CheV; Derived by automated computational analysis using gene prediction method: Protein Homology. (299 aa)
spoIIAAAnti-anti-sigma factor; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the anti-sigma-factor antagonist family. (111 aa)
spoIIABAnti-sigma F factor; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition. (143 aa)
hrcAHeat-inducible transcriptional repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. (342 aa)
grpEMolecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] (207 aa)
dnaKMolecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (614 aa)
dnaJMolecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] (377 aa)
pfkA_16-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (365 aa)
ftsZCell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (379 aa)
sigGRNA polymerase sigma-G factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (257 aa)
nrdRNrdR family transcriptional regulator; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (149 aa)
spoIVAStage IV sporulation protein A; ATPase. Has a role at an early stage in the morphogenesis of the spore coat. (492 aa)
eutDPhosphate acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (333 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa)
acpAcyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (76 aa)
ftsYSignal recognition particle-docking protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). (302 aa)
murEUDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (489 aa)
clpP_2ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (199 aa)
clpXATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (429 aa)
AJG98117.1Pyruvate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pyruvate kinase family. (340 aa)
AJG98216.1Fructose-bisphosphate aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (285 aa)
mraZDivision/cell wall cluster transcriptional repressor MraZ; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the MraZ family. (142 aa)
murE-2UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (486 aa)
murFUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (450 aa)
spoVERod shape-determining protein RodA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SEDS family. (378 aa)
spo0ASporulation transcription factor Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. (273 aa)
dapB4-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (251 aa)
dapA4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa)
asd_1Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (330 aa)
fbaFructose-bisphosphate aldolase; Catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (288 aa)
AJG98792.1Crotonase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the enoyl-CoA hydratase/isomerase family. (261 aa)
acdA_1acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (379 aa)
AJG98798.1CoA-transferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 3-oxoacid CoA-transferase family. (518 aa)
AJG99351.1Fructose-bisphosphate aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (284 aa)
gapNGlyceraldehyde-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (486 aa)
AJG99576.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (210 aa)
AJG99880.1Crotonase; Derived by automated computational analysis using gene prediction method: Protein Homology. (278 aa)
camK_1Crotonase; Derived by automated computational analysis using gene prediction method: Protein Homology. (276 aa)
ftsECell division ATP-binding protein FtsE; Part of the ABC transporter FtsEX involved in cellular division. (228 aa)
AJH00302.2Spore cortex-lytic protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (443 aa)
AJH00389.1CoA-transferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 3-oxoacid CoA-transferase family. (514 aa)
AJH00834.1Sugar kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (297 aa)
ydiF_4CoA-transferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 3-oxoacid CoA-transferase family. (508 aa)
ctfABranched-chain amino acid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (217 aa)
adcAcetoacetate decarboxylase; Catalyzes the conversion of acetoacetate to acetone and carbon dioxide; Belongs to the ADC family. (246 aa)
clpPATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (192 aa)
buk-2Butyrate kinase; Catalyzes the phosphorylation of 2-butanoate to butanoyl phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the acetokinase family. (356 aa)
fliEFlagellar hook-basal body protein FliE; Derived by automated computational analysis using gene prediction method: Protein Homology. (105 aa)
AJH01322.1Flagellin; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (276 aa)
AJH01341.1Hypothetical protein; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (548 aa)
AJH01598.1acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (379 aa)
AJH01600.1Crotonase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the enoyl-CoA hydratase/isomerase family. (258 aa)
fbaAFructose-bisphosphate aldolase; Catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (281 aa)
AJH01617.2Sugar kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (292 aa)
pheABifunctional chorismate mutase/prephenate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (378 aa)
buk2_3Butyrate kinase; Catalyzes the phosphorylation of 2-butanoate to butanoyl phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the acetokinase family. (356 aa)
dapA_24-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa)
pyk_3Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (473 aa)
pfkA_2ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (318 aa)
ftsX_2Cell division protein FtsX; Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation. Belongs to the ABC-4 integral membrane protein family. FtsX subfamily. (296 aa)
ftsE-2Cell division ATP-binding protein FtsE; Part of the ABC transporter FtsEX involved in cellular division. (228 aa)
glcK_2Glucokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (317 aa)
dapA-24-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (289 aa)
AMK50376.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (466 aa)
glgCGlucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (386 aa)
glgAGlycogen synthase; Synthesizes alpha-1,4-glucan chains using ADP-glucose. (479 aa)
Your Current Organism:
Clostridium beijerinckii
NCBI taxonomy Id: 1520
Other names: ATCC 25752, BCRC 14488, C. beijerinckii, CCUG 56442, CIP 104308, Clostridium rubrum, Clostridium sp. H18, DSM 791, LMG 5716, LMG:5716, NCIMB 9362, NCTC 13035
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