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serC serC AJG96954.1 AJG96954.1 AJG96955.1 AJG96955.1 metK_1 metK_1 AJG97225.1 AJG97225.1 cysK cysK cysE_1 cysE_1 AJG97311.1 AJG97311.1 mdeA_1 mdeA_1 metC_1 metC_1 AJG97332.1 AJG97332.1 AJG97469.1 AJG97469.1 ldh-3 ldh-3 AJG97714.1 AJG97714.1 AJG97770.2 AJG97770.2 lysC lysC luxS luxS metA metA AJG98106.1 AJG98106.1 AJG98368.1 AJG98368.1 AJG98522.1 AJG98522.1 asd_1 asd_1 AJG98586.1 AJG98586.1 gshAB gshAB AJG98683.1 AJG98683.1 AJG98845.1 AJG98845.1 AJG99532.1 AJG99532.1 AJG99771.1 AJG99771.1 AJG99772.1 AJG99772.1 metK metK AJG99873.1 AJG99873.1 AJG99879.1 AJG99879.1 AJH00530.1 AJH00530.1 AJH00539.1 AJH00539.1 metK-2 metK-2 ldh ldh AJH01247.1 AJH01247.1 AJH01366.2 AJH01366.2 AJH01368.1 AJH01368.1 AJH01409.1 AJH01409.1 speE speE speD speD AJH01665.1 AJH01665.1 aspC aspC AJH02053.1 AJH02053.1 AJH02064.1 AJH02064.1 metH metH sdhA sdhA AMK50488.1 AMK50488.1 ldh-2 ldh-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
serC3-phosphoserine/phosphohydroxythreonine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (360 aa)
AJG96954.1Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (382 aa)
AJG96955.1Catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology. (378 aa)
metK_1S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (391 aa)
AJG97225.1Aspartate-semialdehyde dehydrogenase; Catalyzes the formation of aspartate semialdehyde from aspartyl phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate-semialdehyde dehydrogenase family. (361 aa)
cysKCysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family. (303 aa)
cysE_1Serine acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (196 aa)
AJG97311.1O-acetylhomoserine aminocarboxypropyltransferase; Catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol; Derived by automated computational analysis using gene prediction method: Protein Homology. (429 aa)
mdeA_1O-acetylhomoserine aminocarboxypropyltransferase; Catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol; Derived by automated computational analysis using gene prediction method: Protein Homology. (432 aa)
metC_1Catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology. (386 aa)
AJG97332.1Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (304 aa)
AJG97469.1O-acetylhomoserine aminocarboxypropyltransferase; Catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol; Derived by automated computational analysis using gene prediction method: Protein Homology. (429 aa)
ldh-3L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (316 aa)
AJG97714.1Branched chain amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (342 aa)
AJG97770.2Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (208 aa)
lysCAspartate kinase; Catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; diaminopimelate sensitive; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (398 aa)
luxSS-ribosylhomocysteinase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (159 aa)
metAHomoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (304 aa)
AJG98106.1Homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (801 aa)
AJG98368.1Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (431 aa)
AJG98522.1Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (396 aa)
asd_1Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (330 aa)
AJG98586.1Homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (593 aa)
gshABGlutathione synthetase; Synthesizes glutathione from L-glutamate and L-cysteine via gamma-L-glutamyl-L-cysteine; In the N-terminal section; belongs to the glutamate--cysteine ligase type 1 family. Type 2 subfamily. (782 aa)
AJG98683.1Aspartate 4-decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (544 aa)
AJG98845.1DNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (505 aa)
AJG99532.1Diguanylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (167 aa)
AJG99771.15-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (378 aa)
AJG99772.15-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the formation of tetrahydropteroyl-L-glutamate and methionine from L-homocysteine and 5-methyltetrahydropteroyltri-L-glutamate; Derived by automated computational analysis using gene prediction method: Protein Homology. (372 aa)
metKCystathionine gamma-lyase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (391 aa)
AJG99873.1Cystathionine beta-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (396 aa)
AJG99879.1Serine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (402 aa)
AJH00530.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (371 aa)
AJH00539.1O-acetylhomoserine aminocarboxypropyltransferase; Catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol; Derived by automated computational analysis using gene prediction method: Protein Homology. (434 aa)
metK-2S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (399 aa)
ldhL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (316 aa)
AJH01247.1Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (437 aa)
AJH01366.2Aminotransferase class IV; Derived by automated computational analysis using gene prediction method: Protein Homology. (244 aa)
AJH01368.1Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (397 aa)
AJH01409.1Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family. (311 aa)
speESpermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine; Belongs to the spermidine/spermine synthase family. (284 aa)
speDS-adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily. (271 aa)
AJH01665.1Hydroxyacid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (314 aa)
aspCAspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (396 aa)
AJH02053.1S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (230 aa)
AJH02064.13-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (302 aa)
metHhistidine--tRNA ligase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1213 aa)
sdhASerine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. (292 aa)
AMK50488.1Serine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. (226 aa)
ldh-2L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. (315 aa)
Your Current Organism:
Clostridium beijerinckii
NCBI taxonomy Id: 1520
Other names: ATCC 25752, BCRC 14488, C. beijerinckii, CCUG 56442, CIP 104308, Clostridium rubrum, Clostridium sp. H18, DSM 791, LMG 5716, LMG:5716, NCIMB 9362, NCTC 13035
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