STRINGSTRING
lpxC lpxC rfaC rfaC lpxB lpxB ispH ispH GCA_900177895_00141 GCA_900177895_00141 GCA_900177895_00182 GCA_900177895_00182 GCA_900177895_00213 GCA_900177895_00213 dxs dxs gpsA gpsA accB accB accC accC GCA_900177895_00318 GCA_900177895_00318 fadM fadM accD accD kdsB kdsB ispD ispD ispF ispF fabF fabF acpP acpP GCA_900177895_00477 GCA_900177895_00477 fabH fabH GCA_900177895_00502 GCA_900177895_00502 kdsC kdsC lex1 lex1 rfbD rfbD GCA_900177895_00597 GCA_900177895_00597 lst lst pseB pseB cat1 cat1 cptA cptA rfaF rfaF kdsA kdsA GCA_900177895_00691 GCA_900177895_00691 ispA ispA suhB_2 suhB_2 dgkA dgkA murG murG fabG fabG GCA_900177895_00835 GCA_900177895_00835 fabD fabD GCA_900177895_00879 GCA_900177895_00879 acpS acpS ispG ispG crtB_1 crtB_1 gspA_1 gspA_1 psd psd GCA_900177895_01058 GCA_900177895_01058 gspA_2 gspA_2 htrB_2 htrB_2 accA accA fadD fadD GCA_900177895_01309 GCA_900177895_01309 GCA_900177895_01316 GCA_900177895_01316 plsC_2 plsC_2 tesA tesA lpxH lpxH GCA_900177895_01331 GCA_900177895_01331 yciK yciK GCA_900177895_01387 GCA_900177895_01387 GCA_900177895_01453 GCA_900177895_01453 pgpB pgpB fabI fabI pgpA pgpA ydfG ydfG htrB_1 htrB_1 GCA_900177895_01662 GCA_900177895_01662 lapB lapB pgsA pgsA lipA lipA plsC_2-2 plsC_2-2 plsY plsY GCA_900177895_01767 GCA_900177895_01767 epsJ_3 epsJ_3 ispE ispE lpxK lpxK GCA_900177895_01956 GCA_900177895_01956 GCA_900177895_02008 GCA_900177895_02008 plsX plsX rssA rssA glmU glmU waaA waaA dxr dxr ispB ispB lpxD lpxD ispU ispU cdsA cdsA lpxA lpxA fabZ fabZ
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lpxCUnannotated protein; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (308 aa)
rfaCUnannotated protein. (325 aa)
lpxBUnannotated protein; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (382 aa)
ispHUnannotated protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (311 aa)
GCA_900177895_00141Unannotated protein. (219 aa)
GCA_900177895_00182Unannotated protein. (207 aa)
GCA_900177895_00213Unannotated protein. (306 aa)
dxsUnannotated protein; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (626 aa)
gpsAUnannotated protein; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (329 aa)
accBUnannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (153 aa)
accCUnannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (453 aa)
GCA_900177895_00318Unannotated protein. (224 aa)
fadMUnannotated protein. (133 aa)
accDUnannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (288 aa)
kdsBUnannotated protein; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (251 aa)
ispDUnannotated protein; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (232 aa)
ispFUnannotated protein; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (159 aa)
fabFUnannotated protein; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (415 aa)
acpPUnannotated protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (77 aa)
GCA_900177895_00477Unannotated protein. (298 aa)
fabHUnannotated protein; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (319 aa)
GCA_900177895_00502Unannotated protein; Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities. Belongs to the phospholipase A1 family. (375 aa)
kdsCUnannotated protein. (179 aa)
lex1Unannotated protein. (263 aa)
rfbDUnannotated protein. (379 aa)
GCA_900177895_00597Unannotated protein. (261 aa)
lstUnannotated protein. (319 aa)
pseBUnannotated protein. (332 aa)
cat1Unannotated protein. (512 aa)
cptAUnannotated protein. (537 aa)
rfaFUnannotated protein. (334 aa)
kdsAUnannotated protein; Belongs to the KdsA family. (279 aa)
GCA_900177895_00691Unannotated protein. (366 aa)
ispAUnannotated protein; Belongs to the FPP/GGPP synthase family. (295 aa)
suhB_2Unannotated protein; Belongs to the inositol monophosphatase superfamily. (264 aa)
dgkAUnannotated protein; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (126 aa)
murGUnannotated protein; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (355 aa)
fabGUnannotated protein; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (248 aa)
GCA_900177895_00835Unannotated protein. (344 aa)
fabDUnannotated protein. (309 aa)
GCA_900177895_00879Unannotated protein. (162 aa)
acpSUnannotated protein; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (126 aa)
ispGUnannotated protein; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (421 aa)
crtB_1Unannotated protein. (286 aa)
gspA_1Unannotated protein. (286 aa)
psdUnannotated protein; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (298 aa)
GCA_900177895_01058Unannotated protein. (227 aa)
gspA_2Unannotated protein. (290 aa)
htrB_2Unannotated protein. (290 aa)
accAUnannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (330 aa)
fadDUnannotated protein. (554 aa)
GCA_900177895_01309Unannotated protein. (71 aa)
GCA_900177895_01316Unannotated protein. (361 aa)
plsC_2Unannotated protein; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (265 aa)
tesAUnannotated protein. (205 aa)
lpxHUnannotated protein; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (247 aa)
GCA_900177895_01331Unannotated protein. (493 aa)
yciKUnannotated protein. (241 aa)
GCA_900177895_01387Unannotated protein. (198 aa)
GCA_900177895_01453Unannotated protein. (230 aa)
pgpBUnannotated protein. (260 aa)
fabIUnannotated protein. (261 aa)
pgpAUnannotated protein; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). (168 aa)
ydfGUnannotated protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (283 aa)
htrB_1Unannotated protein. (289 aa)
GCA_900177895_01662Unannotated protein. (100 aa)
lapBUnannotated protein; Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane; Belongs to the LapB family. (390 aa)
pgsAUnannotated protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (187 aa)
lipAUnannotated protein; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (329 aa)
plsC_2-2Unannotated protein. (243 aa)
plsYUnannotated protein; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (205 aa)
GCA_900177895_01767Unannotated protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (289 aa)
epsJ_3Unannotated protein. (322 aa)
ispEUnannotated protein; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (282 aa)
lpxKUnannotated protein; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (351 aa)
GCA_900177895_01956Unannotated protein. (313 aa)
GCA_900177895_02008Unannotated protein. (549 aa)
plsXUnannotated protein; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (338 aa)
rssAUnannotated protein. (293 aa)
glmUUnannotated protein; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (455 aa)
waaAUnannotated protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (420 aa)
dxrUnannotated protein; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (390 aa)
ispBUnannotated protein; Belongs to the FPP/GGPP synthase family. (324 aa)
lpxDUnannotated protein; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (343 aa)
ispUUnannotated protein; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (249 aa)
cdsAUnannotated protein; Belongs to the CDS family. (264 aa)
lpxAUnannotated protein; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (259 aa)
fabZUnannotated protein; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (175 aa)
Your Current Organism:
Kingella negevensis
NCBI taxonomy Id: 1522312
Other names: CCUG 69806, CSUR P957, K. negevensis, Kingella negevensis El Houmami et al. 2017, Kingella sp. AA267, Kingella sp. AA503, Kingella sp. BB632, Kingella sp. BB713, Kingella sp. CC132, Kingella sp. CC173_6, Kingella sp. CC505b, Kingella sp. CC546, Kingella sp. CHUV31, Kingella sp. D2292, Kingella sp. D2756, Kingella sp. D7323, Kingella sp. EE451, Kingella sp. EPA009, Kingella sp. EPA014, Kingella sp. PED555, Kingella sp. PVC1712, Kingella sp. PVC1735, Kingella sp. SW7208426, Kingella sp. Sch1437, Kingella sp. Sch538, Kingella sp. Sch690, strain Sch538
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