STRINGSTRING
GCA_900177895_02155 GCA_900177895_02155 ribD ribD secB secB secG secG ribA ribA tamB tamB arcD arcD ffh ffh secE secE secY secY yidC yidC zur zur secA secA ttgC ttgC ftsY ftsY GCA_900177895_00276 GCA_900177895_00276 aroG aroG anr anr ftsK_2 ftsK_2 kinB_1 kinB_1 yajC yajC ydgI ydgI ccsB ccsB GCA_900177895_00947 GCA_900177895_00947 ftsK_1 ftsK_1 ftsK_3 ftsK_3 GCA_900177895_01071 GCA_900177895_01071 mphP mphP GCA_900177895_01125 GCA_900177895_01125 fadD fadD GCA_900177895_01211 GCA_900177895_01211 oprM oprM pabA pabA trpE trpE GCA_900177895_01354 GCA_900177895_01354 GCA_900177895_01492 GCA_900177895_01492 GCA_900177895_01494 GCA_900177895_01494 hfq hfq lapB lapB GCA_900177895_01679 GCA_900177895_01679 cya cya fur fur mepM mepM luxS luxS xerC xerC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GCA_900177895_02155Unannotated protein. (153 aa)
ribDUnannotated protein; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (359 aa)
secBUnannotated protein; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. (154 aa)
secGUnannotated protein; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. (114 aa)
ribAUnannotated protein; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. (199 aa)
tamBUnannotated protein. (1287 aa)
arcDUnannotated protein. (473 aa)
ffhUnannotated protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components; Belongs to t [...] (454 aa)
secEUnannotated protein; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. (71 aa)
secYUnannotated protein; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (425 aa)
yidCUnannotated protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. (548 aa)
zurUnannotated protein; Belongs to the Fur family. (154 aa)
secAUnannotated protein; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family. (924 aa)
ttgCUnannotated protein. (486 aa)
ftsYUnannotated protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. (533 aa)
GCA_900177895_00276Unannotated protein. (263 aa)
aroGUnannotated protein; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (343 aa)
anrUnannotated protein. (244 aa)
ftsK_2Unannotated protein. (527 aa)
kinB_1Unannotated protein. (84 aa)
yajCUnannotated protein; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. (107 aa)
ydgIUnannotated protein. (475 aa)
ccsBUnannotated protein. (662 aa)
GCA_900177895_00947Unannotated protein. (170 aa)
ftsK_1Unannotated protein. (841 aa)
ftsK_3Unannotated protein; Belongs to the FtsK/SpoIIIE/SftA family. (963 aa)
GCA_900177895_01071Unannotated protein. (69 aa)
mphPUnannotated protein. (89 aa)
GCA_900177895_01125Unannotated protein. (94 aa)
fadDUnannotated protein. (554 aa)
GCA_900177895_01211Unannotated protein. (175 aa)
oprMUnannotated protein. (541 aa)
pabAUnannotated protein. (188 aa)
trpEUnannotated protein; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. (451 aa)
GCA_900177895_01354Unannotated protein. (467 aa)
GCA_900177895_01492Unannotated protein. (69 aa)
GCA_900177895_01494Unannotated protein. (69 aa)
hfqUnannotated protein; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. (102 aa)
lapBUnannotated protein; Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane; Belongs to the LapB family. (390 aa)
GCA_900177895_01679Unannotated protein. (164 aa)
cyaUnannotated protein. (869 aa)
furUnannotated protein; Belongs to the Fur family. (141 aa)
mepMUnannotated protein. (428 aa)
luxSUnannotated protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (159 aa)
xerCUnannotated protein; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (293 aa)
Your Current Organism:
Kingella negevensis
NCBI taxonomy Id: 1522312
Other names: CCUG 69806, CSUR P957, K. negevensis, Kingella negevensis El Houmami et al. 2017, Kingella sp. AA267, Kingella sp. AA503, Kingella sp. BB632, Kingella sp. BB713, Kingella sp. CC132, Kingella sp. CC173_6, Kingella sp. CC505b, Kingella sp. CC546, Kingella sp. CHUV31, Kingella sp. D2292, Kingella sp. D2756, Kingella sp. D7323, Kingella sp. EE451, Kingella sp. EPA009, Kingella sp. EPA014, Kingella sp. PED555, Kingella sp. PVC1712, Kingella sp. PVC1735, Kingella sp. SW7208426, Kingella sp. Sch1437, Kingella sp. Sch538, Kingella sp. Sch690, strain Sch538
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